Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCO5JZ)

Drug Name
SR141716A Drug Info
Synonyms
Riobant; Slimona; [3H]SR141716A; Acomplia (TN); Bethin (TN); Monaslim (TN); Remonabent (TN); Rimonabant [USAN:INN]; Rimoslim (TN); Riobant (TN); Riomont (TN); Slimona (TN); Zimulti (TN); Rimonabant (JAN/USAN/INN); 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide; 5-(p-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidinopyrazole-3-carboxamide
Indication
Disease Entry ICD 11 Status REF
Obesity 5B81 Approved [1]
Therapeutic Class
Antiobesity Agents
Cross-matching ID
PubChem CID
104850
ChEBI ID
CHEBI:34967
CAS Number
CAS 168273-06-1
TTD Drug ID
DMCO5JZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cannabinoid receptor 1 (CB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [7]
NABILONE DMVRYT2 Insomnia 7A00-7A0Z Approved [8]
Orlistat DMRJSP8 Obesity 5B81 Approved [9]
Tebipenem DMVSX6O Urinary tract infection GC08 Phase 3 [10]
Conatumumab DM2UOSN Colorectal cancer 2B91.Z Phase 2 [11]
GW-42004 DMY3KSU Lipid metabolism disorder 5C52.Z Phase 2 [12]
SR-147778 DMNAECP Obesity 5B81 Phase 2 [13]
Nimacimab DM21Z68 Diabetic nephropathy GB61.Z Phase 2 [14]
AEF0117 DMQ1GH4 Marijuana use disorder 6C41 Phase 2 [15]
V-24343 DMJSX9N Type-2 diabetes 5A11 Phase 1 [16]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [21]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [25]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [26]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Gefitinib DM15F0X Colon adenocarcinoma Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [30]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [31]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [32]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [31]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [33]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [34]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [36]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Selenium DM25CGV N. A. N. A. Approved [39]
Etretinate DM2CZFA Keratosis ED56 Approved [40]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [32]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [41]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
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Drug(s) Affected By Alanine aminotransferase 1 (GPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [44]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [45]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [46]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [44]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [44]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [44]
Gefitinib DM15F0X Colon adenocarcinoma Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [47]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [47]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [51]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [56]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [58]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [59]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [60]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [62]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [63]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [65]
Gefitinib DM15F0X Colon adenocarcinoma Approved [66]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [69]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [60]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [70]
Paclitaxel DMLB81S Breast carcinoma Approved [71]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [72]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [59]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [62]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [63]
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Drug(s) Affected By Hepatocyte nuclear factor 4-alpha (HNF4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [75]
Fructose DM43AN2 Vomiting MD90 Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [80]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [81]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [82]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [83]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [84]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Prednisone DM2HG4X Acute asthma CA23 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [87]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Fluoxetine DM3PD2C Bipolar depression Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [94]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [95]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [97]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [98]
Testosterone DM7HUNW Hot flushes GA30 Approved [99]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [100]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [101]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
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Drug(s) Affected By Aurora kinase B (AURKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [102]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [103]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Leflunomide DMR8ONJ Arthritis FA20 Approved [106]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [107]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cannabinoid receptor 1 (CB1) TT6OEDT CNR1_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Gene/Protein Processing [3]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [5]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [5]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Gene/Protein Processing [4]
Hepatocyte nuclear factor 4-alpha (HNF4A) OTY1TOAB HNF4A_HUMAN Gene/Protein Processing [6]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Protein Interaction/Cellular Processes [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Protein Interaction/Cellular Processes [5]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Gene/Protein Processing [4]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Post-Translational Modifications [4]

References

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62 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
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67 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
68 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
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