Details of the Drug-Related molecule(s) Interaction Atlas

Piperazinyl methyl quinazolinone derivative 2 Drug Info

PMID30185082-Compound-30

Cross-matching ID

PubChem CID

11214940

ChEBI ID

CHEBI:94287

CAS Number

CAS 571203-78-6

TTD Drug ID

DM913KS

General Information of Drug (ID: DM913KS)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Sigma intracellular receptor 2 (TMEM97)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MIN-101	DMCJY35	Schizophrenia	6A20	Phase 3	[6]
CT1812	DMBRKZ7	Alzheimer disease	8A20	Phase 2	[7]
Isoindoline derivative 5	DMIUTQW	N. A.	N. A.	Patented	[1]
Isoindoline derivative 3	DM2MYL9	N. A.	N. A.	Patented	[1]
Isoindoline derivative 4	DMP1NKI	N. A.	N. A.	Patented	[1]
Isoindoline derivative 2	DMTE0S3	N. A.	N. A.	Patented	[1]
Isoindoline derivative 1	DMD19QC	N. A.	N. A.	Patented	[1]
Benzamide derivative 9	DMVFSJZ	N. A.	N. A.	Patented	[1]
Benzamide derivative 10	DM9PKU2	N. A.	N. A.	Patented	[1]
PMID30185082-Compound-57	DMNDF1Z	N. A.	N. A.	Patented	[1]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[8]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[10]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[11]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[12]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[13]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[14]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[15]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
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Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[19]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[23]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Haloperidol	DM96SE0	Delirium		Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
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Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[27]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[34]
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Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[43]
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Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[53]
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Drug(s) Affected By Biglycan (BGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
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Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[62]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
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Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[68]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
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Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[74]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
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Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[80]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
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Drug(s) Affected By TATA box-binding protein-associated factor RNA polymerase I subunit A (TAF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[86]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[87]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[88]
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Drug(s) Affected By Acrosin-binding protein (ACRBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Indomethacin	DMSC4A7	Bursitis		Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[93]
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Drug(s) Affected By Solute carrier family 40 member 1 (SLC40A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[96]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[62]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[97]
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Drug(s) Affected By Denticleless protein homolog (DTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[88]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
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Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[16]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[16]
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Drug(s) Affected By Fumarate hydratase, mitochondrial (FH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
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Drug(s) Affected By Serine/threonine-protein kinase D2 (PRKD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[109]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[110]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
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Drug(s) Affected By GTPase HRas (HRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[116]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[118]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sigma intracellular receptor 2 (TMEM97)	TT9NXW4	SGMR2_HUMAN	Ligand	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acrosin-binding protein (ACRBP)	OT0MK3L1	ACRBP_HUMAN	Gene/Protein Processing	[2]
Biglycan (BGN)	OT3AV6IF	PGS1_HUMAN	Gene/Protein Processing	[2]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Gene/Protein Processing	[2]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Gene/Protein Processing	[3]
Denticleless protein homolog (DTL)	OTC29RYE	DTL_HUMAN	Gene/Protein Processing	[2]
DNA mismatch repair protein Msh2 (MSH2)	OT10H1AB	MSH2_HUMAN	Gene/Protein Processing	[2]
Fumarate hydratase, mitochondrial (FH)	OTEQWU6Q	FUMH_HUMAN	Drug Response	[4]
GTPase HRas (HRAS)	OTWQN0DP	RASH_HUMAN	Drug Response	[5]
Lathosterol oxidase (SC5D)	OT41KMW4	SC5D_HUMAN	Gene/Protein Processing	[2]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Gene/Protein Processing	[2]

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References

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3	Downregulation of Cx43 reduces cisplatin-induced acute renal injury by inhibiting ferroptosis. Food Chem Toxicol. 2021 Dec;158:112672. doi: 10.1016/j.fct.2021.112672. Epub 2021 Nov 13.
4	Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction. Cancer Sci. 2018 Sep;109(9):2757-2766. doi: 10.1111/cas.13701. Epub 2018 Jul 20.
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7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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10	Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
11	COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
12	Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
13	Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
14	Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
15	Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
16	An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
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