Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX8BS5)

• Drug Name: ELLAGIC ACID Drug Info
• Synonyms: ellagic acid; 476-66-4; Benzoaric acid; Lagistase; Eleagic acid; Alizarine Yellow; Elagostasine; 2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione; Ellagic acid dihydrate; Llagic acid; Acide ellagique; Acido elagico; Acidum ellagicum; C.I. 55005; Gallogen (VAN); Gallogen (astringent); C.I. 75270; Ellagate; Ellagic acid [INN:DCF]; UNII-19YRN3ZS9P; Acido elagico [INN-Spanish]; CCRIS 774; Gallogen, astringent; Acide ellagique [INN-French]; Acidum ellagicum [INN-Latin]; MLS000069632; C14H6O8; EINECS 207-508-3; NSC407286; NSC 40728

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5281855
  ChEBI ID: CHEMBL6246
  CAS Number: CAS 476-66-4
  TTD Drug ID: DMX8BS5

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase VI (CA-VI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[12]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[13]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
SAR566658	DM6Q295	Solid tumour/cancer	2A00-2F9Z	Phase 2	[16]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[17]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[18]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[14]

Drug(s) Targeting Carbonic anhydrase I (CA-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[12]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[19]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[19]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[20]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[19]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[21]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[14]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]

Drug(s) Targeting Carbonic anhydrase XII (CA-XII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[12]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[22]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[14]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[18]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[14]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[12]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[22]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[23]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[24]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[25]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[25]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[26]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[27]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[28]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]

Drug(s) Targeting Carbonic anhydrase XIV (CA-XIV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[29]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[17]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[14]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[17]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[18]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[14]

Drug(s) Targeting Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[5]
SIS-3	DMWBCTA	Renal fibrosis	GC01	Preclinical	[30]
GNF-PF-2272	DMONK0F	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Carbonic anhydrase (CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[31]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[13]
Quinethazone	DMWCOSR	Hypertension	BA00-BA04	Approved	[32]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[14]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[33]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
PMID30074415-Compound-21	DM3NPOU	N. A.	N. A.	Patented	[34]

Drug(s) Targeting Heat shock protein 70 (HSP70)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AG-858	DMNQ5T2	leukaemia	2A60-2B33	Phase 2	[35]
AEG-33773	DMSBLOU	Diabetic neuropathy	8C0Z	Phase 2	[36]
Enkastim-ev	DMGLHYU	Solid tumour/cancer	2A00-2F9Z	Phase 1	[37]
Minnelide 001	DM5VEN9	Gastric adenocarcinoma	2B72	Phase 1	[38]
BRX-005	DMTDWIE	Diabetic foot ulcer	BD54	Phase 1	[39]
Minnelide	DMDER9S	Solid tumour/cancer	2A00-2F9Z	Phase 1	[40]
AG-707	DM7PLMJ	Herpes simplex virus infection	1F00	Phase 1	[41]
H-103	DMRCHOU	Metastatic malignant neoplasm	2D50-2E09	Phase 1	[42]
NK-1001	DMZMQDN	Atrial fibrillation	BC81.3	Discontinued in Phase 2	[43]
Bimoclomol	DMOP95G	Diabetic complication	5A2Y	Discontinued in Phase 2	[44]

Drug(s) Targeting Casein kinase II alpha (CSNK2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CX-4945	DMWE7B9	Coronavirus infection	1D92	Phase 2	[40]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[45]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[3]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[46]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[3]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[3]
PMID24900749C1a	DMZPUSO	Discovery agent	N.A.	Investigative	[47]
AdoC(Dpr)2AlaArg6	DM2TWSZ	Discovery agent	N.A.	Investigative	[48]
PMID22115617C2c	DMX5UKA	Discovery agent	N.A.	Investigative	[49]
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole	DM3JB6S	Discovery agent	N.A.	Investigative	[3]

Drug(s) Targeting Carbonic anhydrase IV (CA-IV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[12]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[50]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[19]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[14]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
Sodium pyruvate	DMST6A3	Asthma	CA23	Phase 1/2	[51]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[33]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]

Drug(s) Targeting Tyrosine-protein kinase SYK (SYK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fostamatinib	DM6AUHV	Immune thrombocytopenic purpura	3B64.13	Approved	[52]
Fostamatinib disodium	DM3274D	Thrombocytopenia	3B64	Phase 3	[53]
Cerdulatinib	DMSCR2H	B-cell lymphoma	2A86	Phase 2	[54]
TAK-659	DMJH3U0	Diffuse large B-cell lymphoma	2A81	Phase 2	[55]
GS-9876	DM9Q2B6	Cutaneous lupus erythematosus	EB5Z	Phase 2	[56]
GS-9973	DMKWCTR	Acute myeloid leukaemia	2A60	Phase 2	[57]
Cevidoplenib	DM9QU5G	Rheumatoid arthritis	FA20	Phase 2	[58]
HM43239	DMV1SDA	Acute myeloid leukaemia	2A60	Phase 1/2	[59]
ALXN2075	DM1BSD8	Non-hodgkin lymphoma	2B33.5	Phase 1/2	[60]
SKI-O-703	DMTSKXR	Rheumatoid arthritis	FA20	Phase 1	[56]

Drug(s) Targeting Carbonic anhydrase IX (CA-IX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[14]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
INDISULAM	DM9SX6Y	Lymphoma	2A80-2A86	Phase 2	[61]
Girentuximab I-124	DMG3O2Z	Renal cell carcinoma	2C90	Phase 2	[62]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[63]
BAY 79-4620	DM14XQN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
90Y-cG250	DMJR6TC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[65]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]

Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMO-02	DMJRU3A	Myotonic dystrophy	8C71.0	Phase 2/3	[66]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[67]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[68]
Tideglusib	DME4LA1	Alzheimer disease	8A20	Phase 2	[69]
9-ING-41	DM57TY3	Myelofibrosis	2A20.2	Phase 2	[70]
Neu-120	DMXKOUC	Parkinson disease	8A00.0	Phase 1/2	[71]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[72]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[73]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[74]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[75]

Drug(s) Targeting Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Naftifine	DMHVBG1	Dermatomycosis	EA60	Approved	[76]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[77]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[1]
FR-194738	DMNACIV	Hypercholesterolaemia	5C80.0	Terminated	[78]
SDZ-87-469	DMBY6CQ	Coronary artery disease	BA80	Terminated	[77]
NB-598	DMJVTQN	N. A.	N. A.	Terminated	[79]
1,2,3,4,6-penta-O-galloyl-beta-D-glucose	DMTK650	Discovery agent	N.A.	Investigative	[1]
Pedunculagin	DMKLRCX	Discovery agent	N.A.	Investigative	[1]
CORILAGIN	DMAC698	Discovery agent	N.A.	Investigative	[1]
ETHYLGALLATE	DMJ6PB8	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By Nucleolar protein 56 (NOP56)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[86]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[87]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[80]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[88]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[95]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]

Drug(s) Affected By Regulator of G-protein signaling 5 (RGS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[104]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[106]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[110]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[111]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[112]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]

Drug(s) Affected By Extracellular superoxide dismutase (SOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[118]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[123]

Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[130]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[131]

Drug(s) Affected By Transcription initiation factor IIE subunit beta (GTF2E2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[133]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[133]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[134]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[135]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[136]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[137]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[140]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[141]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[141]

Drug(s) Affected By Epidermal growth factor receptor substrate 15 (EPS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[135]

Drug(s) Affected By Achaete-scute homolog 1 (ASCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[149]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[150]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[135]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[152]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[97]

Drug(s) Affected By GTP-binding nuclear protein Ran (RAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[153]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[154]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[156]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[157]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[104]

Drug(s) Affected By Phosphatidylinositol-glycan-specific phospholipase D (GPLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[161]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[161]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[135]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[162]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[163]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[167]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[169]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[170]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[171]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[175]

Drug(s) Affected By Interferon regulatory factor 9 (IRF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[177]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[185]

Drug(s) Affected By Early growth response protein 3 (EGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[130]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]

Drug(s) Affected By Ras GTPase-activating-like protein IQGAP2 (IQGAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[103]

Drug(s) Affected By cGMP-dependent protein kinase 1 (PRKG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[104]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[194]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[195]
Methamphetamine	DMPM4SK	Anxiety		Approved	[196]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[197]
CP-461	DMEYMTX	Inflammatory bowel disease	DD72	Phase 2	[197]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[135]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[188]

Drug(s) Affected By Septin-2 (SEPTIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[199]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[200]

Drug(s) Affected By Monocyte to macrophage differentiation factor (MMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[203]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[204]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[133]

Drug(s) Affected By TATA box-binding protein-associated factor RNA polymerase I subunit C (TAF1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[205]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[206]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[209]

Drug(s) Affected By Neuronatin (NNAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[212]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[213]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[214]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[209]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[215]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[152]

Drug(s) Affected By Transcription factor E4F1 (E4F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[219]

Drug(s) Affected By General transcription factor IIH subunit 4 (GTF2H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[213]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[161]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[161]

Drug(s) Affected By Histone-lysine N-methyltransferase EZH1 (EZH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[205]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[104]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[221]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[194]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[135]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[222]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[133]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[156]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[134]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[221]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase N2 (PTPRN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[86]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]

Drug(s) Affected By Transcription factor IIIB 90 kDa subunit (BRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[224]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[225]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[135]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Transcription factor 12 (TCF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[228]

Drug(s) Affected By Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[140]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[229]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]

Drug(s) Affected By Neuronal PAS domain-containing protein 2 (NPAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[86]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[104]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[230]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[135]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[207]

Drug(s) Affected By Immediate early response gene 2 protein (IER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[233]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[237]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[238]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]

Drug(s) Affected By Death domain-associated protein 6 (DAXX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[243]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[245]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[140]

Drug(s) Affected By Poly(ADP-ribose) glycohydrolase (PARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[104]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[247]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[248]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[248]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[138]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[248]
Fructose	DM43AN2	Vomiting	MD90	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[248]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[250]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[252]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[110]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[254]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[257]

Drug(s) Affected By Phospholipase A2, membrane associated (PLA2G2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[11]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[209]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[258]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[259]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[263]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]

Drug(s) Affected By Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[264]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[265]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[266]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[233]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[193]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[106]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[267]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[268]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[269]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[270]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[271]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[272]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[274]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[275]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[276]
Fructose	DM43AN2	Vomiting	MD90	Approved	[106]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[278]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[280]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[282]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[283]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[284]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[285]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[278]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[286]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[287]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[289]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[287]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[290]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[291]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[292]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[293]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[294]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[295]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[296]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[297]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[298]

Drug(s) Affected By Biotin--protein ligase (HLCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[10]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[299]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[300]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[80]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[301]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[119]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[86]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[303]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]

Drug(s) Affected By Endonuclease G, mitochondrial (ENDOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[161]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[307]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[308]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[310]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[311]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[312]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[313]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[314]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]

Drug(s) Affected By Mitogen-activated protein kinase 11 (MAPK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[317]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[175]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]

Drug(s) Affected By DNA oxidative demethylase ALKBH2 (ALKBH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[318]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[135]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[319]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[320]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[321]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[323]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[95]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[2]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[2]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[2]
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[2]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[2]
Carbonic anhydrase VI (CA-VI)	TTCFSPE	CAH6_HUMAN	Inhibitor	[2]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[2]
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[2]
Casein kinase II alpha (CSNK2A1)	TTER6YH	CSK21_HUMAN	Inhibitor	[3]
Glycogen synthase kinase-3 beta (GSK-3B)	TTRSMW9	GSK3B_HUMAN	Inhibitor	[4]
Heat shock protein 70 (HSP70)	TTHYBIX	HS71A_HUMAN; HS71B_HUMAN	Inhibitor	[5]
Mothers against decapentaplegic homolog 3 (SMAD3)	TTHQZV7	SMAD3_HUMAN	Inhibitor	[5]
Squalene monooxygenase (SQLE)	TTE14XG	ERG1_HUMAN	Inhibitor	[1]
Tyrosine-protein kinase SYK (SYK)	TTOU65C	KSYK_HUMAN	Inhibitor	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[6]
Achaete-scute homolog 1 (ASCL1)	OTI4X44G	ASCL1_HUMAN	Gene/Protein Processing	[7]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[8]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Gene/Protein Processing	[9]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Gene/Protein Processing	[7]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Gene/Protein Processing	[7]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[9]
Biotin--protein ligase (HLCS)	OTPDUX30	BPL1_HUMAN	Gene/Protein Processing	[10]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Protein Interaction/Cellular Processes	[11]
cGMP-dependent protein kinase 1 (PRKG1)	OTPAS4LF	KGP1_HUMAN	Gene/Protein Processing	[7]

References

• [1] Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4.
• [2] Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
• [3] Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3.
• [4] Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J Med Chem. 2006 Apr 20;49(8):2363-6.
• [5] In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
• [6] Investigation of the effects of some phenolic compounds on the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from human erythrocytes. J Biochem Mol Toxicol. 2014 Nov;28(11):510-4. doi: 10.1002/jbt.21592. Epub 2014 Aug 6.
• [7] Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
• [8] Ellagic acid mitigates SNO-PDI induced aggregation of Parkinsonian biomarkers. ACS Chem Neurosci. 2014 Dec 17;5(12):1209-20. doi: 10.1021/cn500214k. Epub 2014 Oct 8.
• [9] Ellagic acid induces apoptosis in TSGH8301 human bladder cancer cells through the endoplasmic reticulum stress- and mitochondria-dependent signaling pathways. Environ Toxicol. 2014 Nov;29(11):1262-74. doi: 10.1002/tox.21857. Epub 2013 Mar 30.
• [10] Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster. J Nutr Biochem. 2015 Nov;26(11):1379-84. doi: 10.1016/j.jnutbio.2015.07.004. Epub 2015 Jul 26.
• [11] Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chem Biol Interact. 2010 Dec 5;188(3):659-67.
• [12] Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
• [13] Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54.
• [14] Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
• [15] Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
• [16] An Antibody-Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities. Mol Cancer Ther. 2020 Aug;19(8):1660-1669.
• [17] Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22.
• [18] Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44.
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