Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1MBYQ)

Drug Name
Ganciclovir Drug Info
Synonyms
ganciclovir; 82410-32-0; Gancyclovir; Cytovene; Vitrasert; Hydroxyacyclovir; Ganciclovirum; Zirgan; RS-21592; Cymevene; HHEMG; Biolf 62; BW-759U; Ganciclovirum [Latin]; 2'-NDG; 2-Amino-9-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-1H-purin-6(9H)-one; BW 759U; BIOLF-62; 2'-Nor-2'-deoxyguanosine; 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine; BW-B 759U; UNII-P9G3CKZ4P5; DRG-0018; BW 759; 9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE; 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-one; CCRIS 9212; GA2; Cytovene-IV; HSDB 6512
Indication
Disease Entry ICD 11 Status REF
Cytomegalovirus infection 1D82 Approved [1]
Cytomegalovirus retinitis 9B72.00 Approved [1]
Virus infection 1A24-1D9Z Approved [2]
Radiculitis Investigative [1]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
135398740
ChEBI ID
CHEBI:465284
CAS Number
CAS 82410-32-0
TTD Drug ID
DM1MBYQ
VARIDT Drug ID
DR00027
ACDINA Drug ID
D00298

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [13]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [14]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [15]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [14]
Valganciclovir DMS2IUH Virus infection 1A24-1D9Z Approved [16]
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [17]
Famciclovir DMJHLSD Meniere disease AB31.0 Approved [18]
Valacyclovir Hydrochloride DM5I1CE Herpes simplex virus infection 1F00 Approved [14]
Foscavir DM9KJLZ Cytomegalovirus retinitis 9B72.00 Approved [16]
Netivudine DMTKRY1 Virus infection 1A24-1D9Z Phase 3 [19]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [25]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
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Drug(s) Transported By Multidrug and toxin extrusion protein 1 (SLC47A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [8]
Metformin DM89QE1 Colorectal carcinoma Approved [29]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [8]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [30]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [8]
Topotecan DMP6G8T Central nervous system neoplasm Approved [8]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [31]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [32]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [10]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [33]
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Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [34]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [35]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [36]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [37]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
Verapamil DMA7PEW Angina pectoris BA40 Approved [38]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [39]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [40]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [41]
Propranolol DM79NTF Angina pectoris BA40 Approved [42]
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Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Folic Acid DMEMBJC Colorectal carcinoma Approved [44]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [45]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [46]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [47]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [48]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [49]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [50]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [51]
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Drug(s) Transported By Multidrug resistance-associated protein 5 (ABCC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Folic Acid DMEMBJC Colorectal carcinoma Approved [52]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [45]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [53]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [54]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [55]
FLUORESCEIN DMQTFAO Ocular disease 1F00.1Z Approved [56]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [57]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [58]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [59]
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Drug(s) Transported By Organic anion transporter 1 (SLC22A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [62]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [7]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [7]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [63]
Olmesartan medoxomil DMWBHRY High blood pressure BA00 Approved [64]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [65]
FLUORESCEIN DMQTFAO Ocular disease 1F00.1Z Approved [66]
Tenofovir DM1IS6U Chronic hepatitis B virus infection Approved [67]
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Drug(s) Transported By Organic anion transporter 3 (SLC22A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [62]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [7]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [69]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [70]
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [71]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [72]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [73]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [74]
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [75]
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Drug(s) Transported By Multidrug and toxin extrusion protein 2 (SLC47A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [8]
Metformin DM89QE1 Colorectal carcinoma Approved [8]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [8]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [8]
Topotecan DMP6G8T Central nervous system neoplasm Approved [8]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [32]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [10]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [8]
N-methylpyridinium DMVUKEW N. A. N. A. Preclinical [8]
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [8]
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Drug(s) Transported By Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [4]
Levacecarnine hci DMJBOCR Cognitive impairment 6D71 Approved [76]
Glycine DMIOZ29 Allergic rhinitis CA08.0 Approved [77]
L-glutamine DM69G8X Short bowel syndrome KB89.1 Approved [78]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [79]
Valganciclovir DMS2IUH Virus infection 1A24-1D9Z Approved [80]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [81]
D-Serine DM3YH4I N. A. N. A. Phase 4 [82]
L-threonine DMFHTBX Discovery agent N.A. Investigative [82]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [83]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [84]
Fructose DM43AN2 Vomiting MD90 Approved [85]
Ketoprofen DMRKXPT Bursitis Approved [85]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [87]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [88]
Gefitinib DM15F0X Colon adenocarcinoma Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [91]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [94]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [95]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [96]
Paclitaxel DMLB81S Breast carcinoma Approved [97]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [100]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [101]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [102]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [103]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [105]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [85]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [106]
Verapamil DMA7PEW Angina pectoris BA40 Approved [107]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [108]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [87]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [109]
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Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [110]
Flucytosine DM13VTW Cryptococcal meningitis Approved [11]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [94]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [115]
Amifostine DM5FL14 Mucositis CA00 Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DTW7AE3 AAAT_HUMAN Substrate [4]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [5]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [6]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [7]
Multidrug and toxin extrusion protein 2 (SLC47A2) DT3TX4H S47A2_HUMAN Substrate [8]
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [8]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [9]
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [7]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [11]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [11]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Gene/Protein Processing [11]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Protein Interaction/Cellular Processes [12]

References

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3 Application of real time polymerase chain reaction to the diagnosis and treatment of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Zhonghua Xue Ye Xue Za Zhi. 2009 Feb;30(2):77-81.
4 Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):357-64.
5 Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev. 2005;37(1):253-78.
6 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
7 Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24.
8 Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71.
9 Side populations of glioblastoma cells are less sensitive to HSV-TK/GCV suicide gene therapy system than the non-side population. In Vitro Cell Dev Biol Anim. 2010 Jun;46(6):497-501.
10 FDA Drug Development and Drug Interactions
11 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
12 Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
13 Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72.
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17 Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides. Drugs. 2009;69(2):151-66.
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20 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
21 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
22 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
23 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
24 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
25 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
26 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
27 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
28 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
29 Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol. 2010 Apr;298(4):F997-F1005.
30 Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine. Antimicrob Agents Chemother. 2011 Jul;55(7):3091-8.
31 Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010 Aug;334(2):651-6.
32 Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195.
33 Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity. Drug Metab Dispos. 2018 May;46(5):592-599.
34 Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30.
35 Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther. 2006 Nov;319(2):879-86.
36 Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. Leuk Lymphoma. 2008 Apr;49(4):639-42.
37 Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 1;66(17):8847-57.
38 Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33.
39 Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
40 Comparison of type I and type II organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5.
41 Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53.
42 Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145.
43 Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007 Jan;320(1):229-35.
44 Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50.
45 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
46 The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9.
47 Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7.
48 P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010 Dec;4(4):195-201.
49 Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood. 2009 Aug 13;114(7):1383-6.
50 Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503.
51 Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21.
52 The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res. 2005 May 15;65(10):4425-30.
53 Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets. 2008 Aug;8(5):414-20.
54 Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine. Springerplus. 2014 Dec 13;3:732.
55 Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia. 2010 Sep;12(9):740-7.
56 Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem. 2007 Jul 20;282(29):20999-1004.
57 Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32.
58 Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 2002;4(3):E14.
59 The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem. 2000 Sep 29;275(39):30069-74.
60 The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies. Drug Metab Dispos. 2002 Jan;30(1):13-9.
61 Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. Drug Metab Pharmacokinet. 2010;25(2):163-9.
62 Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8.
63 Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004 Jan;21(1):61-7.
64 Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76.
65 Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006 May;61(5):491-2.
66 Apical expression or expression in a non polarized cell of hOAT1 inverses regulation by epidermal growth factor (EGF) as compared to basolateral hOAT1. Cell Physiol Biochem. 2004;14(3):177-86.
67 Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):641-8.
68 Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3. Drug Metab Pharmacokinet. 2004 Oct;19(5):369-74.
69 Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86.
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