Details of Disease

General Information of Disease (ID: DISW53RE)

Disease Name Familial adenomatous polyposis
Synonyms
FPC; hereditary polyposis coli; familial multiple polyposis; familial adenomatous polyposis of the colon; familial polyposis coli; adenomatous polyposis of the colon; colorectal adenomatous polyposis; familial adenomatous polyposis syndrome; Familial Adenomatous Polyposis; APC - adenomatous polyposis coli; polyposis coli; adenomatous polyposis coli; familial polyposis; familial adenomatous polyposis; classic familial adenomatous polyposis; familial adenomatous polyposis coli; FAP; hereditary adenomatous polyposis coli; classic FAP
Disease Class 2B90: Colon cancer
Definition Familial adenomatous polyposis (FAP) is characterized by the development of hundreds to thousands of adenomas in the rectum and colon during the second decade of life.
Disease Hierarchy
DIS99333: Classic or attenuated familial adenomatous polyposis
DISW53RE: Familial adenomatous polyposis
ICD Code
ICD-11
ICD-11: 2B90.Y
Expand ICD-11
'2B90.Y
Disease Identifiers
MONDO ID
MONDO_0021055
MESH ID
D011125
UMLS CUI
C0032580
OMIM ID
175100
MedGen ID
46010
Orphanet ID
733
SNOMED CT ID
423471004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Celecoxib DM6LOQU Approved Small molecular drug [1]
Eflornithine DMJOQM3 Approved Small molecular drug [2]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CEQ-508 DMCR7EF Phase 1/2 siRNA drug [3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 57 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CEACAM5 TTY6DTE Limited Genetic Variation [4]
CHEK2 TT9ABMF Limited Genetic Variation [5]
FAP TTGPQ0F Limited Altered Expression [6]
GSK3B TTRSMW9 Limited Genetic Variation [7]
MSH2 TTCAWRT Limited Genetic Variation [8]
NR3C2 TT26PHO Limited Genetic Variation [9]
OLFM4 TTK1CX7 Limited Biomarker [10]
PHGDH TT8DRCK Limited Genetic Variation [11]
PROC TTZUXYS Limited Genetic Variation [12]
AKT1 TTWTSCV moderate Biomarker [13]
F5 TT1O264 moderate Biomarker [14]
HPGDS TTCYE56 moderate Genetic Variation [15]
MSI1 TTSM4BA moderate Biomarker [16]
PLA2G7 TTDNFMT moderate Altered Expression [17]
POLB TTA0XPV moderate Biomarker [18]
REG4 TTVZEHU moderate Genetic Variation [19]
ANXA10 TT0NL6U Strong Biomarker [20]
APOH TT2OUI9 Strong Biomarker [21]
C9orf72 TTA4SHR Strong Biomarker [22]
CBR1 TTVG0SN Strong Biomarker [23]
CD44 TTWFBT7 Strong Biomarker [24]
CNTN1 TTPR8FK Strong Biomarker [25]
CSF2RB TTPYS82 Strong Altered Expression [26]
CSNK2A2 TT7GR5W Strong Altered Expression [27]
CTSE TTLXC4Q Strong Altered Expression [28]
CYP26A1 TTD7Q0R Strong Biomarker [29]
DLG4 TT9PB26 Strong Biomarker [30]
EPHB3 TT5LM7U Strong Altered Expression [31]
F2R TTL935N Strong Biomarker [32]
FER TTRA9G0 Strong Genetic Variation [33]
FZD7 TTUQMO5 Strong Altered Expression [34]
GAST TT4LRVO Strong Biomarker [35]
GREM1 TTOUZN5 Strong Biomarker [36]
GRIN2A TTKJEMQ Strong Biomarker [37]
GSS TTVEWR4 Strong Biomarker [38]
GSTA1 TT4P8DE Strong Biomarker [39]
GUCY2C TTLDPRG Strong Genetic Variation [40]
HIPK2 TTOB49C Strong Altered Expression [41]
HNF4A TT2F3CD Strong Biomarker [42]
ILK TT7ALZG Strong Altered Expression [43]
MKI67 TTB4UNG Strong Biomarker [44]
MKRN1 TTITER7 Strong Biomarker [45]
MRC1 TTKV8W5 Strong Genetic Variation [46]
ODC1 TTUMGNO Strong Biomarker [47]
PMS1 TTX1ISF Strong Genetic Variation [48]
PRSS1 TT2WR1T Strong Genetic Variation [49]
PTGDR TTNVEIR Strong Genetic Variation [50]
PTGER3 TTPNGDE Strong Biomarker [51]
PTGS2 TTVKILB Strong Altered Expression [52]
PYY TTVFJLX Strong Biomarker [53]
RARB TTISP28 Strong Genetic Variation [54]
SGK1 TTTV8EJ Strong Altered Expression [55]
SLCO2A1 TTKVTQO Strong Genetic Variation [56]
TCF7L2 TT80QAL Strong Genetic Variation [57]
TNKS TTVUSO7 Strong Biomarker [58]
VANGL1 TT18WJB Strong Biomarker [59]
XPO1 TTCJUR4 Strong Biomarker [60]
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⏷ Show the Full List of 57 DTT(s)
This Disease Is Related to 5 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC25A19 DTT82QK Strong Biomarker [61]
SLC25A21 DT2UQYR Strong Altered Expression [62]
SLC25A24 DTVAEDK Strong Biomarker [63]
SLC9A9 DT8LP62 Strong Altered Expression [64]
SLC9C2 DT2N5HO Strong Altered Expression [64]
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This Disease Is Related to 7 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
XPNPEP1 DE8E6X9 moderate Biomarker [65]
ADH1C DEM1HNL Strong Biomarker [20]
BAAT DERA3OF Strong Genetic Variation [66]
FMO3 DEP76YL Strong Genetic Variation [67]
GSTZ1 DEQPEMB Strong Biomarker [68]
RDH5 DESI4OK Strong Genetic Variation [69]
UGT1A3 DEF2WXN Strong Genetic Variation [70]
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⏷ Show the Full List of 7 DME(s)
This Disease Is Related to 155 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
AMER3 OT1XCHBB Limited Biomarker [64]
ANAPC5 OTGTJNNR Limited Genetic Variation [71]
APBA2 OTXD8ID1 Limited Biomarker [72]
AXIN1 OTRGZGZ5 Limited Biomarker [73]
BMPR1A OTQOA4ZH Limited Genetic Variation [74]
BTRC OT2EZDGR Limited Altered Expression [75]
CTBP1 OTVYH2DH Limited Biomarker [76]
CTNNBIP1 OTX9SBJG Limited Biomarker [77]
DLD OT378CU9 Limited Genetic Variation [78]
EEF1G OTW7DH2F Limited Altered Expression [79]
FEN1 OT6QGG7O Limited Biomarker [80]
MLH3 OT91PPBI Limited Genetic Variation [36]
PDIK1L OTISF4KG Limited Biomarker [73]
PKD2 OTIXBU8H Limited Altered Expression [81]
PKHD1 OTAH8SMF Limited Biomarker [82]
PLCG2 OTGVC9MY Limited Altered Expression [83]
PMS2 OTNLWTMI Limited Genetic Variation [8]
POLD1 OTWO4UCJ Limited Genetic Variation [84]
PPP1R1A OTGTAGCV Limited Biomarker [85]
RAPH1 OTMQXW7S Limited Genetic Variation [86]
SFRP1 OT0U9G41 Limited Genetic Variation [87]
TBC1D9 OTSSCTB5 Limited Biomarker [88]
TRIM21 OTA4UJCF Limited Biomarker [89]
BCL9 OTRBIPR4 moderate Genetic Variation [90]
ITIH4 OT460OO1 moderate Biomarker [14]
LRG1 OTLD0KWA moderate Biomarker [14]
NLK OT2LETFS moderate Biomarker [91]
PALB2 OT6DNDBG moderate Genetic Variation [92]
PITX2 OTWMXAOY moderate Biomarker [93]
PLA2G6 OT5FL0WU moderate Genetic Variation [94]
TCHP OTVDMHSY moderate Biomarker [95]
AAGAB OTRGGM2Z Strong Biomarker [96]
ADAM23 OTVWT6JZ Strong Genetic Variation [97]
AFAP1 OTR473H8 Strong Biomarker [84]
ALDH1A3 OT1C9NKQ Strong Biomarker [98]
AMER1 OT8EFJPM Strong Biomarker [99]
AMER2 OTA1Q07C Strong Biomarker [99]
ANAPC1 OT2YY35L Strong Biomarker [63]
ANKS1B OT26DGM9 Strong Genetic Variation [100]
APBA1 OTUH9JPD Strong Biomarker [101]
ARHGEF2 OTBQTFRT Strong Altered Expression [102]
ARHGEF4 OTR2VG0W Strong Altered Expression [103]
ARID2 OTIRJXWM Strong Genetic Variation [104]
ATAD1 OTJ02XFL Strong Biomarker [105]
ATP2A3 OTFYDEES Strong Altered Expression [106]
B3GNT6 OTAX8BNJ Strong Altered Expression [107]
BLM OTEJOAJX Strong Biomarker [108]
CCNH OTKDU3SR Strong Biomarker [96]
CDC73 OT6JASZ1 Strong Biomarker [44]
CDH10 OTK3D5WP Strong Genetic Variation [109]
CDH7 OTQEXCKU Strong Genetic Variation [5]
CDK2AP2 OTR99SJ8 Strong Biomarker [110]
CDX2 OTCG4TSY Strong Biomarker [111]
CHFR OTRAD2TT Strong Genetic Variation [112]
CISD3 OT0MM1MW Strong Genetic Variation [113]
CLASP2 OT5YX0YB Strong Biomarker [114]
CLC OTYMYR85 Strong Genetic Variation [115]
COL4A2 OTJK1LKN Strong Altered Expression [116]
COX2 OTTMVBJJ Strong Altered Expression [117]
COX3 OTNNGBYJ Strong Biomarker [118]
COX7A2L OTY21FKV Strong Genetic Variation [100]
CSNK2B OT2WW7R1 Strong Altered Expression [27]
CYGB OTX153DQ Strong Biomarker [119]
CYP2A7 OTRJ3P2Z Strong Altered Expression [120]
DIO2 OTGPNSLH Strong Altered Expression [121]
DMBT1 OTVNU9D9 Strong Biomarker [122]
DNAJA3 OT61924T Strong Genetic Variation [123]
DVL2 OTMNYNCM Strong Genetic Variation [124]
EIF2S1 OTM0GDTP Strong Biomarker [125]
EIF2S2 OTXF0B09 Strong Biomarker [125]
EIF2S3 OTARRES9 Strong Biomarker [125]
EMP2 OTPS2H0L Strong Biomarker [126]
ENPP7 OTWOBMQ9 Strong Genetic Variation [127]
FANCB OTMZTXB5 Strong Biomarker [128]
FBXW11 OT2A6RLR Strong Biomarker [129]
FMN1 OT9CID5R Strong Biomarker [130]
FZD1 OTZATHVS Strong Biomarker [131]
FZD2 OT952ML1 Strong Biomarker [132]
FZD3 OTIWDN78 Strong Altered Expression [133]
FZD5 OTXFFY56 Strong Biomarker [131]
GALNT12 OTVIBUST Strong Genetic Variation [134]
GEN1 OT1XFQXF Strong Genetic Variation [135]
GPSM2 OT6RPMRM Strong Biomarker [136]
GTF2H3 OT87W5QJ Strong Biomarker [96]
HEY2 OTU4J3ZI Strong Genetic Variation [137]
HLTF OTRX2OSF Strong Biomarker [138]
IHH OT1DWGXC Strong Altered Expression [139]
JRK OTO8E77P Strong Biomarker [140]
KIF2A OT2WQ6QD Strong Biomarker [141]
KIF3A OTMUBSSK Strong Biomarker [142]
KIF3B OT0HJREB Strong Biomarker [37]
LAMTOR2 OTHEDISB Strong Biomarker [110]
LEF1 OTWS5I5H Strong Biomarker [143]
LGALS4 OTKQCG0H Strong Altered Expression [144]
LRRC59 OT6BQJ5E Strong Biomarker [96]
LYPD1 OT0HSGML Strong Genetic Variation [145]
MAGEH1 OTVE05K7 Strong Biomarker [146]
MAPRE1 OTCVQD60 Strong Altered Expression [147]
MAPRE2 OTAE3MX4 Strong Genetic Variation [100]
MAPRE3 OTSCLETV Strong Biomarker [30]
MCC OTQVI1EM Strong Biomarker [146]
MED15 OT0D0JVD Strong Biomarker [148]
MFSD2A OTVG1VG0 Strong Biomarker [149]
MIB1 OT5C404P Strong Biomarker [44]
MISP OTRZDX0N Strong Biomarker [150]
MSH3 OTD3YPVL Strong Genetic Variation [36]
MUC5B OTPW6K5C Strong Biomarker [38]
MUC6 OTPVL723 Strong Biomarker [38]
MXD1 OTS5CTHX Strong Altered Expression [151]
NDC80 OTS7D306 Strong Posttranslational Modification [152]
NTHL1 OTPQXPT1 Strong Genetic Variation [153]
NUDT1 OTZSES3W Strong Genetic Variation [154]
OLIG2 OTMCN6D3 Strong Biomarker [155]
ORM1 OTZKSBRE Strong Altered Expression [156]
PALLD OTZ2MUJZ Strong Genetic Variation [157]
PLAA OTZ7NJGA Strong Biomarker [94]
PLEK OTB73XXA Strong Biomarker [158]
POLE OTFM3MMU Strong Genetic Variation [159]
PPM1L OTGGNG6M Strong Biomarker [160]
PRC1 OTHD0XS0 Strong Biomarker [161]
PRX OT34Z10B Strong Genetic Variation [162]
PSG9 OT0UWPND Strong Biomarker [163]
RAN OT2TER5M Strong Altered Expression [164]
RARRES1 OTETUPP5 Strong Biomarker [148]
RASSF1 OTEZIPB7 Strong Biomarker [165]
RB1CC1 OTZK8PFX Strong Biomarker [75]
REEP5 OTZU4TJI Strong Biomarker [166]
RHBDF1 OTCQ7UDS Strong Biomarker [167]
RLBP1 OTCY4D6B Strong Genetic Variation [69]
RPE OT0XT3JU Strong Biomarker [168]
RPIA OT805SMH Strong Biomarker [169]
RPP14 OT4OYFSK Strong Biomarker [110]
RPS20 OTI8052R Strong Genetic Variation [36]
RSU1 OTO5GHT1 Strong Altered Expression [170]
RUVBL1 OTWV19L7 Strong Altered Expression [171]
SAV1 OTSAEV92 Strong Biomarker [172]
SCGB3A1 OTIR98RB Strong Genetic Variation [173]
SCHIP1 OTF3FR4A Strong Biomarker [174]
SCRIB OTW4N3FV Strong Altered Expression [175]
SF3B6 OTPRKS6S Strong Biomarker [110]
SHOX2 OTLCZZJW Strong Genetic Variation [176]
SIAH1 OT29A838 Strong Biomarker [177]
SLC2A4RG OTW3LX8D Strong Altered Expression [102]
SNED1 OTBQVXY5 Strong Altered Expression [178]
SPEN OT37A2MD Strong Genetic Variation [113]
SRP19 OT8RP8JB Strong Genetic Variation [179]
STRN OTLOZL5I Strong Biomarker [95]
TCF4 OTB9ASTK Strong Genetic Variation [57]
TESC OTI8C76M Strong Biomarker [180]
TFDP1 OT6RZ7VT Strong Genetic Variation [50]
TMEFF2 OT1WZ2QO Strong Genetic Variation [173]
TMEM9 OTXC0JXR Strong Biomarker [181]
TNMD OTHLVA9G Strong Genetic Variation [182]
TSPAN4 OTKFK57F Strong Biomarker [126]
PAQR3 OTTKJ9Y4 Definitive Genetic Variation [183]
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⏷ Show the Full List of 155 DOT(s)

References

1 Celecoxib FDA Label
2 Eflornithine FDA Label
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 A therapeutic cancer vaccine targeting carcinoembryonic antigen in intestinal carcinomas.Hum Gene Ther. 2009 Feb;20(2):125-36. doi: 10.1089/hum.2008.116.
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6 Multi-scale modeling of APC and [Formula: see text]-catenin regulation in the human colonic crypt.J Math Biol. 2018 Jun;76(7):1797-1830. doi: 10.1007/s00285-017-1204-8. Epub 2018 Jan 4.
7 Long non-coding RNA miR143HG predicts good prognosis and inhibits tumor multiplication and metastasis by suppressing mitogen-activated protein kinase and Wnt signaling pathways in hepatocellular carcinoma.Hepatol Res. 2019 Aug;49(8):902-918. doi: 10.1111/hepr.13344. Epub 2019 May 30.
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12 Neuroprotection and vasculoprotection using genetically targeted protease-ligands.Brain Res. 2019 Jul 15;1715:13-20. doi: 10.1016/j.brainres.2019.03.010. Epub 2019 Mar 14.
13 Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells.Mol Cancer Ther. 2018 May;17(5):943-951. doi: 10.1158/1535-7163.MCT-17-0887. Epub 2018 Feb 21.
14 The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats.Cancer Prev Res (Phila). 2014 Nov;7(11):1160-9. doi: 10.1158/1940-6207.CAPR-14-0056. Epub 2014 Sep 8.
15 Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer.Mol Med Rep. 2015 Jul;12(1):141-6. doi: 10.3892/mmr.2015.3402. Epub 2015 Mar 3.
16 Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.BMC Cancer. 2018 Aug 10;18(1):809. doi: 10.1186/s12885-018-4704-z.
17 Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice.Cancer Res. 2013 May 1;73(9):2806-16. doi: 10.1158/0008-5472.CAN-12-2374. Epub 2013 Jan 29.
18 Adenomatous polyposis coli-mediated accumulation of abasic DNA lesions lead to cigarette smoke condensate-induced neoplastic transformation of normal breast epithelial cells.Neoplasia. 2013 Apr;15(4):454-60. doi: 10.1593/neo.13176.
19 A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/-catenin signaling.Int J Cancer. 2020 May 15;146(10):2877-2890. doi: 10.1002/ijc.32728. Epub 2019 Nov 23.
20 Gene Expression Changes Accompanying the Duodenal Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis.Clin Transl Gastroenterol. 2019 Jun;10(6):e00053. doi: 10.14309/ctg.0000000000000053.
21 Evaluation of role of FV, FVIII and APLAs in the pathogenesis of APCR in FV Leiden negative DVT patients: a study in India.J Thromb Thrombolysis. 2017 Feb;43(2):217-223. doi: 10.1007/s11239-016-1469-6.
22 Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.JCI Insight. 2019 Jul 16;5(15):e127736. doi: 10.1172/jci.insight.127736.
23 The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression.Cancer Res. 2000 Mar 15;60(6):1671-6.
24 Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets.Theranostics. 2017 Jan 6;7(2):482-492. doi: 10.7150/thno.16816. eCollection 2017.
25 Umbilical cord gene expression reveals the molecular architecture of the fetal inflammatory response in extremely preterm newborns.Pediatr Res. 2016 Mar;79(3):473-81. doi: 10.1038/pr.2015.233. Epub 2015 Nov 5.
26 A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.Gastroenterology. 2016 Oct;151(4):710-723.e2. doi: 10.1053/j.gastro.2016.06.045. Epub 2016 Jul 1.
27 Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein.Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5959-64. doi: 10.1073/pnas.092143199. Epub 2002 Apr 23.
28 Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system.J Neuroinflammation. 2017 Jun 6;14(1):115. doi: 10.1186/s12974-017-0891-9.
29 Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development.Cancer Res. 2006 Aug 1;66(15):7571-7. doi: 10.1158/0008-5472.CAN-06-1067.
30 A Role for Postsynaptic Density 95 and Its Binding Partners in Models of Traumatic Brain Injury.J Neurotrauma. 2019 Jul 1;36(13):2129-2138. doi: 10.1089/neu.2018.6291. Epub 2019 Mar 28.
31 The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse.J Pathol. 2008 Feb;214(3):294-301. doi: 10.1002/path.2294.
32 Protease-activated receptor-1 impedes prostate and intestinal tumor progression in mice.J Thromb Haemost. 2018 Nov;16(11):2258-2269. doi: 10.1111/jth.14277. Epub 2018 Sep 27.
33 Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer.Hum Genet. 1998 Jan;102(1):63-8. doi: 10.1007/s004390050655.
34 A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10164-9. doi: 10.1073/pnas.95.17.10164.
35 Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis.J Clin Invest. 2000 Aug;106(4):533-9. doi: 10.1172/JCI9476.
36 Update on genetic predisposition to colorectal cancer and polyposis.Mol Aspects Med. 2019 Oct;69:10-26. doi: 10.1016/j.mam.2019.03.001. Epub 2019 Mar 18.
37 Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.EMBO J. 2020 Jan 2;39(1):e101090. doi: 10.15252/embj.2018101090. Epub 2019 Nov 20.
38 Oncocytic papillary neoplasms of the biliary tract: a clinicopathological, mucin core and Wnt pathway protein analysis of four cases.Pathology. 2007 Aug;39(4):413-8. doi: 10.1080/00313020701444531.
39 Duodenal mucosal risk markers in patients with familial adenomatous polyposis: effects of celecoxib/ursodeoxycholic acid co-treatment and comparison with patient controls.Orphanet J Rare Dis. 2013 Nov 19;8:181. doi: 10.1186/1750-1172-8-181.
40 Corruption of homeostatic mechanisms in the guanylyl cyclase C signaling pathway underlying colorectal tumorigenesis.Cancer Biol Ther. 2010 Aug 1;10(3):211-8. doi: 10.4161/cbt.10.3.12539. Epub 2010 Aug 11.
41 Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):735-41. doi: 10.1158/1078-0432.CCR-05-1557.
42 Multiple roles of Adenomatous Polyposis Coli gene in Wnt Signalling - a Computational Model.Biosystems. 2018 Oct;172:26-36. doi: 10.1016/j.biosystems.2018.08.001. Epub 2018 Aug 12.
43 Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
44 Parafibromin, APC, and MIB-1 Are Useful Markers for Distinguishing Parathyroid Carcinomas From Adenomas.Appl Immunohistochem Mol Morphol. 2017 Nov/Dec;25(10):731-735. doi: 10.1097/PAI.0000000000000378.
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46 Alternative pre-mRNA splicing in digestive tract malignancy.Cancer Sci. 2011 Feb;102(2):309-16. doi: 10.1111/j.1349-7006.2010.01797.x. Epub 2010 Dec 7.
47 Ornithine decarboxylase G316A genotype and colorectal cancer risk.Colorectal Dis. 2011 Aug;13(8):860-4. doi: 10.1111/j.1463-1318.2010.02300.x. Epub 2010 Apr 29.
48 An update of HNPCC (Lynch syndrome).Cancer Genet Cytogenet. 1997 Jan;93(1):84-99. doi: 10.1016/s0165-4608(96)00290-7.
49 Three female familial cases of solid pseudopapillary tumors with a protease serine 1 gene mutation.Pancreas. 2013 Jan;42(1):168-73. doi: 10.1097/MPA.0b013e3182554276.
50 Three submicroscopic deletions at the APC locus and their rapid detection by quantitative-PCR analysis.Eur J Hum Genet. 1999 Sep;7(6):695-703. doi: 10.1038/sj.ejhg.5200344.
51 Mucosal prostanoid receptors and synthesis in familial adenomatous polyposis.Histochem Cell Biol. 2001 Aug;116(2):171-81. doi: 10.1007/s004180100287.
52 n-6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer.Nutrients. 2019 Jan 15;11(1):171. doi: 10.3390/nu11010171.
53 Colonic endocrine cells in patients with familial amyloidotic polyneuropathy.J Intern Med. 1999 May;245(5):469-73. doi: 10.1046/j.1365-2796.1999.00484.x.
54 Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells.Eur J Pharmacol. 2014 Jan 15;723:276-87. doi: 10.1016/j.ejphar.2013.11.021. Epub 2013 Dec 1.
55 SGK1-dependent intestinal tumor growth in APC-deficient mice.Cell Physiol Biochem. 2010;25(2-3):271-8. doi: 10.1159/000276561. Epub 2010 Jan 12.
56 A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer.Sci Rep. 2017 Nov 29;7(1):16567. doi: 10.1038/s41598-017-16738-y.
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58 APC truncating mutations in Middle Eastern Population: Tankyrase inhibitor is an effective strategy to sensitize APC mutant CRC To 5-FU chemotherapy.Biomed Pharmacother. 2020 Jan;121:109572. doi: 10.1016/j.biopha.2019.109572. Epub 2019 Nov 5.
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