General Information of Drug (ID: DMEQH6J)

Drug Name
flavone Drug Info
Synonyms
Flavone; FLAVONE; 525-82-6; 2-Phenylchromone; 2-Phenyl-4H-chromen-4-one; 2-Phenyl-4-chromone; Asmacoril; 2-Phenyl-4H-1-benzopyran-4-one; 2-Phenyl-4-benzopyron; 4H-1-Benzopyran-4-one, 2-phenyl-; Chromocor; Cromaril; 2-phenylchromen-4-one; Phenylchromone; 2-Phenyl-chromen-4-one; 2-Phenyl-gamma-benzopyrone; 2-Phenylbenzopyran-4-one; Cromarile; 2-Phenyl-4H-benzopyran-4-one; Flavon; 2-Phenylchrome; UNII-S2V45N7G3B; NSC 19028; 2-Phenyl-4H-chromen-4-on; CCRIS 4288; NSC19028; EINECS 208-383-8; NSC-19028; BRN 0157598
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10680
ChEBI ID
CHEMBL275638
CAS Number
CAS 525-82-6
TTD Drug ID
DMEQH6J
INTEDE Drug ID
DR2144

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Patented Agent(s)
Investigative Drug(s)
Drug(s) Targeting Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Anastrozole DMNP60F Breast cancer 2C60-2C65 Approved [13]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [14]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [14]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [15]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [16]
Testolactone DMVY4GN Breast cancer 2C60-2C65 Approved [17]
LIAROZOLE DM4OYXE Dermatological disease DA24.Y Phase 2/3 [4]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [18]
BGS-649 DMO4MNQ Endometriosis GA10 Phase 2 [19]
NARINGENIN DMHAZLM N. A. N. A. Phase 1 [4]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
IB-MECA DM9G5XD Psoriasis vulgaris EA90 Phase 3 [20]
Tonapofylline DMBH316 Acute and chronic heart failure BD1Z Phase 2 [21]
NITD609 DMQHBSX Malaria 1F40-1F45 Phase 2 [22]
CF102 DMP56WJ Hepatocellular carcinoma 2C12.02 Phase 2 [23]
SCH-442416 DMQ2K1V N. A. N. A. Phase 1 [24]
AST-004 DM5WMG7 Stroke 8B20 Phase 1 [25]
BEMESETRON DMSPJX9 N. A. N. A. Discontinued in Phase 3 [26]
BAY 60-6583 DMTEJV1 Myocardial ischemia BA6Z Preclinical [27]
CF602 DM0ULO2 Inflammation 1A00-CA43.1 Preclinical [23]
CF502 DMQSJ20 Inflammation 1A00-CA43.1 Preclinical [23]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [28]
BAY 86-5044 DMRZLU4 Breast cancer 2C60-2C65 Phase 2 [29]
TRC-253 DMXI8CD Prostate cancer 2C82.0 Phase 1/2 [30]
IONIS-AR-2.5Rx DMF2DMS Prostate cancer 2C82.0 Phase 1/2 [31]
ISIS-AR DM8P3N5 Prostate cancer 2C82.0 Phase 1 [32]
EZN-4176 DMNPS59 Prostate cancer 2C82.0 Phase 1 [33]
EUGENOL DM7US1H Discovery agent N.A. Patented [34]
RU-58841 DMMEAZ2 Acne vulgaris ED80 Discontinued in Phase 1 [35]
APIGENIN DMI3491 Discovery agent N.A. Investigative [3]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [3]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [36]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [37]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [36]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [36]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [38]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [36]
Hexobarbital DMQ314B Anaesthesia 9A78.6 Approved [36]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [39]
Meprobamate DMHM93Y Anxiety Approved [36]
Zaleplon DMGFWSM Insomnia 7A00-7A0Z Approved [40]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [36]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [41]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [39]
Clonazepam DMTO13J Absence epilepsy Approved [42]
Piperazine DMTY9LU Ascariasis 1F62 Approved [43]
Alpidem DMN7Y9K Anxiety disorder 6B00-6B0Z Approved [44]
Moxidectin DMYGHX5 Onchocerciasis 1F6A Approved [45]
DP-VPA DMGOXPQ Bipolar disorder 6A60 Approved [46]
ANDROSTERONE DMITJAK N. A. N. A. Phase 3 [41]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [47]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [40]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [40]
A295 DM55GO2 Aggressive cancer 2A00-2F9Z IND submitted [48]
Tonapofylline DMBH316 Acute and chronic heart failure BD1Z Phase 2 [21]
YT-146 DM3YVKQ Hypertension BA00-BA04 Phase 2 [49]
AB928 DMDOXMN Metastatic colorectal cancer 2B91 Phase 1/2 [30]
KF-17837 DMQ6DLZ Parkinson disease 8A00.0 Phase 1 [50]
Xanthine DMFBOQ7 Apnea MD11.0 Phase 1 [51]
CVT-6883 DMY84TW Asthma CA23 Phase 1 [52]
PBF-1129 DMOPGXM Non-small-cell lung cancer 2C25.Y Phase 1 [30]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [53]
Rolofylline DMSZPR3 Heart failure BD10-BD13 Phase 3 [54]
Tonapofylline DMBH316 Acute and chronic heart failure BD1Z Phase 2 [21]
AMP-579 DMJ4GPR Hyperlipidaemia 5C80 Phase 2 [55]
SELODENOSON DMQM3IX Cardiac arrhythmias BC9Z Phase 2 [56]
Apaxifylline DMQMV9F Cognitive impairment 6D71 Phase 2 [57]
SLV320 DM867BJ Heart failure BD10-BD13 Phase 2 [58]
DTI-0009 DMV84OK Atrial fibrillation BC81.3 Phase 2 [56]
Capadenoson DMYWO62 Atrial fibrillation BC81.3 Phase 2 [59]
BAY 1067197 DM4JGNH Heart failure BD10-BD13 Phase 2 [60]
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Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [61]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [62]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [64]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Metronidazole DMTIVEN Abscess Approved [66]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [67]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
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Drug(s) Metabolized By Biphenyl dioxygenase (bphC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isoflavone DM7U58J N. A. N. A. Phase 4 [8]
AUS-131 DMUXO3Z Hot flushes GA30 Phase 2 [8]
Flavanone DMNWIYM Discovery agent N.A. Investigative [8]
Drug(s) Metabolized By Naphthalene dioxygenase (doxB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isoflavone DM7U58J N. A. N. A. Phase 4 [8]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [74]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [75]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [77]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [78]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Selenium DM25CGV N. A. N. A. Approved [81]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Panobinostat DM58WKG Chronic graft versus host disease Approved [84]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [85]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [86]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
Selenium DM25CGV N. A. N. A. Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Panobinostat DM58WKG Chronic graft versus host disease Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [92]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [93]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [94]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [95]
Cepharanthine DM9Y5JB N. A. N. A. Approved [96]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [97]
Clozapine DMFC71L Schizophrenia 6A20 Approved [98]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [99]
Trifluoperazine DMKBYWI Anxiety Approved [100]
Olanzapine DMPFN6Y Bipolar depression Approved [98]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [101]
Gefitinib DM15F0X Colon adenocarcinoma Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [104]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [105]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [106]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [105]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [107]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Etretinate DM2CZFA Keratosis ED56 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [9]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [115]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [116]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [118]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [119]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [120]
Gefitinib DM15F0X Colon adenocarcinoma Approved [121]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [122]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [123]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [124]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [125]
Methotrexate DM2TEOL Anterior urethra cancer Approved [126]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [129]
Etretinate DM2CZFA Keratosis ED56 Approved [111]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [130]
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [133]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [134]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [135]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [78]
Benzatropine DMF7EXL Parkinsonian disorder Approved [137]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [138]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [139]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [81]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [140]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [141]
MG-132 DMKA2YS N. A. N. A. Preclinical [142]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [80]
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Drug(s) Affected By Lamin-B2 (LMNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [143]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [138]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [144]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [145]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [146]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [147]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [148]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [149]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [151]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [152]
Artemether DM48QOT Malaria 1F40-1F45 Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [155]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [156]
Estrone DM5T6US Acne vulgaris ED80 Approved [157]
Leflunomide DMR8ONJ Arthritis FA20 Approved [158]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [143]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [160]
Arsenic DMTL2Y1 N. A. N. A. Approved [161]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [162]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [163]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [9]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [159]
Testosterone enanthate DMB6871 N. A. N. A. Approved [166]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [78]
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Drug(s) Affected By Centromere protein J (CENPJ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [168]
Quercetin DM3NC4M Obesity 5B81 Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Testosterone DM7HUNW Hot flushes GA30 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [159]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [170]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [162]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [171]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [172]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [172]
Gefitinib DM15F0X Colon adenocarcinoma Approved [173]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [174]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [175]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [176]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [177]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [178]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [180]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [181]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [143]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [170]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Arsenic DMTL2Y1 N. A. N. A. Approved [161]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [162]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [183]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [184]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [185]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [143]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [138]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [159]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [80]
ORG2058 DMH1M6N Discovery agent N.A. Investigative [186]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenosine A1 receptor (ADORA1) TTK25J1 AA1R_HUMAN Antagonist [2]
Adenosine A2b receptor (ADORA2B) TTNE7KG AA2BR_HUMAN Antagonist [2]
Adenosine A3 receptor (ADORA3) TTJFY5U AA3R_HUMAN Antagonist [2]
Androgen receptor messenger RNA (AR mRNA) TTKPW01 ANDR_HUMAN Inhibitor [3]
Aromatase (CYP19A1) TTSZLWK CP19A_HUMAN Inhibitor [4]
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Inhibitor [5]
Gamma-aminobutyric acid receptor (GAR) TTNJYV2 NOUNIPROTAC Inhibitor [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Substrate [7]
Naphthalene dioxygenase (doxB) DEE76YZ NDOB_PSEU8 Substrate [8]
Biphenyl dioxygenase (bphC) DEUX61H BPHC_PSEFK Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
26S proteasome regulatory subunit 4 (PSMC1) OTLHD56E PRS4_HUMAN Gene/Protein Processing [9]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Gene/Protein Processing [9]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Gene/Protein Processing [9]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [10]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [11]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [12]
Centromere protein J (CENPJ) OTZCQZN5 CENPJ_HUMAN Gene/Protein Processing [9]
Centrosomal protein of 83 kDa (CEP83) OTNJGQ11 CEP83_HUMAN Gene/Protein Processing [9]
DNA repair protein RAD50 (RAD50) OTYMU9G1 RAD50_HUMAN Gene/Protein Processing [9]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Gene/Protein Processing [9]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 409).
2 Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301.
3 Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10.
4 Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64.
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133 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
134 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
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139 Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
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143 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
144 New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20.
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146 Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
147 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
148 Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
149 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
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