Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTS5NIZ3)

DOT Name GRB2-related adapter protein 2 (GRAP2)
Synonyms
Adapter protein GRID; GRB-2-like protein; GRB2L; GRBLG; GRBX; Grf40 adapter protein; Grf-40; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein GrpL; P38; Protein GADS; SH3-SH2-SH3 adapter Mona
Gene Name GRAP2
Related Disease
Lung cancer ( )
Lung carcinoma ( )
Advanced cancer ( )
Alzheimer disease ( )
Arteriosclerosis ( )
Arthritis ( )
Atherosclerosis ( )
B-cell neoplasm ( )
Breast cancer ( )
Breast carcinoma ( )
Chronic obstructive pulmonary disease ( )
Colon cancer ( )
Colon carcinoma ( )
Congestive heart failure ( )
Depression ( )
Diabetic kidney disease ( )
Endometriosis ( )
Glioma ( )
Head-neck squamous cell carcinoma ( )
Hepatocellular carcinoma ( )
Hyperglycemia ( )
Melanoma ( )
Myelodysplastic syndrome ( )
Myocardial infarction ( )
Neoplasm ( )
Non-small-cell lung cancer ( )
Obesity ( )
Osteoarthritis ( )
Parkinson disease ( )
Plasma cell myeloma ( )
Pneumonia ( )
Pneumonitis ( )
Prostate cancer ( )
Prostate carcinoma ( )
Rheumatoid arthritis ( )
Cardiac failure ( )
Colorectal carcinoma ( )
leukaemia ( )
Leukemia ( )
Lung adenocarcinoma ( )
Nervous system inflammation ( )
Neuralgia ( )
Non-insulin dependent diabetes ( )
Pancreatic cancer ( )
Tuberculosis ( )
Osteosarcoma ( )
Bone osteosarcoma ( )
Neuroblastoma ( )
Type-1/2 diabetes ( )
UniProt ID
GRAP2_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
PDB ID
5GJH
Pfam ID
PF00017 ; PF00018
Sequence
MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFH
EGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTE
KFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRP
SMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDIN
DGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEV
LDSSNPSWWTGRLHNKLGLFPANYVAPMTR
Function Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
KEGG Pathway
T cell receptor sig.ling pathway (hsa04660 )
Reactome Pathway
Generation of second messenger molecules (R-HSA-202433 )
DAP12 signaling (R-HSA-2424491 )
FCERI mediated MAPK activation (R-HSA-2871796 )
FCERI mediated Ca+2 mobilization (R-HSA-2871809 )
CD28 co-stimulation (R-HSA-389356 )
FLT3 Signaling (R-HSA-9607240 )
Signaling by CSF1 (M-CSF) in myeloid cells (R-HSA-9680350 )
Signaling by SCF-KIT (R-HSA-1433557 )

Molecular Interaction Atlas (MIA) of This DOT

49 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Lung cancer DISCM4YA Definitive Biomarker [1]
Lung carcinoma DISTR26C Definitive Biomarker [1]
Advanced cancer DISAT1Z9 Strong Altered Expression [2]
Alzheimer disease DISF8S70 Strong Biomarker [3]
Arteriosclerosis DISK5QGC Strong Altered Expression [4]
Arthritis DIST1YEL Strong Biomarker [5]
Atherosclerosis DISMN9J3 Strong Altered Expression [4]
B-cell neoplasm DISVY326 Strong Posttranslational Modification [6]
Breast cancer DIS7DPX1 Strong Altered Expression [7]
Breast carcinoma DIS2UE88 Strong Altered Expression [7]
Chronic obstructive pulmonary disease DISQCIRF Strong Altered Expression [8]
Colon cancer DISVC52G Strong Biomarker [9]
Colon carcinoma DISJYKUO Strong Biomarker [9]
Congestive heart failure DIS32MEA Strong Altered Expression [10]
Depression DIS3XJ69 Strong Biomarker [11]
Diabetic kidney disease DISJMWEY Strong Biomarker [12]
Endometriosis DISX1AG8 Strong Altered Expression [13]
Glioma DIS5RPEH Strong Altered Expression [14]
Head-neck squamous cell carcinoma DISF7P24 Strong Altered Expression [15]
Hepatocellular carcinoma DIS0J828 Strong Biomarker [16]
Hyperglycemia DIS0BZB5 Strong Biomarker [17]
Melanoma DIS1RRCY Strong Biomarker [18]
Myelodysplastic syndrome DISYHNUI Strong Biomarker [19]
Myocardial infarction DIS655KI Strong Altered Expression [20]
Neoplasm DISZKGEW Strong Posttranslational Modification [21]
Non-small-cell lung cancer DIS5Y6R9 Strong Biomarker [22]
Obesity DIS47Y1K Strong Altered Expression [23]
Osteoarthritis DIS05URM Strong Biomarker [24]
Parkinson disease DISQVHKL Strong Biomarker [25]
Plasma cell myeloma DIS0DFZ0 Strong Biomarker [26]
Pneumonia DIS8EF3M Strong Biomarker [27]
Pneumonitis DIS88E0K Strong Biomarker [27]
Prostate cancer DISF190Y Strong Altered Expression [28]
Prostate carcinoma DISMJPLE Strong Altered Expression [28]
Rheumatoid arthritis DISTSB4J Strong Biomarker [29]
Cardiac failure DISDC067 moderate Biomarker [30]
Colorectal carcinoma DIS5PYL0 moderate Biomarker [31]
leukaemia DISS7D1V moderate Biomarker [32]
Leukemia DISNAKFL moderate Biomarker [32]
Lung adenocarcinoma DISD51WR moderate Altered Expression [1]
Nervous system inflammation DISB3X5A moderate Altered Expression [33]
Neuralgia DISWO58J moderate Altered Expression [34]
Non-insulin dependent diabetes DISK1O5Z moderate Biomarker [35]
Pancreatic cancer DISJC981 moderate Biomarker [36]
Tuberculosis DIS2YIMD moderate Biomarker [37]
Osteosarcoma DISLQ7E2 Disputed Biomarker [38]
Bone osteosarcoma DIST1004 Limited Biomarker [38]
Neuroblastoma DISVZBI4 Limited Altered Expression [39]
Type-1/2 diabetes DISIUHAP Limited Altered Expression [40]
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⏷ Show the Full List of 49 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
4 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Triclosan DMZUR4N Approved Triclosan decreases the expression of GRB2-related adapter protein 2 (GRAP2). [41]
Dexamethasone DMMWZET Approved Dexamethasone increases the expression of GRB2-related adapter protein 2 (GRAP2). [42]
Demecolcine DMCZQGK Approved Demecolcine decreases the expression of GRB2-related adapter protein 2 (GRAP2). [43]
Formaldehyde DM7Q6M0 Investigative Formaldehyde decreases the expression of GRB2-related adapter protein 2 (GRAP2). [43]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene affects the methylation of GRB2-related adapter protein 2 (GRAP2). [44]
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References

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