Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM91LGU)

Drug Name
Abexinostat Drug Info
Synonyms
PCI-24781; 783355-60-2; ABEXINOSTAT; PCI 24781; CRA-024781; CRA 024781; UNII-IYO470654U; 3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide; CRA-02478; Abexinostat(PCI-24781); PCI-24781 (Abexinostat); Abexinostat (PCI-24781); IYO470654U; 3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide; 3-((Dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)-phenoxy)ethyl)benzofuran-2-carboxamide
Indication
Disease Entry ICD 11 Status REF
Follicular lymphoma 2A80 Phase 3 [1]
Renal cell carcinoma 2C90 Phase 3 [2]
Acute myeloid leukaemia 2A60 Phase 2 [1]
Breast cancer 2C60-2C65 Phase 2 [1]
Diffuse large B-cell lymphoma 2A81 Phase 2 [1]
Gynecologic cancer 2F33-2F76 Phase 2 [1]
Peripheral T-cell lymphoma 2A90.C Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Cross-matching ID
PubChem CID
11749858
ChEBI ID
CHEBI:92223
CAS Number
CAS 783355-60-2
TTD Drug ID
DM91LGU

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histone deacetylase (HDAC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [6]
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [7]
HBI-8000 DMDWYUN Non-small-cell lung cancer 2C25.Y Registered [1]
ITF2357 DMFZBNE Duchenne dystrophy 8C70 Phase 3 [8]
Pracinostat DMTD7AB Acute myeloid leukaemia 2A60 Phase 3 [9]
NVP-LAQ824 DM8JWNA Mood disorder 6A60-6E23 Phase 3 [10]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [1]
CMS-024-02 DMC4X7L Solid tumour/cancer 2A00-2F9Z Phase 3 [11]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [12]
MGCD-0103 DM726HX Non-small-cell lung cancer 2C25.Y Phase 2 [1]
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Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [13]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [15]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [16]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [13]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [17]
Testosterone DM7HUNW Hot flushes GA30 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Ibrutinib DMHZCPO Mantle cell lymphoma 2A85.5 Approved [20]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [21]
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Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Gefitinib DM15F0X Colon adenocarcinoma Approved [23]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [16]
Panobinostat DM58WKG Chronic graft versus host disease Approved [25]
Testosterone DM7HUNW Hot flushes GA30 Approved [26]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [29]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [31]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [32]
Gefitinib DM15F0X Colon adenocarcinoma Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Selenium DM25CGV N. A. N. A. Approved [35]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [36]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [37]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [40]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [42]
Verapamil DMA7PEW Angina pectoris BA40 Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Selenium DM25CGV N. A. N. A. Approved [46]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [47]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Gefitinib DM15F0X Colon adenocarcinoma Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [52]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [53]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [54]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [53]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [55]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
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Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [62]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [63]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [64]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [64]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [58]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [40]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [65]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
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Drug(s) Affected By Heme oxygenase 2 (HMOX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [74]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [75]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [76]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [77]
Urethane DM7NSI0 N. A. N. A. Phase 4 [78]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [79]
SB-431542 DM0YOXQ Pulmonary fibrosis CB03.4 Preclinical [80]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [81]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [83]
Gefitinib DM15F0X Colon adenocarcinoma Approved [84]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Etretinate DM2CZFA Keratosis ED56 Approved [87]
Prednisone DM2HG4X Acute asthma CA23 Approved [88]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [54]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [89]
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Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Testosterone DM7HUNW Hot flushes GA30 Approved [26]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [96]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [97]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [99]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [52]
Meloxicam DM2AR7L Arthritis FA20 Approved [102]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [103]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [104]
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Drug(s) Affected By C-C motif chemokine 7 (CCL7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Isoproterenol DMK7MEY Atrioventricular block Approved [107]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [108]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [109]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [110]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [111]
Nickel chloride DMI12Y8 Discovery agent N.A. Investigative [112]
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Drug(s) Affected By Transcription factor RelB (RELB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [116]
Testosterone DM7HUNW Hot flushes GA30 Approved [26]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [26]
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Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [119]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [120]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Testosterone DM7HUNW Hot flushes GA30 Approved [26]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [122]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [26]
Leflunomide DMR8ONJ Arthritis FA20 Approved [123]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [125]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [126]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Gefitinib DM15F0X Colon adenocarcinoma Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [129]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [52]
Selenium DM25CGV N. A. N. A. Approved [130]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone deacetylase (HDAC) TTBH0VX NOUNIPROTAC Modulator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Gene/Protein Processing [4]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Gene/Protein Processing [5]
C-C motif chemokine 7 (CCL7) OTDIS99H CCL7_HUMAN Gene/Protein Processing [5]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [5]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [5]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [5]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Gene/Protein Processing [4]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) OT8V1J4M GA45G_HUMAN Gene/Protein Processing [4]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [5]
Heme oxygenase 2 (HMOX2) OTG40XBT HMOX2_HUMAN Gene/Protein Processing [5]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT03592472) A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV). U.S. National Institutes of Health.
3 Phase 1 study of the oral histone deacetylase inhibitor abexinostat in patients with Hodgkin lymphoma, non-Hodgkin lymphoma, or chronic lymphocytic leukaemia. Invest New Drugs. 2015 Apr;33(2):423-31.
4 HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19482-7. doi: 10.1073/pnas.0707828104. Epub 2007 Nov 27.
5 PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells. Clin Cancer Res. 2009 May 15;15(10):3354-65. doi: 10.1158/1078-0432.CCR-08-2365. Epub 2009 May 5.
6 Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo. PLoS One. 2009 Jun 30;4(6):e6086.
7 Histone Deacetylase inhibitors: new promise in the treatment of immune and inflammatory diseases. Curr Drug Targets. 2010 Nov;11(11):1430-8.
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8365).
10 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
11 US patent application no. 2012,0302,505, Cyclodextrin-based polymers for therapeutic delivery.
12 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
13 Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct;99(2):402-15. doi: 10.1111/j.1471-4159.2006.04005.x.
14 Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKbeta. Apoptosis. 2009 Jul;14(7):913-22. doi: 10.1007/s10495-009-0367-1.
15 Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. J Immunol. 2007 Feb 15;178(4):2507-16. doi: 10.4049/jimmunol.178.4.2507.
16 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
17 Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. J Biol Chem. 2005 Dec 9;280(49):41047-56. doi: 10.1074/jbc.M503713200. Epub 2005 Sep 30.
18 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
19 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
20 Blockade of oncogenic IB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11365-70. doi: 10.1073/pnas.1411701111. Epub 2014 Jul 21.
21 Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. Endocrinology. 2005 Mar;146(3):1491-7. doi: 10.1210/en.2004-0809. Epub 2004 Nov 24.
22 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
23 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
24 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
25 SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-B/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis. 2013 May 16;4(5):e635. doi: 10.1038/cddis.2013.159.
26 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
27 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
28 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
29 Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Toxicol Sci. 2022 Sep 24;189(2):216-224. doi: 10.1093/toxsci/kfac073.
30 Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
31 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
32 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
33 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
34 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
35 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
36 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
37 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
38 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
39 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
40 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
41 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
42 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
43 Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
44 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
45 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
46 High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage. Clin Chim Acta. 2010 Sep 6;411(17-18):1312-8.
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