Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOWZ6B)

Drug Name
Fluconazole Drug Info
Synonyms
Afungil; Alflucoz; Baten; Beagyne; Biocanol; Biozolene; Canzol; Cryptal; Diflazon; Diflucan; Dimycon; Elazor; FCZ; FLCZ; Flucazol; FlucoLich; Flucobeta; Fluconazol; Fluconazolum; Flucostat; Flukezol; Flunazul; Flunizol; Fluzone; Forcan; Fuconal; Fungata; Lavisa; Loitin; Mutum; Neofomiral; Oxifugol; Oxifungol; Pritenzol; Solacap; Syscan; TPF; Triflucan; Zemyc; Zoltec; Zonal; AbZ Brand of Fluconazole; Aliud Brand of Fluconazole; Alpharma Brand of Fluconazole; Apo Fluconazole; Apotex Brand of Fluconazole; Armstrong Brand of Fluconazole; Betapharm Brand of Fluconazole; Chemia Brand of Fluconazole; Ct Arzneimittel Brand of Fluconazole; Effik Brand of Fluconazole; Fluc Hexal; Fluconazol AL; Fluconazol AbZ; Fluconazol Isis; Fluconazol Stada; Fluconazol [Spanish]; Fluconazol ratiopharm; Fluconazol von ct; Fluconazolum [Latin]; Hexal Brand of Fluconazole; Lesvi Brand of Fluconazole; Lichtenstein Brand of Fluconazole; Mack Brand of Fluconazole; Pfizer Brand of Fluconazole; Pfleger Brand of Fluconazole; Ratiopharm Brand of Fluconazole; SAT Brand of Fluconazole; Silanes Brand of Fluconazole; Stada Brand of Fluconazole; Vita Brand of Fluconazole; F0677; Fluconazole in combination with MGCD290; UK 49858; UK49858; Alfumet (TN); Apo-Fluconazole; Ct-Arzneimittel Brand of Fluconazole; DIFLUCAN IN DEXTROSE 5% IN PLASTIC CONTAINER; DRG-0005; Diflucan (TN); Fluconazol-Isis; Fluconazol-ratiopharm; Fluconazole & Bovine Lactoferrin; Fluconazole & Human recombinant granulocyte colony stimulating factor; Fluconazole & hGCSF; Fluconazole in dextrose 5% in plastic container; Flucytosine & Nyotran; GL663142 & Fluconazole; KS-1059; Trican (TN); UK-49858; DIFLUCAN IN SODIUM CHLORIDE 0.9%; DIFLUCAN IN SODIUM CHLORIDE 0.9%IN PLASTIC CONTAINER; Fluconazole in sodium chloride 0.9%; Fluconazole in sodium chloride 0.9% in plastic container; Flucytosine & Nyotran(Liposomal Nystatin); XMP.284 & Fluconazole; XMP.366 & Fluconazole; XMP.391 & Fluconazole; Diflucan, Trican, Alfumet, Fluconazole; Fluconazole & MC-510,011; Fluconazole (JAN/USAN/INN); Fluconazole [USAN:INN:BAN:JAN]; 2,4-Difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol; 2,4-difluoro-,1-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol; 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL; 2-(2,4-Difluoro-phenyl)-1,3-bis-[1,2,4]triazol-1-yl-propan-2-ol; 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)-2-propanol; 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol; 2-(2,4-Difluorophenyl)-1,3-di-1H-1,2,4-triazol-1-ylpropan-2-ol; 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
Indication
Disease Entry ICD 11 Status REF
Cryptococcal meningitis Approved [1]
Fungal infection 1F29-1F2F Approved [2]
Invasive candidiasis 1F23 Approved [1]
Mycoses 1F2Z Approved [1]
Oral candidiasis 1F23.0 Approved [1]
Autoimmune polyendocrine syndrome type 1 Investigative [1]
Candidemia 1F23.3Y Investigative [1]
Esophageal candidiasis Investigative [1]
Therapeutic Class
Antifungal Agents
Cross-matching ID
PubChem CID
3365
ChEBI ID
CHEBI:46081
CAS Number
CAS 86386-73-4
TTD Drug ID
DMOWZ6B
VARIDT Drug ID
DR00578
INTEDE Drug ID
DR0704
ACDINA Drug ID
D00280

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Candida Cytochrome P450 51 (Candi ERG11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [3]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [3]
Posaconazole DMUL5EW Aspergillosis 1F20 Approved [12]
Ketoconazole DMPZI3Q Blastomycosis 1F22 Approved [13]
Miconazole DMPMYE8 Cutaneous candidiasis 1F23.14 Approved [3]
Oxiconazole DME7KRM Tinea corporis 1F28.Y Approved [14]
Terconazole DMJ13KI Candidiasis 1F23 Approved [15]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [16]
Tioconazole DMNYPGS Onychomycosis EE12.1 Approved [17]
Econazole DMFSWGH Cutaneous candidiasis 1F23.14 Approved [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [19]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [21]
Verapamil DMA7PEW Angina pectoris BA40 Approved [23]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [24]
Estrone DM5T6US Acne vulgaris ED80 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [28]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [29]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [8]
Capsaicin DMGMF6V Back pain ME84.Z Approved [30]
Zafirlukast DMHNQOG Asthma CA23 Approved [31]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [29]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [32]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [34]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [35]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [8]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [29]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [36]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [37]
Capsaicin DMGMF6V Back pain ME84.Z Approved [38]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [40]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [44]
Testosterone DM7HUNW Hot flushes GA30 Approved [44]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [45]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [46]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [46]
ABIRATERONE DM8V75C Prostate cancer 2C82.0 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [48]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [50]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [41]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Fluoxetine DM3PD2C Bipolar depression Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Ethanol DMDRQZU Chronic pain MG30 Approved [61]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [62]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lanosterol 14-alpha demethylase (CYP51A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [65]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [70]
Leflunomide DMR8ONJ Arthritis FA20 Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [72]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [73]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [74]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [75]
Cepharanthine DM9Y5JB N. A. N. A. Approved [76]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [77]
Clozapine DMFC71L Schizophrenia 6A20 Approved [78]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [79]
Trifluoperazine DMKBYWI Anxiety Approved [80]
Olanzapine DMPFN6Y Bipolar depression Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [81]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [8]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [82]
Capsaicin DMGMF6V Back pain ME84.Z Approved [30]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [29]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [83]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [29]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [81]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Candida Cytochrome P450 51 (Candi ERG11) TTTSOUD CP51_CANAL Modulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C9 (CYP2C9) Main DME DE5IED8 CP2C9_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Gene/Protein Processing [5]
ATP-dependent bile acid permease OTPQCBKA YBT1_YEAST Drug Response [6]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Drug Response [6]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Regulation of Drug Effects [7]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Gene/Protein Processing [8]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [9]
Lanosterol 14-alpha demethylase (CYP51A1) OTAYHG9C CP51A_HUMAN Drug Response [10]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Gene/Protein Processing [5]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Gene/Protein Processing [11]

References

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57 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
58 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
59 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
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62 Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure. Toxicol Lett. 2019 Mar 1;302:7-17.
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67 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
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69 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
70 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
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