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Differences in expression and function of LEF1 isoforms in normal versus leukemic hematopoiesis.Leukemia. 2020 Apr;34(4):1027-1037. doi: 10.1038/s41375-019-0635-1. Epub 2019 Nov 22.
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Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion.EMBO J. 2018 Aug 1;37(15):e97115. doi: 10.15252/embj.201797115. Epub 2018 Jun 14.
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miR-103/107 promote ER stress-mediated apoptosis via targeting the Wnt3a/-catenin/ATF6 pathway in preadipocytes.J Lipid Res. 2018 May;59(5):843-853. doi: 10.1194/jlr.M082602. Epub 2018 Feb 26.
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LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer.Int J Cancer. 2020 Jun 1;146(11):3170-3183. doi: 10.1002/ijc.32742. Epub 2019 Nov 11.
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Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.J Exp Med. 2016 Oct 17;213(11):2503-2523. doi: 10.1084/jem.20160397. Epub 2016 Oct 10.
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Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment.Am J Cancer Res. 2017 Jun 1;7(6):1389-1406. eCollection 2017.
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Epstein-Barr virus stably confers an invasive phenotype to epithelial cells through reprogramming of the WNT pathway.Oncotarget. 2018 Jan 2;9(12):10417-10435. doi: 10.18632/oncotarget.23824. eCollection 2018 Feb 13.
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Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation.Cell Commun Signal. 2019 Oct 17;17(1):129. doi: 10.1186/s12964-019-0444-1.
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Differential expression of LEF1/TCFs family members in colonic carcinogenesis.Mol Carcinog. 2017 Nov;56(11):2372-2381. doi: 10.1002/mc.22530. Epub 2017 May 22.
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The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression.Cancer Lett. 2018 Jun 28;424:9-18. doi: 10.1016/j.canlet.2018.03.022. Epub 2018 Mar 15.
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The transcription factor LEF1 promotes tumorigenicity and activates the TGF- signaling pathway in esophageal squamous cell carcinoma.J Exp Clin Cancer Res. 2019 Jul 11;38(1):304. doi: 10.1186/s13046-019-1296-7.
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Putative tumor suppressor EDD interacts with and up-regulates APC.Genes Cells. 2007 Dec;12(12):1339-45. doi: 10.1111/j.1365-2443.2007.01138.x.
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Overexpression of MYC binding protein promotes invasion and migration in gastric cancer.Oncol Lett. 2018 Apr;15(4):5243-5249. doi: 10.3892/ol.2018.7944. Epub 2018 Feb 2.
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Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway.Oncogene. 2019 May;38(21):4061-4074. doi: 10.1038/s41388-019-0704-y. Epub 2019 Jan 29.
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MicroRNA-124 represses wound healing by targeting SERP1 and inhibiting the Wnt/-catenin pathway.Adv Clin Exp Med. 2019 Jun;28(6):711-718. doi: 10.17219/acem/94163.
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Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin.Mol Cancer Ther. 2012 Nov;11(11):2362-72. doi: 10.1158/1535-7163.MCT-12-0107. Epub 2012 Aug 29.
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Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma.Cytometry B Clin Cytom. 2018 Jan;94(1):148-150. doi: 10.1002/cyto.b.21512. Epub 2017 Feb 24.
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The lower risk MDS patient at risk of rapid progression.Leuk Res. 2010 Dec;34(12):1551-5. doi: 10.1016/j.leukres.2010.05.023. Epub 2010 Jun 22.
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SNAIL1 employs -Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation.Int J Cancer. 2020 Apr 15;146(8):2229-2242. doi: 10.1002/ijc.32644. Epub 2019 Sep 18.
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microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma.Clin Cancer Res. 2017 Jun 1;23(11):2905-2918. doi: 10.1158/1078-0432.CCR-16-1591. Epub 2016 Dec 21.
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Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis.Nat Commun. 2019 Jan 18;10(1):313. doi: 10.1038/s41467-018-08277-5.
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Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34(+) cells.Blood. 2014 Apr 17;123(16):2550-61. doi: 10.1182/blood-2012-09-456889. Epub 2014 Jan 6.
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Cortactin expression in non-Hodgkin B-cell lymphomas: a new marker for the differential diagnosis between chronic lymphocytic leukemia and mantle cell lymphoma.Hum Pathol. 2019 Mar;85:251-259. doi: 10.1016/j.humpath.2018.10.038. Epub 2018 Nov 17.
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The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation.Biochem Biophys Res Commun. 2004 Feb 27;315(1):73-8. doi: 10.1016/j.bbrc.2004.01.025.
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Genome-Wide mRNA-Seq Profiling Reveals that LEF1 and SMAD3 Regulate Epithelial-Mesenchymal Transition Through the Hippo Signaling Pathway During Palatal Fusion.Genet Test Mol Biomarkers. 2019 Mar;23(3):197-203. doi: 10.1089/gtmb.2018.0221. Epub 2019 Feb 15.
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The Disruption of the -Catenin/TCF-1/STAT3 Signaling Axis by 4-Acetylantroquinonol B Inhibits the Tumorigenesis and Cancer Stem-Cell-Like Properties of Glioblastoma Cells, In Vitro and In Vivo.Cancers (Basel). 2018 Dec 5;10(12):491. doi: 10.3390/cancers10120491.
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microRNA-219-5p inhibits epithelial-mesenchymal transition and metastasis of colorectal cancer by targeting lymphoid enhancer-binding factor 1.Cancer Sci. 2017 Oct;108(10):1985-1995. doi: 10.1111/cas.13338. Epub 2017 Aug 29.
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Expression of LEF1 and TCF1 (TCF7) proteins associates with clinical progression of nasopharyngeal carcinoma.J Clin Pathol. 2019 Jun;72(6):425-430. doi: 10.1136/jclinpath-2019-205698. Epub 2019 Mar 27.
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Role of miR-34a-5p in Hematopoietic Progenitor Cells Proliferation and Fate Decision: Novel Insights into the Pathogenesis of Primary Myelofibrosis.Int J Mol Sci. 2017 Jan 13;18(1):145. doi: 10.3390/ijms18010145.
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Effects of microRNA-708 on Epithelial-Mesenchymal Transition, Cell Proliferation and Apoptosis in Melanoma Cells by Targeting LEF1 through the Wnt Signaling Pathway.Pathol Oncol Res. 2019 Jan;25(1):377-389. doi: 10.1007/s12253-017-0334-z. Epub 2017 Nov 14.
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Long noncoding RNA LEF1-AS1 silencing suppresses the initiation and development of prostate cancer by acting as a molecular sponge of miR-330-5p via LEF1 repression.J Cell Physiol. 2019 Aug;234(8):12727-12744. doi: 10.1002/jcp.27893. Epub 2019 Jan 5.
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Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells.J Exp Med. 2019 Apr 1;216(4):847-866. doi: 10.1084/jem.20182010. Epub 2019 Mar 5.
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CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of -catenin/LEF1 complex via effects on chromatin remodeling.Mol Cancer. 2019 Oct 29;18(1):150. doi: 10.1186/s12943-019-1076-1.
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Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer.Oncotarget. 2012 Dec;3(12):1546-56. doi: 10.18632/oncotarget.667.
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Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1.Med Mol Morphol. 2013 Mar;46(1):14-9. doi: 10.1007/s00795-012-0002-z. Epub 2013 Jan 17.
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Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
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Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia. Leukemia. 2009 Sep;23(9):1658-66. doi: 10.1038/leu.2009.86. Epub 2009 Apr 23.
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Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
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Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
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Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci Lett. 2007 Feb 2;412(3):211-6. doi: 10.1016/j.neulet.2006.07.045. Epub 2007 Jan 17.
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Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/-Catenin Pathway Stimulation by Regulating GSK3b Activity. Int J Mol Sci. 2021 May 25;22(11):5571. doi: 10.3390/ijms22115571.
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Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14;4(12):e8294. doi: 10.1371/journal.pone.0008294.
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Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
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Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res. 2009 Apr 3;1:25-37.
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Thymoquinone suppresses invasion and metastasis in bladder cancer cells by reversing EMT through the Wnt/-catenin signaling pathway. Chem Biol Interact. 2020 Apr 1;320:109022. doi: 10.1016/j.cbi.2020.109022. Epub 2020 Feb 27.
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Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
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Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
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Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
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From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
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Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
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Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
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Comparison of the global gene expression profiles produced by methylparaben, n-butylparaben and 17beta-oestradiol in MCF7 human breast cancer cells. J Appl Toxicol. 2007 Jan-Feb;27(1):67-77. doi: 10.1002/jat.1200.
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Aberrant Wnt/Beta-Catenin Pathway Activation in Dialysate-Induced Peritoneal Fibrosis. Front Pharmacol. 2017 Oct 30;8:774. doi: 10.3389/fphar.2017.00774. eCollection 2017.
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Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
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Transcriptome Analysis Reveals the Anti-Tumor Mechanism of Eucalyptol Treatment on Neuroblastoma Cell Line SH-SY5Y. Neurochem Res. 2022 Dec;47(12):3854-3862. doi: 10.1007/s11064-022-03786-8. Epub 2022 Nov 4.
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