Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8Y4JS)

Drug Name
Quizartinib Drug Info
Synonyms AC220
Indication
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Approved [1]
leukaemia 2A60-2B33 Phase 3 [2]
Cross-matching ID
PubChem CID
24889392
ChEBI ID
CHEBI:90217
CAS Number
CAS 950769-58-1
TTD Drug ID
DM8Y4JS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Fms-like tyrosine kinase 3 (FLT-3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
Ponatinib DMYGJQO Acute lymphoblastic leukaemia 2A85 Approved [7]
Intedanib DMSTA36 Colorectal cancer 2B91.Z Approved [8]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [9]
Gilteritinib DMTI0ZO Acute myeloid leukaemia 2A60 Approved [10]
Pexidartinib DMS2J0Z Tenosynovial giant cell tumour 2F7B Approved [11]
Pacritinib DM1T6ZN Myelofibrosis 2A20.2 Approved [6]
Lestaurtinib DMQ2AIJ Acute myeloid leukaemia 2A60 Approved (orphan drug) [12]
Famitinib DMSFWT7 Solid tumour/cancer 2A00-2F9Z Phase 2 [13]
BMS-690514 DMX302C Chronic pain MG30 Phase 2 [14]
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Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [15]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [16]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Venetoclax DM8I94Y Chronic lymphocytic leukaemia 2A82.0 Approved [20]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [21]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [22]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [34]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [35]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [38]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [39]
Panobinostat DM58WKG Chronic graft versus host disease Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [42]
Testosterone DM7HUNW Hot flushes GA30 Approved [43]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Gefitinib DM15F0X Colon adenocarcinoma Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Selenium DM25CGV N. A. N. A. Approved [49]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [50]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [56]
Paclitaxel DMLB81S Breast carcinoma Approved [57]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [58]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [60]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [65]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [66]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [67]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [66]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [68]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [71]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [72]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [73]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [74]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [75]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Verapamil DMA7PEW Angina pectoris BA40 Approved [76]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [77]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [80]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Selenium DM25CGV N. A. N. A. Approved [49]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [84]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
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Drug(s) Affected By Replication protein A 32 kDa subunit (RPA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Etretinate DM2CZFA Keratosis ED56 Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [34]
Testosterone DM7HUNW Hot flushes GA30 Approved [88]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [88]
Leflunomide DMR8ONJ Arthritis FA20 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [91]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [92]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Selenium DM25CGV N. A. N. A. Approved [95]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [96]
Etretinate DM2CZFA Keratosis ED56 Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [97]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [98]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [99]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [102]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [103]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [107]
Gefitinib DM15F0X Colon adenocarcinoma Approved [108]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [111]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [103]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [112]
Paclitaxel DMLB81S Breast carcinoma Approved [113]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [114]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [102]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [75]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [105]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [116]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [117]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
Gefitinib DM15F0X Colon adenocarcinoma Approved [118]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [119]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [120]
Selenium DM25CGV N. A. N. A. Approved [95]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [121]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [50]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [122]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [123]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [124]
Gefitinib DM15F0X Colon adenocarcinoma Approved [125]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Prednisone DM2HG4X Acute asthma CA23 Approved [128]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [67]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [129]
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Drug(s) Affected By Signal transducer and activator of transcription 5A (STAT5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [130]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [131]
Testosterone DM7HUNW Hot flushes GA30 Approved [88]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [88]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [132]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [133]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [137]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [56]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [138]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [139]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [140]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [141]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [142]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [143]
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Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [145]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [130]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [146]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [133]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [148]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [149]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [150]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [151]
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Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [152]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [153]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [155]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Panobinostat DM58WKG Chronic graft versus host disease Approved [40]
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Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [157]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [158]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [159]
Testosterone DM7HUNW Hot flushes GA30 Approved [88]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [88]
Leflunomide DMR8ONJ Arthritis FA20 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [132]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fms-like tyrosine kinase 3 (FLT-3) TTGJCWZ FLT3_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [5]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [5]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Gene/Protein Processing [5]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [4]

References

1 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 216993
2 ClinicalTrials.gov (NCT02039726) An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD. Mol Cancer Ther. 2014 Oct;13(10):2315-27. doi: 10.1158/1535-7163.MCT-14-0258. Epub 2014 Jul 22.
5 Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3. Arch Toxicol. 2022 Jan;96(1):177-193. doi: 10.1007/s00204-021-03174-1. Epub 2021 Oct 19.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1807).
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
8 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
9 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
10 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
11 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
12 Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with ... Blood. 2008 Jun 15;111(12):5663-71.
13 Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706.
14 Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93.
15 Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells. PLoS One. 2011;6(9):e25351. doi: 10.1371/journal.pone.0025351. Epub 2011 Sep 28.
16 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
17 SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. Blood. 2003 Aug 1;102(3):795-801. doi: 10.1182/blood-2002-10-3023. Epub 2003 Mar 20.
18 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
19 Arsenic trioxide affects signal transducer and activator of transcription proteins through alteration of protein tyrosine kinase phosphorylation. Clin Cancer Res. 2006 Nov 15;12(22):6817-25. doi: 10.1158/1078-0432.CCR-06-1354.
20 HSP90 Inhibitor PU-H71 in Combination with BH3-Mimetics in the Treatment of Acute Myeloid Leukemia. Curr Issues Mol Biol. 2023 Aug 23;45(9):7011-7026. doi: 10.3390/cimb45090443.
21 Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6. Blood. 2016 Jun 9;127(23):2890-902. doi: 10.1182/blood-2015-11-683581. Epub 2016 Apr 20.
22 Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias. Clin Cancer Res. 2010 Feb 15;16(4):1149-58. doi: 10.1158/1078-0432.CCR-09-2416. Epub 2010 Feb 9.
23 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
24 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
25 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
26 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
27 Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
28 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
29 Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
30 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
31 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
32 Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci. 2009 Sep;111(1):120-30. doi: 10.1093/toxsci/kfp136. Epub 2009 Jun 18.
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