General Information of Drug Off-Target (DOT) (ID: OTWS5I5H)

DOT Name Lymphoid enhancer-binding factor 1 (LEF1)
Synonyms LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha
Gene Name LEF1
Related Disease
Acute myelogenous leukaemia ( )
Adult glioblastoma ( )
B-cell neoplasm ( )
Breast cancer ( )
Breast carcinoma ( )
Breast neoplasm ( )
Burkitt lymphoma ( )
Carcinoma ( )
Childhood acute lymphoblastic leukemia ( )
Colon carcinoma ( )
Colonic neoplasm ( )
Colorectal carcinoma ( )
Esophageal squamous cell carcinoma ( )
Familial adenomatous polyposis ( )
Gastric cancer ( )
Hepatocellular carcinoma ( )
Leukemia ( )
Lung cancer ( )
Mantle cell lymphoma ( )
Myelodysplastic syndrome ( )
Neoplasm ( )
Neuroblastoma ( )
Osteoarthritis ( )
Severe congenital neutropenia ( )
Small lymphocytic lymphoma ( )
Stomach cancer ( )
X-linked hypohidrotic ectodermal dysplasia ( )
Cleft palate ( )
Glioblastoma multiforme ( )
Isolated cleft palate ( )
leukaemia ( )
Metastatic malignant neoplasm ( )
Nasopharyngeal carcinoma ( )
Primary myelofibrosis ( )
Melanoma ( )
Prostate cancer ( )
Prostate carcinoma ( )
Acute lymphocytic leukaemia ( )
Autoimmune disease ( )
Bone osteosarcoma ( )
Colon cancer ( )
Endometrial cancer ( )
Endometrial carcinoma ( )
Lymphoid leukemia ( )
Osteosarcoma ( )
UniProt ID
LEF1_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Pfam ID
PF08347 ; PF00505
Sequence
MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE
SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM
NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS
KQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWQGQPVYPITGGFRQPYPSSLSVDTSMS
RFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIK
KPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHM
QLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI
Function
Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. May play a role in hair cell differentiation and follicle morphogenesis; [Isoform 1]: Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells; [Isoform 3]: Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling; [Isoform 5]: Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells.
Tissue Specificity
Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.
KEGG Pathway
Wnt sig.ling pathway (hsa04310 )
Hippo sig.ling pathway (hsa04390 )
Adherens junction (hsa04520 )
Melanogenesis (hsa04916 )
Cushing syndrome (hsa04934 )
Alcoholic liver disease (hsa04936 )
Salmonella infection (hsa05132 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Pathways in cancer (hsa05200 )
Colorectal cancer (hsa05210 )
Endometrial cancer (hsa05213 )
Prostate cancer (hsa05215 )
Thyroid cancer (hsa05216 )
Basal cell carcinoma (hsa05217 )
Acute myeloid leukemia (hsa05221 )
Breast cancer (hsa05224 )
Hepatocellular carcinoma (hsa05225 )
Gastric cancer (hsa05226 )
Arrhythmogenic right ventricular cardiomyopathy (hsa05412 )
Reactome Pathway
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402 )
Ca2+ pathway (R-HSA-4086398 )
Binding of TCF/LEF (R-HSA-4411364 )
Repression of WNT target genes (R-HSA-4641265 )
Transcriptional Regulation by VENTX (R-HSA-8853884 )
RUNX3 regulates WNT signaling (R-HSA-8951430 )
Transcriptional regulation of granulopoiesis (R-HSA-9616222 )
Cardiogenesis (R-HSA-9733709 )
Germ layer formation at gastrulation (R-HSA-9754189 )
Formation of paraxial mesoderm (R-HSA-9793380 )
Formation of axial mesoderm (R-HSA-9796292 )
Somitogenesis (R-HSA-9824272 )
Formation of the beta-catenin (R-HSA-201722 )

Molecular Interaction Atlas (MIA) of This DOT

45 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Acute myelogenous leukaemia DISCSPTN Strong Biomarker [1]
Adult glioblastoma DISVP4LU Strong Biomarker [2]
B-cell neoplasm DISVY326 Strong Biomarker [3]
Breast cancer DIS7DPX1 Strong Altered Expression [4]
Breast carcinoma DIS2UE88 Strong Altered Expression [4]
Breast neoplasm DISNGJLM Strong Biomarker [5]
Burkitt lymphoma DIS9D5XU Strong Biomarker [6]
Carcinoma DISH9F1N Strong Biomarker [7]
Childhood acute lymphoblastic leukemia DISJ5D6U Strong Biomarker [6]
Colon carcinoma DISJYKUO Strong Biomarker [8]
Colonic neoplasm DISSZ04P Strong Altered Expression [9]
Colorectal carcinoma DIS5PYL0 Strong Altered Expression [10]
Esophageal squamous cell carcinoma DIS5N2GV Strong Altered Expression [11]
Familial adenomatous polyposis DISW53RE Strong Biomarker [12]
Gastric cancer DISXGOUK Strong Biomarker [13]
Hepatocellular carcinoma DIS0J828 Strong Altered Expression [14]
Leukemia DISNAKFL Strong Biomarker [15]
Lung cancer DISCM4YA Strong Biomarker [16]
Mantle cell lymphoma DISFREOV Strong Biomarker [17]
Myelodysplastic syndrome DISYHNUI Strong Genetic Variation [18]
Neoplasm DISZKGEW Strong Biomarker [19]
Neuroblastoma DISVZBI4 Strong Altered Expression [20]
Osteoarthritis DIS05URM Strong Altered Expression [21]
Severe congenital neutropenia DISES99N Strong Altered Expression [22]
Small lymphocytic lymphoma DIS30POX Strong Altered Expression [23]
Stomach cancer DISKIJSX Strong Biomarker [13]
X-linked hypohidrotic ectodermal dysplasia DISST0XM Strong Altered Expression [24]
Cleft palate DIS6G5TF moderate Biomarker [25]
Glioblastoma multiforme DISK8246 moderate Biomarker [26]
Isolated cleft palate DISV80CD moderate Biomarker [25]
leukaemia DISS7D1V moderate Biomarker [15]
Metastatic malignant neoplasm DIS86UK6 moderate Altered Expression [27]
Nasopharyngeal carcinoma DISAOTQ0 moderate Biomarker [28]
Primary myelofibrosis DIS6L0CN moderate Altered Expression [29]
Melanoma DIS1RRCY Disputed Biomarker [30]
Prostate cancer DISF190Y Disputed Altered Expression [31]
Prostate carcinoma DISMJPLE Disputed Altered Expression [31]
Acute lymphocytic leukaemia DISPX75S Limited Biomarker [6]
Autoimmune disease DISORMTM Limited Biomarker [32]
Bone osteosarcoma DIST1004 Limited Altered Expression [33]
Colon cancer DISVC52G Limited Biomarker [8]
Endometrial cancer DISW0LMR Limited Altered Expression [34]
Endometrial carcinoma DISXR5CY Limited Altered Expression [34]
Lymphoid leukemia DIS65TYQ Limited Biomarker [35]
Osteosarcoma DISLQ7E2 Limited Altered Expression [33]
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⏷ Show the Full List of 45 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the methylation of Lymphoid enhancer-binding factor 1 (LEF1). [36]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of Lymphoid enhancer-binding factor 1 (LEF1). [47]
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19 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Doxorubicin DMVP5YE Approved Doxorubicin decreases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [37]
Decitabine DMQL8XJ Approved Decitabine decreases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [38]
Hydroquinone DM6AVR4 Approved Hydroquinone decreases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [39]
Acocantherin DM7JT24 Approved Acocantherin decreases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [40]
Adenosine DMM2NSK Approved Adenosine increases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [42]
Ethacrynic acid DM60QMR Approved Ethacrynic acid decreases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [43]
SNDX-275 DMH7W9X Phase 3 SNDX-275 increases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [44]
Resveratrol DM3RWXL Phase 3 Resveratrol decreases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [45]
Thymoquinone DMVDTR2 Phase 2/3 Thymoquinone decreases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [46]
(+)-JQ1 DM1CZSJ Phase 1 (+)-JQ1 decreases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [48]
PMID28460551-Compound-2 DM4DOUB Patented PMID28460551-Compound-2 increases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [49]
Trichostatin A DM9C8NX Investigative Trichostatin A increases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [50]
Milchsaure DM462BT Investigative Milchsaure increases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [51]
Deguelin DMXT7WG Investigative Deguelin increases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [52]
methyl p-hydroxybenzoate DMO58UW Investigative methyl p-hydroxybenzoate increases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [53]
D-glucose DMMG2TO Investigative D-glucose increases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [54]
QUERCITRIN DM1DH96 Investigative QUERCITRIN affects the expression of Lymphoid enhancer-binding factor 1 (LEF1). [55]
Cordycepin DM72Y01 Investigative Cordycepin increases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [42]
eucalyptol DME5CK3 Investigative eucalyptol decreases the expression of Lymphoid enhancer-binding factor 1 (LEF1). [56]
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⏷ Show the Full List of 19 Drug(s)
1 Drug(s) Affected the Protein Interaction/Cellular Processes of This DOT
Drug Name Drug ID Highest Status Interaction REF
Lovastatin DM9OZWQ Approved Lovastatin affects the localization of Lymphoid enhancer-binding factor 1 (LEF1). [41]
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References

1 Differences in expression and function of LEF1 isoforms in normal versus leukemic hematopoiesis.Leukemia. 2020 Apr;34(4):1027-1037. doi: 10.1038/s41375-019-0635-1. Epub 2019 Nov 22.
2 Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion.EMBO J. 2018 Aug 1;37(15):e97115. doi: 10.15252/embj.201797115. Epub 2018 Jun 14.
3 miR-103/107 promote ER stress-mediated apoptosis via targeting the Wnt3a/-catenin/ATF6 pathway in preadipocytes.J Lipid Res. 2018 May;59(5):843-853. doi: 10.1194/jlr.M082602. Epub 2018 Feb 26.
4 LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer.Int J Cancer. 2020 Jun 1;146(11):3170-3183. doi: 10.1002/ijc.32742. Epub 2019 Nov 11.
5 Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.J Exp Med. 2016 Oct 17;213(11):2503-2523. doi: 10.1084/jem.20160397. Epub 2016 Oct 10.
6 Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment.Am J Cancer Res. 2017 Jun 1;7(6):1389-1406. eCollection 2017.
7 Epstein-Barr virus stably confers an invasive phenotype to epithelial cells through reprogramming of the WNT pathway.Oncotarget. 2018 Jan 2;9(12):10417-10435. doi: 10.18632/oncotarget.23824. eCollection 2018 Feb 13.
8 Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation.Cell Commun Signal. 2019 Oct 17;17(1):129. doi: 10.1186/s12964-019-0444-1.
9 Differential expression of LEF1/TCFs family members in colonic carcinogenesis.Mol Carcinog. 2017 Nov;56(11):2372-2381. doi: 10.1002/mc.22530. Epub 2017 May 22.
10 The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression.Cancer Lett. 2018 Jun 28;424:9-18. doi: 10.1016/j.canlet.2018.03.022. Epub 2018 Mar 15.
11 The transcription factor LEF1 promotes tumorigenicity and activates the TGF- signaling pathway in esophageal squamous cell carcinoma.J Exp Clin Cancer Res. 2019 Jul 11;38(1):304. doi: 10.1186/s13046-019-1296-7.
12 Putative tumor suppressor EDD interacts with and up-regulates APC.Genes Cells. 2007 Dec;12(12):1339-45. doi: 10.1111/j.1365-2443.2007.01138.x.
13 Overexpression of MYC binding protein promotes invasion and migration in gastric cancer.Oncol Lett. 2018 Apr;15(4):5243-5249. doi: 10.3892/ol.2018.7944. Epub 2018 Feb 2.
14 Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway.Oncogene. 2019 May;38(21):4061-4074. doi: 10.1038/s41388-019-0704-y. Epub 2019 Jan 29.
15 MicroRNA-124 represses wound healing by targeting SERP1 and inhibiting the Wnt/-catenin pathway.Adv Clin Exp Med. 2019 Jun;28(6):711-718. doi: 10.17219/acem/94163.
16 Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin.Mol Cancer Ther. 2012 Nov;11(11):2362-72. doi: 10.1158/1535-7163.MCT-12-0107. Epub 2012 Aug 29.
17 Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma.Cytometry B Clin Cytom. 2018 Jan;94(1):148-150. doi: 10.1002/cyto.b.21512. Epub 2017 Feb 24.
18 The lower risk MDS patient at risk of rapid progression.Leuk Res. 2010 Dec;34(12):1551-5. doi: 10.1016/j.leukres.2010.05.023. Epub 2010 Jun 22.
19 SNAIL1 employs -Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation.Int J Cancer. 2020 Apr 15;146(8):2229-2242. doi: 10.1002/ijc.32644. Epub 2019 Sep 18.
20 microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma.Clin Cancer Res. 2017 Jun 1;23(11):2905-2918. doi: 10.1158/1078-0432.CCR-16-1591. Epub 2016 Dec 21.
21 Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis.Nat Commun. 2019 Jan 18;10(1):313. doi: 10.1038/s41467-018-08277-5.
22 Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34(+) cells.Blood. 2014 Apr 17;123(16):2550-61. doi: 10.1182/blood-2012-09-456889. Epub 2014 Jan 6.
23 Cortactin expression in non-Hodgkin B-cell lymphomas: a new marker for the differential diagnosis between chronic lymphocytic leukemia and mantle cell lymphoma.Hum Pathol. 2019 Mar;85:251-259. doi: 10.1016/j.humpath.2018.10.038. Epub 2018 Nov 17.
24 The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation.Biochem Biophys Res Commun. 2004 Feb 27;315(1):73-8. doi: 10.1016/j.bbrc.2004.01.025.
25 Genome-Wide mRNA-Seq Profiling Reveals that LEF1 and SMAD3 Regulate Epithelial-Mesenchymal Transition Through the Hippo Signaling Pathway During Palatal Fusion.Genet Test Mol Biomarkers. 2019 Mar;23(3):197-203. doi: 10.1089/gtmb.2018.0221. Epub 2019 Feb 15.
26 The Disruption of the -Catenin/TCF-1/STAT3 Signaling Axis by 4-Acetylantroquinonol B Inhibits the Tumorigenesis and Cancer Stem-Cell-Like Properties of Glioblastoma Cells, In Vitro and In Vivo.Cancers (Basel). 2018 Dec 5;10(12):491. doi: 10.3390/cancers10120491.
27 microRNA-219-5p inhibits epithelial-mesenchymal transition and metastasis of colorectal cancer by targeting lymphoid enhancer-binding factor 1.Cancer Sci. 2017 Oct;108(10):1985-1995. doi: 10.1111/cas.13338. Epub 2017 Aug 29.
28 Expression of LEF1 and TCF1 (TCF7) proteins associates with clinical progression of nasopharyngeal carcinoma.J Clin Pathol. 2019 Jun;72(6):425-430. doi: 10.1136/jclinpath-2019-205698. Epub 2019 Mar 27.
29 Role of miR-34a-5p in Hematopoietic Progenitor Cells Proliferation and Fate Decision: Novel Insights into the Pathogenesis of Primary Myelofibrosis.Int J Mol Sci. 2017 Jan 13;18(1):145. doi: 10.3390/ijms18010145.
30 Effects of microRNA-708 on Epithelial-Mesenchymal Transition, Cell Proliferation and Apoptosis in Melanoma Cells by Targeting LEF1 through the Wnt Signaling Pathway.Pathol Oncol Res. 2019 Jan;25(1):377-389. doi: 10.1007/s12253-017-0334-z. Epub 2017 Nov 14.
31 Long noncoding RNA LEF1-AS1 silencing suppresses the initiation and development of prostate cancer by acting as a molecular sponge of miR-330-5p via LEF1 repression.J Cell Physiol. 2019 Aug;234(8):12727-12744. doi: 10.1002/jcp.27893. Epub 2019 Jan 5.
32 Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells.J Exp Med. 2019 Apr 1;216(4):847-866. doi: 10.1084/jem.20182010. Epub 2019 Mar 5.
33 CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of -catenin/LEF1 complex via effects on chromatin remodeling.Mol Cancer. 2019 Oct 29;18(1):150. doi: 10.1186/s12943-019-1076-1.
34 Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer.Oncotarget. 2012 Dec;3(12):1546-56. doi: 10.18632/oncotarget.667.
35 Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1.Med Mol Morphol. 2013 Mar;46(1):14-9. doi: 10.1007/s00795-012-0002-z. Epub 2013 Jan 17.
36 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
37 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
38 Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia. Leukemia. 2009 Sep;23(9):1658-66. doi: 10.1038/leu.2009.86. Epub 2009 Apr 23.
39 Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
40 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
41 Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci Lett. 2007 Feb 2;412(3):211-6. doi: 10.1016/j.neulet.2006.07.045. Epub 2007 Jan 17.
42 Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/-Catenin Pathway Stimulation by Regulating GSK3b Activity. Int J Mol Sci. 2021 May 25;22(11):5571. doi: 10.3390/ijms22115571.
43 Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14;4(12):e8294. doi: 10.1371/journal.pone.0008294.
44 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
45 Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res. 2009 Apr 3;1:25-37.
46 Thymoquinone suppresses invasion and metastasis in bladder cancer cells by reversing EMT through the Wnt/-catenin signaling pathway. Chem Biol Interact. 2020 Apr 1;320:109022. doi: 10.1016/j.cbi.2020.109022. Epub 2020 Feb 27.
47 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
48 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
49 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
50 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
51 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
52 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
53 Comparison of the global gene expression profiles produced by methylparaben, n-butylparaben and 17beta-oestradiol in MCF7 human breast cancer cells. J Appl Toxicol. 2007 Jan-Feb;27(1):67-77. doi: 10.1002/jat.1200.
54 Aberrant Wnt/Beta-Catenin Pathway Activation in Dialysate-Induced Peritoneal Fibrosis. Front Pharmacol. 2017 Oct 30;8:774. doi: 10.3389/fphar.2017.00774. eCollection 2017.
55 Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
56 Transcriptome Analysis Reveals the Anti-Tumor Mechanism of Eucalyptol Treatment on Neuroblastoma Cell Line SH-SY5Y. Neurochem Res. 2022 Dec;47(12):3854-3862. doi: 10.1007/s11064-022-03786-8. Epub 2022 Nov 4.