Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUK75B)

Drug Name
Urea Drug Info
Synonyms
carbamide; 57-13-6; Isourea; Carbonyldiamide; Ureophil; Carbonyldiamine; Carbamimidic acid; Pseudourea; Ureaphil; Urevert; Carbaderm; Alphadrate; Keratinamin; Calmurid; Aquadrate; Carbonyl diamide; Pastaron; Urepearl; Carbamide resin; Ultra Mide; Varioform ii; Aqua Care; Prespersion, 75 urea; carmol; basodexan; Harnstoff; Nutraplus; Mocovina; Urea solution; Supercel 3000; Aqua Care HP; Ureacin-20; Ureacin-40 Creme; Ureacin-10 lotion; Polyurea; Panafil; Onychomal; Hyanit; Caswell No. 902; Carbonyl Diamine; Mocovina [Czech]; Harnstoff [Ge
Indication
Disease Entry ICD 11 Status REF
Dermatological disease DA24.Y Approved [1]
Exanthem Approved [2]
Impacted cerumen AA42 Approved [2]
Pityriasis simplex Approved [2]
Skin disease EA00-EM0Z Approved [2]
Tinea versicolor 1F2D.0 Approved [2]
Cross-matching ID
PubChem CID
1176
ChEBI ID
CHEBI:16199
CAS Number
CAS 57-13-6
TTD Drug ID
DMUK75B
VARIDT Drug ID
DR00048

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [13]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [14]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [15]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [16]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [17]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [18]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [19]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [20]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [21]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [22]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [12]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [24]
Diazepam DM08E9O Alcohol withdrawal Approved [25]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [26]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [27]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [28]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
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Drug(s) Affected By Alpha-fetoprotein (AFP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [32]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [39]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [40]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [42]
Verapamil DMA7PEW Angina pectoris BA40 Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Selenium DM25CGV N. A. N. A. Approved [46]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [47]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
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Drug(s) Affected By Fibroblast growth factor receptor 1 (FGFR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [53]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [54]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [54]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
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Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [59]
Haloperidol DM96SE0 Delirium Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Clozapine DMFC71L Schizophrenia 6A20 Approved [60]
Menthol DMG2KW7 Back pain ME84.Z Approved [62]
Orlistat DMRJSP8 Obesity 5B81 Approved [63]
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Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [71]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [72]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
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Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [65]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [76]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [77]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
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Drug(s) Affected By Aquaporin-10 (AQP10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Folic Acid DMEMBJC Colorectal carcinoma Approved [83]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [84]
Arsenic DMTL2Y1 N. A. N. A. Approved [82]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [85]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [86]
1,6-hexamethylene diisocyanate DMLB3RT Discovery agent N.A. Investigative [87]
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Drug(s) Affected By Arginase-2, mitochondrial (ARG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Selenium DM25CGV N. A. N. A. Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [52]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [92]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [93]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [94]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Selenium DM25CGV N. A. N. A. Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [96]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [97]
Epinephrine DM3KJBC Acute asthma CA23 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [100]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
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Drug(s) Affected By Aquaporin-9 (AQP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [105]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [103]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [106]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [107]
Arsenic DMTL2Y1 N. A. N. A. Approved [108]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [109]
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Drug(s) Affected By Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [55]
Paricalcitol DMYBV3G Hyperparathyroidism 5A51 Approved [12]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [110]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [111]
Arsenic DMTL2Y1 N. A. N. A. Approved [112]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [113]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [114]
Acetazolamide DM1AF5U Absence epilepsy Approved [12]
Ethanol DMDRQZU Chronic pain MG30 Approved [12]
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Drug(s) Affected By Hemoglobin subunit alpha (HBA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [116]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [117]
Folic Acid DMEMBJC Colorectal carcinoma Approved [83]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [118]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [119]
Orlistat DMRJSP8 Obesity 5B81 Approved [120]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [121]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [122]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [4]
Alpha-fetoprotein (AFP) OT9GG3ZI FETA_HUMAN Gene/Protein Processing [5]
Aquaporin-10 (AQP10) OT8Q5UWS AQP10_HUMAN Regulation of Drug Effects [6]
Aquaporin-9 (AQP9) OTLGH5ZY AQP9_HUMAN Regulation of Drug Effects [7]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Biotransformations [8]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Gene/Protein Processing [9]
Fibroblast growth factor receptor 1 (FGFR1) OT4GLCXW FGFR1_HUMAN Gene/Protein Processing [10]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [11]
Hemoglobin subunit alpha (HBA1) OTW2BQF4 HBA_HUMAN Drug Response [12]
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) OTQF5ZAK PTH1R_HUMAN Drug Response [12]

References

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2 Urea FDA Label
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4 Urea-induced denaturation of human serum albumin labeled with acrylodan. J Protein Chem. 2002 Feb;21(2):75-9. doi: 10.1023/a:1014508610017.
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11 Urea and hypertonicity increase expression of heme oxygenase-1 in murine renal medullary cells. Am J Physiol Renal Physiol. 2001 Nov;281(5):F983-91. doi: 10.1152/ajprenal.0358.2000.
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13 Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther. 2006 Aug;318(2):521-9.
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27 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
28 Use of peak decay analysis and affinity microcolumns containing silica monoliths for rapid determination of drug-protein dissociation rates. J Chromatogr A. 2011 Apr 15;1218(15):2072-8. doi: 10.1016/j.chroma.2010.09.070. Epub 2010 Oct 16.
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32 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
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34 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
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38 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
39 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
40 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
41 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
42 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
43 Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
44 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
45 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
46 High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage. Clin Chim Acta. 2010 Sep 6;411(17-18):1312-8.
47 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
48 Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogen-activated protein kinases. Oncol Rep. 2008 Aug;20(2):379-84.
49 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
50 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
51 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
52 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
53 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
54 Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
55 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
56 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
57 SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. Blood. 2003 Aug 1;102(3):795-801. doi: 10.1182/blood-2002-10-3023. Epub 2003 Mar 20.
58 Low dosage of arsenic trioxide (As(2)O(3)) inhibits angiogenesis in epithelial ovarian cancer without cell apoptosis. J Biol Inorg Chem. 2018 Aug;23(6):939-947. doi: 10.1007/s00775-018-1595-z. Epub 2018 Jul 16.
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