Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8F5LR)

• Drug Name: NAPQI Drug Info
• Synonyms: Napqi; Acetimidoquinone; 50700-49-7; N-acetyl-4-benzoquinone imine; N-Acetyl-4-benzoquinoneimine; N-Acetyl-p-benzoquinone imine; N-Acetylbenzoquinoneimine; N-Acetyl-P-benzoquinoneimine; N-Acetyl-p-quinonimine; N-Acetyl-p-benzoquinone; N-(4-oxocyclohexa-2,5-dien-1-ylidene)acetamide; UNII-G6S9BN13TI; CCRIS 5789; N-acetyl-1,4-benzoquinone imine; BRN 2435621; G6S9BN13TI; 2,5-Cyclohexadien-1-one, 4-acetylimino-; N-(4-Oxo-2,5-cyclohexadienylidene)acetamide; CHEBI:29132; N-(4-Oxo-2,5-cyclohexadien-1-ylidene)acetamide; Acetamide, N-(4

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune disease	4A40-4A45	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 39763
  ChEBI ID: CHEBI:29132
  CAS Number: CAS 50700-49-7
  TTD Drug ID: DM8F5LR

Molecule-Related Drug Atlas

Drug(s) Targeting Macrophage migration inhibitory factor (MIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[5]
Anti-MIF antibodies	DM8EKSV	Autoimmune diabetes	5A10	Phase 4	[6]
ISO-1	DMDB7KU	N. A.	N. A.	Phase 1	[7]
COR100140	DMN0GTR	Inflammation	1A00-CA43.1	Preclinical	[8]
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE	DMPSOIF	Discovery agent	N.A.	Investigative	[9]
4-hydroxyphenylpyruvic acid	DM0564K	Discovery agent	N.A.	Investigative	[9]
AVP-13546	DMDTONZ	Autoimmune disease	4A40-4A45	Investigative	[2]
AVP-13748	DMBNDYK	Autoimmune disease	4A40-4A45	Investigative	[2]
4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME	DM7WPGN	Discovery agent	N.A.	Investigative	[9]

Drug(s) Affected By Transient receptor potential cation channel subfamily A member 1 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[13]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[14]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[11]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[15]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[16]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[17]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[18]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[27]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[32]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[33]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[34]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[38]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[42]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[43]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[47]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[54]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[61]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[27]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[69]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]

Drug(s) Affected By Bone morphogenetic protein 2 (BMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[87]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[89]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[90]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[92]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[93]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[96]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[87]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[97]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[98]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[99]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[89]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[90]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[106]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]

Drug(s) Affected By Guanine nucleotide exchange factor for Rab-3A (RAB3IL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[116]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[117]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[19]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[120]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[120]

Drug(s) Affected By CD9 antigen (CD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]
Bortezomib	DMNO38U	Leukemia		Approved	[125]

Drug(s) Affected By Carboxypeptidase A6 (CPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[127]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[129]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[75]

Drug(s) Affected By Doublesex- and mab-3-related transcription factor 1 (DMRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[16]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]

Drug(s) Affected By Ethanolamine kinase 2 (ETNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[133]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[136]

Drug(s) Affected By Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[139]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[142]

Drug(s) Affected By Zinc transporter ZIP11 (SLC39A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]

Drug(s) Affected By Nebulin (NEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[146]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[127]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[116]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[117]

Drug(s) Affected By Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[147]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[146]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[148]

Drug(s) Affected By NHL repeat-containing protein 3 (NHLRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]

Drug(s) Affected By CD166 antigen (ALCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]

Drug(s) Affected By Microtubule-associated tumor suppressor candidate 2 (MTUS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[126]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[154]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[155]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[156]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[16]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[149]

Drug(s) Affected By Double-stranded RNA-specific editase B2 (ADARB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[139]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[158]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[117]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[159]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[149]

Drug(s) Affected By Cannabinoid receptor 1 (CNR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[161]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[61]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[162]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[163]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]

Drug(s) Affected By LIM homeobox transcription factor 1-alpha (LMX1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]

Drug(s) Affected By Potassium channel subfamily U member 1 (KCNU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]
ROSMARINIC ACID	DMQ6SJT	Rheumatoid arthritis	FA20	Investigative	[165]

Drug(s) Affected By Tyrosine-protein kinase FRK (FRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[168]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[169]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[170]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]

Drug(s) Affected By Nesprin-3 (SYNE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]

Drug(s) Affected By Laminin subunit alpha-4 (LAMA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[133]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[133]

Drug(s) Affected By Cystatin-D (CST5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[172]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[174]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[175]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[176]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[19]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[19]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[180]

Drug(s) Affected By G protein-activated inward rectifier potassium channel 1 (KCNJ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[19]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[19]
Haloperidol	DM96SE0	Delirium		Approved	[19]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[182]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]

Drug(s) Affected By Sperm-associated antigen 16 protein (SPAG16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[184]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[146]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[185]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[186]

Drug(s) Affected By Uncharacterized protein C3orf38 (C3ORF38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[4]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[127]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[187]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[56]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[188]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[188]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[188]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[189]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[190]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[191]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[192]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[193]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[194]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[19]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[195]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[196]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[196]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[197]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[200]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[201]

Drug(s) Affected By Slit homolog 2 protein (SLIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[203]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[61]

Drug(s) Affected By Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Herbimycin A	DM6YWBF	Solid tumour/cancer	2A00-2F9Z	Approved	[204]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[161]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[110]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[154]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[205]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[205]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[205]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[205]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[205]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[205]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[205]

Drug(s) Affected By Coiled-coil domain-containing protein 25 (CCDC25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[126]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[127]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[207]

Drug(s) Affected By Caldesmon (CALD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[208]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[210]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[211]

Drug(s) Affected By F-box only protein 39 (FBXO39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]

Drug(s) Affected By Rap1 GTPase-activating protein 2 (RAP1GAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[16]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[212]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[213]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[216]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[217]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[217]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[218]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[219]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[220]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[221]

Drug(s) Affected By Histone deacetylase 4 (HDAC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[225]
Bortezomib	DMNO38U	Leukemia		Approved	[226]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[227]

Drug(s) Affected By Tumor protein D53 (TPD52L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[120]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[120]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]

Drug(s) Affected By Multiple C2 and transmembrane domain-containing protein 1 (MCTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[228]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[229]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[16]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]

Drug(s) Affected By Interleukin-23 receptor (IL23R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[230]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[231]
SGC-CBP30	DMTLRGZ	Discovery agent	N.A.	Investigative	[232]

Drug(s) Affected By Major facilitator superfamily domain-containing protein 4A (MFSD4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[203]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[154]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[129]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[233]

Drug(s) Affected By Protein HID1 (HID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[117]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[234]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[149]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[235]

Drug(s) Affected By Stabilin-1 (STAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]

Drug(s) Affected By Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]

Drug(s) Affected By Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[240]

Drug(s) Affected By Desmocollin-3 (DSC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[241]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[126]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[242]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[243]

Drug(s) Affected By Sorting nexin-16 (SNX16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[244]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[146]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[127]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[132]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[245]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[85]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[246]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[248]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[249]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[250]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[251]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[252]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[164]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[254]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[255]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[256]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[257]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[258]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[189]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[217]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[259]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[260]

Drug(s) Affected By Centrosomal protein of 44 kDa (CEP44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[203]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[4]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[127]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Macrophage migration inhibitory factor (MIF)	TT2AST1	MIF_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[3]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[3]
Bone morphogenetic protein 2 (BMP2)	OT23T37S	BMP2_HUMAN	Gene/Protein Processing	[3]
Brorin	OT3NEG5M	VWC2_HUMAN	Drug Response	[4]
Caldesmon (CALD1)	OTNJKJ6Q	CALD1_HUMAN	Drug Response	[4]
Cannabinoid receptor 1 (CNR1)	OTEALO6G	CNR1_HUMAN	Drug Response	[4]
Carboxypeptidase A6 (CPA6)	OT43RD23	CBPA6_HUMAN	Drug Response	[4]
CD166 antigen (ALCAM)	OTCO4LP7	CD166_HUMAN	Drug Response	[4]
CD9 antigen (CD9)	OT2184XU	CD9_HUMAN	Drug Response	[4]
Centrosomal protein of 44 kDa (CEP44)	OTZLD83K	CEP44_HUMAN	Drug Response	[4]

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