General Information of Drug (ID: DM42EVG)

Drug Name
Ganoderic acid A Drug Info
Synonyms
Ganoderic acid A; 81907-62-2; UNII-548G37DF65; 548G37DF65; (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid; (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxo-heptanoic acid; CHEMBL602899; Ganoderic-acid-A; AC1LAM6R; HY-N1447; ZINC49767216; CS-5856; Lanost-8-en-26-oic
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
471002
CAS Number
CAS 81907-62-2
TTD Drug ID
DM42EVG

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RG-7234 DM5RAB9 Type-2 diabetes 5A11 Phase 2 [3]
[(125)I] RB129 DMX0G7E Discovery agent N.A. Investigative [4]
3-acetyl-11-keto-beta-boswellic acid DMGO2D7 Discovery agent N.A. Investigative [1]
11-keto-beta-boswellicacid DMM6CJI Discovery agent N.A. Investigative [1]
Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [6]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Methotrexate DM2TEOL Anterior urethra cancer Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [9]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
Fructose DM43AN2 Vomiting MD90 Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [11]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [16]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [15]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [18]
Testosterone DM7HUNW Hot flushes GA30 Approved [19]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [21]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [16]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [25]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [26]
Bortezomib DMNO38U Leukemia Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Desogestrel DM27U4Y Contraception QA21 Approved [28]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [30]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein E (APOE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [33]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [34]
Selenium DM25CGV N. A. N. A. Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [41]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [31]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [42]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
Clozapine DMFC71L Schizophrenia 6A20 Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [43]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Squalene synthase (FDFT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Leflunomide DMR8ONJ Arthritis FA20 Approved [55]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [57]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lanosterol synthase (LSS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [58]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [58]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Fluoxetine DM3PD2C Bipolar depression Approved [58]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [59]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [60]
Selenium DM25CGV N. A. N. A. Approved [35]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [44]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-citrate synthase (ACLY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [68]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [69]
OPC-34712 DMHG57U Major depressive disorder 6A70.3 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [6]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Fluoxetine DM3PD2C Bipolar depression Approved [6]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [11]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mevalonate kinase (MVK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [35]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [5]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [27]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [75]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [76]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [35]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [77]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [16]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [79]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [16]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [83]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [15]
Testosterone DM7HUNW Hot flushes GA30 Approved [85]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [19]
Leflunomide DMR8ONJ Arthritis FA20 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [88]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [89]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [90]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [76]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [91]
OLEIC ACID DM54O1Z Discovery agent N.A. Investigative [92]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [25]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [95]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [96]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [35]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Fluoxetine DM3PD2C Bipolar depression Approved [13]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [100]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) TT9H85R DHI2_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Gene/Protein Processing [2]
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Gene/Protein Processing [2]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Gene/Protein Processing [2]
Acyl-CoA 6-desaturase (FADS2) OTUX531P FADS2_HUMAN Gene/Protein Processing [2]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Gene/Protein Processing [2]
ATP-citrate synthase (ACLY) OTRL9ZRP ACLY_HUMAN Gene/Protein Processing [2]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Gene/Protein Processing [2]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Gene/Protein Processing [2]
Galactoside alpha-(1,2)-fucosyltransferase 2 (FUT2) OTLXM6WI FUT2_HUMAN Gene/Protein Processing [2]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Gene/Protein Processing [2]

References

1 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15.
2 Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway. Chem Biol Interact. 2018 Jun 25;290:77-87.
3 New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131).
4 Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation. Oncogene. 2003 Mar 20;22(11):1663-7.
5 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
6 Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
7 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
8 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
9 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
10 Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
11 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
12 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
13 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
14 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
15 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
16 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
17 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
18 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
19 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
20 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
21 Troglitazone downregulates delta-6 desaturase gene expression in human skeletal muscle cell cultures. Diabetes. 2002 Apr;51(4):1060-5. doi: 10.2337/diabetes.51.4.1060.
22 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
23 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
24 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
25 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
26 Phospholipidosis induced by PPARgama signaling in human bronchial epithelial (BEAS-2B) cells exposed to amiodarone. Toxicol Sci. 2011 Mar;120(1):98-108.
27 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
28 Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEG-3 cell line and placental tissue. Contraception. 2007 Oct;76(4):297-305. doi: 10.1016/j.contraception.2007.06.011. Epub 2007 Sep 14.
29 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
30 Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression. J Biol Chem. 2020 Nov 20;295(47):15870-15882. doi: 10.1074/jbc.RA120.015623. Epub 2020 Sep 10.
31 Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin. J Lipid Res. 1999 Jun;40(6):1078-89.
32 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
33 Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes. Biochem Pharmacol. 2006 Feb 28;71(5):605-14.
34 Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin. Pharmacol Res. 2007 Apr;55(4):310-7. doi: 10.1016/j.phrs.2006.12.009. Epub 2007 Jan 14.
35 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
36 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
37 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
38 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
39 Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
40 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
41 Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. Biochem J. 2009 May 13;420(2):305-15.
42 Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin. Circulation. 2008 Jul 22;118(4):355-62. doi: 10.1161/CIRCULATIONAHA.108.773267. Epub 2008 Jun 16.
43 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
44 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
45 PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages. FEBS Lett. 2002 Jun 5;520(1-3):177-81.
46 Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J Clin Endocrinol Metab. 2013 Mar;98(3):E455-62.
47 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
48 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
49 Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 2006 Oct 20;7:69.
50 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
51 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
52 Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice. J Pharmacol Exp Ther. 2018 Mar;364(3):452-461. doi: 10.1124/jpet.117.243105. Epub 2018 Jan 9.
53 Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. Eur J Pharmacol. 2007 Oct 1;571(2-3):97-105.
54 Inhibition of liver x receptor/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in vitro. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1228-36. doi: 10.1161/ATVBAHA.110.205500. Epub 2010 Mar 25.
55 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
56 Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase. Biochem Pharmacol. 1993 Jun 9;45(11):2203-8.
57 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
58 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
59 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
60 Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease. Oncotarget. 2016 Jun 7;7(23):33689-702. doi: 10.18632/oncotarget.9399.
61 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
62 Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol. 2001 Dec 1;62(11):1545-55. doi: 10.1016/s0006-2952(01)00790-0.
63 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
64 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
65 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
66 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
67 Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies. Arch Toxicol. 2018 Sep;92(9):2829-2844. doi: 10.1007/s00204-018-2263-3. Epub 2018 Jul 13.
68 Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBP-SIRT1 pathway. Toxicology. 2019 Apr 1;417:23-34. doi: 10.1016/j.tox.2019.02.008. Epub 2019 Feb 15.
69 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
70 Brexpiprazole suppresses cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in colorectal cancer. Environ Toxicol. 2023 Oct;38(10):2352-2360. doi: 10.1002/tox.23871. Epub 2023 Jun 22.
71 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
72 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
73 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
74 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
75 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
76 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
77 Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy. Biochem Pharmacol. 2010 Apr 15;79(8):1200-9. doi: 10.1016/j.bcp.2009.12.007. Epub 2009 Dec 14.
78 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
79 Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005 Oct;135(10):2305-12. doi: 10.1093/jn/135.10.2305.
80 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
81 Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
82 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
83 Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
84 Comparative effects of fructose and glucose on lipogenic gene expression and intermediary metabolism in HepG2 liver cells. PLoS One. 2011;6(11):e26583. doi: 10.1371/journal.pone.0026583. Epub 2011 Nov 11.
85 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
86 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
87 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
88 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
89 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
90 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
91 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
92 Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells. Toxicol Appl Pharmacol. 2019 Feb 15;365:61-70.
93 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
94 Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: results from a crossover study. Atherosclerosis. 2011 Jul;217(1):165-70. doi: 10.1016/j.atherosclerosis.2011.02.012. Epub 2011 Feb 22.
95 Peroxisome Proliferator-activated receptor activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. J Biol Chem. 2012 Jul 6;287(28):23667-77. doi: 10.1074/jbc.M112.350181. Epub 2012 May 16.
96 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
97 Hydroxychloroquine decreases human MSC-derived osteoblast differentiation and mineralization in vitro. J Cell Mol Med. 2018 Feb;22(2):873-882. doi: 10.1111/jcmm.13373. Epub 2017 Oct 3.
98 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
99 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
100 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.