Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJWE3I)

Drug Name
Gossypol Drug Info
Synonyms
gossypol; 303-45-7; (-)-Gossypol; 90141-22-3; (+)-Gossypol; Pogosin; Tash 1; racemic-Gossypol; (R)-(-)-Gossypol; (R)-Gossypol; (+-)-Gossypol; (+/-)-Gossypol; CCRIS 2689; NSC56817; NSC 56817; NSC 624336; BRN 1917878; CHEMBL51483; AI3-22957; 20300-26-9; 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde; 2,2'-bi[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]; 2,2'-Bis(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthalene); NSC624336; Gossypol acetate
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Phase 2 [1]
Cross-matching ID
PubChem CID
3503
CAS Number
CAS 20300-26-9
TTD Drug ID
DMJWE3I
VARIDT Drug ID
DR00896

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Apoptosis regulator Bcl-2 (BCL-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MCI-186 DM8ZHP1 Amyotrophic lateral sclerosis 8B60.0 Approved [5]
Taxol DMUOT9V Breast cancer 2C60-2C65 Approved [6]
GDC-0199 DMH0QKA Chronic lymphocytic leukaemia 2A82.0 Approved [7]
ABT-263 DMNE56X Myelofibrosis 2A20.2 Phase 3 [8]
Taxol/Paraplatin/Herceptin DML6GAN Breast cancer 2C60-2C65 Phase 3 [9]
Oblimersen DM7KI4E Melanoma 2C30 Phase 3 [10]
RG7601 DMDVAFP Chronic lymphocytic leukaemia 2A82.0 Phase 3 [7]
Thymoquinone DMVDTR2 Polycystic ovarian syndrome 5A80.1 Phase 2/3 [11]
Obatoclax DMPF9ZM Solid tumour/cancer 2A00-2F9Z Phase 2 [12]
PI-88/Taxotere DM4FIWC Solid tumour/cancer 2A00-2F9Z Phase 2 [13]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [14]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [18]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [19]
Panobinostat DM58WKG Chronic graft versus host disease Approved [20]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [21]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [22]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
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Drug(s) Affected By Fibroblast growth factor 2 (FGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Diazepam DM08E9O Alcohol withdrawal Approved [26]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [27]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [32]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [33]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [34]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [35]
Gefitinib DM15F0X Colon adenocarcinoma Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [38]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [39]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
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Drug(s) Affected By Midkine (MDK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [50]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [51]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [52]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [53]
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Drug(s) Affected By Fibroblast growth factor receptor 3 (FGFR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [55]
Panobinostat DM58WKG Chronic graft versus host disease Approved [20]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [56]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [57]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [57]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [58]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
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Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [56]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [69]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [70]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [71]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [72]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [73]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [74]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [75]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [76]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [80]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [81]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [83]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [84]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [85]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [86]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [87]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [89]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [92]
Meloxicam DM2AR7L Arthritis FA20 Approved [93]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [94]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [95]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [92]
Selenium DM25CGV N. A. N. A. Approved [44]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [99]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [102]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [103]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [104]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [105]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [110]
Ethacrynic acid DM60QMR Edema MG29 Approved [111]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [92]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [113]
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [115]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [116]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [109]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [117]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [118]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [22]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Apoptosis regulator Bcl-2 (BCL-2) TTJGNVC BCL2_HUMAN Regulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [3]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [3]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Gene/Protein Processing [4]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Gene/Protein Processing [4]
Fibroblast growth factor receptor 3 (FGFR3) OTSAXDIL FGFR3_HUMAN Gene/Protein Processing [4]

References

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20 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
21 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
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23 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
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25 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
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38 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
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49 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
50 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
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57 Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
58 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
59 Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia. Leukemia. 2003 Dec;17(12):2418-25. doi: 10.1038/sj.leu.2403152.
60 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
61 Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. Br J Pharmacol. 2014 Oct;171(19):4464-77. doi: 10.1111/bph.12803. Epub 2014 Sep 5.
62 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
63 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
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