Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLWQ27)

• Drug Name: ANGIOTENSIN II Drug Info
• Synonyms: Human angiotensin II; Angiotensin II human; 4474-91-3; Angiotensin II (mouse); Angiotensin II (human); Giapreza; Ang II; 5-Isoleucine-angiotensin II; 5-L-Isoleucineangiotensin II; Ile(5)-angiotensin II; 1-8-Angiotensin I; isoleucine(5)-angiotensin II;Angiotensin II, human; Isoleucine5-angiotensin II; Angiotensin II, ile(5)-; Angiotensin ii [INN:JAN]

Indication

Disease Entry	ICD 11	Status	REF
Increase blood pressure	BA04	Approved	[1]

• Cross-matching ID:
  PubChem CID: 172198
  ChEBI ID: CHEBI:2719
  CAS Number: CAS 4474-91-3
  TTD Drug ID: DMLWQ27
  ACDINA Drug ID: D00839

Molecule-Related Drug Atlas

Drug(s) Targeting Angiotensin II receptor type-2 (AGTR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SARALASIN	DMKS1DV	Hypertension	BA00-BA04	Approved	[6]
EMA-401	DMYOUB6	Peripheral neuropathy	8C0Z	Phase 2	[7]
MP-157	DM5VXWO	Hypertension	BA00-BA04	Phase 1	[8]
PMID25416646-Compound-Figure5-E	DMYO7VH	N. A.	N. A.	Patented	[9]
Phenylpyridine derivative 3	DMDT5JI	N. A.	N. A.	Patented	[9]
1-(biphenyl-4-yl-methyl)-1H-imidazole derivative 1	DMGYZQ2	N. A.	N. A.	Patented	[9]
Fonsartan	DM15LAP	Hypertension	BA00-BA04	Discontinued in Phase 2	[10]
L-158282	DMKSEIY	N. A.	N. A.	Discontinued in Phase 2	[11]
TAK-591	DM25DB4	Hypertension	BA00-BA04	Discontinued in Phase 1	[12]
L-159689	DM9JE7Y	Hypertension	BA00-BA04	Terminated	[13]

Drug(s) Targeting Angiotensin II receptor type-1 (AGTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[14]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[15]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[14]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[14]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[16]
Telmisartan	DMS3GX2	Hypertension	BA00-BA04	Approved	[17]
SARALASIN	DMKS1DV	Hypertension	BA00-BA04	Approved	[18]
Tasosartan	DMM13DI	Hypertension	BA00-BA04	Approved	[19]
Eprosartan	DM07K2I	Hypertension	BA00-BA04	Approved	[20]
Sparsentan	DMMP51W	IgA nephropathy	MF8Y	Approved	[21]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[22]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[23]
Fructose	DM43AN2	Vomiting	MD90	Approved	[5]
Ketoprofen	DMRKXPT	Bursitis		Approved	[5]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[25]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[26]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[27]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[28]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[31]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[32]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[33]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[37]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[38]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[42]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[43]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[35]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[43]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[45]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[47]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[48]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[53]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[55]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[56]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[57]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[60]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[61]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[25]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[56]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[67]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[68]

Drug(s) Affected By NADPH oxidase 4 (NOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[75]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[76]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[77]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[78]

Drug(s) Affected By Mitochondrial fission 1 protein (FIS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[87]

Drug(s) Affected By Beta-1 adrenergic receptor (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[88]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[92]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[93]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[96]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin II receptor type-1 (AGTR1)	TT8DBY3	AGTR1_HUMAN	Inhibitor	[2]
Angiotensin II receptor type-2 (AGTR2)	TTQVOEI	AGTR2_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Beta-1 adrenergic receptor (ADRB1)	OTQBWN4U	ADRB1_HUMAN	Drug Response	[5]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[4]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Gene/Protein Processing	[4]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Gene/Protein Processing	[4]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Gene/Protein Processing	[4]
Mitochondrial fission 1 protein (FIS1)	OT2HL10J	FIS1_HUMAN	Gene/Protein Processing	[4]
NADPH oxidase 4 (NOX4)	OTTYQ097	NOX4_HUMAN	Gene/Protein Processing	[4]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Gene/Protein Processing	[4]

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