Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEMBJC)

Drug Name
Folic acid Drug Info
Synonyms
folic acid; 59-30-3; Folate; Pteroylglutamic acid; Vitamin M; Folacin; Folacid; PteGlu; Vitamin B9; Folvite; Pteroyl-L-glutamic acid; Vitamin Bc; Acifolic; Cytofol; Incafolic; Foliamin; Folsaure; Folicet; Millafol; Folipac; Folettes; Folsan; Folbal; Folsav; Vitamin Be; Pteroyl-L-monoglutamic acid; Mittafol; Folan; Facid; Pteroylmonoglutamic acid; Antianemia factor; Factor U; Folico (Italy); Folina (Italy); Foldine [France]; Pteroylmonoglutamate; Acfol (Spain); Foldine; Folcysteine; Folasic (Australia); Folcidin; Folaemin [Netherlands]; Nifolin; [3H]folic acid
Indication
Disease Entry ICD 11 Status REF
Folate-deficiency anemia 3A02.Y Approved [1]
Vitamin deficiency 5B55-5B71 Approved [2] , [3] , [4]
Therapeutic Class
Vitamins
Cross-matching ID
PubChem CID
135398658
ChEBI ID
CHEBI:27470
CAS Number
CAS 59-30-3
TTD Drug ID
DMEMBJC
VARIDT Drug ID
DR00134
INTEDE Drug ID
DR0742
ACDINA Drug ID
D00291

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By RNA cytidine acetyltransferase (hALP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Caffeine DMKBJWP Orthostatic hypotension BA21 Approved [32]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [33]
Sulfamethoxazole DMB08GE Bacterial infection 1A00-1C4Z Approved [34]
Sulfadiazine DMTW3R8 Rheumatic fever 1B40-1B42 Approved [35]
Tobramycin DMUI0CH Bacterial infection 1A00-1C4Z Approved [36]
Mesalazine DMOL5IU Ulcerative colitis DD71 Approved [37]
Allopurinol DMLPAOB Hyperuricaemia 5C55.Y Approved [38]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [39]
Clonazepam DMTO13J Epilepsy 8A60-8A68 Approved [40]
Hydralazine DMU8JGH Hypertension BA00-BA04 Approved [41]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [44]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [45]
Oxaliplatin DMQNWRD Colorectal cancer 2B91.Z Approved [46]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [47]
Estrone DM5T6US Menopausal and postmenopausal disorder GA30 Approved [48]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [49]
Ethanol DMDRQZU Chronic pain MG30 Approved [50]
Nicotine DMWX5CO Nicotine dependence 6C4A.2 Approved [51]
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Drug(s) Metabolized By Methylenetetrahydrofolate reductase (MTHFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [52]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [53]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [54]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [55]
ISO-901 DMBQ8CA Rheumatoid arthritis FA20 Phase 1 [56]
Drug(s) Metabolized By Dihydrofolate reductase (DHFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [52]
Drug(s) Metabolized By Gamma-Glu-X carboxypeptidase (GGH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [52]
Drug(s) Metabolized By Vitamin B12 methionine synthase (MTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levomefolic acid DMUV5JB Contraception QA21 Approved [57]
Drug(s) Metabolized By Methionine synthase reductase (MTRR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [58]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [58]
Dichloroindophenol DMAEI51 Discovery agent N.A. Investigative [58]
Ferricyanide DM1TH08 Discovery agent N.A. Investigative [58]
Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [59]
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [13]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [60]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [61]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [62]
Irinotecan DMP6SC2 Colorectal cancer 2B91.Z Approved [63]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [64]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [65]
Daunorubicin DMQUSBT Acute myeloid leukaemia 2A60 Approved [66]
Docetaxel DMDI269 Solid tumour/cancer 2A00-2F9Z Approved [62]
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Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [67]
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [68]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [69]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [70]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [71]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [72]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [73]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [74]
Oxaliplatin DMQNWRD Colorectal cancer 2B91.Z Approved [75]
Ampicillin DMHWE7P Bacterial infection 1A00-1C4Z Approved [76]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Bacterial infection 1A00-1C4Z Approved [62]
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [77]
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [76]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [76]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [76]
Progesterone DMUY35B Premature labour JB00 Approved [78]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [76]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [79]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [80]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [81]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [82]
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [83]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [84]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [85]
Progesterone DMUY35B Premature labour JB00 Approved [86]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [87]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [86]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [88]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [89]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [90]
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Drug(s) Transported By Multidrug resistance-associated protein 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [91]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [92]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [93]
Ezetimibe DM7A8TW Hypercholesterolaemia 5C80.0 Approved [94]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [95]
Morphine DMRMS0L Chronic pain MG30 Approved [96]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [97]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [98]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [99]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [100]
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Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [101]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [92]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [102]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [62]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [103]
Irinotecan DMP6SC2 Colorectal cancer 2B91.Z Approved [104]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [105]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [106]
Ganciclovir DM1MBYQ Virus infection 1A24-1D9Z Approved [62]
Cefazolin DMPDYFR Bacterial infection 1A00-1C4Z Approved [97]
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Drug(s) Transported By Multidrug resistance-associated protein 5 (ABCC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [12]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [92]
Irinotecan DMP6SC2 Colorectal cancer 2B91.Z Approved [107]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [108]
Ganciclovir DM1MBYQ Virus infection 1A24-1D9Z Approved [109]
Gemcitabine DMSE3I7 Solid tumour/cancer 2A00-2F9Z Approved [110]
Fluorescein DMQTFAO Ocular disease 1F00.1Z Approved [111]
Pemetrexed DMMX2E6 Malignant pleural mesothelioma 2C26.0 Approved [112]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [113]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [114]
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Drug(s) Transported By Folate transporter 1 (SLC19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [10]
Pemetrexed DMMX2E6 Malignant pleural mesothelioma 2C26.0 Approved [10]
Pralatrexate DMAO80I Breast cancer 2C60-2C65 Approved [115]
Drug(s) Transported By Sodium-coupled neutral amino acid transporter 3 (SLC38A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-glutamine DM69G8X Short bowel syndrome KB89.1 Approved [116]
L-alanine DMZDN4W Dietary shortage 5B5K Approved [116]
Aminosalicylic acid DMENSL5 Inflammatory bowel disease DD72 Approved [117]
Drug(s) Transported By Proton-coupled folate transporter (SLC46A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [118]
Pemetrexed DMMX2E6 Malignant pleural mesothelioma 2C26.0 Approved [119]
Pralatrexate DMAO80I Breast cancer 2C60-2C65 Approved [115]
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [6]
PREMETREXED DMVOGT4 Discovery agent N.A. Investigative [6]
[3H]N5-methylfolate DM0THB9 Discovery agent N.A. Investigative [6]
[3H]folinic acid DME0XHN Discovery agent N.A. Investigative [6]
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Drug(s) Targeting Solute carrier family 19 member 1 (SLC19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [7]
Drug(s) Targeting Folate receptor (FOLR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tetrahydrofolic acid DMH15UV Malnutrition 5B50-5B71 Approved [120]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Folate receptor (FOLR) TTQOD3G NOUNIPROTAC Binder [5]
Proton-coupled folate transporter (SLC46A1) TTY8Z2E PCFT_HUMAN Modulator [6]
Solute carrier family 19 member 1 (SLC19A1) TT09I7D S19A1_HUMAN Modulator [7]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Sodium-coupled neutral amino acid transporter 3 (SLC38A3) DTKWJH3 S38A3_HUMAN Substrate [8]
Mitochondrial folate transporter/carrier (SLC25A32) DTM8E7H MFTC_HUMAN Substrate [9]
Folate transporter 1 (SLC19A1) DTOSN46 S19A1_HUMAN Substrate [10]
Proton-coupled folate transporter (SLC46A1) DTDJEMI PCFT_HUMAN Substrate [11]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [12]
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [13]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [14]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [15]
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [16]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [17]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [18]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [19]
Dihydrofolate reductase (DHFR) DE4EGMZ DYR_HUMAN Substrate [20]
Methylenetetrahydrofolate reductase (MTHFR) DEOXTPZ MTHR_HUMAN Substrate [21]
Gamma-Glu-X carboxypeptidase (GGH) DEU7MWJ GGH_HUMAN Substrate [22]
RNA cytidine acetyltransferase (hALP) DEZV4AP NAT10_HUMAN Substrate [23]
Methionine synthase reductase (MTRR) DE6NIY9 MTRR_HUMAN Substrate [24]
Vitamin B12 methionine synthase (MTR) DEWSHL5 METH_HUMAN Substrate [25]
Folylpolyglutamate synthetase (fpgS) DEW0GI5 FPGS_LACCA Substrate [26]
Dihydrofolate reductase (folA) DERGIEC DYR_ECOLI Substrate [27] , [28]
Dihydrofolate reductase (folA) DEEBFXM DYR_LACCA Substrate [29]
Dihydrofolate reductase (folA) DE1GYMX Q9PJC7_CHLMU Substrate [30] , [31]

References

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66 Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83.
67 Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7.
68 Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61.
69 Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
70 Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8.
71 Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55.
72 Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8.
73 Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7.
74 Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
75 Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727.
76 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
77 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
78 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
79 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
80 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
81 Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharm Res. 2003 Aug;20(8):1200-9.
82 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
83 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
84 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
85 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
86 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
87 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
88 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
89 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
90 Characterization of 3-methoxy flavones for their interaction with ABCG2 as suggested by ATPase activity. Biochim Biophys Acta. 2014 Nov;1838(11):2929-38.
91 Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13;42(18):5429-37.
92 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
93 Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry. 2009 May 26;48(20):4423-30.
94 Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702.
95 Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102.
96 Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 2007 Feb;453(5):661-73.
97 Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21.
98 Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7.
99 Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol Pharmacol. 2008 May;73(5):1474-83.
100 Induction of multiple drug transporters by efavirenz. J Pharmacol Sci. 2009 Feb;109(2):242-50.
101 Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007 Jan;320(1):229-35.
102 The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9.
103 Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7.
104 P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010 Dec;4(4):195-201.
105 Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood. 2009 Aug 13;114(7):1383-6.
106 Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503.
107 Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets. 2008 Aug;8(5):414-20.
108 Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine. Springerplus. 2014 Dec 13;3:732.
109 Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev. 2005;37(1):253-78.
110 Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia. 2010 Sep;12(9):740-7.
111 Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem. 2007 Jul 20;282(29):20999-1004.
112 Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32.
113 Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 2002;4(3):E14.
114 The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem. 2000 Sep 29;275(39):30069-74.
115 Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat. 2012 Aug;15(4):183-210.
116 Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.
117 Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2. Biochem J. 2000 May 15;348 Pt 1:159-66.
118 Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats. J Pharm Pharmacol. 2009 Jul;61(7):911-8.
119 The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol. 2008 Sep;74(3):854-62.
120 Common mutations at the homocysteine metabolism pathway and pediatric stroke. Thromb Res. 2001 Apr 15;102(2):115-20.