Details of Disease

General Information of Disease (ID: DIS9DIA4)

Disease Name	Cardiac arrest
Synonyms	circulatory arrest; cardiopulmonary arrest
Disease Class	MC82: Cardiac arrest
Definition	Cessation of breathing and/or cardiac function.
Disease Hierarchy	DIS1W8PP: Tachyarrhythmias DIS9DIA4: Cardiac arrest
ICD Code	ICD-11 ICD-11: MC82 Expand ICD-11 'MC82 Expand ICD-10 'I46; 'I46.0; 'I46.1; 'I46.9
Disease Identifiers	MONDO ID MONDO_0000745 MESH ID D006323 UMLS CUI C0018790 MedGen ID 5456 HPO ID HP:0001695 SNOMED CT ID 397829000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 5 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Calcium Acetate	DM40MBV	Approved	Small molecular drug	[1]
Calcium Chloride	DMYVFR3	Approved	Small molecular drug	[2]
Calcium Gluceptate	DM05ZXO	Approved	Small molecular drug	[3]
Isoproterenol	DMK7MEY	Approved	Small molecular drug	[4]
Metoprolol	DMOJ0V6	Approved	Small molecular drug	[5]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Neu-2000	DMNJTLC	Phase 1	NA	[6]
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This Disease is Treated as An Indication in 3 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Beta-aminopropionitrile	DMSJ2I6	Preclinical	Small molecular drug	[7]
CA-074Me	DMVN3FU	Preclinical	Small molecular drug	[7]
SHP-627	DMHAONP	Preclinical	Small molecular drug	[7]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PD98059	DMZC90M	Investigative	Small molecular drug	[8]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 46 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BCL11A	TTR61MW	Limited	Biomarker	[9]
HBB	TTM6HK1	Limited	Genetic Variation	[10]
ITPR1	TT5HWAT	Limited	Genetic Variation	[11]
KCNQ1	TT846HF	Limited	Genetic Variation	[12]
OAT	TTTSCQ2	Limited	Genetic Variation	[13]
POR	TTOQ9GZ	Limited	Genetic Variation	[14]
SERPIND1	TT8XSKJ	Limited	Altered Expression	[15]
SLCO1A2	TTUGD21	Limited	Genetic Variation	[16]
INS	TTZOPHG	moderate	Therapeutic	[17]
PRKCG	TTRFOXJ	moderate	Altered Expression	[18]
ABCC8	TTP835K	Strong	Altered Expression	[19]
ACLY	TT0Z6Y2	Strong	Biomarker	[20]
ANGPTL3	TT59GO7	Strong	Biomarker	[21]
ASIC1	TTRJYB6	Strong	Biomarker	[22]
AVPR1B	TTL9MHW	Strong	Altered Expression	[23]
AVPR2	TTK8R02	Strong	Biomarker	[24]
CACNA1C	TTZIFHC	Strong	Genetic Variation	[25]
CACNA1G	TT729IR	Strong	Genetic Variation	[26]
CCL5	TT9DWLC	Strong	Biomarker	[27]
CDC7	TTSMTDI	Strong	Altered Expression	[28]
CYP46A1	TT4EB85	Strong	Biomarker	[29]
FPR1	TT5Y4EM	Strong	Biomarker	[30]
G6PD	TTKN8W0	Strong	Biomarker	[31]
GFAP	TTI6FFX	Strong	Biomarker	[32]
HBA2	TTQO71U	Strong	Genetic Variation	[33]
HCRT	TTU5HJP	Strong	Altered Expression	[34]
HTR1E	TTCPG9S	Strong	Biomarker	[35]
IL18	TTRICUF	Strong	Genetic Variation	[36]
ITPR3	TTH1769	Strong	Altered Expression	[37]
KCND3	TTPLQO0	Strong	Genetic Variation	[38]
KCNH2	TTQ6VDM	Strong	Genetic Variation	[39]
KCNJ2	TTH7UO3	Strong	Genetic Variation	[40]
LTC4S	TTW7OTG	Strong	Genetic Variation	[41]
MASP2	TTR01E9	Strong	Altered Expression	[42]
MYB	TT8V13P	Strong	Biomarker	[43]
OSCAR	TT71Q5Y	Strong	Biomarker	[44]
PLA2R1	TTHKW7D	Strong	Biomarker	[45]
SCN5A	TTZOVE0	Strong	Genetic Variation	[46]
SLC25A4	TTU5A6Q	Strong	Biomarker	[47]
SSTR1	TTIND6G	Strong	Biomarker	[48]
SSTR5	TT2BC4G	Strong	Biomarker	[48]
TNF	TTF8CQI	Strong	Biomarker	[49]
TNNI3	TTNLDK6	Strong	Biomarker	[50]
TRPM4	TTJ2HKA	Strong	Altered Expression	[19]
UGCG	TTPHEX3	Strong	Genetic Variation	[51]
UGT1A1	TT34ZAF	Strong	Genetic Variation	[52]
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⏷ Show the Full List of 46 DTT(s)

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC4A3	DT4X2AH	moderate	Biomarker	[53]
SLC25A6	DTLMGFJ	Strong	Biomarker	[47]
SLC7A7	DTE4HJ8	Strong	Biomarker	[54]
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This Disease Is Related to 10 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ACSS2	DEE76VW	Strong	Biomarker	[55]
ADH5	DEIOH6A	Strong	Biomarker	[56]
FXN	DEXVHDB	Strong	Biomarker	[57]
TGM6	DEUWCVD	Strong	Genetic Variation	[58]
UBASH3B	DE10BJ5	Strong	Biomarker	[59]
UGT1A10	DEL5N6Y	Strong	Genetic Variation	[60]
UGT1A4	DELOY3P	Strong	Genetic Variation	[60]
UGT1A6	DESD26P	Strong	Genetic Variation	[60]
UGT1A7	DEZO4N3	Strong	Genetic Variation	[60]
UGT1A8	DE2GB8N	Strong	Genetic Variation	[60]
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⏷ Show the Full List of 10 DME(s)

This Disease Is Related to 61 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ADCY6	OTFOY4WW	Limited	Genetic Variation	[61]
CPLANE1	OTXGGNNB	Limited	Biomarker	[62]
ENO2	OTRODL0T	Limited	Biomarker	[63]
TBP	OT6C0S52	Limited	Genetic Variation	[64]
ATXN7	OTL3YF1H	Disputed	Biomarker	[65]
DYNLL1	OTR69LHT	moderate	Biomarker	[66]
ELOVL4	OT2M9W26	moderate	Genetic Variation	[67]
LUC7L3	OTKDED8A	moderate	Biomarker	[68]
MTMR11	OTHL2O08	moderate	Biomarker	[68]
PRKAG2	OTHTAM54	moderate	Genetic Variation	[69]
ACCS	OTHIHI9D	Strong	Biomarker	[55]
AFG3L2	OTRPMAUX	Strong	Genetic Variation	[70]
AGBL2	OTCX9987	Strong	Biomarker	[71]
ATN1	OTNZFLKY	Strong	Biomarker	[72]
ATP1A3	OTM8EG6H	Strong	Genetic Variation	[73]
ATXN10	OTKRDUNN	Strong	Biomarker	[74]
BTBD8	OT3A3RD7	Strong	Biomarker	[75]
CALM2	OTNYA92F	Strong	Genetic Variation	[76]
CAPS	OTC9GZ2M	Strong	Genetic Variation	[77]
CASQ2	OT09MNQ8	Strong	Genetic Variation	[78]
DAB1	OTPL9MA3	Strong	Genetic Variation	[79]
ELOVL5	OT375W1Z	Strong	Genetic Variation	[80]
ERBIN	OTNWTUA8	Strong	Genetic Variation	[81]
FAN1	OT1LM1HZ	Strong	Genetic Variation	[82]
GPC5	OT8NR7GC	Strong	Genetic Variation	[40]
HBA1	OTW2BQF4	Strong	Genetic Variation	[33]
HBG1	OTVL4NSU	Strong	Altered Expression	[83]
HBG2	OT4J48JJ	Strong	Biomarker	[84]
HBS1L	OTA3U1N6	Strong	Genetic Variation	[85]
IGFALS	OTTWCZYM	Strong	Genetic Variation	[86]
KCND2	OTIFUVV7	Strong	Genetic Variation	[87]
KCNE1	OTZNQUW9	Strong	Genetic Variation	[88]
LPCAT1	OTCV7AGV	Strong	Biomarker	[89]
MIPEP	OTB2IHCT	Strong	Genetic Variation	[90]
MLC1	OTCNZLSP	Strong	Biomarker	[91]
MTSS1	OT5DTDO2	Strong	Biomarker	[92]
NEFL	OTQESJV4	Strong	Altered Expression	[93]
NHS	OTKE8QAT	Strong	Biomarker	[94]
NLK	OT2LETFS	Strong	Altered Expression	[95]
NOP56	OTT67SRZ	Strong	Biomarker	[96]
NOS1AP	OTDFOBRU	Strong	Genetic Variation	[12]
OR2AG1	OTEITRP4	Strong	Genetic Variation	[97]
PDYN	OTEJ6430	Strong	Genetic Variation	[98]
PHLPP1	OTIFXW8D	Strong	Altered Expression	[99]
PLA2G15	OT6VJTPA	Strong	Biomarker	[55]
PLEKHG4	OT3RBPFL	Strong	Genetic Variation	[100]
PPA2	OTRKV8WW	Strong	Genetic Variation	[101]
PPP1R15A	OTYG179K	Strong	Altered Expression	[102]
PPP2R2B	OTSFVC82	Strong	Genetic Variation	[103]
RAN	OT2TER5M	Strong	Biomarker	[104]
RAPGEF5	OT53VS75	Strong	Genetic Variation	[105]
RHBDF1	OTCQ7UDS	Strong	Biomarker	[106]
SEMA3F	OTQFMS8S	Strong	Biomarker	[107]
SLITRK1	OT1QQ7FR	Strong	Biomarker	[108]
SPTBN2	OTDMJ75N	Strong	Genetic Variation	[109]
SS18L1	OT9ZEGV7	Strong	Biomarker	[110]
STUB1	OTSUYI9A	Strong	Genetic Variation	[111]
SYN1	OTMNPWC1	Strong	Genetic Variation	[112]
TBX19	OTXEMR2U	Strong	Altered Expression	[23]
TRDN	OTXVE9SF	Strong	Genetic Variation	[113]
TTBK2	OT90YSM5	Strong	Genetic Variation	[114]
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⏷ Show the Full List of 61 DOT(s)

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