Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS60RB)

• Drug Name: Levofloxacin Drug Info
• Synonyms: Aeroquin; Cravit; Elequine; Floxacin; Floxel; Iquix; LFX; LVX; Leroxacin; Lesacin; Levaquin; Levofloxacine; Levofloxacino; Levofloxacinum; Levokacin; Levox; Levoxacin; Mosardal; Nofaxin; Oftaquix; Quixin; Reskuin; Tavanic; Volequin; Cravit Ophthalmic; DR 3354; DR3355; HR 355; Cravit (TN); D-Levofloxacin; DR-3355; HR-355; Iquix (TN); L-Ofloxacin; LEVAQUIN IN DEXTROSE 5% IN PLASTIC CONTAINER; Levaquin (TN); Levofloxacin (INN); Levofloxacin tablet, suspension or intravenous; Levofloxacine [INN-French]; Levofloxacino [INN-Spanish]; Levofloxacinum [INN-Latin]; MP-376; Oftaquix (TN); Quixin (TN); R-Ofloxacin; RWJ 25213-097; RWJ-25213; Tavanic (TN); Levofloxacin [USAN:INN:JAN]; DR-3355: L-isomer of ofloxacin; Ofloxacin S-(-)-form; S-(-)-Ofloxacin; (-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hemihydrate; (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7Hpyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hemihydrate; (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; (R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (R)-isomer; (S)-(-)-Ofloxacin; (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (S)-Ofloxacin

Indication

Disease Entry	ICD 11	Status	REF
Acute maxillary sinusitis		Approved	[1]
Anthrax	1B97	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Latent tuberculosis infection		Approved	[1]
Mycoplasma pneumoniae pneumonia		Approved	[1]
Pyelonephritis		Approved	[1]
Staphylococcal pneumonia		Approved	[1]
Staphylococcus aureus infection		Approved	[1]
Streptococcal pneumonia		Approved	[1]
Pneumonia caused by chlamydia		Investigative	[1]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 149096
  ChEBI ID: CHEBI:63598
  CAS Number: CAS 100986-85-4
  TTD Drug ID: DMS60RB
  VARIDT Drug ID: DR00046
  INTEDE Drug ID: DR2456
  ACDINA Drug ID: D00361

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial DNA gyrase (Bact gyrase)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Grepafloxacin	DMGLX0T	Chronic bronchitis	CA20.1	Approved	[10]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[3]
Gatifloxacin	DMSL679	Acute gonococcal cervicitis		Approved	[3]
Norfloxacin	DMIZ6W2	Acute gonococcal cervicitis		Approved	[3]
Ozenoxacin	DM6KZMG	Impetigo	1B72	Approved	[11]
Sparfloxacin	DMB4HCT	Bacterial infection	1A00-1C4Z	Approved	[3]
Gemifloxacin	DMHT34O	Bacterial infection	1A00-1C4Z	Approved	[3]
Besifloxacin	DMPHXMI	Ocular inflammation	9C61.24	Approved	[12]
Finafloxacin	DMZEONG	Urinary tract infection	GC08	Approved	[13]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[3]

Drug(s) Targeting Staphylococcus Topoisomerase IV (Stap-coc parC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[3]
Gatifloxacin	DMSL679	Acute gonococcal cervicitis		Approved	[3]
Ozenoxacin	DM6KZMG	Impetigo	1B72	Approved	[11]
Sparfloxacin	DMB4HCT	Bacterial infection	1A00-1C4Z	Approved	[3]
Gemifloxacin	DMHT34O	Bacterial infection	1A00-1C4Z	Approved	[3]
Besifloxacin	DMPHXMI	Ocular inflammation	9C61.24	Approved	[12]
Finafloxacin	DMZEONG	Urinary tract infection	GC08	Approved	[13]
Delafloxacin Meglumine	DMVTU5Q	Acute bacterial skin infection	1C41	Approved	[14]
Moxifloxacin	DMU8V4S	Bacterial infection	1A00-1C4Z	Approved	[3]
Zabofloxacin	DMEY1F3	Pneumonia	CA40	Phase 3	[15]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[5]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[18]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[5]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[5]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[19]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[5]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[21]

Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[23]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[25]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[26]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[27]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[28]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[29]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[30]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[31]

Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[6]
Aztreonam	DMDNJHG	Bacterial infection	1A00-1C4Z	Approved	[6]
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[6]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[6]
Cotrimoxazole	DMSW5QP	N. A.	N. A.	Phase 4	[6]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[36]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[37]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[7]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[7]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[7]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[7]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[46]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[47]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[48]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[49]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[50]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[53]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[7]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[7]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[7]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[55]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[57]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[58]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[59]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[61]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[62]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[63]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]

Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[7]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[7]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[7]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]

Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[7]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[7]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[7]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[7]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[7]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[7]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[79]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[9]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[82]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[83]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[87]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial DNA gyrase (Bact gyrase)	TTN6J5F	GYRA_STAAU; GYRB_STAAU	Modulator	[3]
Staphylococcus Topoisomerase IV (Stap-coc parC)	TTIXTO3	PARC_STAAS	Modulator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 1A2 (SLCO1A2)	DTE2B1D	SO1A2_HUMAN	Substrate	[4]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-lactamase (blaB) Main DME	DEP0IWS	A0A378EHS6_KLEPR	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Gene/Protein Processing	[7]
Bone morphogenetic protein 6 (BMP6)	OT9WN536	BMP6_HUMAN	Gene/Protein Processing	[7]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Gene/Protein Processing	[7]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Gene/Protein Processing	[8]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Gene/Protein Processing	[7]
Interleukin-24 (IL24)	OT4VUWH1	IL24_HUMAN	Gene/Protein Processing	[7]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[7]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Gene/Protein Processing	[9]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Gene/Protein Processing	[7]
PTB-containing, cubilin and LRP1-interacting protein (PID1)	OT5YJ7FI	PCLI1_HUMAN	Gene/Protein Processing	[7]

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