General Information of Disease (ID: DISFREOV)

Disease Name Mantle cell lymphoma
Synonyms lymphoma, mantle cell; LCM; mantle zone lymphoma; MCL; mantle cell lymphoma; classical mantle cell lymphoma
Disease Class 2A85: Mature B-cell lymphoma
Definition Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma affecting B lymphocytes in the lymph nodes in a region called the ``mantle zone''.
Disease Hierarchy
DISD8DU7: Aggressive B-cell non-Hodgkin lymphoma
DISFREOV: Mantle cell lymphoma
ICD Code
ICD-11
ICD-11: 2A85.5
ICD-10
ICD-10: C83.1
Disease Identifiers
MONDO ID
MONDO_0018876
MESH ID
D020522
UMLS CUI
C4721414
MedGen ID
1668377
Orphanet ID
52416
SNOMED CT ID
443487006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 7 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Acalabrutinib DM7GCVW Approved NA [1]
Axicabtagene ciloleucel DMYHN59 Approved CAR T Cell Therapy [2]
Bortezomib DMNO38U Approved Small molecular drug [3]
Ibritumomab DMG594T Approved Antibody [4]
Ibrutinib DMHZCPO Approved Small molecular drug [5]
Tecartus DMYQCWT Approved CAR T Cell Therapy [6]
Zanubrutinib DMJWRQP Approved NA [7]
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⏷ Show the Full List of 7 Drug(s)
This Disease is Treated as An Indication in 30 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Telcyta canfosfamide DM94IQ3 Phase 3 NA [8]
CART-19 DMHQKN6 Phase 2 CAR T Cell Therapy [9]
Cirmtuzumab DM98RW0 Phase 2 NA [10]
INCB50465 DMZJP2T Phase 2 NA [10]
ISF35 DMBZK3P Phase 2 NA [11]
KTE-C19 CAR-T cell therapy DMLUZJR Phase 2 NA [10]
P276-00 DM9DJL2 Phase 2 Small molecular drug [12]
Polivy DMFCIKN Phase 2 Antibody [13]
Zilovertamab DMMEJ6K Phase 2 Monoclonal antibody [14]
Anti-CD19 CAR-T cells DMDRYZK Phase 1/2 CAR T Cell Therapy [15]
Anti-CD19-CAR PBL DM1WB8H Phase 1/2 CAR T Cell Therapy [16]
Anti-CD19-CAR vector-transduced T cells DMQXU4C Phase 1/2 CAR T Cell Therapy [17]
Anti-CD19/22-CAR vector-transduced T cells DMMUSHR Phase 1/2 CAR T Cell Therapy [18]
Anti-CD20-CAR vector-transduced autologous T cells DMCDUJY Phase 1/2 CAR T Cell Therapy [19]
Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T Lymphocytes DM2YTGQ Phase 1/2 CAR T Cell Therapy [20]
CD19 CAR T Cells DMUARWH Phase 1/2 CAR T Cell Therapy [21]
CD19.CAR T Cells DM79GPF Phase 1/2 CAR T Cell Therapy [22]
CD19.CAR-T cells DMNZ7F2 Phase 1/2 CAR T Cell Therapy [23]
CD20-Specific CAR T Cells DMHPZ8G Phase 1/2 CAR T Cell Therapy [24]
Eptacog beta DMTY96S Phase 1/2 Small molecular drug [25]
GEN3013 DMZABYH Phase 1/2 Antibody [26]
JCAR017 DMJV2IF Phase 1/2 CAR T Cell Therapy [27]
JCARH125 DM8P7FC Phase 1/2 CAR T Cell Therapy [27]
PCAR-019 DM9DR13 Phase 1/2 CAR T Cell Therapy [28]
SNS01-T DM66DIW Phase 1/2 NA [29]
AMG 562 DMQ0N5Z Phase 1 Antibody [30]
BCL201 DMZ51EX Phase 1 NA [10]
Retroviral vector-transduced autologous T cells to express CD22-specific CARs DMZ8WAQ Phase 1 CAR T Cell Therapy [31]
ROR1 CAR-specific Autologous T-Lymphocytes DM5EUIY Phase 1 CAR T Cell Therapy [32]
Anti-CD19/20-CAR vector-transduced T cells DM3M9OY Clinical trial CAR T Cell Therapy [33]
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⏷ Show the Full List of 30 Drug(s)
This Disease is Treated as An Indication in 2 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
AZ-TAK1 DMD4LGN Investigative NA [34]
Curcumin-ND DMAY0ZZ Investigative NA [35]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 53 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CCND3 TT1JXNR Limited Biomarker [36]
CDK4 TT0PG8F Limited Biomarker [37]
HDAC10 TTYHPU6 Limited Altered Expression [38]
MCL1 TTL53M6 Limited Biomarker [39]
WEE1 TTJFOAL Limited Biomarker [40]
BTLA TTER58P moderate Altered Expression [41]
CD160 TTOFEAS moderate Altered Expression [42]
HOXA13 TTN26OM moderate Biomarker [43]
ACLY TT0Z6Y2 Strong Biomarker [44]
AICDA TTKRTP6 Strong Biomarker [45]
ATR TT8ZYBQ Strong Altered Expression [40]
BMI1 TTIPNSR Strong Altered Expression [46]
BTK TTGM6VW Strong Biomarker [47]
CAMKK2 TTV298Y Strong Altered Expression [48]
CD22 TTM6QSK Strong Biomarker [49]
CD276 TT6CQUM Strong Biomarker [50]
CD37 TTFCW29 Strong Biomarker [51]
CD38 TTPURFN Strong Altered Expression [52]
CD5 TTEGYK1 Strong Posttranslational Modification [53]
CD74 TTCMYP9 Strong Biomarker [54]
CD79B TTBN5I7 Strong Altered Expression [55]
CDC20 TTBKFDV Strong Altered Expression [56]
CDC42BPA TT5Z0EF Strong Biomarker [57]
CHEK1 TTTU902 Strong Biomarker [40]
CRBN TTDKGTC Strong Biomarker [58]
CTSC TT4H0V2 Strong Altered Expression [59]
DCK TTJOCE4 Strong Altered Expression [60]
EGLN2 TTMHFRY Strong Altered Expression [61]
EIF4EBP1 TTKGEBL Strong Altered Expression [62]
EZH1 TTNJA0C Strong Biomarker [63]
FCER2 TTCH6MU Strong Genetic Variation [64]
GMNN TT390KA Strong Altered Expression [65]
HAX1 TT21BYA Strong Biomarker [66]
HDAC6 TT5ZKDI Strong Biomarker [67]
LAIR1 TTSI7A8 Strong Genetic Variation [68]
LTB TTHQ6US Strong Altered Expression [69]
MALT1 TTCI81G Strong Biomarker [70]
MCM6 TTQGKSD Strong Biomarker [71]
NCL TTK1V5Q Strong Altered Expression [72]
PDE3B TTN34SQ Strong Altered Expression [73]
PDE7B TTWIEY9 Strong Altered Expression [73]
PDPK1 TTYMGWX Strong Biomarker [74]
PIM2 TT69J2Z Strong Biomarker [75]
PMS1 TTX1ISF Strong Altered Expression [76]
PRMT5 TTR1D7X Strong Altered Expression [77]
PTPRJ TTWMKXP Strong Genetic Variation [78]
ROR1 TTDEJAU Strong Biomarker [79]
SCN10A TT90XZ8 Strong Biomarker [80]
TCL1A TTUKRDV Strong Altered Expression [81]
TNFSF13B TTWMIDN Strong Biomarker [82]
USP2 TTUEQ1W Strong Biomarker [83]
XPO1 TTCJUR4 Strong Biomarker [84]
ZAP70 TTUMHT8 Strong Altered Expression [85]
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⏷ Show the Full List of 53 DTT(s)
This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCA6 DTLMZUF Strong Altered Expression [86]
SLC35B2 DT81RKJ Strong Biomarker [87]
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This Disease Is Related to 2 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
MGST1 DEAPJSO Strong Altered Expression [88]
MT1A DE5ME8A Strong Genetic Variation [89]
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This Disease Is Related to 85 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
DOHH OTDRAT3F Limited Genetic Variation [90]
FCRL1 OTXOYT29 Limited Altered Expression [91]
MEF2B OT880SE6 Limited Biomarker [92]
ACSBG1 OTM040MW moderate Biomarker [42]
ARHGAP29 OT8JH4TY moderate Posttranslational Modification [93]
BNIP3L OTJKOMXE moderate Biomarker [93]
CCDC50 OTSE1YM5 moderate Biomarker [94]
MNX1 OTXP9FH1 moderate Biomarker [43]
MS4A4A OTWV82RP moderate Biomarker [95]
PRELP OT9EEBUJ moderate Altered Expression [96]
RAPH1 OTMQXW7S moderate Biomarker [42]
ATRIP OT78O9LF Strong Posttranslational Modification [97]
BACH2 OT17GS18 Strong Biomarker [98]
BCL10 OT47MCLI Strong Biomarker [70]
BCL2L11 OTNQQWFJ Strong Biomarker [99]
BCR OTCN76C1 Strong Biomarker [100]
BIK OTTH1T3D Strong Biomarker [101]
CARD11 OTRCTLYC Strong Biomarker [70]
CCND2 OTDULQF9 Strong Altered Expression [102]
CCNG1 OT17IA9L Strong Genetic Variation [103]
CD79A OTOJC8DV Strong Biomarker [104]
CDC6 OTX93FE7 Strong Altered Expression [65]
CDT1 OTVY53VG Strong Altered Expression [65]
CFDP1 OTXY7J96 Strong Biomarker [67]
CIB1 OT4BVCRU Strong Altered Expression [105]
CNTNAP1 OT5Y03EU Strong Biomarker [106]
CRADD OT02TZ4S Strong Genetic Variation [107]
CTNNA2 OTJ8G92T Strong Biomarker [108]
DCTN6 OTI8PIN9 Strong Biomarker [109]
DVL2 OTMNYNCM Strong Altered Expression [110]
E2F8 OTQKZGFP Strong Biomarker [111]
EIF4G2 OTEO98CR Strong Biomarker [67]
FBLIM1 OTFHXMON Strong Altered Expression [112]
FBXO10 OTAGWV4B Strong Biomarker [113]
FBXO25 OTDFA7F4 Strong Biomarker [66]
FUBP1 OT77SC9N Strong Genetic Variation [114]
GEMIN4 OTX7402E Strong Biomarker [67]
GLIS2 OTOUUV1X Strong Biomarker [115]
GNAZ OTLTDTR8 Strong Biomarker [116]
GOPC OTRBGH71 Strong Altered Expression [112]
HACD1 OTEC7EP7 Strong Biomarker [117]
HILPDA OTEID3ZM Strong Biomarker [118]
IBTK OTB2GM4G Strong Biomarker [119]
IFI27 OTI2XGIT Strong Biomarker [109]
IGLL5 OT9XQFL5 Strong Biomarker [120]
LAT2 OTWJDKIH Strong Altered Expression [121]
LEF1 OTWS5I5H Strong Biomarker [122]
MAP2 OT6UYT3X Strong Biomarker [123]
MCPH1 OTYT3TT5 Strong Biomarker [124]
MLC1 OTCNZLSP Strong Genetic Variation [125]
MOB3A OTILIOXF Strong Altered Expression [124]
MSX1 OT5U41ZP Strong Altered Expression [115]
NECTIN2 OTIE0W6O Strong Altered Expression [126]
NSD2 OTQ6SW4R Strong Genetic Variation [127]
NUP214 OTWEA19O Strong Genetic Variation [114]
OMP OT7JH0DY Strong Altered Expression [128]
PCNT OTW4Z65J Strong Altered Expression [48]
PDZK1IP1 OTWA6M5K Strong Biomarker [129]
PIK3IP1 OTWE5G4T Strong Biomarker [130]
PLSCR1 OTGY9B5T Strong Altered Expression [131]
PMAIP1 OTXEE550 Strong Altered Expression [132]
PMCH OT3D9SA4 Strong Genetic Variation [133]
PSMD2 OT6HZHN7 Strong Biomarker [67]
PSMD9 OT6Y5CC3 Strong Biomarker [109]
RAB35 OTRH1E2T Strong Biomarker [134]
RAD1 OT886MA8 Strong Biomarker [135]
RAD51AP1 OTXM7UTD Strong Altered Expression [136]
RANGAP1 OTZGD3LJ Strong Altered Expression [137]
RGS13 OTPAMQ18 Strong Biomarker [86]
RGS18 OTJ6ZOCN Strong Altered Expression [86]
RING1 OTCWTAX0 Strong Altered Expression [138]
RTEL1 OTI3PJCT Strong Biomarker [139]
SERPINB6 OT7G55IK Strong Biomarker [117]
SETMAR OTE2MIMZ Strong Biomarker [140]
SH3YL1 OTVXOONW Strong Biomarker [134]
SLC7A4 OTAVC6QS Strong Biomarker [141]
SMUG1 OT2YIOCQ Strong Biomarker [142]
SORBS1 OTWH8762 Strong Biomarker [117]
SOX12 OT93P8C9 Strong Altered Expression [143]
SPIB OTO4YKYI Strong Altered Expression [144]
SRY OT516T6D Strong Altered Expression [145]
TCL1B OT4CSO39 Strong Altered Expression [81]
TICAM2 OTK7GIJ5 Strong Biomarker [109]
TMED7 OTONO8E6 Strong Biomarker [109]
TP53INP1 OT2363Z9 Strong Biomarker [63]
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⏷ Show the Full List of 85 DOT(s)

References

1 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6777).
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6912).
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
8 Phase 3 randomised study of canfosfamide (Telcyta, TLK286) versus pegylated liposomal doxorubicin or topotecan as third-line therapy in patients with platinum-refractory or -resistant ovarian cancer.Eur J Cancer. 2009 Sep;45(13):2324-32.
9 ClinicalTrials.gov (NCT01029366) CART19 to Treat B-Cell Leukemia or Lymphoma That Are Resistant or Refractory to Chemotherapy
10 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
11 ClinicalTrials.gov (NCT00942409) Study of Repeat Intranodal Injection of Memgen's Cancer Vaccine, Ad-ISF35, in Subjects With Non-Hodgkin's Lymphoma (Follicular, Diffuse Large Cell, Mantle Cell, and Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia. U.S. National Institutes of Health.
12 A phase II, single-arm, open-label, multicenter study to evaluate the efficacy and safety of P276-00, a cyclin-dependent kinase inhibitor, in patients with relapsed or refractory mantle cell lymphoma. Clin Lymphoma Myeloma Leuk. 2015 Jul;15(7):392-7.
13 ClinicalTrials.gov (NCT04659044) Polatuzumab Vedotin, Venetoclax, and Rituximab and Hyaluronidase Human for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma. U.S. National Institutes of Health.
14 ClinicalTrials.gov (NCT03088878) A Phase 1b/2 Study of the ROR1-Targeting Monoclonal Antibody, Cirmtuzumab (UC-961), and the Bruton Tyrosine Kinase Inhibitor, Ibrutinib, in Patients With B-Cell Lymphoid Malignancies. U.S.National Institutes of Health.
15 ClinicalTrials.gov (NCT02851589) Study Evaluating the Efficacy and Safety of PCAR-019 in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma
16 ClinicalTrials.gov (NCT00924326) CAR T Cell Receptor Immunotherapy for Patients With B-cell Lymphoma
17 ClinicalTrials.gov (NCT02081937) CART-19 Immunotherapy in Mantle Cell Lymphoma
18 ClinicalTrials.gov (NCT03185494) Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22
19 ClinicalTrials.gov (NCT01735604) Genetically Engineered Lymphocyte Therapy in Treating Patients With Lymphoma That is Resistant or Refractory to Chemotherapy
20 ClinicalTrials.gov (NCT01865617) Laboratory Treated T Cells in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma, or Acute Lymphoblastic Leukemia
21 ClinicalTrials.gov (NCT01475058) CD19 CAR T Cells for B Cell Malignancies After Allogeneic Transplant
22 ClinicalTrials.gov (NCT03676504) Treatment of Patients With Relapsed or Refractory CD19+ Lymphoid Disease With T Cells Expressing a Third-generation CAR
23 ClinicalTrials.gov (NCT02652910) Memory-enriched CAR-T Cells Immunotherapy for B Cell Lymphoma
24 ClinicalTrials.gov (NCT03277729) A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphomas
25 ClinicalTrials.gov (NCT04419389) APR-246 in Combination With Ibrutinib or Venetoclax-R in Subjects With TP53-Mutant R/R Non Hodgkin Lymphomas (NHL) (R/R). U.S. National Institutes of Health.
26 ClinicalTrials.gov (NCT03625037) GEN3013 Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma. U.S. National Institutes of Health.
27 ClinicalTrials.gov (NCT03436771) Long-term Follow-up Study for Patients Previously Treated With a Juno CAR T-Cell Product
28 ClinicalTrials.gov (NCT02819583) CAR-T Cell Immunotherapy in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma
29 ClinicalTrials.gov (NCT01435720) Safety and Tolerability Study of SNS01-T in Relapsed or Refractory B Cell Malignancies (Multiple Myeloma, B Cell Lymphoma, or Plasma Cell Leukemia (PCL). U.S. National Institutes of Health.
30 ClinicalTrials.gov (NCT03571828) Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 562 in Subjects With r/r Diffuse Large B-cell Lymphoma, Mantle Cell Lymphoma, or Follicular Lymphoma. U.S. National Institutes of Health.
31 ClinicalTrials.gov (NCT02721407) Anti-CD22 CAR-T Therapy for CD19-refractory or Resistant Lymphoma Patients
32 ClinicalTrials.gov (NCT02706392) Genetically Modified T-Cell Therapy in Treating Patients With Advanced ROR1+ Malignancies
33 ClinicalTrials.gov (NCT03097770) Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20
34 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2082).
35 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
36 Update on lymphoproliferative disorders of the gastrointestinal tract: disease spectrum from indolent lymphoproliferations to aggressive lymphomas.Virchows Arch. 2020 May;476(5):667-681. doi: 10.1007/s00428-019-02704-8. Epub 2019 Nov 26.
37 A phase 1 trial of ibrutinib plus palbociclib in previously treated mantle cell lymphoma.Blood. 2019 Mar 14;133(11):1201-1204. doi: 10.1182/blood-2018-11-886457. Epub 2019 Jan 28.
38 Expression and Function of Histone Deacetylase 10 (HDAC10) in B Cell Malignancies.Methods Mol Biol. 2016;1436:129-45. doi: 10.1007/978-1-4939-3667-0_10.
39 Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma.Oncogene. 2020 Feb;39(9):2009-2023. doi: 10.1038/s41388-019-1122-x. Epub 2019 Nov 26.
40 DNA Damage Response Inhibitor Combinations Exert Synergistic Antitumor Activity in Aggressive B-Cell Lymphomas.Mol Cancer Ther. 2019 Jul;18(7):1255-1264. doi: 10.1158/1535-7163.MCT-18-0919. Epub 2019 May 7.
41 High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia.Am J Clin Pathol. 2009 Oct;132(4):589-96. doi: 10.1309/AJCPPHKGYYGGL39C.
42 Differential and tumor-specific expression of CD160 in B-cell malignancies.Blood. 2011 Aug 25;118(8):2174-83. doi: 10.1182/blood-2011-02-334326. Epub 2011 Jun 28.
43 Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia.Am J Hematol. 2012 Apr;87(4):361-7. doi: 10.1002/ajh.23115. Epub 2012 Feb 28.
44 Kinematic effects of repeated turns while running.Eur J Sport Sci. 2019 Sep;19(8):1072-1081. doi: 10.1080/17461391.2019.1578416. Epub 2019 Mar 5.
45 Phosphatidylinositol 3-kinase blockade increases genomic instability in B cells.Nature. 2017 Feb 23;542(7642):489-493. doi: 10.1038/nature21406. Epub 2017 Feb 15.
46 Targeting of BMI-1 expression by the novel small molecule PTC596 in mantle cell lymphoma.Oncotarget. 2018 Jun 19;9(47):28547-28560. doi: 10.18632/oncotarget.25558. eCollection 2018 Jun 19.
47 An in-depth evaluation of acalabrutinib for the treatment of mantle-cell lymphoma.Expert Opin Pharmacother. 2020 Jan;21(1):29-38. doi: 10.1080/14656566.2019.1689959. Epub 2019 Nov 18.
48 Expression of centrosome-associated gene products is linked to tetraploidization in mantle cell lymphoma.Int J Cancer. 2007 Apr 15;120(8):1669-77. doi: 10.1002/ijc.22404.
49 Paclitaxel synergizes with exposure time adjusted CD22-targeting immunotoxins against B-cell malignancies.Oncotarget. 2017 May 9;8(19):30644-30655. doi: 10.18632/oncotarget.16141.
50 MicroRNA-506 inhibits the proliferation and invasion of mantle cell lymphoma cells by targeting B7H3.Biochem Biophys Res Commun. 2019 Jan 22;508(4):1067-1073. doi: 10.1016/j.bbrc.2018.12.055. Epub 2018 Dec 12.
51 Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma.Blood. 2010 Aug 19;116(7):1025-34. doi: 10.1182/blood-2009-12-257485. Epub 2010 Apr 28.
52 Phase 2 Study of Daratumumab in Relapsed/Refractory Mantle-Cell Lymphoma, Diffuse Large B-Cell Lymphoma, and Follicular Lymphoma.Clin Lymphoma Myeloma Leuk. 2019 May;19(5):275-284. doi: 10.1016/j.clml.2018.12.013. Epub 2019 Jan 2.
53 Polymorphism in the CD5 gene promoter in B-cell chronic lymphocytic leukemia and mantle cell lymphoma.Am J Clin Pathol. 2005 May;123(5):646-50.
54 ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo.Exp Hematol. 2015 Sep;43(9):770-4.e2. doi: 10.1016/j.exphem.2015.04.008. Epub 2015 Apr 29.
55 Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19.Clin Cancer Res. 2019 Dec 1;25(23):7046-7057. doi: 10.1158/1078-0432.CCR-19-1337. Epub 2019 Aug 22.
56 The anaphase-promoting complex/cyclosome: a new promising target in diffuse large B-cell lymphoma and mantle cell lymphoma.Br J Cancer. 2019 Jun;120(12):1137-1146. doi: 10.1038/s41416-019-0471-0. Epub 2019 May 15.
57 Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma.J Hematol Oncol. 2016 Mar 29;9:30. doi: 10.1186/s13045-016-0260-7.
58 Synergistic Cytotoxicity of Lenalidomide and Dexamethasone in Mantle Cell Lymphoma via Cereblon-dependent Targeting of the IL-6/STAT3/PI3K Axis.EBioMedicine. 2017 Jun;20:70-78. doi: 10.1016/j.ebiom.2017.04.037. Epub 2017 May 10.
59 The mTOR kinase inhibitor everolimus synergistically enhances the anti-tumor effect of the Bruton's tyrosine kinase (BTK) inhibitor PLS-123 on Mantle cell lymphoma.Int J Cancer. 2018 Jan 1;142(1):202-213. doi: 10.1002/ijc.31044. Epub 2017 Oct 16.
60 Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents.Mol Cancer. 2014 Jun 27;13:159. doi: 10.1186/1476-4598-13-159.
61 Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1.J Cell Mol Med. 2019 Nov;23(11):7785-7795. doi: 10.1111/jcmm.14655. Epub 2019 Sep 13.
62 Novel treatment for mantle cell lymphoma including therapy-resistant tumor by NF-B and mTOR dual-targeting approach.Mol Cancer Ther. 2013 Oct;12(10):2006-17. doi: 10.1158/1535-7163.MCT-13-0239. Epub 2013 Aug 20.
63 Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57(CDKN1C) and TP53INP1 in mantle cell lymphoma.Cancer Biol Med. 2019 Aug;16(3):530-541. doi: 10.20892/j.issn.2095-3941.2018.0380.
64 SOX11-negative Mantle Cell Lymphoma: Clinicopathologic and Prognostic Features of 75 Patients.Am J Surg Pathol. 2019 May;43(5):710-716. doi: 10.1097/PAS.0000000000001233.
65 Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability.Int J Cancer. 2006 Dec 15;119(12):2768-74. doi: 10.1002/ijc.22146.
66 Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.Nat Med. 2014 Dec;20(12):1401-9. doi: 10.1038/nm.3740. Epub 2014 Nov 24.
67 Functional cooperativity of p97 and histone deacetylase 6 in mediating DNA repair in mantle cell lymphoma cells.Leukemia. 2019 Jul;33(7):1675-1686. doi: 10.1038/s41375-018-0355-y. Epub 2019 Jan 21.
68 A high mutation rate of immunoglobulin heavy chain variable region gene associates with a poor survival and chemotherapy response of mantle cell lymphoma patients.Medicine (Baltimore). 2019 May;98(22):e15811. doi: 10.1097/MD.0000000000015811.
69 Lymphotoxin beta expression is high in chronic lymphocytic leukemia but low in small lymphocytic lymphoma: a quantitative real-time reverse transcriptase polymerase chain reaction analysis.Haematologica. 2003 Jun;88(6):654-8.
70 B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma.Blood. 2017 Jan 19;129(3):333-346. doi: 10.1182/blood-2016-05-718775. Epub 2016 Nov 18.
71 Minichromosome maintenance protein 6, a proliferation marker superior to Ki-67 and independent predictor of survival in patients with mantle cell lymphoma.Br J Cancer. 2005 Oct 17;93(8):939-45. doi: 10.1038/sj.bjc.6602795.
72 Cyclin D1 transcriptional activation in MCL.Blood. 2014 Mar 27;123(13):1979-80. doi: 10.1182/blood-2014-02-553057.
73 High expression of cyclic nucleotide phosphodiesterase 7B mRNA predicts poor prognosis in mantle cell lymphoma.Leuk Res. 2013 May;37(5):536-40. doi: 10.1016/j.leukres.2013.02.006. Epub 2013 Feb 28.
74 Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.Exp Hematol. 2018 Mar;59:72-81.e2. doi: 10.1016/j.exphem.2017.12.006. Epub 2017 Dec 26.
75 Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma.Blood. 2012 Oct 25;120(17):3491-500. doi: 10.1182/blood-2012-02-412643. Epub 2012 Sep 6.
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81 TCL1 expression predicts overall survival in patients with mantle cell lymphoma.Eur J Haematol. 2015 Dec;95(6):583-94. doi: 10.1111/ejh.12539. Epub 2015 Mar 16.
82 Bax345/BLyS: a novel, completely human fusion protein targeting malignant B cells and delivering a unique mitochondrial toxin.Cancer Lett. 2012 Sep 28;322(2):159-68. doi: 10.1016/j.canlet.2012.02.029. Epub 2012 Mar 1.
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94 Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia.Leukemia. 2009 Nov;23(11):2018-26. doi: 10.1038/leu.2009.144. Epub 2009 Jul 30.
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97 The interaction between ATRIP and MCM complex is essential for ATRIP chromatin loading and its phosphorylation in mantle cell lymphoma cells.Pharmazie. 2017 Nov 1;72(11):670-673. doi: 10.1691/ph.2017.7676.
98 Bifurcated BACH2 control coordinates mantle cell lymphoma survival and dispersal during hypoxia.Blood. 2017 Aug 10;130(6):763-776. doi: 10.1182/blood-2017-02-767293. Epub 2017 Jun 7.
99 Proapoptotic protein BIM as a novel prognostic marker in mantle cell lymphoma.Hum Pathol. 2019 Nov;93:54-64. doi: 10.1016/j.humpath.2019.08.008. Epub 2019 Aug 16.
100 Pleiotropic Action of Novel Bruton's Tyrosine Kinase Inhibitor BGB-3111 in Mantle Cell Lymphoma.Mol Cancer Ther. 2019 Feb;18(2):267-277. doi: 10.1158/1535-7163.MCT-18-0478. Epub 2018 Nov 9.
101 Combination of lenalidomide with vitamin D3 induces apoptosis in mantle cell lymphoma via demethylation of BIK.Cell Death Dis. 2014 Aug 28;5(8):e1389. doi: 10.1038/cddis.2014.346.
102 Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas.Oncol Rep. 2016 May;35(5):2673-80. doi: 10.3892/or.2016.4658. Epub 2016 Mar 7.
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104 SOX11 augments BCR signaling to drive MCL-like tumor development.Blood. 2018 May 17;131(20):2247-2255. doi: 10.1182/blood-2018-02-832535. Epub 2018 Apr 3.
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108 Modified VR-CAP, Alternating With Rituximab and High-dose Cytarabine: An Effective Pre-transplant Induction Regimen for Mantle Cell Lymphoma.Clin Lymphoma Myeloma Leuk. 2019 Jan;19(1):48-52. doi: 10.1016/j.clml.2018.10.006. Epub 2018 Oct 17.
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115 Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma.Leuk Lymphoma. 2014 Aug;55(8):1893-903. doi: 10.3109/10428194.2013.864762. Epub 2014 Feb 17.
116 Expression of GNAZ, encoding the G(z) protein, predicts survival in mantle cell lymphoma.Br J Haematol. 2019 May;185(4):708-712. doi: 10.1111/bjh.15810. Epub 2019 Feb 20.
117 Frontline bortezomib, rituximab, cyclophosphamide, doxorubicin, and prednisone (VR-CAP) versus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in transplantation-ineligible patients with newly diagnosed mantle cell lymphoma: final overall survival results of a randomised, open-label, phase 3 study.Lancet Oncol. 2018 Nov;19(11):1449-1458. doi: 10.1016/S1470-2045(18)30685-5. Epub 2018 Oct 19.
118 SOX11 and HIG-2 are cross-regulated and affect growth in mantle cell lymphoma.Leuk Lymphoma. 2016 Aug;57(8):1883-92. doi: 10.3109/10428194.2015.1121257. Epub 2016 Jan 12.
119 Ibrutinib increases the risk of hypertension and atrial fibrillation: Systematic review and meta-analysis.PLoS One. 2019 Feb 20;14(2):e0211228. doi: 10.1371/journal.pone.0211228. eCollection 2019.
120 Mantle cell lymphoma cell lines show no evident immunoglobulin heavy chain stereotypy but frequent light chain stereotypy.Leuk Lymphoma. 2013 Aug;54(8):1747-55. doi: 10.3109/10428194.2012.758843. Epub 2013 Jan 23.
121 The lipid raft protein NTAL participates in AKT signaling in mantle cell lymphoma.Leuk Lymphoma. 2019 Nov;60(11):2658-2668. doi: 10.1080/10428194.2019.1607326. Epub 2019 May 7.
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126 TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma.Cancer Immunol Res. 2019 Mar;7(3):355-362. doi: 10.1158/2326-6066.CIR-18-0351. Epub 2019 Jan 18.
127 Genomic landscape and prognostic analysis of mantle cell lymphoma.Cancer Gene Ther. 2018 Jun;25(5-6):129-140. doi: 10.1038/s41417-018-0022-5. Epub 2018 May 14.
128 Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy.J Exp Clin Cancer Res. 2019 Nov 1;38(1):446. doi: 10.1186/s13046-019-1458-7.
129 MAP17 (PDZKIP1) Expression Determines Sensitivity to the Proteasomal Inhibitor Bortezomib by Preventing Cytoprotective Autophagy and NFB Activation in Breast Cancer.Mol Cancer Ther. 2015 Jun;14(6):1454-65. doi: 10.1158/1535-7163.MCT-14-1053. Epub 2015 Apr 2.
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131 Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma.Oncotarget. 2016 Jul 5;7(27):41913-41928. doi: 10.18632/oncotarget.9630.
132 Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma.Clin Cancer Res. 2019 Jul 15;25(14):4455-4465. doi: 10.1158/1078-0432.CCR-18-3275. Epub 2019 Apr 19.
133 Mantle Cell Lymphoma Involving Skin: A Clinicopathologic Study of 37 Cases.Am J Surg Pathol. 2019 Oct;43(10):1421-1428. doi: 10.1097/PAS.0000000000001312.
134 Health-related quality of life data from a phase 3, international, randomized, open-label, multicenter study in patients with previously treated mantle cell lymphoma treated with ibrutinib versus temsirolimus.Leuk Lymphoma. 2017 Dec;58(12):2824-2832. doi: 10.1080/10428194.2017.1326034. Epub 2017 May 30.
135 The therapeutic effectiveness of (177)Lu-lilotomab in B-cell non-Hodgkin lymphoma involves modulation of G2/M cell cycle arrest.Leukemia. 2020 May;34(5):1315-1328. doi: 10.1038/s41375-019-0677-4. Epub 2019 Dec 13.
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137 Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma. PLoS One. 2013 Nov 6;8(11):e79863. doi: 10.1371/journal.pone.0079863. eCollection 2013.
138 The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma.Br J Haematol. 2001 Mar;112(4):950-8. doi: 10.1046/j.1365-2141.2001.02641.x.
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140 Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma.PLoS One. 2010 Nov 22;5(11):e14085. doi: 10.1371/journal.pone.0014085.
141 Immunoglobulin V(H) gene mutational analysis suggests that blastic variant of mantle cell lymphoma derives from different stages of B-cell maturation.Leuk Res. 2000 Jan;24(1):27-31. doi: 10.1016/s0145-2126(99)00156-3.
142 Prognostic impact of interim positron emission tomography in mantle cell lymphoma patients treated with frontline R-CHOP.Br J Haematol. 2020 Mar;188(6):860-871. doi: 10.1111/bjh.16257. Epub 2019 Nov 16.
143 SOXC transcription factors in mantle cell lymphoma: the role of promoter methylation in SOX11 expression.Sci Rep. 2013;3:1400. doi: 10.1038/srep01400.
144 Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-B activity.BMC Cancer. 2018 Apr 25;18(1):466. doi: 10.1186/s12885-018-4346-1.
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