Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLN4V5)

Drug Name
EPZ-004777 Drug Info
Synonyms DOT1L inhibitors (mixed lineage leukemia); DOT1L inhibitors (leukemia), Epizyme/GSK; DOT1L inhibitors (mixed lineage leukemia), Epizyme/GlaxoSmithKline
Indication
Disease Entry ICD 11 Status REF
leukaemia 2A60-2B33 Investigative [1]
Cross-matching ID
PubChem CID
56962336
ChEBI ID
CHEBI:124920
CAS Number
CAS 1338466-77-5
TTD Drug ID
DMLN4V5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histone-lysine N-methyltransferase (HLNM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
EPZ-5676 DMN2FS3 Acute myeloid leukaemia 2A60 Phase 1/2 [6]
bromo-deaza-SAH DMX2U7G Discovery agent N.A. Investigative [7]
SGC0946 DMP35VS Discovery agent N.A. Investigative [8]
Drug(s) Affected By Homeobox protein Meis1 (MEIS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [11]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [12]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [10]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [13]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [10]
Arsenic DMTL2Y1 N. A. N. A. Approved [14]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [15]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [16]
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Drug(s) Affected By RNA polymerase II elongation factor ELL2 (ELL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [20]
Leflunomide DMR8ONJ Arthritis FA20 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [11]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [24]
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Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [25]
Diazepam DM08E9O Alcohol withdrawal Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Selenium DM25CGV N. A. N. A. Approved [26]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [25]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [25]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [25]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [25]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [25]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [25]
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Drug(s) Affected By E3 ubiquitin-protein ligase MYCBP2 (MYCBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [12]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [13]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [31]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [33]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [34]
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Drug(s) Affected By Fatty acid CoA ligase Acsl3 (ACSL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluoxetine DM3PD2C Bipolar depression Approved [35]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [20]
Testosterone DM7HUNW Hot flushes GA30 Approved [36]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [37]
Leflunomide DMR8ONJ Arthritis FA20 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [11]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [39]
Capsaicin DMGMF6V Back pain ME84.Z Approved [40]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [41]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Gefitinib DM15F0X Colon adenocarcinoma Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [48]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [49]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
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Drug(s) Affected By Prostate-specific antigen (KLK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [53]
Selenium DM25CGV N. A. N. A. Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [57]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [58]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [59]
Testosterone DM7HUNW Hot flushes GA30 Approved [60]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [37]
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Drug(s) Affected By Tripartite motif-containing protein 49 (TRIM49)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [61]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [63]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [63]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [63]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [64]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [67]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [54]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [69]
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Drug(s) Affected By Homeobox protein Hox-B3 (HOXB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [13]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Arsenic DMTL2Y1 N. A. N. A. Approved [14]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [72]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [16]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [73]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [74]
Nitrobenzanthrone DMN6L70 N. A. N. A. Investigative [75]
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Drug(s) Affected By Homeobox protein Hox-B8 (HOXB8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [78]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [79]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [80]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [73]
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Drug(s) Affected By Kallikrein-2 (KLK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Testosterone DM7HUNW Hot flushes GA30 Approved [81]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [37]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [82]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [23]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [83]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [84]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [15]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [85]
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Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [87]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [89]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [91]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [92]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [9]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [87]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Selenium DM25CGV N. A. N. A. Approved [47]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [97]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
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Drug(s) Affected By Homeobox protein Hox-A9 (HOXA9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [102]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [103]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [104]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [105]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [106]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [80]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [73]
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Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC3 (HERC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [12]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [108]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [39]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [108]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [108]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [109]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [33]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone-lysine N-methyltransferase (HLNM) TTSZ8T1 DOT1L_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Gene/Protein Processing [3]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [4]
E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) OTHODA1F MYCB2_HUMAN Gene/Protein Processing [3]
Fatty acid CoA ligase Acsl3 (ACSL3) OT3MWER1 ACSL3_HUMAN Gene/Protein Processing [3]
Homeobox protein Hox-A9 (HOXA9) OTKNK5H0 HXA9_HUMAN Gene/Protein Processing [5]
Homeobox protein Hox-B3 (HOXB3) OT9UC5PE HXB3_HUMAN Gene/Protein Processing [5]
Homeobox protein Hox-B8 (HOXB8) OTKHOD17 HXB8_HUMAN Gene/Protein Processing [5]
Homeobox protein Meis1 (MEIS1) OTH9DKAD MEIS1_HUMAN Gene/Protein Processing [5]
Kallikrein-2 (KLK2) OT9RE37R KLK2_HUMAN Gene/Protein Processing [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7377).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7377).
3 Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer. Nat Commun. 2020 Aug 19;11(1):4153. doi: 10.1038/s41467-020-18013-7.
4 Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer. Clin Epigenetics. 2019 Dec 30;11(1):199. doi: 10.1186/s13148-019-0778-y.
5 DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016 Aug 18;128(7):971-81. doi: 10.1182/blood-2015-11-684225. Epub 2016 Jun 22.
6 Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood. 2013 August 8; 122(6): 1017-1025.
7 Bromo-deaza-SAH: a potent and selective DOT1L inhibitor. Bioorg Med Chem. 2013 Apr 1;21(7):1787-94.
8 Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun. 2012;3:1288.
9 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
10 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
11 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
12 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
13 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
14 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
15 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
16 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
17 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
18 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
19 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
20 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
21 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
22 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
23 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
24 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
25 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
26 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
27 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
28 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
29 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
30 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
31 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
32 Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
33 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
34 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
35 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
36 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
37 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
38 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
39 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
40 Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
41 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
42 Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
43 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
44 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
45 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
46 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
47 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
48 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
49 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
50 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
51 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
52 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
53 Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim Acta. 2001 Oct;312(1-2):213-9. doi: 10.1016/s0009-8981(01)00626-x.
54 Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res. 2004 Jan 1;64(1):19-22. doi: 10.1158/0008-5472.can-03-2789.
55 Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis. 2001 Mar;22(3):409-14. doi: 10.1093/carcin/22.3.409.
56 EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer. Oncotarget. 2015 Feb 28;6(6):3811-24.
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