Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8F5LR)

• Drug Name: NAPQI Drug Info
• Synonyms: Napqi; Acetimidoquinone; 50700-49-7; N-acetyl-4-benzoquinone imine; N-Acetyl-4-benzoquinoneimine; N-Acetyl-p-benzoquinone imine; N-Acetylbenzoquinoneimine; N-Acetyl-P-benzoquinoneimine; N-Acetyl-p-quinonimine; N-Acetyl-p-benzoquinone; N-(4-oxocyclohexa-2,5-dien-1-ylidene)acetamide; UNII-G6S9BN13TI; CCRIS 5789; N-acetyl-1,4-benzoquinone imine; BRN 2435621; G6S9BN13TI; 2,5-Cyclohexadien-1-one, 4-acetylimino-; N-(4-Oxo-2,5-cyclohexadienylidene)acetamide; CHEBI:29132; N-(4-Oxo-2,5-cyclohexadien-1-ylidene)acetamide; Acetamide, N-(4

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune disease	4A40-4A45	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 39763
  ChEBI ID: CHEMBL33232
  CAS Number: CAS 50700-49-7
  TTD Drug ID: DM8F5LR

Molecule-Related Drug Atlas

Drug(s) Targeting Macrophage migration inhibitory factor (MIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[5]
Anti-MIF antibodies	DM8EKSV	Autoimmune diabetes	5A10	Phase 4	[6]
ISO-1	DMDB7KU	N. A.	N. A.	Phase 1	[7]
COR100140	DMN0GTR	Inflammation	1A00-CA43.1	Preclinical	[8]
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE	DMPSOIF	Discovery agent	N.A.	Investigative	[9]
4-hydroxyphenylpyruvic acid	DM0564K	Discovery agent	N.A.	Investigative	[9]
AVP-13546	DMDTONZ	Autoimmune disease	4A40-4A45	Investigative	[2]
AVP-13748	DMBNDYK	Autoimmune disease	4A40-4A45	Investigative	[2]
4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME	DM7WPGN	Discovery agent	N.A.	Investigative	[9]

Drug(s) Affected By Transient receptor potential cation channel subfamily A member 1 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[13]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[14]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[11]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[15]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[16]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[17]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[18]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[27]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[32]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[33]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[34]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[38]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[42]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[43]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[47]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[54]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[61]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[62]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[63]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[65]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[66]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[68]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[69]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[72]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[63]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[73]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[74]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[75]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[62]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[65]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[66]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[82]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]

Drug(s) Affected By Guanine nucleotide exchange factor for Rab-3A (RAB3IL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[91]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[19]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]

Drug(s) Affected By CD9 antigen (CD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Bortezomib	DMNO38U	Leukemia		Approved	[102]

Drug(s) Affected By Carboxypeptidase A6 (CPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[104]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Doublesex- and mab-3-related transcription factor 1 (DMRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[109]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[16]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Ethanolamine kinase 2 (ETNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[111]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[101]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[115]

Drug(s) Affected By Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]

Drug(s) Affected By Zinc transporter ZIP11 (SLC39A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]

Drug(s) Affected By Nebulin (NEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[101]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[126]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[127]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[126]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[128]

Drug(s) Affected By NHL repeat-containing protein 3 (NHLRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]

Drug(s) Affected By CD166 antigen (ALCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[132]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]

Drug(s) Affected By Microtubule-associated tumor suppressor candidate 2 (MTUS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[135]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[136]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[137]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[16]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Double-stranded RNA-specific editase B2 (ADARB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[140]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By LIM homeobox transcription factor 1-alpha (LMX1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Potassium channel subfamily U member 1 (KCNU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
ROSMARINIC ACID	DMQ6SJT	Rheumatoid arthritis	FA20	Investigative	[142]

Drug(s) Affected By Tyrosine-protein kinase FRK (FRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[146]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]

Drug(s) Affected By Nesprin-3 (SYNE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[116]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[91]

Drug(s) Affected By Laminin subunit alpha-4 (LAMA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[123]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[111]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[111]

Drug(s) Affected By Cystatin-D (CST5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[150]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[152]

Drug(s) Affected By G protein-activated inward rectifier potassium channel 1 (KCNJ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[19]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[19]
Haloperidol	DM96SE0	Delirium		Approved	[19]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[154]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]

Drug(s) Affected By Sperm-associated antigen 16 protein (SPAG16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[156]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[157]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[126]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[157]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[158]

Drug(s) Affected By Uncharacterized protein C3orf38 (C3ORF38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[4]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[104]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[159]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[56]

Drug(s) Affected By Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Herbimycin A	DM6YWBF	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[161]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[86]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[135]

Drug(s) Affected By Coiled-coil domain-containing protein 25 (CCDC25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[104]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[162]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[163]

Drug(s) Affected By Caldesmon (CALD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[164]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[60]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[166]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[167]

Drug(s) Affected By F-box only protein 39 (FBXO39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Rap1 GTPase-activating protein 2 (RAP1GAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[16]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]

Drug(s) Affected By Tumor protein D53 (TPD52L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[132]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]

Drug(s) Affected By Multiple C2 and transmembrane domain-containing protein 1 (MCTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[169]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[171]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[16]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[120]

Drug(s) Affected By Major facilitator superfamily domain-containing protein 4A (MFSD4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[172]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[173]

Drug(s) Affected By Protein HID1 (HID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[129]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[175]

Drug(s) Affected By Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Selenium	DM25CGV	N. A.	N. A.	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]

Drug(s) Affected By Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[178]

Drug(s) Affected By Desmocollin-3 (DSC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[135]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]

Drug(s) Affected By Sorting nexin-16 (SNX16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[124]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[126]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[183]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[109]

Drug(s) Affected By Centrosomal protein of 44 kDa (CEP44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[172]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[4]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[104]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[98]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Macrophage migration inhibitory factor (MIF)	TT2AST1	MIF_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[3]
Brorin	OT3NEG5M	VWC2_HUMAN	Drug Response	[4]
Caldesmon (CALD1)	OTNJKJ6Q	CALD1_HUMAN	Drug Response	[4]
Carboxypeptidase A6 (CPA6)	OT43RD23	CBPA6_HUMAN	Drug Response	[4]
CD166 antigen (ALCAM)	OTCO4LP7	CD166_HUMAN	Drug Response	[4]
CD9 antigen (CD9)	OT2184XU	CD9_HUMAN	Drug Response	[4]
Centrosomal protein of 44 kDa (CEP44)	OTZLD83K	CEP44_HUMAN	Drug Response	[4]
Coiled-coil domain-containing protein 25 (CCDC25)	OTNC58MD	CCD25_HUMAN	Drug Response	[4]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Gene/Protein Processing	[3]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Gene/Protein Processing	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6299).
• [2] MIF in autoimmunity and novel therapeutic approaches. Autoimmun Rev. 2009 Jan;8(3):244-9.
• [3] Long-term acetaminophen treatment induced liver fibrosis in mice and the involvement of Egr-1. Toxicology. 2017 May 1;382:47-58. doi: 10.1016/j.tox.2017.03.008. Epub 2017 Mar 9.
• [4] Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. Toxicol Sci. 2011 Mar;120(1):33-41. doi: 10.1093/toxsci/kfq375. Epub 2010 Dec 22.
• [5] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [6] Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the beta-Sheet Structure of MIF. J Biol Chem. 2012 March 2; 287(10): 7446-7455.
• [7] The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82.
• [8] Cortical Pty Ltd Presents MIF Antagonist Data at World Congress on Inflammation. Cortical Pty Ltd. 2005.
• [9] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [10] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [11] Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP. Chem Res Toxicol. 2011 Jun 20;24(6):950-9. doi: 10.1021/tx200123z. Epub 2011 May 25.
• [12] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [13] The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel. Toxicol Appl Pharmacol. 2017 Dec 1;336:55-65. doi: 10.1016/j.taap.2017.10.012. Epub 2017 Oct 18.
• [14] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
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