Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8ZHP1)

• Drug Name: MCI-186 Drug Info
• Synonyms: Edarabone; Edaravone; Methylphenylpyrazolone; Monopyrazolone; Norantipyrine; Norphenazone; Phenylmethylpyrazolone; Radicut; Developer Z; Edaravone [INN]; Phenyl methyl pyrazolone; CDS1_000986; CI Developer 1; IN1263; M0687; MCI 186; Edaravone(jan); Radicut (TN); AE-641/00371017; C.I. Developer 1; Edaravone (JAN/INN); (MCI-186); 1-Fenyl-3-methyl-2-pyrazolin-5-on; 1-Fenyl-3-methyl-2-pyrazolin-5-on [Czech]; 1-Phenyl-3-methyl-5-oxo-2-pyrazoline; 1-Phenyl-3-methyl-5-pyrazolone; 1-Phenyl-3-methylpyrazolone; 1-Phenyl-3-methylpyrazolone-5; 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one; 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE; 3-Methyl-1-phenyl-2-pyrazoline-5-one; 3-Methyl-1-phenyl-5-pyrazolone; 3-Methyl-1-phenylpyrazol-5-one; 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one; 5-methyl-2-phenyl-4H-pyrazol-3-one

Indication

Disease Entry	ICD 11	Status	REF
Amyotrophic lateral sclerosis	8B60.0	Approved	[1]

• Cross-matching ID:
  PubChem CID: 4021
  ChEBI ID: CHEBI:31530
  CAS Number: CAS 89-25-8
  TTD Drug ID: DM8ZHP1
  VARIDT Drug ID: DR00101
  INTEDE Drug ID: DR1756
  ACDINA Drug ID: D01030

Molecule-Related Drug Atlas

Drug(s) Targeting Apoptosis regulator Bcl-2 (BCL-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Taxol	DMUOT9V	Breast cancer	2C60-2C65	Approved	[9]
GDC-0199	DMH0QKA	Chronic lymphocytic leukaemia	2A82.0	Approved	[10]
ABT-263	DMNE56X	Myelofibrosis	2A20.2	Phase 3	[11]
Taxol/Paraplatin/Herceptin	DML6GAN	Breast cancer	2C60-2C65	Phase 3	[12]
Oblimersen	DM7KI4E	Melanoma	2C30	Phase 3	[13]
RG7601	DMDVAFP	Chronic lymphocytic leukaemia	2A82.0	Phase 3	[10]
Thymoquinone	DMVDTR2	Polycystic ovarian syndrome	5A80.1	Phase 2/3	[14]
Obatoclax	DMPF9ZM	Solid tumour/cancer	2A00-2F9Z	Phase 2	[15]
PI-88/Taxotere	DM4FIWC	Solid tumour/cancer	2A00-2F9Z	Phase 2	[16]
Gossypol	DMJWE3I	Prostate cancer	2C82.0	Phase 2	[17]

Drug(s) Transported By Organic anion transporter 1 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[20]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[21]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[21]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[22]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[23]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[24]
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[25]

Drug(s) Transported By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[20]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[27]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[28]
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[29]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[30]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[31]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[32]
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[33]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[37]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[40]
Metronidazole	DMTIVEN	Abscess		Approved	[41]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[42]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[43]

Drug(s) Affected By Beta-nerve growth factor (NGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[51]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[56]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[57]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[61]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[62]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[66]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[67]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[68]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[67]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[69]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Fructose	DM43AN2	Vomiting	MD90	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[84]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[85]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[86]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[90]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[91]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[98]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[99]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[96]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[100]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[104]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[105]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[107]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[108]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[109]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[110]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[111]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[112]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[66]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[115]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[116]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[117]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis regulator Bcl-2 (BCL-2)	TTJGNVC	BCL2_HUMAN	Regulator (upregulator)	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporter 1 (SLC22A6)	DTQ23VB	S22A6_HUMAN	Substrate	[3]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) Main DME	DEYGVN4	UD11_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Beta-nerve growth factor (NGF)	OTOLABJT	NGF_HUMAN	Gene/Protein Processing	[5]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[6]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Gene/Protein Processing	[6]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[6]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Gene/Protein Processing	[7]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Post-Translational Modifications	[5]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Protein Interaction/Cellular Processes	[8]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[6]

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