Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM96SE0)

• Drug Name: Haloperidol Drug Info
• Synonyms: Aldo; Aloperidin; Aloperidol; Aloperidolo; Aloperidon; Bioperidolo; Brotopon; Dozic; Dozix; Eukystol; Fortunan; Galoperidol; Haldol; Halidol; Halojust; Halol; Halopal; Haloperido; Haloperidolum; Halopidol; Halopoidol; Halosten; Keselan; Linton; Mixidol; Pekuces; Peluces; Peridol; Pernox; Serenace; Serenase; Serenelfi; Sernas; Sernel; Sigaperidol; Ulcolind; Uliolind; Vesalium; Aloperidolo [DCIT]; Aloperidolo [Italian]; Einalon S; Haldol La; Haldol Solutab; Lealgin compositum; Pms Haloperidol; H 1512; R 1625; Aloperidin (TN); Apo-Haloperidol; Bioperidolo (TN); Brotopon (TN); Dozic (TN); Duraperidol (TN); Einalon S (TN); Eukystol (TN); Haldol (TN); Haloperidolum [INN-Latin]; Halosten (TN); Keselan (TN); Linton (TN);Novo-Peridol; Peluces (TN); R-1625; Serenace (TN); Serenase (TN); Sigaperidol (TN); Haloperidol (JP15/USP); McN-JR-1625; Haloperidol (JP15/USP/INN); Haloperidol [USAN:INN:BAN:JAN]

Indication

Disease Entry	ICD 11	Status	REF
Delirium		Approved	[1]
Nausea	MD90	Approved	[1]
Psychotic disorder	6A20-6A25	Approved	[1]
Schizophrenia	6A20	Approved	[2]
Vomiting	MD90	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[3]
Tourette syndrome	8A05.00	Investigative	[1]

• Therapeutic Class: Antipsychotic Agents
• Cross-matching ID:
  PubChem CID: 3559
  ChEBI ID: CHEBI:5613
  CAS Number: CAS 52-86-8
  TTD Drug ID: DM96SE0
  VARIDT Drug ID: DR00426
  INTEDE Drug ID: DR0801
  ACDINA Drug ID: D00310

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[17]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[18]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[19]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[20]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[21]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[22]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[23]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[24]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[25]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[26]

Drug(s) Targeting HUMAN opioid receptor sigma 1 (OPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PB28	DMMNQ1B	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[5]
E-52862	DMLZU09	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[5]
PD-144418	DMJKH28	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[5]
RS-PPCC	DMN3ZOD	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[5]

Drug(s) Targeting HUMAN sigma intracellular receptor 2 (TMEM97)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PB28	DMMNQ1B	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[5]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[30]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[31]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[33]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[35]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[41]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[35]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[11]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[42]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[43]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[47]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[48]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[49]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[50]

Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[51]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[48]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[55]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[56]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[57]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[58]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[59]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[60]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[61]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[63]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[64]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[65]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[66]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[101]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[102]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[104]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[105]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[106]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[107]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[108]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[109]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[68]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[69]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[72]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[74]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[75]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[10]

Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[76]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[10]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[10]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[77]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[78]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[10]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[10]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[10]
Metronidazole	DMTIVEN	Abscess		Approved	[79]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[80]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[81]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[77]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[84]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[85]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[88]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[80]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[77]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[91]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[92]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[93]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[95]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[97]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[11]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[11]
Naproxen	DMZ5RGV	Bursitis		Approved	[99]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[110]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[111]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[112]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[113]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[114]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[115]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[116]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[117]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[118]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[116]

Drug(s) Affected By D(1A) dopamine receptor (DRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[119]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[120]
Pergolide mesylate	DM5GKOV	N. A.	N. A.	Approved	[121]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[122]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[125]
Methamphetamine	DMPM4SK	Anxiety		Approved	[126]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[127]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[128]

Drug(s) Affected By D(4) dopamine receptor (DRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Methamphetamine	DMPM4SK	Anxiety		Approved	[133]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[134]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[119]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[119]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[119]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[143]

Drug(s) Affected By D(3) dopamine receptor (DRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[144]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[145]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[146]
Methamphetamine	DMPM4SK	Anxiety		Approved	[147]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[148]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[119]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[119]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[119]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[119]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[119]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[150]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[153]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[162]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[163]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]

Drug(s) Affected By G protein-activated inward rectifier potassium channel 1 (KCNJ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[119]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[119]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[169]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[170]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[175]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[175]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[176]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[180]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[181]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[182]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[185]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[186]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[187]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[188]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[189]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[190]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[190]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[191]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[192]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[192]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[193]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[192]
Fructose	DM43AN2	Vomiting	MD90	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[192]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[196]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[197]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[198]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[201]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[204]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[200]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[205]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[209]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[210]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[192]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[192]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]

Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[201]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[216]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[220]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[221]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[15]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[225]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[224]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[15]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[225]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[224]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[224]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[193]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[209]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[209]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[224]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[229]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[224]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[231]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[224]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[225]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[224]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[224]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[213]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[15]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[224]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[233]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[225]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[235]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[225]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[237]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[191]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[224]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[224]

Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[225]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[224]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[224]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[240]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]

Drug(s) Affected By Fibronectin type III domain-containing protein 4 (FNDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[224]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[224]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[224]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[15]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[224]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[224]

Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[15]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[243]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[224]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[15]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[15]

Drug(s) Affected By AP-3 complex subunit beta-1 (AP3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[247]

Drug(s) Affected By Importin subunit alpha-3 (KPNA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[250]

Drug(s) Affected By Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[252]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[252]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[252]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[253]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[254]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[254]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[254]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[254]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[254]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[254]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[254]

Drug(s) Affected By Period circadian protein homolog 1 (PER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[255]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[256]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[257]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[258]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[250]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[259]

Drug(s) Affected By Kinesin heavy chain isoform 5C (KIF5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]

Drug(s) Affected By Copine-3 (CPNE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[265]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[266]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[267]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[268]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]

Drug(s) Affected By CCR4-NOT transcription complex subunit 3 (CNOT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[271]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[273]

Drug(s) Affected By Pyridoxal phosphate homeostasis protein (PLPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[271]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[275]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[276]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[277]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[278]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[280]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[281]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[282]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[283]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[284]

Drug(s) Affected By Fatty acid-binding protein, heart (FABP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[201]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[285]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[252]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[286]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[287]
Methamphetamine	DMPM4SK	Anxiety		Approved	[288]

Drug(s) Affected By Prothymosin alpha (PTMA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[292]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[264]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[293]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]

Drug(s) Affected By Corticoliberin (CRH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[294]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[294]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[294]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Terbutaline	DMD4381	Asthma	CA23	Approved	[296]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[294]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[297]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[294]

Drug(s) Affected By Profilin-1 (PFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[300]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[301]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[302]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]

Drug(s) Affected By Signal recognition particle receptor subunit alpha (SRPRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[303]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[271]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[262]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[304]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[168]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[218]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[231]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[209]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[231]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[209]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]

Drug(s) Affected By Glycogen phosphorylase, muscle form (PYGM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[307]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[308]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[307]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[307]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[309]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]

Drug(s) Affected By Histidine--tRNA ligase, cytoplasmic (HARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[179]

Drug(s) Affected By Plastin-3 (PLS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[311]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[250]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[312]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[313]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[314]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[119]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[315]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[316]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[317]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[146]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[319]
Fructose	DM43AN2	Vomiting	MD90	Approved	[194]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[320]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[321]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[241]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[322]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[323]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[324]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[325]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[328]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]

Drug(s) Affected By V-type proton ATPase subunit B, kidney isoform (ATP6V1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[330]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[211]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX5 (DDX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[331]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[333]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[333]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[334]

Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[336]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[337]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[339]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]

Drug(s) Affected By Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[340]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[195]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[261]

Drug(s) Affected By Cofilin-1 (CFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[342]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[343]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[344]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[345]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[345]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]

Drug(s) Affected By 5-hydroxytryptamine receptor 2A (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[119]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[346]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[347]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[348]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[266]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[349]
Ketanserin	DMVLMW6	Hypertension	BA00-BA04	Approved	[350]

Drug(s) Affected By General transcription factor IIE subunit 1 (GTF2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[351]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[353]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[354]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[355]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[355]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[356]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[357]

Drug(s) Affected By Catenin alpha-1 (CTNNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[359]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[359]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]

Drug(s) Affected By Radixin (RDX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[360]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[361]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[362]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[363]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[271]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[364]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[365]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[367]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[368]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[369]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[370]

Drug(s) Affected By Transgelin-2 (TAGLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]

Drug(s) Affected By Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[371]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[287]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[361]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[372]

Drug(s) Affected By Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[373]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[374]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[233]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[373]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[375]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[211]

Drug(s) Affected By Small ribosomal subunit protein eS27 (RPS27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[376]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[377]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[378]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[179]

Drug(s) Affected By Cell surface glycoprotein MUC18 (MCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[379]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[381]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[257]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]

Drug(s) Affected By Vesicle-fusing ATPase (NSF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[187]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[382]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[372]

Drug(s) Affected By Serine--tRNA ligase, cytoplasmic (SARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[322]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[252]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[383]

Drug(s) Affected By Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[344]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[385]

Drug(s) Affected By Peroxisomal multifunctional enzyme type 2 (HSD17B4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[386]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[386]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[213]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]

Drug(s) Affected By Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[252]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[252]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[387]
Bortezomib	DMNO38U	Leukemia		Approved	[265]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein K (HNRNPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[388]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[390]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[389]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[391]

Drug(s) Affected By Small ribosomal subunit protein uS9 (RPS16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[328]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[361]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[376]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[304]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[334]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[392]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[393]

Drug(s) Affected By Large ribosomal subunit protein eL30 (RPL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[266]

Drug(s) Affected By Microtubule-associated protein 1A (MAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[394]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[311]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]

Drug(s) Affected By Large ribosomal subunit protein eL19 (RPL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[396]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[377]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[351]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[275]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[393]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[247]

Drug(s) Affected By Transcriptional activator protein Pur-alpha (PURA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[363]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
Celastrol	DMWQIJX	Motor neurone disease	8B60	Preclinical	[397]

Drug(s) Affected By Protein Dr1 (DR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[357]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[179]

Drug(s) Affected By Synaptic vesicular amine transporter (SLC18A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[398]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[398]
Methamphetamine	DMPM4SK	Anxiety		Approved	[399]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[400]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[322]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[400]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[394]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[401]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]

Drug(s) Affected By Mitochondrial-processing peptidase subunit alpha (PMPCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[402]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[403]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[404]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[334]

Drug(s) Affected By Aspartyl/asparaginyl beta-hydroxylase (ASPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[405]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[406]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[407]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[408]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[408]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[409]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[410]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[411]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[412]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[408]

Drug(s) Affected By Translation initiation factor eIF2B subunit epsilon (EIF2B5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[413]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[414]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[415]

Drug(s) Affected By Transcription intermediary factor 1-beta (TRIM28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[416]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[417]

Drug(s) Affected By Condensin complex subunit 2 (NCAPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[229]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[419]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[420]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[339]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]

Drug(s) Affected By Inorganic pyrophosphatase (PPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[287]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[357]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[372]

Drug(s) Affected By Reticulocalbin-1 (RCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[343]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[361]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[212]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[311]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]

Drug(s) Affected By Splicing factor 3B subunit 4 (SF3B4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[421]

Drug(s) Affected By Disks large homolog 2 (DLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[422]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[423]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[312]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[262]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]

Drug(s) Affected By Striated muscle preferentially expressed protein kinase (SPEG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[266]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[424]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[267]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[309]

Drug(s) Affected By Cryptochrome-1 (CRY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[255]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[258]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[372]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[426]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]

Drug(s) Affected By Histone H2A type 2-C (H2AC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[331]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[427]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[330]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[212]

Drug(s) Affected By Tau-tubulin kinase 1 (TTBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[428]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[429]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[351]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[211]

Drug(s) Affected By Coiled-coil domain-containing protein 121 (CCDC121)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[233]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[334]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[339]

Drug(s) Affected By Nucleoporin p54 (NUP54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]

Drug(s) Affected By Retinol dehydrogenase 11 (RDH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Bortezomib	DMNO38U	Leukemia		Approved	[265]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]

Drug(s) Affected By Dynein axonemal heavy chain 3 (DNAH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[431]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[428]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[432]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[211]

Drug(s) Affected By Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (DHX38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[433]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[334]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]

Drug(s) Affected By Small ribosomal subunit protein mS31 (MRPS31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[322]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[250]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[434]

Drug(s) Affected By AP-2 complex subunit mu (AP2M1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[435]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[404]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[351]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX27 (DDX27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[266]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[436]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[436]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[437]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[275]

Drug(s) Affected By PDZ and LIM domain protein 5 (PDLIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[146]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]

Drug(s) Affected By Kremen protein 1 (KREMEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]

Drug(s) Affected By KH domain-containing RNA-binding protein QKI (QKI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[266]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[439]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[271]

Drug(s) Affected By Transcriptional regulator protein Pur-beta (PURB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[440]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[351]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[441]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[351]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[414]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[393]

Drug(s) Affected By Melanin-concentrating hormone receptor 1 (MCHR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[267]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[313]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[267]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[442]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[211]

Drug(s) Affected By Transmembrane 9 superfamily member 2 (TM9SF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[250]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[404]

Drug(s) Affected By COP9 signalosome complex subunit 4 (COPS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[443]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[392]

Drug(s) Affected By Histone H2A.J (H2AJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[287]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[257]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[212]

Drug(s) Affected By MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[445]

Drug(s) Affected By ATP-dependent DNA/RNA helicase DHX36 (DHX36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[267]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[446]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[351]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[351]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[414]

Drug(s) Affected By tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[447]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[187]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[250]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[171]

Drug(s) Affected By Tropomodulin-3 (TMOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[372]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[404]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[448]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[351]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[168]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[211]

Drug(s) Affected By Endoplasmic reticulum aminopeptidase 1 (ERAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[449]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[267]

Drug(s) Affected By Ribosome-binding protein 1 (RRBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[450]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[447]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[451]

Drug(s) Affected By DnaJ homolog subfamily B member 11 (DNAJB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[445]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[452]

Drug(s) Affected By Translocation protein SEC63 homolog (SEC63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Indomethacin	DMSC4A7	Bursitis		Approved	[453]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[179]

Drug(s) Affected By Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[361]

Drug(s) Affected By Unconventional myosin-Vb (MYO5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[250]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]

Drug(s) Affected By Pre-mRNA-processing factor 19 (PRPF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[375]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[454]

Drug(s) Affected By E3 ubiquitin-protein ligase PDZRN3 (PDZRN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[217]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[260]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[262]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[211]

Drug(s) Affected By DNA-binding protein SATB2 (SATB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[286]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[372]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[455]

Drug(s) Affected By TRPM8 channel-associated factor 1 (TCAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[339]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[361]

Drug(s) Affected By Talin-2 (TLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[456]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[14]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[353]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[458]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[459]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[460]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[461]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[462]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[463]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[464]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[465]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[466]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[467]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[468]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[469]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[470]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[468]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]

Drug(s) Affected By Dysbindin (DTNBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[249]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[471]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[269]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[351]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[351]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[233]

Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 1 (ND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[472]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[473]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[474]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[475]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[476]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[119]
Thiothixene	DMDINC4	Schizophrenia	6A20	Approved	[119]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[477]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[478]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[479]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[480]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[458]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[481]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[482]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[483]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[484]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[481]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[462]

Drug(s) Affected By Synaptosomal-associated protein 25 (SNAP25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Selenium	DM25CGV	N. A.	N. A.	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[485]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[486]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[245]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[330]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Antagonist	[4]
HUMAN opioid receptor sigma 1 (OPRS1)	TTTPE1L	SGMR1_HUMAN	Modulator	[5]
HUMAN sigma intracellular receptor 2 (TMEM97)	TTIS0R2	SGMR2_HUMAN	Modulator	[5]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[7]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[8]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[9]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Substrate	[9]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[9]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[9]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[7]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[10]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DE85D2P	UD19_HUMAN	Substrate	[11]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[12]
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Protein Interaction/Cellular Processes	[13]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)	OTJC60Q7	THIL_HUMAN	Gene/Protein Processing	[14]
Alpha-1-antichymotrypsin (SERPINA3)	OT9BP2S0	AACT_HUMAN	Gene/Protein Processing	[15]
AP-2 complex subunit mu (AP2M1)	OTQCOSFN	AP2M1_HUMAN	Gene/Protein Processing	[14]
AP-3 complex subunit beta-1 (AP3B1)	OTYTIH5Q	AP3B1_HUMAN	Gene/Protein Processing	[14]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Gene/Protein Processing	[15]
Aspartyl/asparaginyl beta-hydroxylase (ASPH)	OT3KGDEE	ASPH_HUMAN	Gene/Protein Processing	[14]
ATP-dependent DNA/RNA helicase DHX36 (DHX36)	OT8IGL9Y	DHX36_HUMAN	Gene/Protein Processing	[14]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[16]

References

• [1] Haloperidol FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 86).
• [3] Sigma-1Rs are upregulated via PERK/eIF2/ATF4 pathway and execute protective function in ER stress. Biochem Biophys Res Commun. 2011 Nov 25;415(3):519-25.
• [4] Dopaminergic synapses in the matrix of the ventrolateral striatum after chronic haloperidol treatment. Synapse. 2002 Aug;45(2):78-85.
• [5] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
• [6] Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75.
• [7] Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway. Drug Metab Dispos. 2003 Mar;31(3):243-9.
• [8] Use of antidepressant drugs in schizophrenic patients with depression. Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9.
• [9] In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes. Drug Metab Dispos. 2001 Dec;29(12):1638-43.
• [10] Drug Interactions Flockhart Table
• [11] Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
• [12] Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? Pharmacogenomics J. 2005;5(5):298-304.
• [13] Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12.
• [14] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [15] Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
• [16] Reversal effect of haloperidol on doxorubicin resistance and chloride channel inhibition in erythroleukemic cell K562/Dox. Zhonghua Zhong Liu Za Zhi. 2005 Feb;27(2):81-5.
• [17] The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. Iran J Allergy Asthma Immunol. 2004 Dec;3(4):169-74.
• [18] CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine. Pharmacogenet Genomics. 2007 Nov;17(11):989-93.
• [19] Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands. Bioorg Med Chem. 2005 Jan 3;13(1):77-87.
• [20] Screening of domperidone in wastewater by high performance liquid chromatography and solid phase extraction methods. Talanta. 2006 Jan 15;68(3):928-31.
• [21] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3639).
• [22] Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors. Eur J Pharmacol. 2009 Apr 1;607(1-3):35-40.
• [23] [The benzamides tiapride, sulpiride, and amisulpride in treatment for Tourette's syndrome]. Nervenarzt. 2007 Mar;78(3):264, 266-8, 270-1.
• [24] Modulatory role of dopamine D2 receptors and fundamental role of L-type Ca2+ channels in the induction of long-term potentiation in the basolateral... Eur J Pharmacol. 2009 Mar 15;606(1-3):90-3.
• [25] Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
• [26] Randomized clinical comparison of perospirone and risperidone in patients with schizophrenia: Kansai Psychiatric Multicenter Study. Psychiatry Clin Neurosci. 2009 Jun;63(3):322-8.
• [27] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [28] MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
• [29] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [30] Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
• [31] Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
• [32] Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
• [33] Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
• [34] Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
• [35] Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
• [36] Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
• [37] Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
• [38] Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
• [39] Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
• [40] Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
• [41] The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
• [42] Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
• [43] Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. Mol Carcinog. 2004 Jul;40(3):180-8.
• [44] Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
• [45] Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
• [46] PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.
• [47] The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. Biomed Res Int. 2013;2013:789184.
• [48] The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
• [49] Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7.
• [50] Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
• [51] Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics. 2000 Aug;10(6):519-30.
• [52] Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74.
• [53] Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Metabolism. 2007 Jul;56(7):887-94.
• [54] Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies. J Med Chem. 1994 Mar 18;37(6):860-7.
• [55] Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
• [56] A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clin Chem Lab Med. 2005;43(7):702-6.
• [57] Cytochromes P450 in crustacea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):157-72.
• [58] Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone. Biochem J. 1998 Apr 1;331 ( Pt 1):273-81.
• [59] Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy. Curr Drug Metab. 2007 Aug;8(6):554-62.
• [60] Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes. Cancer Chemother Pharmacol. 1993;32(6):491-5.
• [61] Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6. Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):117-23.
• [62] CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep. 2010 Jan;12(1):7-15.
• [63] Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues. Chem Res Toxicol. 2003 Apr;16(4):450-9.
• [64] Effects of propofol on human hepatic microsomal cytochrome P450 activities. Xenobiotica. 1998 Sep;28(9):845-53.
• [65] Pharmacogenetics of schizophrenia. Am J Med Genet. 2000 Spring;97(1):98-106.
• [66] Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
• [67] Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82.
• [68] Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer. J Urol. 2008 Dec;180(6):2389-95.
• [69] Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein. Biochem Biophys Res Commun. 1999 Jul 14;260(3):676-81.
• [70] Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. Cancer Lett. 2005 Jan 10;217(1):61-72.
• [71] Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation. Drug Metab Dispos. 2007 Oct;35(10):1754-8.
• [72] Urinary 6 beta-hydroxycortisol excretion in rheumatoid arthritis. Br J Rheumatol. 1997 Jan;36(1):54-8.
• [73] Clinical pharmacokinetics of imatinib. Clin Pharmacokinet. 2005;44(9):879-94.
• [74] Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug Metab Dispos. 2004 Sep;32(9):993-1000.
• [75] Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab Dispos. 2005 May;33(5):664-71.
• [76] The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver. J Steroid Biochem Mol Biol. 1993 Jan;44(1):61-7.
• [77] Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
• [78] Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites. Drug Metab Dispos. 2004 Feb;32(2):259-66.
• [79] The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94.
• [80] Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
• [81] Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
• [82] Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
• [83] Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore). 2016 Oct;95(40):e5076.
• [84] Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30.
• [85] New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126.
• [86] A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7.
• [87] A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63.
• [88] High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8.
• [89] Cytochrome P450 pharmacogenetics and cancer. Oncogene. 2006 Mar 13;25(11):1679-91.
• [90] CYP2C19*17 is associated with decreased breast cancer risk. Breast Cancer Res Treat. 2009 May;115(2):391-6.
• [91] Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec;353(1):116-21.
• [92] Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33.
• [93] Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95.
• [94] Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336.
• [95] Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35.
• [96] Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma. Invest New Drugs. 2011 Dec;29(6):1511-4.
• [97] The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011 Jan;50(1):1-24.
• [98] The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene. J Biol Chem. 2003 Apr 18;278(16):13975-83.
• [99] S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33.
• [100] Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions. Toxicol Sci. 2014 Oct;141(2):344-52. doi: 10.1093/toxsci/kfu133. Epub 2014 Jul 24.
• [101] Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone. Psychopharmacology (Berl). 1999 Dec;147(3):300-5. doi: 10.1007/s002130051171.
• [102] Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450. J Toxicol Sci. 2016 Feb;41(1):143-6.
• [103] Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos. 2011 Nov;39(11):2049-56. doi: 10.1124/dmd.111.041384. Epub 2011 Aug 5.
• [104] Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. Biol Pharm Bull. 2005 Feb;28(2):328-34.
• [105] Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl. Eur J Clin Pharmacol. 2007 Feb;63(2):159-63.
• [106] Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
• [107] Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
• [108] Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test. Clin Pharmacol Ther. 2001 Oct;70(4):327-35.
• [109] Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro. Drug Metab Dispos. 2003 Jun;31(6):768-72.
• [110] Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
• [111] Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
• [112] Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
• [113] Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
• [114] Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
• [115] Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
• [116] Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
• [117] Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
• [118] Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
• [119] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [120] Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry. 1992 Jul;49(7):538-44. doi: 10.1001/archpsyc.1992.01820070032005.
• [121] Pergolide is an inhibitor of voltage-gated potassium channels, including Kv1.5, and causes pulmonary vasoconstriction. Circulation. 2005 Sep 6;112(10):1494-9. doi: 10.1161/CIRCULATIONAHA.105.556704. Epub 2005 Aug 29.
• [122] Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. Chem Res Toxicol. 2013 Jun 17;26(6):878-95.
• [123] Dopamine-mediated inhibition of renal Na+/K+-ATPase in HK-2 cells is reduced by ouabain. Clin Exp Pharmacol Physiol. 2010 May;37(5-6):613-8. doi: 10.1111/j.1440-1681.2010.05364.x. Epub 2010 Feb 4.
• [124] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [125] Characterizing fucoxanthin as a selective dopamine D(3)/D(4) receptor agonist: Relevance to Parkinson's disease. Chem Biol Interact. 2019 Sep 1;310:108757. doi: 10.1016/j.cbi.2019.108757. Epub 2019 Jul 16.
• [126] Dopamine D1 receptor protein is elevated in nucleus accumbens of human, chronic methamphetamine users. Mol Psychiatry. 2000 Nov;5(6):664-72. doi: 10.1038/sj.mp.4000760.
• [127] Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response. J Psychopharmacol. 2007 Sep;21(7):718-27. doi: 10.1177/0269881106072341. Epub 2006 Nov 8.
• [128] Characterization of the potent, selective Nrf2 activator, 3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one, in cellular and in vivo models of pulmonary oxidative stress. J Pharmacol Exp Ther. 2017 Oct;363(1):114-125.
• [129] Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine. Int J Neurosci. 2005 Nov;115(11):1539-47. doi: 10.1080/00207450590957863.
• [130] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [131] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [132] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [133] Association analysis of the DRD4 and COMT genes in methamphetamine abuse. Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):120-4. doi: 10.1002/ajmg.b.30024.
• [134] Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents?. Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 5;144B(8):1034-41. doi: 10.1002/ajmg.b.30540.
• [135] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [136] Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food Chem Toxicol. 2017 Dec;110:189-199. doi: 10.1016/j.fct.2017.10.031. Epub 2017 Oct 20.
• [137] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [138] LncRNA SNHG12 ameliorates bupivacaine-induced neurotoxicity by sponging miR-497-5p to upregulate NLRX1. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089001. doi: 10.1177/09603271221089001.
• [139] Mechanism of arsenic trioxide inhibiting angiogenesis in multiple myeloma. J Huazhong Univ Sci Technolog Med Sci. 2006;26(1):43-6. doi: 10.1007/BF02828035.
• [140] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [141] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [142] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [143] Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. J Psychopharmacol. 2007 Nov;21(8):820-5. doi: 10.1177/0269881107078491. Epub 2007 Aug 22.
• [144] Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant. Pharmacogenomics J. 2010 Jun;10(3):200-18. doi: 10.1038/tpj.2009.65. Epub 2009 Dec 22.
• [145] A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms. Pharmacogenomics J. 2009 Dec;9(6):404-10. doi: 10.1038/tpj.2009.26. Epub 2009 Jun 9.
• [146] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [147] Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity. J Neurosci. 2009 Nov 25;29(47):14734-40. doi: 10.1523/JNEUROSCI.3765-09.2009.
• [148] Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion. Am J Psychiatry. 2009 Oct;166(10):1170-7. doi: 10.1176/appi.ajp.2009.08121801. Epub 2009 Sep 1.
• [149] Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity. Anat Cell Biol. 2016 Sep;49(3):165-176. doi: 10.5115/acb.2016.49.3.165. Epub 2016 Sep 29.
• [150] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [151] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [152] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [153] Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide. J Neurochem. 2010 Jan;112(1):183-92. doi: 10.1111/j.1471-4159.2009.06441.x. Epub 2009 Oct 20.
• [154] Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. Brain. 2006 Jul;129(Pt 7):1693-709. doi: 10.1093/brain/awl118. Epub 2006 May 15.
• [155] Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
• [156] Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
• [157] Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer. Cancer Biol Ther. 2005 Sep;4(9):949-55.
• [158] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [159] Role of antioxidant systems in human androgen-independent prostate cancer cells. Prostate. 2000 May 1;43(2):144-9. doi: 10.1002/(sici)1097-0045(20000501)43:2<144::aid-pros9>3.0.co;2-h.
• [160] Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
• [161] Selenium deficiency alters epithelial cell morphology and responses to influenza. Free Radic Biol Med. 2007 Jun 15;42(12):1826-37.
• [162] Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: a quantitative study. Hepatology. 1991 Nov;14(5):811-7.
• [163] Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment. Eur Arch Psychiatry Clin Neurosci. 2004 Aug;254(4):231-5.
• [164] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [165] The effect of statins on lipids peroxidation and activities of antioxidants enzymes in patients with dyslipidemia. Przegl Lek. 2006;63(9):738-42.
• [166] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [167] Atrial-like Engineered Heart Tissue: An In?Vitro Model of the Human Atrium. Stem Cell Reports. 2018 Dec 11;11(6):1378-1390. doi: 10.1016/j.stemcr.2018.10.008. Epub 2018 Nov 8.
• [168] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [169] Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines. BMC Cancer. 2004 Dec 16;4:93. doi: 10.1186/1471-2407-4-93.
• [170] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [171] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [172] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [173] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [174] Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2010 Dec 1;55(6):1172-9. doi: 10.1002/pbc.22739.
• [175] The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance. J Pharmacol Exp Ther. 2000 Aug;294(2):480-7.
• [176] Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
• [177] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [178] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [179] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [180] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [181] Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain. Acta Biochim Pol. 2004;51(1):207-12.
• [182] Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. Toxicol Lett. 2015 Jun 15;235(3):189-98. doi: 10.1016/j.toxlet.2015.04.005. Epub 2015 Apr 9.
• [183] Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8.
• [184] Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
• [185] Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46.
• [186] Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer. 2004 Sep 10;111(4):484-93. doi: 10.1002/ijc.20230.
• [187] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [188] Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells. Chem Biol Interact. 2015 Dec 5;242:13-23. doi: 10.1016/j.cbi.2015.08.023. Epub 2015 Sep 1.
• [189] Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
• [190] Functional analysis of MRP1 cloned from bovine. FEBS Lett. 2002 Jun 19;521(1-3):211-3. doi: 10.1016/s0014-5793(02)02816-8.
• [191] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [192] Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
• [193] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [194] Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
• [195] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [196] Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. Biochem J. 2009 May 13;420(2):305-15.
• [197] Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin. J Lipid Res. 1999 Jun;40(6):1078-89.
• [198] Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin. Circulation. 2008 Jul 22;118(4):355-62. doi: 10.1161/CIRCULATIONAHA.108.773267. Epub 2008 Jun 16.
• [199] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [200] Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
• [201] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [202] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [203] PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages. FEBS Lett. 2002 Jun 5;520(1-3):177-81.
• [204] Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease. Oncotarget. 2016 Jun 7;7(23):33689-702. doi: 10.18632/oncotarget.9399.
• [205] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [206] Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol. 2001 Dec 1;62(11):1545-55. doi: 10.1016/s0006-2952(01)00790-0.
• [207] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [208] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [209] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [210] Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
• [211] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [212] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [213] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [214] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [215] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [216] Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 2006 Oct 20;7:69.
• [217] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [218] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [219] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [220] Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEG-3 cell line and placental tissue. Contraception. 2007 Oct;76(4):297-305. doi: 10.1016/j.contraception.2007.06.011. Epub 2007 Sep 14.
• [221] Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression. J Biol Chem. 2020 Nov 20;295(47):15870-15882. doi: 10.1074/jbc.RA120.015623. Epub 2020 Sep 10.
• [222] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [223] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [224] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [225] In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
• [226] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [227] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [228] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [229] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [230] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [231] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [232] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [233] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [234] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [235] Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
• [236] Differentiation of human embryonic stem cells into smooth muscle cells in adherent monolayer culture. Biochem Biophys Res Commun. 2006 Dec 15;351(2):321-7. doi: 10.1016/j.bbrc.2006.09.171. Epub 2006 Oct 17.
• [237] Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
• [238] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [239] Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. PLoS One. 2012;7(4):e35895. doi: 10.1371/journal.pone.0035895. Epub 2012 Apr 23.
• [240] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [241] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [242] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [243] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [244] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [245] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [246] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [247] Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
• [248] DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Biomed Res. 2006 Jun;27(3):99-109. doi: 10.2220/biomedres.27.99.
• [249] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [250] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [251] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [252] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [253] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [254] Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
• [255] Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man. PLoS One. 2011;6(9):e25612. doi: 10.1371/journal.pone.0025612. Epub 2011 Sep 28.
• [256] SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
• [257] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [258] Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues. Mol Endocrinol. 2006 Mar;20(3):573-83. doi: 10.1210/me.2005-0165. Epub 2005 Nov 3.
• [259] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [260] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [261] Effect of mood stabilizers on gene expression in lymphoblastoid cells. J Neural Transm (Vienna). 2010 Feb;117(2):155-64.
• [262] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [263] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [264] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [265] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [266] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [267] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [268] Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
• [269] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [270] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [271] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [272] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [273] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [274] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [275] Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
• [276] Verapamil-induced hyperprolactinemia complicated by a pituitary incidentaloma. Ann Pharmacother. 1995 Oct;29(10):999-1001. doi: 10.1177/106002809502901009.
• [277] [Impotence and gynecomastia secondary to hyperprolactinemia induced by ranitidine]. Therapie. 1994 Jul-Aug;49(4):361-2.
• [278] Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release. Mol Cell Endocrinol. 2005 Jul 15;239(1-2):27-36. doi: 10.1016/j.mce.2005.04.008.
• [279] Cholinergic modulation of the cerebral metabolic response to citalopram in Alzheimer's disease. Brain. 2009 Feb;132(Pt 2):392-401. doi: 10.1093/brain/awn326. Epub 2009 Jan 19.
• [280] The effect of thioridazine on prolactinoma growth in a schizophrenic man: case report. Gen Hosp Psychiatry. 1985 Oct;7(4):364-6. doi: 10.1016/0163-8343(85)90053-2.
• [281] Influence of naloxone on muscle sympathetic nerve activity, systemic and calf haemodynamics and ambulatory blood pressure after exercise in mild essential hypertension. J Hypertens. 1995 Apr;13(4):447-61.
• [282] The efficacy, safety, and tolerability of aripiprazole for the treatment of schizoaffective disorder: results from a pooled analysis of a sub-population of subjects from two randomized, double-blind, placebo-controlled, pivotal trials. J Affect Disord. 2009 May;115(1-2):18-26. doi: 10.1016/j.jad.2008.12.017. Epub 2009 Feb 23.
• [283] Serum prolactin levels among outpatients with major depressive disorder during the acute phase of treatment with fluoxetine. J Clin Psychiatry. 2006 Jun;67(6):952-7. doi: 10.4088/jcp.v67n0612.
• [284] Massive breast enlargement in a patient receiving D-penicillamine for systemic sclerosis. J Rheumatol. 1985 Oct;12(5):990-1.
• [285] Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun. 2001 Jan 26;280(3):664-74. doi: 10.1006/bbrc.2000.4216.
• [286] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [287] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [288] Methamphetamine alters the normal progression by inducing cell cycle arrest in astrocytes. PLoS One. 2014 Oct 7;9(10):e109603.
• [289] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [290] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [291] Time-series analysis in imatinib-resistant chronic myeloid leukemia K562-cells under different drug treatments. J Huazhong Univ Sci Technolog Med Sci. 2017 Aug;37(4):621-627. doi: 10.1007/s11596-017-1781-1. Epub 2017 Aug 8.
• [292] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [293] Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
• [294] Antipsychotic drugs inhibit the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells-an involvement of protein kinases. Neuropsychopharmacology. 2006 Apr;31(4):853-65. doi: 10.1038/sj.npp.1300911.
• [295] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [296] Terbutaline inhibits corticotropin-releasing hormone (CRH) expression in human trophoblast cells. J Matern Fetal Neonatal Med. 2006 Nov;19(11):735-9. doi: 10.1080/14767050600886724.
• [297] Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
• [298] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [299] Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
• [300] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [301] Proteomics investigation of protein expression changes in ouabain induced apoptosis in human umbilical vein endothelial cells. J Cell Biochem. 2008 Jun 1;104(3):1054-64. doi: 10.1002/jcb.21691.
• [302] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
• [303] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [304] Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
• [305] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [306] Muscle glycogen of steroid myopathy patients. J Neurol Sci. 1996 Mar;136(1-2):192-5. doi: 10.1016/0022-510x(95)00331-u.
• [307] Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. Arch Toxicol. 2016 Nov;90(11):2763-2777.
• [308] Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
• [309] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [310] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [311] The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
• [312] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [313] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [314] Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. Toxicol Appl Pharmacol. 2008 Jan 15;226(2):199-205. doi: 10.1016/j.taap.2007.09.004. Epub 2007 Sep 15.
• [315] miRNA expression profiling in a human stem cell-based model as a tool for developmental neurotoxicity testing. Cell Biol Toxicol. 2013 Aug;29(4):239-57. doi: 10.1007/s10565-013-9250-5. Epub 2013 Aug 1.
• [316] A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica. Tohoku J Exp Med. 2008 May;215(1):55-9. doi: 10.1620/tjem.215.55.
• [317] Aspirin-induced blockade of NF-kappaB activity restrains up-regulation of glial fibrillary acidic protein in human astroglial cells. Biochim Biophys Acta. 2006 Mar;1763(3):282-9. doi: 10.1016/j.bbamcr.2006.01.005. Epub 2006 Feb 21.
• [318] Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
• [319] Anti-diabetic effect of oligosaccharides from seaweed Sargassum confusum via JNK-IRS1/PI3K signalling pathways and regulation of gut microbiota. Food Chem Toxicol. 2019 Sep;131:110562. doi: 10.1016/j.fct.2019.110562. Epub 2019 Jun 7.
• [320] Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
• [321] Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia. 2010 May;53(5):955-65. doi: 10.1007/s00125-010-1676-1. Epub 2010 Feb 18.
• [322] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [323] Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBP-controlled gene expression. Arch Toxicol. 2020 Oct;94(10):3463-3473. doi: 10.1007/s00204-020-02835-x. Epub 2020 Jul 4.
• [324] Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1. Diabetologia. 2005 Jun;48(6):1173-9. doi: 10.1007/s00125-005-1741-3. Epub 2005 Apr 30.
• [325] Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells. J Psychiatr Res. 2006 Jun;40(4):374-9. doi: 10.1016/j.jpsychires.2005.04.016. Epub 2005 Jul 5.
• [326] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [327] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [328] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [329] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [330] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [331] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [332] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [333] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [334] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [335] Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
• [336] Effect of arsenic trioxide on vascular endothelial cell proliferation and expression of vascular endothelial growth factor receptors Flt-1 and KDR in gastric cancer in nude mice. World J Gastroenterol. 2007 Dec 28;13(48):6498-505. doi: 10.3748/wjg.v13.i48.6498.
• [337] 9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts. Reprod Toxicol. 2019 Aug;87:21-31. doi: 10.1016/j.reprotox.2019.04.008. Epub 2019 May 1.
• [338] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [339] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [340] Dopamine down-regulation of protein L-isoaspartyl methyltransferase is dependent on reactive oxygen species in SH-SY5Y cells. Neuroscience. 2014 May 16;267:263-76. doi: 10.1016/j.neuroscience.2014.03.001. Epub 2014 Mar 12.
• [341] Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
• [342] Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
• [343] Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
• [344] Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
• [345] Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation. Biochem Biophys Res Commun. 2004 Oct 22;323(3):782-8.
• [346] Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11927-32. doi: 10.1073/pnas.0609752104. Epub 2007 Jul 2.
• [347] No evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulation. Pharmacogenomics J. 2007 Aug;7(4):275-81. doi: 10.1038/sj.tpj.6500418. Epub 2006 Sep 19.
• [348] Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules. Chem Biol Interact. 2021 Nov 1;349:109662. doi: 10.1016/j.cbi.2021.109662. Epub 2021 Sep 21.
• [349] Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
• [350] The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells. Toxicol Sci. 2012 Feb;125(2):569-77. doi: 10.1093/toxsci/kfr305. Epub 2011 Nov 1.
• [351] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [352] Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
• [353] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [354] Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
• [355] Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
• [356] Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
• [357] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [358] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [359] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [360] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [361] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [362] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [363] Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
• [364] Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells. J Nutr. 2007 Apr;137(4):964-72.
• [365] SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. Blood. 2003 Aug 1;102(3):795-801. doi: 10.1182/blood-2002-10-3023. Epub 2003 Mar 20.
• [366] Low dosage of arsenic trioxide (As(2)O(3)) inhibits angiogenesis in epithelial ovarian cancer without cell apoptosis. J Biol Inorg Chem. 2018 Aug;23(6):939-947. doi: 10.1007/s00775-018-1595-z. Epub 2018 Jul 16.
• [367] Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res. 2004 Aug 15;64(16):5617-23. doi: 10.1158/0008-5472.CAN-03-3927.
• [368] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [369] Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor. FASEB J. 2006 Oct;20(12):2027-35. doi: 10.1096/fj.05-5404com.
• [370] Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor. Mol Cancer Ther. 2009 Jan;8(1):152-9. doi: 10.1158/1535-7163.MCT-08-0553.
• [371] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [372] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [373] Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
• [374] Neuroleptic Drugs and PACAP Differentially Affect the mRNA Expression of Genes Encoding PAC1/VPAC Type Receptors. Neurochem Res. 2017 Apr;42(4):943-952. doi: 10.1007/s11064-016-2127-2. Epub 2016 Nov 30.
• [375] Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
• [376] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [377] Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
• [378] Clinical response to Nabiximols correlates with the downregulation of immune pathways in multiple sclerosis. Eur J Neurol. 2018 Jul;25(7):934-e70. doi: 10.1111/ene.13623. Epub 2018 Apr 16.
• [379] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [380] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [381] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [382] Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
• [383] The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
• [384] Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
• [385] The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009 Feb;41(2):178-186.
• [386] Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33.
• [387] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [388] Chronic cyclophosphamide exposure alters the profile of rat sperm nuclear matrix proteins. Biol Reprod. 2007 Aug;77(2):303-11. doi: 10.1095/biolreprod.107.060244. Epub 2007 May 2.
• [389] Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. Exp Cell Res. 2009 Nov 15;315(19):3250-8. doi: 10.1016/j.yexcr.2009.09.005. Epub 2009 Sep 10.
• [390] Arsenic modulates posttranslational S-nitrosylation and translational proteome in keratinocytes. ScientificWorldJournal. 2014;2014:360153.
• [391] Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26.
• [392] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
• [393] ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
• [394] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [395] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [396] Differential proteomics identifies PDIA3 as a novel chemoprevention target in human colon cancer cells. Mol Carcinog. 2014 Feb;53 Suppl 1:E11-22. doi: 10.1002/mc.21986. Epub 2012 Dec 19.
• [397] Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell. 2006 Oct;10(4):321-30.
• [398] The effect of rare human sequence variants on the function of vesicular monoamine transporter 2. Pharmacogenetics. 2004 Sep;14(9):587-94. doi: 10.1097/00008571-200409000-00003.
• [399] Assessing Vesicular Monoamine Transport and Toxicity Using Fluorescent False Neurotransmitters. Chem Res Toxicol. 2021 May 17;34(5):1256-1264. doi: 10.1021/acs.chemrestox.0c00380. Epub 2020 Dec 30.
• [400] Synaptic vesicular monoamine transporter expression: distribution and pharmacologic profile. Brain Res Mol Brain Res. 1994 Mar;22(1-4):219-26. doi: 10.1016/0169-328x(94)90050-7.
• [401] Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users. Am J Psychiatry. 2003 Jan;160(1):47-55. doi: 10.1176/appi.ajp.160.1.47.
• [402] Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
• [403] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [404] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [405] Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. doi: 10.1159/000083234. Epub 2005 Jan 7.
• [406] Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005 Jan;16(1):54-8. doi: 10.1046/j.1540-8167.2005.04470.x.
• [407] Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds. Assay Drug Dev Technol. 2004 Oct;2(5):497-506. doi: 10.1089/adt.2004.2.497.
• [408] Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.
• [409] Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. Br J Pharmacol. 2008 Nov;155(6):957-66. doi: 10.1038/bjp.2008.325. Epub 2008 Aug 25.
• [410] Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol. 2006 Mar;147(6):642-52. doi: 10.1038/sj.bjp.0706508.
• [411] Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):212-9. doi: 10.1007/pl00005344.
• [412] Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation. FEBS Lett. 2000 May 26;474(1):111-5. doi: 10.1016/s0014-5793(00)01586-6.
• [413] Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
• [414] Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
• [415] Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells. Oncogene. 2006 Nov 23;25(55):7311-23.
• [416] Comparison of protective effect of ascorbic acid on redox and endocannabinoid systems interactions in in vitro cultured human skin fibroblasts exposed to UV radiation and hydrogen peroxide. Arch Dermatol Res. 2017 May;309(4):285-303. doi: 10.1007/s00403-017-1729-0. Epub 2017 Mar 11.
• [417] Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One. 2014 Jun 16;9(6):e97969. doi: 10.1371/journal.pone.0097969. eCollection 2014.
• [418] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [419] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [420] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [421] Benzo[a]pyrene treatment leads to changes in nuclear protein expression and alternative splicing. Mutat Res. 2010 Apr 1;686(1-2):47-56. doi: 10.1016/j.mrfmmm.2010.01.015. Epub 2010 Jan 25.
• [422] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [423] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [424] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [425] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [426] Exploring pradimicin-IRD antineoplastic mechanisms and related DNA repair pathways. Chem Biol Interact. 2023 Feb 1;371:110342. doi: 10.1016/j.cbi.2023.110342. Epub 2023 Jan 10.
• [427] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [428] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [429] Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
• [430] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [431] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [432] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [433] Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Res. 2007 Dec 15;67(24):12007-17. doi: 10.1158/0008-5472.CAN-07-2464.
• [434] NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells. PLoS One. 2011 Apr 4;6(4):e18306. doi: 10.1371/journal.pone.0018306.
• [435] Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
• [436] Identification of novel ER-alpha target genes in breast cancer cells: gene- and cell-selective co-regulator recruitment at target promoters determines the response to 17beta-estradiol and tamoxifen. Mol Cell Endocrinol. 2010 Jan 15;314(1):90-100.
• [437] Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
• [438] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [439] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [440] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [441] Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
• [442] Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
• [443] Proteomic signatures in thapsigargin-treated hepatoma cells. Chem Res Toxicol. 2011 Aug 15;24(8):1215-22. doi: 10.1021/tx200109y. Epub 2011 Jul 1.
• [444] [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
• [445] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [446] Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
• [447] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [448] Label-free quantitative proteomic analysis identifies the oncogenic role of FOXA1 in BaP-transformed 16HBE cells. Toxicol Appl Pharmacol. 2020 Sep 15;403:115160. doi: 10.1016/j.taap.2020.115160. Epub 2020 Jul 25.
• [449] Gamma-irradiation and doxorubicin treatment of normal human cells cause cell cycle arrest via different pathways. Mol Cells. 2005 Dec 31;20(3):331-8.
• [450] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [451] Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
• [452] Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. Autophagy. 2010 Aug;6(6):711-24. doi: 10.4161/auto.6.6.12397. Epub 2010 Aug 17.
• [453] Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
• [454] Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol Cell Endocrinol. 2004 Jun 30;221(1-2):47-55. doi: 10.1016/j.mce.2004.04.010.
• [455] Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
• [456] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [457] Madecassoside ameliorates cisplatin-induced nephrotoxicity by inhibiting activation of the mitogen activated protein kinase pathway. Environ Toxicol. 2023 Jul;38(7):1473-1483. doi: 10.1002/tox.23777. Epub 2023 Apr 23.
• [458] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [459] Inflammation in methotrexate-induced pulmonary toxicity occurs via the p38 MAPK pathway. Toxicology. 2009 Feb 27;256(3):183-90. doi: 10.1016/j.tox.2008.11.016. Epub 2008 Nov 28.
• [460] Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem Biol Interact. 2012 Jan 25;195(2):154-64.
• [461] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [462] Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
• [463] Arsenic trioxide promotes ERK1/2-mediated phosphorylation and degradation of BIM(EL) to attenuate apoptosis in BEAS-2B cells. Chem Biol Interact. 2023 Jan 5;369:110304. doi: 10.1016/j.cbi.2022.110304. Epub 2022 Dec 10.
• [464] Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. Mol Pharmacol. 2004 Feb;65(2):470-8.
• [465] Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine. Neurosci Lett. 2005 Nov 25;389(1):12-6. doi: 10.1016/j.neulet.2005.06.048.
• [466] Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline. Int J Neuropsychopharmacol. 2003 Dec;6(4):339-46. doi: 10.1017/S1461145703003663.
• [467] Serotonin transporter mRNA expression is decreased by lamivudine and ribavirin and increased by interferon in immune cells. Scand J Immunol. 2006 Feb;63(2):106-15. doi: 10.1111/j.1365-3083.2005.01715.x.
• [468] Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
• [469] Cholesterol-lowering therapy evokes time-limited changes in serotonergic transmission. Psychiatry Res. 2005 Feb 28;133(2-3):197-203. doi: 10.1016/j.psychres.2004.11.005.
• [470] Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter. J Med Chem. 2011 Sep 22;54(18):6305-18. doi: 10.1021/jm200682b. Epub 2011 Aug 23.
• [471] The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation. Pharmacogenet Genomics. 2009 Jun;19(6):437-46. doi: 10.1097/FPC.0b013e32832b9cfc.
• [472] Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
• [473] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [474] The effect of ethidium bromide and chloramphenicol on mitochondrial biogenesis in primary human fibroblasts. Toxicol Appl Pharmacol. 2012 May 15;261(1):42-9. doi: 10.1016/j.taap.2012.03.009.
• [475] Human 3D multicellular microtissues: an upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicol Lett. 2019 Sep 15;312:34-44.
• [476] Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutations. Food Chem Toxicol. 2018 Oct;120:89-97. doi: 10.1016/j.fct.2018.07.014. Epub 2018 Jul 6.
• [477] Beneficial effects of resveratrol on respiratory chain defects in patients' fibroblasts involve estrogen receptor and estrogen-related receptor alpha signaling. Hum Mol Genet. 2014 Apr 15;23(8):2106-19.
• [478] Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radic Biol Med. 2019 Feb 1;131:225-236. doi: 10.1016/j.freeradbiomed.2018.12.008. Epub 2018 Dec 11.
• [479] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [480] Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
• [481] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [482] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [483] Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
• [484] Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts. J Cell Biochem. 2008 May 1;104(1):38-50. doi: 10.1002/jcb.21597.
• [485] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
• [486] Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.