Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFJTDI)

Drug Name
Sibutramine Drug Info
Synonyms
Butramin; Medaria; Meridia; Reductil; Sibutramina; Sibutraminum; Sibutramina [Spanish]; Sibutraminum [Latin]; BTS-54524; Butramin (TN); Ectiva (TN); Meridia (TN); Reductil (TN); Sibutramine (INN); Sibutramine [INN:BAN]; N-1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutyl-N,N-dimethylamine HCl; 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
Indication
Disease Entry ICD 11 Status REF
Obesity 5B81 Approved [1]
Therapeutic Class
Appetite Depressants
Cross-matching ID
PubChem CID
5210
ChEBI ID
CHEBI:9137
CAS Number
CAS 106650-56-0
TTD Drug ID
DMFJTDI
VARIDT Drug ID
DR00566
INTEDE Drug ID
DR1479
ACDINA Drug ID
D00400

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Norepinephrine transporter (NET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [7]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [8]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [9]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [7]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [10]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [11]
Tapentadol hydrochloride DMXLSH3 Acute pain MG31 Approved [12]
Venlafaxine DMR6QH0 Anxiety disorder 6B00-6B0Z Approved [11]
Trimipramine DM1SC8M Major depressive disorder 6A70.3 Approved [13]
Duloxetine DM9BI7M Depression 6A70-6A7Z Approved [14]
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Drug(s) Targeting Serotonin transporter (SERT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [7]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [8]
Fluoxetine DM3PD2C Bipolar depression Approved [2]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [15]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [16]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [10]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [11]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [2]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [2]
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [2]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [19]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
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Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [27]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [28]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [30]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [31]
Capsaicin DMGMF6V Back pain ME84.Z Approved [32]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [33]
Quinidine DMLPICK N. A. N. A. Approved [34]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [35]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [36]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [37]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [38]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [39]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [40]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [41]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [42]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [43]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [44]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [45]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [47]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [48]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [36]
Capsaicin DMGMF6V Back pain ME84.Z Approved [32]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [33]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [49]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [33]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [47]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [50]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [51]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [54]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Verapamil DMA7PEW Angina pectoris BA40 Approved [56]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [57]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [58]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
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Drug(s) Affected By Proteasome subunit beta type-8 (PSMB8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [66]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [67]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [68]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [69]
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Drug(s) Affected By Proteasome subunit beta type-5 (PSMB5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [70]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [66]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [71]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [72]
Bortezomib DMNO38U Leukemia Approved [73]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [74]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [75]
WP-1066 DMUGHWR Recurrent glioblastoma 2A00.00 Phase 1/2 [74]
MG-132 DMKA2YS N. A. N. A. Preclinical [76]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [77]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [79]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [81]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [87]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [90]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [91]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [92]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [93]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [94]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [95]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [96]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [97]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [51]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [97]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Verapamil DMA7PEW Angina pectoris BA40 Approved [56]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [98]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [99]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Meloxicam DM2AR7L Arthritis FA20 Approved [102]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [103]
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Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clozapine DMFC71L Schizophrenia 6A20 Approved [104]
Leflunomide DMR8ONJ Arthritis FA20 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Folic Acid DMEMBJC Colorectal carcinoma Approved [107]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [108]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [109]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [110]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [111]
Almogran DM7I64Z Migraine 8A80 Approved [112]
Eletriptan DMW649X Migraine 8A80 Approved [112]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Modulator [2]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [4]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Gene/Protein Processing [5]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [5]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Gene/Protein Processing [5]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [4]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3) OTA6HYBA GBB3_HUMAN Drug Response [6]
Proteasome subunit beta type-5 (PSMB5) OTOZXAS6 PSB5_HUMAN Gene/Protein Processing [4]
Proteasome subunit beta type-8 (PSMB8) OTW5XGMF PSB8_HUMAN Gene/Protein Processing [4]

References

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55 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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63 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
64 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
65 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
66 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
67 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
68 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
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