Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEK4TJ)

Drug Name
PI-103 Drug Info
Synonyms
PI-103; 371935-74-9; PI103; 3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol; UNII-YQX02F616F; PI 103; PIK-103; Phenol, 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-; YQX02F616F; CHEBI:90524; AK163162; 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol; 3-(4-Morpholin-4-Ylpyrido[3',2':4,5]furo[3,2-D]pyrimidin-2-Yl)phenol; Phenol, 3-(4-(4-morpholinyl)pyrido(3',2':4,5)furo(3,2-d)pyrimidin-2-yl)-; 3-(4-(4-Morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol
Indication
Disease Entry ICD 11 Status REF
Haematological malignancy 2B33.Y Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
9884685
ChEBI ID
CHEBI:90524
CAS Number
CAS 371935-74-9
TTD Drug ID
DMEK4TJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting PI3-kinase gamma (PIK3CG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAY 80-6946 DMLOS5R Follicular lymphoma 2A80 Approved [7]
IPI-145 DMWA24P Follicular lymphoma 2A80 Approved [8]
Buparlisib DM1WEHC Breast cancer 2C60-2C65 Phase 3 [9]
Enzastaurin DM5H0R9 Diffuse large B-cell lymphoma 2A81 Phase 3 [10]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [11]
GDC-0032 DMT4QHD Breast cancer 2C60-2C65 Phase 3 [10]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [12]
SAR245409 DMQM7IL Solid tumour/cancer 2A00-2F9Z Phase 2 [13]
XL147 DMML7BE Solid tumour/cancer 2A00-2F9Z Phase 2 [13]
SF1126 DML10K3 Head and neck cancer 2D42 Phase 2 [14]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [15]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [16]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [17]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [18]
Cepharanthine DM9Y5JB N. A. N. A. Approved [19]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [20]
Clozapine DMFC71L Schizophrenia 6A20 Approved [21]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [22]
Trifluoperazine DMKBYWI Anxiety Approved [23]
Olanzapine DMPFN6Y Bipolar depression Approved [21]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [24]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [27]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [28]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Verapamil DMA7PEW Angina pectoris BA40 Approved [30]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [31]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [32]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [33]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [35]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [32]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [37]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [39]
Gefitinib DM15F0X Colon adenocarcinoma Approved [40]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [43]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [35]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [44]
Paclitaxel DMLB81S Breast carcinoma Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [28]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [32]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [37]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [48]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [33]
Gefitinib DM15F0X Colon adenocarcinoma Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [53]
Selenium DM25CGV N. A. N. A. Approved [54]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [55]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [56]
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Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [57]
Folic Acid DMEMBJC Colorectal carcinoma Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [61]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [62]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [63]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [65]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [65]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Selenium DM25CGV N. A. N. A. Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [72]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [73]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [74]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Ethacrynic acid DM60QMR Edema MG29 Approved [77]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [78]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [79]
Testosterone DM7HUNW Hot flushes GA30 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [81]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [74]
Menthol DMG2KW7 Back pain ME84.Z Approved [82]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [84]
Selenium DM25CGV N. A. N. A. Approved [54]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [87]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [90]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [32]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [91]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [97]
Ethacrynic acid DM60QMR Edema MG29 Approved [98]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Prednisone DM2HG4X Acute asthma CA23 Approved [101]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [101]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [102]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [103]
Epinephrine DM3KJBC Acute asthma CA23 Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Fluoxetine DM3PD2C Bipolar depression Approved [105]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [106]
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Drug(s) Affected By Carbonic anhydrase 9 (CA9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [107]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [108]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [110]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [111]
Ampicillin DMHWE7P Acute epiglottitis Approved [112]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [113]
Bortezomib DMNO38U Leukemia Approved [114]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [115]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [4]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Carbonic anhydrase 9 (CA9) OTNA51XT CAH9_HUMAN Post-Translational Modifications [5]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Post-Translational Modifications [6]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Post-Translational Modifications [6]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Post-Translational Modifications [5]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [6]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [6]

References

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3 The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of sorafenib-treated melanoma cells. Int J Cancer. 2010 Apr 1;126(7):1549-61. doi: 10.1002/ijc.24926.
4 PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells. PLoS One. 2012;7(12):e52898. doi: 10.1371/journal.pone.0052898. Epub 2012 Dec 31.
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24 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
25 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
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29 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
30 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
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36 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
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41 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
42 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
43 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
44 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
45 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
46 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
47 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
48 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
49 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
50 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
51 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
52 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
53 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
54 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
55 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
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