Details of the Drug Combination

General Information of Drug Combination (ID: DCECZA8)

• Drug Combination Name: Fluorouracil + Erlotinib
• Indication: Adenocarcinoma; Status: Investigative [1]
• Component Drugs:
  Fluorouracil (DMUM7HZ): Small molecular drug
  Erlotinib (DMCMBHA): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: HT29
  Zero Interaction Potency (ZIP) Score: 9.63
  Bliss Independence Score: 10.89
  Loewe Additivity Score: 10.59
  LHighest Single Agent (HSA) Score: 15.58

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Fluorouracil

Disease Entry	ICD 11	Status	REF
Adenocarcinoma	2D40	Approved	[2]
Biliary tract cancer	2C17	Approved	[2]
Colon adenocarcinoma	N.A.	Approved	[2]
Esophageal squamous cell carcinoma	2E60.1	Approved	[2]
Gastric intestinal type adenocarcinoma	N.A.	Approved	[2]
Gastroesophageal junction adenocarcinoma	2B71	Approved	[2]
Metastasis from malignant tumor of colon	N.A.	Approved	[2]
Pancreatic adenocarcinoma	N.A.	Approved	[2]
Rectal adenocarcinoma	2B92	Approved	[2]
Rectum mucinous adenocarcinoma	N.A.	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Colon cancer	2B90.Z	Investigative	[2]
Colon mucinous adenocarcinoma	N.A.	Investigative	[2]
Colorectal cancer	2B91.Z	Investigative	[4]
Gastric cancer	2B72	Investigative	[2]
Tumour	2A00-2F9Z	Investigative	[5]

Fluorouracil Interacts with 4 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
TERT messenger RNA (TERT mRNA)	TTQY2EJ	TERT_HUMAN	.	[5]
Candida Thymidylate synthase (Candi TMP1)	TTU6BFZ	TYSY_CANAL	Inhibitor	[40]
Dihydrothymine dehydrogenase (DPYD)	TTZPS91	DPYD_HUMAN	Inhibitor	[41]
Thymidylate synthase messenger RNA (TYMS mRNA)	TTP1UKZ	TYSY_HUMAN	.	[5]

Fluorouracil Interacts with 8 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[42]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[43]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[44]
Organic anion transporter 2 (SLC22A7)	DT0OC1Q	S22A7_HUMAN	Substrate	[45]
Multidrug resistance-associated protein 3 (ABCC3)	DTQ3ZHF	MRP3_HUMAN	Substrate	[46]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[46]
Multidrug resistance-associated protein 5 (ABCC5)	DTYVM24	MRP5_HUMAN	Substrate	[46]
Equilibrative nucleoside transporter 1 (SLC29A1)	DTXD1TQ	S29A1_HUMAN	Substrate	[47]

Fluorouracil Interacts with 12 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[48]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Metabolism	[48]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[48]
Dihydrothymine dehydrogenase (DPYD)	DESOEW1	DPYD_HUMAN	Metabolism	[49]
Methylenetetrahydrofolate reductase (MTHFR)	DEOXTPZ	MTHR_HUMAN	Metabolism	[50]
Thymidine phosphorylase (TYMP)	DE4HCYL	TYPH_HUMAN	Metabolism	[50]
Amidophosphoribosyltransferase (GPAT)	DEMJ7R2	PUR1_HUMAN	Metabolism	[51]
Thymidylate synthase (TYMS)	DEASG0Q	TYSY_HUMAN	Metabolism	[50]
Uridine 5'-monophosphate synthase (UMPS)	DEWJYTE	UMPS_HUMAN	Metabolism	[52]
Uridine phosphorylase 1 (UPP1)	DEFZWAX	UPP1_HUMAN	Metabolism	[53]
Uridine phosphorylase 2 (UPP2)	DEBQ2WU	UPP2_HUMAN	Metabolism	[53]
Uracil phosphoribosyltransferase (UPRT)	DE20ETR	UPP_HUMAN	Metabolism	[54]

Fluorouracil Interacts with 1026 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Increases Chemical Synthesis	[55]
Methylenetetrahydrofolate reductase (MTHFR)	OTUBJSR7	MTHR_HUMAN	Increases Response To Substance	[56]
Dihydropyrimidine dehydrogenase (DPYD)	OTWRF2NR	DPYD_HUMAN	Increases Response To Substance	[57]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Expression	[58]
Equilibrative nucleoside transporter 1 (SLC29A1)	OTLOOZZS	S29A1_HUMAN	Increases Expression	[59]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Affects Response To Substance	[35]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Decreases Response To Substance	[46]
Solute carrier family 22 member 7 (SLC22A7)	OTKTNH1W	S22A7_HUMAN	Increases Transport	[45]
Glutathione S-transferase P (GSTP1)	OTLP0A0Y	GSTP1_HUMAN	Increases Expression	[12]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Increases Expression	[60]
Fanconi anemia group G protein (FANCG)	OT7MC8TZ	FANCG_HUMAN	Increases Expression	[9]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)	OTJKOMXE	BNI3L_HUMAN	Decreases Expression	[9]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Increases Expression	[9]
Annexin A4 (ANXA4)	OTUCRYXL	ANXA4_HUMAN	Decreases Expression	[9]
Thymidylate kinase (DTYMK)	OTJXYQYK	KTHY_HUMAN	Increases Expression	[9]
Flap endonuclease 1 (FEN1)	OT6QGG7O	FEN1_HUMAN	Increases Expression	[9]
Interleukin-1 receptor-associated kinase 1 (IRAK1)	OT133G8J	IRAK1_HUMAN	Increases Expression	[9]
UV excision repair protein RAD23 homolog B (RAD23B)	OT0PGOG3	RD23B_HUMAN	Increases Expression	[9]
Programmed cell death protein 4 (PDCD4)	OTZ6NXUX	PDCD4_HUMAN	Decreases Expression	[9]
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)	OTM3H5OA	MALT1_HUMAN	Increases Expression	[9]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Increases Expression	[61]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Increases Expression	[61]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[61]
Enoyl-CoA hydratase, mitochondrial (ECHS1)	OTS0593S	ECHM_HUMAN	Increases Expression	[61]
Spermine synthase (SMS)	OT8JYKNH	SPSY_HUMAN	Increases Expression	[61]
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Increases Expression	[61]
Thymosin beta-4 (TMSB4X)	OT9HPLP3	TYB4_HUMAN	Increases Expression	[61]
Large ribosomal subunit protein uL14 (RPL23)	OTXI1YLM	RL23_HUMAN	Increases Expression	[61]
Small ribosomal subunit protein eS28 (RPS28)	OT12IES1	RS28_HUMAN	Increases Expression	[61]
Thymosin beta-10 (TMSB10)	OTLVZ13T	TYB10_HUMAN	Increases Expression	[61]
FXYD domain-containing ion transport regulator 3 (FXYD3)	OT9PPRHE	FXYD3_HUMAN	Increases Expression	[61]
Cocaine esterase (CES2)	OTC647SQ	EST2_HUMAN	Increases Expression	[12]
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Decreases Expression	[12]
Regulator of G-protein signaling 16 (RGS16)	OTBKZASI	RGS16_HUMAN	Affects Expression	[12]
Securin (PTTG1)	OTIMYS4W	PTTG1_HUMAN	Decreases Expression	[12]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[12]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Increases Expression	[12]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[12]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[12]
Elastin (ELN)	OTFSO7PG	ELN_HUMAN	Affects Expression	[12]
Integrin beta-4 (ITGB4)	OT28UK84	ITB4_HUMAN	Decreases Expression	[12]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[12]
NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR)	OTPDCK1F	ADRO_HUMAN	Increases Expression	[12]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)	OTGP6GA4	NR4A1_HUMAN	Affects Expression	[12]
Corticotropin-releasing factor-binding protein (CRHBP)	OT9AB48G	CRHBP_HUMAN	Affects Expression	[12]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[12]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Affects Expression	[12]
DNA replication licensing factor MCM4 (MCM4)	OT19PNNG	MCM4_HUMAN	Affects Expression	[12]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Decreases Expression	[12]
Chitinase-3-like protein 1 (CHI3L1)	OT2Z7VJH	CH3L1_HUMAN	Increases Expression	[12]
L-dopachrome tautomerase (DCT)	OTYVNTBG	TYRP2_HUMAN	Affects Expression	[12]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[12]
Serine/threonine-protein kinase PLK1 (PLK1)	OTRZX45T	PLK1_HUMAN	Decreases Expression	[12]
GTP-binding protein GEM (GEM)	OT6SK8ZV	GEM_HUMAN	Affects Expression	[12]
DNA-binding protein inhibitor ID-3 (ID3)	OTUULW5Z	ID3_HUMAN	Increases Expression	[12]
Regulator of G-protein signaling 1 (RGS1)	OTGXJYMG	RGS1_HUMAN	Affects Expression	[12]
Dihydropyrimidinase-related protein 3 (DPYSL3)	OTINJV20	DPYL3_HUMAN	Affects Expression	[12]
Elongin-A (ELOA)	OTOQTF5K	ELOA1_HUMAN	Affects Expression	[12]
Squalene monooxygenase (SQLE)	OT0GGRDO	ERG1_HUMAN	Decreases Expression	[12]
Cyclin-dependent kinase 5 activator 1 (CDK5R1)	OTJELWK0	CD5R1_HUMAN	Affects Expression	[12]
Quinone oxidoreductase PIG3 (TP53I3)	OTSCM68G	QORX_HUMAN	Increases Expression	[12]
Probable carboxypeptidase X1 (CPXM1)	OTRCSQPG	CPXM1_HUMAN	Affects Expression	[12]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Decreases Expression	[12]
Epiphycan (EPYC)	OTTRI5WO	EPYC_HUMAN	Affects Expression	[12]
Collagen alpha-1(XII) chain (COL12A1)	OTHLTV53	COCA1_HUMAN	Decreases Expression	[12]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[12]
Spondin-1 (SPON1)	OTC06MY4	SPON1_HUMAN	Affects Expression	[12]
Ras-related protein Rab-21 (RAB21)	OTH3WGLG	RAB21_HUMAN	Affects Expression	[12]
Homeobox protein Hox-C11 (HOXC11)	OT8NMHM6	HXC11_HUMAN	Affects Expression	[13]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[13]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Increases Expression	[13]
Ribonucleoside-diphosphate reductase large subunit (RRM1)	OTXGQOR9	RIR1_HUMAN	Increases Expression	[13]
Serine/arginine-rich splicing factor 11 (SRSF11)	OTZSV6CZ	SRS11_HUMAN	Increases Expression	[13]
Unconventional myosin-Ie (MYO1E)	OTM9YSIZ	MYO1E_HUMAN	Increases Expression	[13]
Cleavage stimulation factor subunit 3 (CSTF3)	OT1Y7B5U	CSTF3_HUMAN	Increases Expression	[13]
Centromere protein Q (CENPQ)	OT3M6WAI	CENPQ_HUMAN	Increases Expression	[13]
Arginine/serine-rich coiled-coil protein 2 (RSRC2)	OTLE0KQM	RSRC2_HUMAN	Increases Expression	[13]
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1)	OTM3KHIE	ARFG1_HUMAN	Increases Expression	[13]
DNA damage-binding protein 2 (DDB2)	OTO8HVVB	DDB2_HUMAN	Increases Expression	[13]
Spermatogenesis-associated protein 25 (SPATA25)	OTJMFF0A	SPT25_HUMAN	Increases Expression	[13]
G-protein coupled receptor 35 (GPR35)	OTO23NRK	GPR35_HUMAN	Increases Expression	[13]
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B)	OTB41D5K	RPR1B_HUMAN	Increases Expression	[13]
Transcription factor 19 (TCF19)	OT7NKLF9	TCF19_HUMAN	Increases Expression	[13]
Mitogen-activated protein kinase 13 (MAPK13)	OT0W9GE7	MK13_HUMAN	Increases Expression	[14]
Eukaryotic translation initiation factor 3 subunit H (EIF3H)	OT61RBF5	EIF3H_HUMAN	Increases Expression	[14]
Mitotic checkpoint protein BUB3 (BUB3)	OTU91HAU	BUB3_HUMAN	Decreases Expression	[14]
Cytohesin-3 (CYTH3)	OTBXAT3Z	CYH3_HUMAN	Decreases Expression	[14]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10)	OTBURQ3A	NDUAA_HUMAN	Increases Expression	[14]
GTPase KRas (KRAS)	OT78QCN8	RASK_HUMAN	Decreases Expression	[14]
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)	OT47AK4C	HNRPC_HUMAN	Increases Expression	[14]
Histone H1.3 (H1-3)	OTT7VPRB	H13_HUMAN	Increases Expression	[14]
Cation-dependent mannose-6-phosphate receptor (M6PR)	OTFEWOSB	MPRD_HUMAN	Increases Expression	[14]
Long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADL)	OTP7Y0UF	ACADL_HUMAN	Increases Expression	[14]
Endoplasmic reticulum resident protein 29 (ERP29)	OTNKANMH	ERP29_HUMAN	Decreases Expression	[14]
Glutathione S-transferase theta-1 (GSTT1)	OTRFMWBK	GSTT1_HUMAN	Increases Expression	[14]
Large ribosomal subunit protein uL3 (RPL3)	OTX6VXLB	RL3_HUMAN	Decreases Expression	[14]
Aminomethyltransferase, mitochondrial (AMT)	OTQYEWZQ	GCST_HUMAN	Increases Expression	[14]
Translation initiation factor eIF2B subunit beta (EIF2B2)	OTQQMHM1	EI2BB_HUMAN	Decreases Expression	[14]
Adenosine 5'-monophosphoramidase HINT1 (HINT1)	OTQIR8LF	HINT1_HUMAN	Increases Expression	[14]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1)	OT62RL5P	BDH_HUMAN	Decreases Expression	[14]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA)	OT58PUEN	PP2BA_HUMAN	Increases Expression	[14]
Src substrate cortactin (CTTN)	OTJRG4ES	SRC8_HUMAN	Decreases Expression	[14]
Prostaglandin reductase 1 (PTGR1)	OTMAR351	PTGR1_HUMAN	Increases Expression	[14]
Eukaryotic translation initiation factor 4H (EIF4H)	OTGZI072	IF4H_HUMAN	Increases Expression	[14]
Telomeric repeat-binding factor 2 (TERF2)	OTBSAS0V	TERF2_HUMAN	Increases Expression	[14]
snRNA-activating protein complex subunit 1 (SNAPC1)	OTAPN1NI	SNPC1_HUMAN	Decreases Expression	[14]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)	OTL4VJC5	NUCKS_HUMAN	Decreases Expression	[14]
Lipid transferase CIDEB (CIDEB)	OT873IYM	CIDEB_HUMAN	Increases Expression	[14]
Homeobox protein BarH-like 2 (BARX2)	OT0R3QD3	BARX2_HUMAN	Increases Expression	[14]
Protocadherin alpha-5 (PCDHA5)	OTHZT1GR	PCDA5_HUMAN	Decreases Expression	[14]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Decreases Expression	[62]
Solute carrier family 15 member 1 (SLC15A1)	OT1P16B5	S15A1_HUMAN	Decreases Expression	[62]
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1)	OTBV52DR	SMHD1_HUMAN	Increases Expression	[15]
Ankyrin repeat domain-containing protein 36A (ANKRD36)	OT3XEYKG	AN36A_HUMAN	Increases Expression	[15]
Pyridoxal kinase (PDXK)	OT40AJ5J	PDXK_HUMAN	Decreases Expression	[15]
Inositol monophosphatase 2 (IMPA2)	OTNFB9YN	IMPA2_HUMAN	Increases Expression	[15]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Decreases Expression	[15]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4)	OT3LOE2J	MAST4_HUMAN	Increases Expression	[15]
Monocarboxylate transporter 7 (SLC16A6)	OT7BIIZX	MOT7_HUMAN	Increases Expression	[15]
Nucleoplasmin-3 (NPM3)	OTIAM1A3	NPM3_HUMAN	Decreases Expression	[15]
Ubiquitin-like protein ATG12 (ATG12)	OTJRO09Y	ATG12_HUMAN	Decreases Expression	[15]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Decreases Expression	[15]
Microtubule-associated protein 2 (MAP2)	OT6UYT3X	MTAP2_HUMAN	Increases Expression	[15]
Ribose-phosphate pyrophosphokinase 2 (PRPS2)	OTCY1B1O	PRPS2_HUMAN	Decreases Expression	[15]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[15]
Folate receptor alpha (FOLR1)	OT0QZ0H6	FOLR1_HUMAN	Decreases Expression	[15]
Calretinin (CALB2)	OTSNMCG9	CALB2_HUMAN	Increases Expression	[15]
Signal transducer CD24 (CD24)	OT7CODJ4	CD24_HUMAN	Increases Expression	[15]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Decreases Expression	[15]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1)	OT6LIGJP	MA1A1_HUMAN	Increases Expression	[15]
Proteasome subunit beta type-10 (PSMB10)	OTURUR9B	PSB10_HUMAN	Decreases Expression	[15]
Regulator of G-protein signaling 2 (RGS2)	OT0FSRW7	RGS2_HUMAN	Decreases Expression	[15]
Nuclear receptor-interacting protein 1 (NRIP1)	OTIZOJQV	NRIP1_HUMAN	Decreases Expression	[15]
CCN family member 3 (CCN3)	OTOW5YL4	CCN3_HUMAN	Increases Expression	[15]
Caveolin-2 (CAV2)	OT1FGRQX	CAV2_HUMAN	Decreases Expression	[15]
ADP-ribosylation factor-like protein 4C (ARL4C)	OTQ3QNNU	ARL4C_HUMAN	Increases Expression	[15]
Transmembrane protein 33 (TMEM33)	OTRG1DOY	TMM33_HUMAN	Decreases Expression	[15]
Epiplakin (EPPK1)	OT7BAU8C	EPIPL_HUMAN	Increases Expression	[15]
Triosephosphate isomerase (TPI1)	OT14KP4B	TPIS_HUMAN	Decreases Expression	[15]
Protein jagged-1 (JAG1)	OT3LGT6K	JAG1_HUMAN	Increases Expression	[15]
High mobility group nucleosome-binding domain-containing protein 5 (HMGN5)	OTUUAHVQ	HMGN5_HUMAN	Increases Expression	[15]
Small EDRK-rich factor 2 (SERF2)	OTZQDYCZ	SERF2_HUMAN	Decreases Expression	[15]
Transcription factor SOX-4 (SOX4)	OTSS40SS	SOX4_HUMAN	Increases Expression	[15]
Proline-rich nuclear receptor coactivator 1 (PNRC1)	OTQMLEE1	PNRC1_HUMAN	Increases Expression	[15]
S-methyl-5'-thioadenosine phosphorylase (MTAP)	OTOWN2K9	MTAP_HUMAN	Decreases Expression	[15]
Spliceosome RNA helicase DDX39B (DDX39B)	OTEVCFVU	DX39B_HUMAN	Increases Expression	[15]
Beta-1-syntrophin (SNTB1)	OTSRBECI	SNTB1_HUMAN	Increases Expression	[15]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Decreases Expression	[15]
Semaphorin-3A (SEMA3A)	OTQJSV7W	SEM3A_HUMAN	Increases Expression	[15]
Uncharacterized protein KIAA0040 (KIAA0040)	OT27EBY3	K0040_HUMAN	Increases Expression	[15]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[15]
Dual specificity protein phosphatase 6 (DUSP6)	OT4H6RKW	DUS6_HUMAN	Increases Expression	[15]
Pre-rRNA-processing protein TSR1 homolog (TSR1)	OTCVZFL9	TSR1_HUMAN	Decreases Expression	[15]
Fibronectin type III domain-containing protein 3B (FNDC3B)	OTBILGDR	FND3B_HUMAN	Decreases Expression	[15]
Nucleolar MIF4G domain-containing protein 1 (NOM1)	OTWZSJJC	NOM1_HUMAN	Decreases Expression	[15]
Protein FAM76B (FAM76B)	OT4RG5U7	FA76B_HUMAN	Decreases Expression	[15]
MAGUK p55 subfamily member 7 (MPP7)	OT3G3HTZ	MPP7_HUMAN	Decreases Expression	[15]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48)	OTSR6DEJ	SNR48_HUMAN	Decreases Expression	[15]
Parafibromin (CDC73)	OT6JASZ1	CDC73_HUMAN	Decreases Expression	[15]
Neuroblastoma breakpoint family member 10 (NBPF10)	OTGOCELY	NBPFA_HUMAN	Increases Expression	[15]
Kelch-like protein 24 (KLHL24)	OTWZSX5C	KLH24_HUMAN	Increases Expression	[15]
Ankyrin repeat domain-containing protein 11 (ANKRD11)	OTV0V70M	ANR11_HUMAN	Increases Expression	[15]
MAM domain-containing protein 2 (MAMDC2)	OT4GICNY	MAMC2_HUMAN	Increases Expression	[15]
Coiled-coil domain-containing protein 186 (CCDC186)	OTONSQAD	CC186_HUMAN	Increases Expression	[15]
Serologically defined colon cancer antigen 8 (SDCCAG8)	OTV2ZGV9	SDCG8_HUMAN	Increases Expression	[15]
Liprin-beta-1 (PPFIBP1)	OTRA2S7B	LIPB1_HUMAN	Increases Expression	[15]
Homeobox protein Mohawk (MKX)	OT7H7Z50	MKX_HUMAN	Decreases Expression	[15]
Mastermind-like protein 2 (MAML2)	OT1TSVAR	MAML2_HUMAN	Increases Expression	[15]
Delta and Notch-like epidermal growth factor-related receptor (DNER)	OT2GH2E5	DNER_HUMAN	Increases Expression	[15]
Ribosome biogenesis protein BRX1 homolog (BRIX1)	OTQ5F1D1	BRX1_HUMAN	Decreases Expression	[15]
Tribbles homolog 2 (TRIB2)	OTHSX3MX	TRIB2_HUMAN	Increases Expression	[15]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1)	OT2363Z9	T53I1_HUMAN	Increases Expression	[15]
Alkylated DNA repair protein alkB homolog 8 (ALKBH8)	OTXN70DV	ALKB8_HUMAN	Decreases Expression	[15]
EF-hand domain-containing protein D2 (EFHD2)	OTM9VMN3	EFHD2_HUMAN	Decreases Expression	[15]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1)	OTMJKJAK	NAF1_HUMAN	Decreases Expression	[15]
Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST2)	OT8A3H9Y	H6ST2_HUMAN	Decreases Expression	[15]
Transmembrane protein 74 (TMEM74)	OT3IZBM0	TMM74_HUMAN	Increases Expression	[15]
Small integral membrane protein 14 (SMIM14)	OT47IF19	SIM14_HUMAN	Increases Expression	[15]
Peptide deformylase, mitochondrial (PDF)	OTZ75ZK5	DEFM_HUMAN	Increases Expression	[15]
Synaptotagmin-like protein 2 (SYTL2)	OTUIOWKL	SYTL2_HUMAN	Increases Expression	[15]
Uncharacterized protein C14orf132 (C14ORF132)	OTBVC3AO	CN132_HUMAN	Increases Expression	[15]
Cell death regulator Aven (AVEN)	OTGIN5YK	AVEN_HUMAN	Decreases Expression	[15]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)	OTPL0AI1	ABC3C_HUMAN	Increases Expression	[15]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Increases Expression	[15]
Cysteine-rich motor neuron 1 protein (CRIM1)	OTTZNV6Y	CRIM1_HUMAN	Decreases Expression	[15]
Protein DBF4 homolog A (DBF4)	OTBL7JHQ	DBF4A_HUMAN	Decreases Expression	[15]
Pleckstrin homology domain-containing family B member 1 (PLEKHB1)	OTC7TNAX	PKHB1_HUMAN	Increases Expression	[15]
Switch-associated protein 70 (SWAP70)	OTPHT2QD	SWP70_HUMAN	Decreases Expression	[15]
Carboxypeptidase A4 (CPA4)	OT66MP0F	CBPA4_HUMAN	Decreases Expression	[15]
Endoribonuclease Dicer (DICER1)	OTTVSEY0	DICER_HUMAN	Decreases Expression	[15]
RRP15-like protein (RRP15)	OTE8CQ7K	RRP15_HUMAN	Decreases Expression	[15]
AP-4 complex subunit sigma-1 (AP4S1)	OTM3QBU8	AP4S1_HUMAN	Decreases Expression	[15]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Increases Expression	[16]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)	OTKOZRZP	PLOD2_HUMAN	Decreases Expression	[16]
Nuclear factor 1 B-type (NFIB)	OTX94PD0	NFIB_HUMAN	Decreases Expression	[16]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Increases Expression	[16]
Suppressor of cytokine signaling 1 (SOCS1)	OTWA9KFU	SOCS1_HUMAN	Increases Expression	[16]
Krueppel-like factor 4 (KLF4)	OT4O9RQW	KLF4_HUMAN	Increases Expression	[16]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Decreases Expression	[16]
Cell division control protein 45 homolog (CDC45)	OT6NNLOD	CDC45_HUMAN	Affects Expression	[16]
Transcription factor Maf (MAF)	OT1GR3IZ	MAF_HUMAN	Increases Expression	[16]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Decreases Expression	[16]
Fibrinogen silencer-binding protein (RAD54B)	OTMWB2P2	FSBP_HUMAN	Decreases Expression	[16]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[16]
GTPase HRas (HRAS)	OTWQN0DP	RASH_HUMAN	Increases Expression	[16]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Increases Expression	[16]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Affects Expression	[16]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[16]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Decreases Expression	[16]
Myb-related protein B (MYBL2)	OTZ3JX8Q	MYBB_HUMAN	Increases Expression	[16]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Increases Expression	[16]
Transcription factor JunB (JUNB)	OTG2JXV5	JUNB_HUMAN	Increases Expression	[16]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Increases Expression	[16]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[16]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Increases Expression	[16]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[16]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Increases Expression	[16]
Lysine-specific demethylase 5A (KDM5A)	OTLYFX8A	KDM5A_HUMAN	Decreases Expression	[16]
2'-5'-oligoadenylate synthase 2 (OAS2)	OT64CCTM	OAS2_HUMAN	Increases Expression	[16]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Decreases Expression	[16]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Expression	[16]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT)	OT0THBVA	DUT_HUMAN	Decreases Expression	[16]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Increases Expression	[16]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Increases Expression	[16]
Protein phosphatase inhibitor 2 (PPP1R2)	OTNLOUQR	IPP2_HUMAN	Decreases Expression	[16]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C)	OTCLOV90	CDN2C_HUMAN	Decreases Expression	[16]
DNA mismatch repair protein Msh2 (MSH2)	OT10H1AB	MSH2_HUMAN	Decreases Expression	[16]
Histone deacetylase 4 (HDAC4)	OTQNGD32	HDAC4_HUMAN	Decreases Expression	[16]
Protein S100-A10 (S100A10)	OTI71243	S10AA_HUMAN	Increases Expression	[16]
Large ribosomal subunit protein eL37 (RPL37)	OTB6SDZ1	RL37_HUMAN	Decreases Expression	[16]
Fanconi anemia group C protein (FANCC)	OTTIDM3P	FANCC_HUMAN	Decreases Expression	[16]
DNA-binding protein inhibitor ID-2 (ID2)	OT0U1D53	ID2_HUMAN	Increases Expression	[16]
Transforming growth factor beta receptor type 3 (TGFBR3)	OTQOOUC4	TGBR3_HUMAN	Increases Expression	[16]
Histone-binding protein RBBP4 (RBBP4)	OTG3BT3M	RBBP4_HUMAN	Decreases Expression	[16]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Increases Expression	[16]
Ribosomal protein eS27-like (RPS27L)	OTZWHU0N	RS27L_HUMAN	Increases Expression	[16]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)	OTE8GBUR	RIR2B_HUMAN	Increases Expression	[16]
Pantothenate kinase 1 (PANK1)	OT2CZVRT	PANK1_HUMAN	Increases Expression	[16]
Cullin-5 (CUL5)	OTMTZD47	CUL5_HUMAN	Increases Expression	[16]
RNA-binding protein 14 (RBM14)	OTO9GMBD	RBM14_HUMAN	Increases Expression	[16]
Endothelial PAS domain-containing protein 1 (EPAS1)	OTRE3O8U	EPAS1_HUMAN	Increases Expression	[16]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1)	OTYKB9G3	SIN1_HUMAN	Increases Expression	[16]
E3 ubiquitin-protein ligase SMURF1 (SMURF1)	OT5UIZR8	SMUF1_HUMAN	Increases Expression	[16]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Increases Expression	[16]
SERTA domain-containing protein 1 (SERTAD1)	OTBHKZQP	SRTD1_HUMAN	Increases Expression	[16]
Heat shock protein beta-8 (HSPB8)	OT0I83YS	HSPB8_HUMAN	Increases Expression	[16]
F-box only protein 5 (FBXO5)	OTTR957W	FBX5_HUMAN	Decreases Expression	[16]
Pleckstrin homology-like domain family A member 3 (PHLDA3)	OTXFUDO2	PHLA3_HUMAN	Increases Expression	[16]
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18)	OTCW8HT6	TNR18_HUMAN	Increases Expression	[16]
Regulator of G-protein signaling 13 (RGS13)	OTPAMQ18	RGS13_HUMAN	Decreases Expression	[17]
Pre-mRNA-processing factor 17 (CDC40)	OTOYUNHN	PRP17_HUMAN	Increases Expression	[17]
Synaptosomal-associated protein 29 (SNAP29)	OTT30ZON	SNP29_HUMAN	Increases Expression	[17]
Protein phosphatase 1 regulatory subunit 17 (PPP1R17)	OT19635T	PPR17_HUMAN	Increases Expression	[17]
RAC-beta serine/threonine-protein kinase (AKT2)	OTBB632K	AKT2_HUMAN	Increases Expression	[17]
Serpin B4 (SERPINB4)	OT88LHZ8	SPB4_HUMAN	Decreases Expression	[17]
Cullin-4B (CUL4B)	OT2QX4DO	CUL4B_HUMAN	Increases Expression	[17]
TRAF family member-associated NF-kappa-B activator (TANK)	OTZSGFIK	TANK_HUMAN	Increases Expression	[17]
Engulfment and cell motility protein 2 (ELMO2)	OTKDOC2M	ELMO2_HUMAN	Increases Expression	[17]
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2)	OT24ZO59	MD2L2_HUMAN	Decreases Expression	[17]
Peptidyl-prolyl cis-trans isomerase E (PPIE)	OTIE5OAD	PPIE_HUMAN	Increases Expression	[17]
Transmembrane gamma-carboxyglutamic acid protein 1 (PRRG1)	OTMH6OWG	TMG1_HUMAN	Decreases Expression	[18]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Increases Expression	[18]
Protein sprouty homolog 1 (SPRY1)	OT764FXI	SPY1_HUMAN	Increases Expression	[18]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)	OTRNDZXB	HNRPQ_HUMAN	Decreases Expression	[18]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[18]
Fibrinogen gamma chain (FGG)	OT5BJSEX	FIBG_HUMAN	Decreases Expression	[18]
Plasma serine protease inhibitor (SERPINA5)	OTTZXPGD	IPSP_HUMAN	Increases Expression	[18]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Increases Expression	[18]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)	OTXOQDSG	IFIT1_HUMAN	Increases Expression	[18]
Annexin A3 (ANXA3)	OTDD8OI7	ANXA3_HUMAN	Increases Expression	[18]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Decreases Expression	[18]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Increases Expression	[18]
Myristoylated alanine-rich C-kinase substrate (MARCKS)	OT7N056G	MARCS_HUMAN	Decreases Expression	[18]
Lysophosphatidic acid receptor 6 (LPAR6)	OT4BY3W4	LPAR6_HUMAN	Decreases Expression	[18]
Eukaryotic translation initiation factor 5 (EIF5)	OT79PQUN	IF5_HUMAN	Increases Expression	[18]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Decreases Expression	[18]
Ras-related protein Rab-11A (RAB11A)	OTC4FW0J	RB11A_HUMAN	Decreases Expression	[18]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[18]
Metallothionein-1X (MT1X)	OT9AKFVS	MT1X_HUMAN	Decreases Expression	[18]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[18]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Increases Expression	[18]
Four and a half LIM domains protein 3 (FHL3)	OTMPRLZ5	FHL3_HUMAN	Increases Expression	[18]
PCNA-associated factor (PCLAF)	OTMVIOUU	PAF15_HUMAN	Decreases Expression	[18]
Ankyrin repeat domain-containing protein 1 (ANKRD1)	OTHJ7JV9	ANKR1_HUMAN	Increases Expression	[18]
Adipogenesis regulatory factor (ADIRF)	OTTJP8D4	ADIRF_HUMAN	Increases Expression	[18]
Protein mono-ADP-ribosyltransferase PARP14 (PARP14)	OTFXJAKK	PAR14_HUMAN	Increases Expression	[18]
Centrosomal protein of 55 kDa (CEP55)	OTGSG2PA	CEP55_HUMAN	Decreases Expression	[18]
ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1)	OT416O2G	SUV3_HUMAN	Decreases Expression	[18]
Membrane progestin receptor beta (PAQR8)	OTGZ8W9F	PAQR8_HUMAN	Decreases Expression	[18]
Programmed cell death 6-interacting protein (PDCD6IP)	OTS8T6A7	PDC6I_HUMAN	Decreases Expression	[18]
BTB/POZ domain-containing protein KCTD12 (KCTD12)	OTPYKT4Z	KCD12_HUMAN	Decreases Expression	[18]
Cytoplasmic FMR1-interacting protein 2 (CYFIP2)	OTCAY35T	CYFP2_HUMAN	Increases Expression	[18]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Decreases Expression	[18]
Mini-chromosome maintenance complex-binding protein (MCMBP)	OTQ6WO7A	MCMBP_HUMAN	Increases Expression	[18]
Netrin-4 (NTN4)	OTDRRMP3	NET4_HUMAN	Increases Expression	[18]
Serine/threonine-protein kinase Nek6 (NEK6)	OT8PQSO1	NEK6_HUMAN	Decreases Expression	[18]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Decreases Expression	[19]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[19]
Protein phosphatase 1D (PPM1D)	OT8NLZ9D	PPM1D_HUMAN	Increases Expression	[19]
TP53-regulated inhibitor of apoptosis 1 (TRIAP1)	OTEAUJXN	TRIA1_HUMAN	Increases Expression	[19]
Glutathione peroxidase 1 (GPX1)	OTE2O72Q	GPX1_HUMAN	Increases Expression	[19]
Protein S100-A2 (S100A2)	OTTGHJ1H	S10A2_HUMAN	Increases Expression	[19]
Serpin B5 (SERPINB5)	OTSMXQRJ	SPB5_HUMAN	Increases Expression	[19]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Decreases Expression	[19]
Elongation factor 1-alpha 1 (EEF1A1)	OT00THXS	EF1A1_HUMAN	Increases Expression	[19]
Protein BTG2 (BTG2)	OTZF6K1H	BTG2_HUMAN	Increases Expression	[19]
Antigen peptide transporter 1 (TAP1)	OTJL27PW	TAP1_HUMAN	Increases Expression	[19]
Quinone oxidoreductase (CRYZ)	OTD2F4C8	QOR_HUMAN	Decreases Expression	[19]
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP)	OTVFQEPA	IKIP_HUMAN	Increases Expression	[19]
DNA damage-regulated autophagy modulator protein 1 (DRAM1)	OTIJTXEN	DRAM1_HUMAN	Increases Expression	[19]
Protein ECT2 (ECT2)	OTQDUCT6	ECT2_HUMAN	Decreases Expression	[19]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Decreases Expression	[19]
Serine/threonine-protein kinase PLK2 (PLK2)	OTKMJXJ8	PLK2_HUMAN	Increases Expression	[19]
Sestrin-1 (SESN1)	OTSFDZWL	SESN1_HUMAN	Increases Expression	[19]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Increases Phosphorylation	[63]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Increases Phosphorylation	[63]
Thymidine kinase 2, mitochondrial (TK2)	OTS1V4XB	KITM_HUMAN	Increases Expression	[20]
Adenylate cyclase type 9 (ADCY9)	OT1IZT5K	ADCY9_HUMAN	Decreases Expression	[20]
DNA polymerase alpha catalytic subunit (POLA1)	OT1WXFVY	DPOLA_HUMAN	Decreases Expression	[20]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)	OTPG0K7E	IMDH2_HUMAN	Increases Expression	[20]
CTP synthase 1 (CTPS1)	OTZ9J6ZG	PYRG1_HUMAN	Decreases Expression	[20]
Trifunctional purine biosynthetic protein adenosine-3 (GART)	OT01JWJB	PUR2_HUMAN	Increases Expression	[20]
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)	OTMZN747	PUR6_HUMAN	Increases Expression	[20]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)	OT6E2OW6	ENTP1_HUMAN	Decreases Expression	[20]
AMP deaminase 2 (AMPD2)	OTBS30JU	AMPD2_HUMAN	Decreases Expression	[20]
Guanylate cyclase soluble subunit beta-1 (GUCY1B1)	OTSHPHVB	GCYB1_HUMAN	Decreases Expression	[20]
5'(3')-deoxyribonucleotidase, mitochondrial (NT5M)	OTJF73BA	NT5M_HUMAN	Increases Expression	[20]
Protein shisa-9 (SHISA9)	OTZI2V0J	SHSA9_HUMAN	Increases Expression	[21]
Transmembrane protein 150C (TMEM150C)	OTUNPHV7	T150C_HUMAN	Decreases Expression	[21]
Left-right determination factor 2 (LEFTY2)	OT3RX4QF	LFTY2_HUMAN	Decreases Expression	[21]
Fatty acid-binding protein, brain (FABP7)	OTRE2H4G	FABP7_HUMAN	Decreases Expression	[21]
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5)	OTMVHF9E	LGR5_HUMAN	Decreases Expression	[21]
Cerberus (CER1)	OTTAJJ63	CER1_HUMAN	Decreases Expression	[21]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Increases Expression	[21]
Collagen alpha-1(II) chain (COL2A1)	OT5E59C8	CO2A1_HUMAN	Decreases Expression	[21]
Proto-oncogene DBL (MCF2)	OTB9N93T	MCF2_HUMAN	Increases Expression	[21]
Myosin light chain 4 (MYL4)	OTURFCSE	MYL4_HUMAN	Decreases Expression	[21]
Protein Cripto (CRIPTO)	OT46DZXJ	TDGF1_HUMAN	Decreases Expression	[21]
Secretogranin-2 (SCG2)	OTUHXX8U	SCG2_HUMAN	Increases Expression	[21]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Increases Expression	[21]
Homeobox protein Hox-B3 (HOXB3)	OT9UC5PE	HXB3_HUMAN	Decreases Expression	[21]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Increases Expression	[21]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Decreases Expression	[21]
Stomatin (STOM)	OTC8R6EH	STOM_HUMAN	Decreases Expression	[21]
Metalloproteinase inhibitor 3 (TIMP3)	OTDGQAD1	TIMP3_HUMAN	Increases Expression	[21]
Glioma pathogenesis-related protein 1 (GLIPR1)	OT0FGQK7	GLIP1_HUMAN	Increases Expression	[21]
LIM/homeobox protein Lhx1 (LHX1)	OT6WI2XS	LHX1_HUMAN	Decreases Expression	[21]
Homeobox protein Hox-A1 (HOXA1)	OTMSOJ7D	HXA1_HUMAN	Decreases Expression	[21]
Paired mesoderm homeobox protein 1 (PRRX1)	OTTZK5G8	PRRX1_HUMAN	Decreases Expression	[21]
Cadherin-6 (CDH6)	OT81Y80S	CADH6_HUMAN	Decreases Expression	[21]
Heart- and neural crest derivatives-expressed protein 2 (HAND2)	OTCXYW4Y	HAND2_HUMAN	Increases Expression	[21]
Protein delta homolog 1 (DLK1)	OTE1VLNB	DLK1_HUMAN	Increases Expression	[21]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Decreases Expression	[21]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Increases Expression	[21]
Testican-1 (SPOCK1)	OTLTDGK7	TICN1_HUMAN	Increases Expression	[21]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)	OTZVUOOB	FBLN3_HUMAN	Increases Expression	[21]
Protein ABHD12B (ABHD12B)	OTBHGWTF	AB12B_HUMAN	Decreases Expression	[21]
Secreted frizzled-related protein 2 (SFRP2)	OT8GZ0CA	SFRP2_HUMAN	Decreases Expression	[21]
Protein LRATD1 (LRATD1)	OT65IL83	LRAT1_HUMAN	Increases Expression	[21]
Neuroserpin (SERPINI1)	OTUJHIJW	NEUS_HUMAN	Increases Expression	[21]
Homeobox protein CDX-2 (CDX2)	OTCG4TSY	CDX2_HUMAN	Decreases Expression	[21]
G-protein coupled receptor 87 (GPR87)	OTQX45UM	GPR87_HUMAN	Increases Expression	[21]
Homeobox protein Hox-D1 (HOXD1)	OTN4V9ZF	HXD1_HUMAN	Decreases Expression	[21]
Transcription factor SOX-17 (SOX17)	OT9H4WWE	SOX17_HUMAN	Decreases Expression	[21]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Decreases Expression	[21]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)	OTTVT4MB	TNR19_HUMAN	Decreases Expression	[21]
Dynein axonemal heavy chain 2 (DNAH2)	OT7J5LDI	DYH2_HUMAN	Decreases Expression	[21]
Histone deacetylase 9 (HDAC9)	OTO8O0LF	HDAC9_HUMAN	Increases Expression	[21]
Thrombospondin type-1 domain-containing protein 7A (THSD7A)	OT7249HH	THS7A_HUMAN	Increases Expression	[21]
Nuclear factor erythroid 2-related factor 3 (NFE2L3)	OT1MGXT0	NF2L3_HUMAN	Increases Expression	[21]
Transcription factor E2F8 (E2F8)	OTQKZGFP	E2F8_HUMAN	Affects Expression	[23]
Aquaporin-12B (AQP12B)	OTNU5Z4K	AQ12B_HUMAN	Decreases Expression	[22]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Increases Expression	[64]
DNA fragmentation factor subunit alpha (DFFA)	OTFPFMT8	DFFA_HUMAN	Decreases Expression	[22]
Forkhead box protein N3 (FOXN3)	OTOJYJZP	FOXN3_HUMAN	Decreases Expression	[24]
Butyrophilin subfamily 3 member A3 (BTN3A3)	OTKMSJRA	BT3A3_HUMAN	Increases Expression	[32]
Cytochrome c oxidase subunit NDUFA4 (NDUFA4)	OTDVH3QG	NDUA4_HUMAN	Affects Expression	[22]
Importin subunit alpha-4 (KPNA3)	OTLI3TM2	IMA4_HUMAN	Decreases Expression	[28]
CCN family member 1 (CCN1)	OTKJBEMD	CCN1_HUMAN	Increases Expression	[65]
Pirin (PIR)	OT8ALXHU	PIR_HUMAN	Decreases Expression	[24]
Claudin-4 (CLDN4)	OT9C4PZ4	CLD4_HUMAN	Decreases Expression	[24]
Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD)	OTYZ8XRH	DHSD_HUMAN	Affects Expression	[22]
Acyl carrier protein, mitochondrial (NDUFAB1)	OTF906UR	ACPM_HUMAN	Affects Expression	[22]
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT)	OTZX703K	CDIPT_HUMAN	Affects Expression	[23]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Increases Expression	[66]
Tripeptidyl-peptidase 1 (TPP1)	OT2LQ771	TPP1_HUMAN	Affects Expression	[23]
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C)	OTVHOL9B	TR10C_HUMAN	Increases Expression	[67]
Ras-related protein M-Ras (MRAS)	OTNCVCQW	RASM_HUMAN	Affects Expression	[23]
Tax1-binding protein 3 (TAX1BP3)	OTQ6IB4T	TX1B3_HUMAN	Increases Expression	[28]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)	OT9RDS3H	IKKB_HUMAN	Decreases Expression	[68]
Angiopoietin-2 (ANGPT2)	OTEQK65P	ANGP2_HUMAN	Decreases Expression	[69]
Actin-related protein 2/3 complex subunit 3 (ARPC3)	OTKWVF8P	ARPC3_HUMAN	Decreases Expression	[28]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[28]
Toll-like receptor 3 (TLR3)	OT8QPYXZ	TLR3_HUMAN	Increases Expression	[70]
Melanoma-associated antigen B2 (MAGEB2)	OTAGUVU5	MAGB2_HUMAN	Decreases Expression	[24]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Decreases Expression	[71]
ATP-dependent RNA helicase DHX15 (DHX15)	OT4F98TK	DHX15_HUMAN	Increases Expression	[23]
Prominin-1 (PROM1)	OTBHV8NX	PROM1_HUMAN	Increases Expression	[24]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Expression	[72]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Increases Expression	[25]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[73]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1)	OTJ5TNHB	NDUC1_HUMAN	Affects Expression	[22]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[28]
Keratin, type II cuticular Hb6 (KRT86)	OT93MMAK	KRT86_HUMAN	Decreases Expression	[24]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Affects Expression	[23]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Affects Expression	[23]
Serine protease inhibitor Kazal-type 4 (SPINK4)	OTHTCW94	ISK4_HUMAN	Affects Expression	[23]
Cystatin-8 (CST8)	OTT2FRCJ	CST8_HUMAN	Affects Expression	[23]
Histone H2B type 1-K (H2BC12)	OTQ8V0KG	H2B1K_HUMAN	Decreases Expression	[32]
Receptor activity-modifying protein 1 (RAMP1)	OT7UT2XB	RAMP1_HUMAN	Decreases Expression	[24]
Sodium channel subunit beta-2 (SCN2B)	OTFAHJ38	SCN2B_HUMAN	Affects Expression	[23]
Probable phospholipid-transporting ATPase IIA (ATP9A)	OT328F1L	ATP9A_HUMAN	Decreases Expression	[24]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Increases Expression	[74]
Breast cancer anti-estrogen resistance protein 3 (BCAR3)	OTPJ17M8	BCAR3_HUMAN	Decreases Expression	[24]
Tumor necrosis factor ligand superfamily member 13 (TNFSF13)	OT90OWIO	TNF13_HUMAN	Increases Expression	[75]
Signal recognition particle subunit SRP72 (SRP72)	OTPV73W7	SRP72_HUMAN	Increases Expression	[23]
Cystatin-F (CST7)	OTQWZUVQ	CYTF_HUMAN	Decreases Expression	[24]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Decreases Expression	[24]
Tight junction protein ZO-3 (TJP3)	OTC1K8HC	ZO3_HUMAN	Affects Expression	[23]
Mitofusin-2 (MFN2)	OTPYN8A3	MFN2_HUMAN	Increases Expression	[76]
NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2)	OT4717TF	NDUB2_HUMAN	Increases Expression	[22]
RCC1 and BTB domain-containing protein 2 (RCBTB2)	OTECBF4R	RCBT2_HUMAN	Affects Expression	[23]
ATP-binding cassette sub-family C member 6 (ABCC6)	OTZT0LKT	MRP6_HUMAN	Increases Expression	[24]
Phenylalanine--tRNA ligase, mitochondrial (FARS2)	OTXAK6F0	SYFM_HUMAN	Decreases Expression	[32]
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1)	OTTR5311	STAU1_HUMAN	Decreases Expression	[28]
Mitochondrial uncoupling protein 4 (SLC25A27)	OTSBOPGD	UCP4_HUMAN	Decreases Expression	[22]
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10)	OTFLILEO	NDUBA_HUMAN	Affects Expression	[22]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Decreases Activity	[77]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Decreases Expression	[28]
Coagulation factor XII (F12)	OTBFD2FU	FA12_HUMAN	Decreases Expression	[24]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Increases Expression	[32]
Thyrotropin subunit beta (TSHB)	OTFDI39D	TSHB_HUMAN	Affects Expression	[78]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[79]
Hemoglobin subunit epsilon (HBE1)	OTJPKMX4	HBE_HUMAN	Decreases Expression	[24]
Keratin, type II cytoskeletal 6A (KRT6A)	OT392M5T	K2C6A_HUMAN	Affects Expression	[23]
Prelamin-A/C (LMNA)	OT3SG7ZR	LMNA_HUMAN	Increases Cleavage	[80]
Apolipoprotein C-III (APOC3)	OTW3520C	APOC3_HUMAN	Decreases Expression	[74]
Metallothionein-2 (MT2A)	OTHOACHD	MT2_HUMAN	Decreases Expression	[31]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Increases Expression	[79]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Decreases Activity	[77]
Vitamin K-dependent protein C (PROC)	OTGVH484	PROC_HUMAN	Decreases Activity	[81]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Decreases Expression	[24]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Decreases Expression	[74]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	OTBPMIMW	G3P_HUMAN	Affects Splicing	[82]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[28]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Increases Expression	[24]
Integrin beta-2 (ITGB2)	OTEKPEPR	ITB2_HUMAN	Decreases Expression	[83]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Increases Expression	[28]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Increases Expression	[32]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Phosphorylation	[84]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[85]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Increases Expression	[86]
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Affects Expression	[22]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Increases Phosphorylation	[87]
Progesterone receptor (PGR)	OT0FZ3QE	PRGR_HUMAN	Affects Expression	[22]
Eukaryotic translation initiation factor 4E (EIF4E)	OTDAWNLA	IF4E_HUMAN	Increases Expression	[23]
Protein disulfide-isomerase (P4HB)	OTTYNYPF	PDIA1_HUMAN	Decreases Expression	[74]
Trypsin-2 (PRSS2)	OTOMVUWL	TRY2_HUMAN	Affects Expression	[23]
Bifunctional glutamate/proline--tRNA ligase (EPRS1)	OTXK0FLB	SYEP_HUMAN	Decreases Expression	[28]
Cathepsin B (CTSB)	OTP9G5QB	CATB_HUMAN	Increases Cleavage	[88]
DNA excision repair protein ERCC-1 (ERCC1)	OTNPYQHI	ERCC1_HUMAN	Decreases Expression	[89]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Increases Expression	[90]
Zinc finger protein GLI1 (GLI1)	OT1BTAJO	GLI1_HUMAN	Decreases Expression	[91]
Collagen alpha-2(IV) chain (COL4A2)	OTJK1LKN	CO4A2_HUMAN	Decreases Expression	[24]
Nuclear factor 1 C-type (NFIC)	OTLMCUIB	NFIC_HUMAN	Increases Expression	[23]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Affects Expression	[23]
Keratin, type I cytoskeletal 16 (KRT16)	OTGA0EQN	K1C16_HUMAN	Increases Expression	[79]
CD63 antigen (CD63)	OT2UGZA9	CD63_HUMAN	Decreases Expression	[83]
Retinol-binding protein 1 (RBP1)	OTRP1MFC	RET1_HUMAN	Decreases Expression	[24]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)	OTIRPN6B	ROA1_HUMAN	Decreases Expression	[32]
Pro-cathepsin H (CTSH)	OTLFL0DG	CATH_HUMAN	Increases Expression	[24]
Cytochrome c oxidase subunit 6C (COX6C)	OT3V7JE5	COX6C_HUMAN	Affects Expression	[22]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Expression	[29]
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2)	OTI4EOAR	IFIT2_HUMAN	Increases Expression	[32]
Serum amyloid A-1 protein (SAA1)	OTO2D8S0	SAA1_HUMAN	Increases Expression	[32]
Heat shock 70 kDa protein 1A (HSPA1A)	OTKGIE76	HS71A_HUMAN	Decreases Expression	[24]
Small integral membrane protein 10-like protein 2A (SMIM10L2B)	OT04IG2N	SIL2A_HUMAN	Decreases Expression	[22]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[85]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[92]
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B)	OTDP94F3	COX5B_HUMAN	Affects Expression	[22]
T-cell surface glycoprotein CD8 beta chain (CD8B)	OTMZ1T7J	CD8B_HUMAN	Decreases Expression	[24]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Decreases Expression	[74]
DNA topoisomerase 1 (TOP1)	OT51O0CF	TOP1_HUMAN	Decreases Expression	[28]
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA)	OT0LHOZB	ODBA_HUMAN	Affects Expression	[23]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Decreases Expression	[24]
Interferon-induced transmembrane protein 1 (IFITM1)	OTECO1G8	IFM1_HUMAN	Increases Expression	[32]
Platelet glycoprotein Ib beta chain (GP1BB)	OTD7XNLL	GP1BB_HUMAN	Affects Expression	[23]
Keratin, type II cytoskeletal 5 (KRT5)	OTVGI9HT	K2C5_HUMAN	Decreases Expression	[24]
Protein disulfide-isomerase A4 (PDIA4)	OTVFUJ13	PDIA4_HUMAN	Decreases Expression	[28]
Troponin T, slow skeletal muscle (TNNT1)	OT8PBOAR	TNNT1_HUMAN	Decreases Expression	[24]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Increases Expression	[25]
Aspartate--tRNA ligase, cytoplasmic (DARS1)	OT0WGC2T	SYDC_HUMAN	Affects Expression	[23]
Protein C-ets-1 (ETS1)	OT4LVGDN	ETS1_HUMAN	Increases Expression	[68]
Fos-related antigen 1 (FOSL1)	OT9YTYMB	FOSL1_HUMAN	Affects Expression	[22]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Increases Expression	[28]
Transcription factor E2-alpha (TCF3)	OTW6FR32	TFE2_HUMAN	Affects Expression	[22]
Cytochrome c oxidase subunit 7C, mitochondrial (COX7C)	OTREWSBF	COX7C_HUMAN	Affects Expression	[22]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Phosphorylation	[64]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Decreases Expression	[93]
Carboxypeptidase E (CPE)	OTXNTV79	CBPE_HUMAN	Increases Expression	[24]
Interferon alpha/beta receptor 1 (IFNAR1)	OTD4OOFK	INAR1_HUMAN	Increases Expression	[94]
HLA class I histocompatibility antigen, alpha chain G (HLA-G)	OTMLK1KN	HLAG_HUMAN	Increases Expression	[32]
Regulator of chromosome condensation (RCC1)	OT25AGMB	RCC1_HUMAN	Decreases Expression	[28]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[84]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)	OTAFHAVI	ATF6A_HUMAN	Affects Expression	[22]
ATP synthase-coupling factor 6, mitochondrial (ATP5PF)	OTDAE8FP	ATP5J_HUMAN	Increases Expression	[22]
Nucleolin (NCL)	OTBXPKMP	NUCL_HUMAN	Affects Splicing	[82]
Troponin I, cardiac muscle (TNNI3)	OT65E12V	TNNI3_HUMAN	Decreases Expression	[24]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Affects Expression	[22]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Phosphorylation	[25]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Decreases Expression	[22]
Hepatocyte nuclear factor 1-alpha (HNF1A)	OT9DOUKL	HNF1A_HUMAN	Affects Expression	[22]
C4b-binding protein beta chain (C4BPB)	OTJ70B0K	C4BPB_HUMAN	Affects Expression	[23]
Kit ligand (KITLG)	OTB9AVQ4	SCF_HUMAN	Increases Expression	[86]
Lactoperoxidase (LPO)	OTJ9QKX9	PERL_HUMAN	Decreases Expression	[95]
Cornifin-B (SPRR1B)	OTXNW3P6	SPR1B_HUMAN	Affects Expression	[23]
Paired box protein Pax-3 (PAX3)	OTN5PJZV	PAX3_HUMAN	Decreases Expression	[27]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[96]
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB)	OTPOAAUW	AT5F1_HUMAN	Affects Expression	[22]
Insulin-like growth factor-binding protein 6 (IGFBP6)	OTW878VI	IBP6_HUMAN	Decreases Expression	[24]
Cyclin-C (CCNC)	OTMVK4K4	CCNC_HUMAN	Decreases Expression	[28]
G1/S-specific cyclin-E1 (CCNE1)	OTLD7UID	CCNE1_HUMAN	Decreases Expression	[33]
Cytochrome P450 2F1 (CYP2F1)	OTY3HJH1	CP2F1_HUMAN	Affects Expression	[23]
DNA replication licensing factor MCM3 (MCM3)	OTOOHQPM	MCM3_HUMAN	Decreases Expression	[28]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Decreases Expression	[24]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Decreases Degradation	[97]
Paired box protein Pax-6 (PAX6)	OTOC9876	PAX6_HUMAN	Decreases Expression	[76]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Decreases Expression	[24]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[98]
G0/G1 switch protein 2 (G0S2)	OT8FL49L	G0S2_HUMAN	Increases Expression	[24]
Probable global transcription activator SNF2L1 (SMARCA1)	OT0Y6PTU	SMCA1_HUMAN	Increases Expression	[24]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[98]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Affects Expression	[23]
Tripeptidyl-peptidase 2 (TPP2)	OT91OVAU	TPP2_HUMAN	Affects Localization	[99]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Increases Cleavage	[100]
Cellular retinoic acid-binding protein 1 (CRABP1)	OTISDG5X	RABP1_HUMAN	Increases Expression	[24]
ATP synthase subunit delta, mitochondrial (ATP5F1D)	OTXTAG2V	ATPD_HUMAN	Affects Expression	[22]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Increases Expression	[24]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Increases Expression	[28]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Decreases Expression	[28]
HLA class I histocompatibility antigen, alpha chain F (HLA-F)	OT76CM19	HLAF_HUMAN	Increases Expression	[32]
Adenylosuccinate synthetase isozyme 2 (ADSS2)	OTW26XXB	PURA2_HUMAN	Decreases Expression	[28]
Neurotensin receptor type 1 (NTSR1)	OTTJUTE3	NTR1_HUMAN	Decreases Expression	[24]
CAMPATH-1 antigen (CD52)	OT02LDQN	CD52_HUMAN	Affects Expression	[23]
Neural cell adhesion molecule L1 (L1CAM)	OTNWAQ4Y	L1CAM_HUMAN	Decreases Expression	[24]
Homeobox protein OTX2 (OTX2)	OTTV05B1	OTX2_HUMAN	Decreases Expression	[76]
Cyclin-dependent kinases regulatory subunit 2 (CKS2)	OTPTMHIV	CKS2_HUMAN	Decreases Expression	[73]
Protein S100-A3 (S100A3)	OTVIZJ2R	S10A3_HUMAN	Decreases Expression	[24]
Heat shock 70 kDa protein 4 (HSPA4)	OT5HR0AR	HSP74_HUMAN	Decreases Expression	[24]
5-hydroxytryptamine receptor 7 (HTR7)	OT44DEWB	5HT7R_HUMAN	Affects Expression	[23]
Profilin-2 (PFN2)	OT5SSSA7	PROF2_HUMAN	Increases Expression	[24]
Radixin (RDX)	OTNSYUN6	RADI_HUMAN	Affects Expression	[23]
Cornifin-A (SPRR1A)	OTJMI34A	SPR1A_HUMAN	Increases Expression	[23]
Homeobox protein MSX-2 (MSX2)	OT1WDKE1	MSX2_HUMAN	Decreases Expression	[24]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[101]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Affects Expression	[22]
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Affects Expression	[23]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A)	OTE2KVZV	SCNNA_HUMAN	Decreases Expression	[24]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Decreases Expression	[24]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[102]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[103]
Hepatocyte nuclear factor 4-alpha (HNF4A)	OTY1TOAB	HNF4A_HUMAN	Affects Expression	[22]
Neuroblastoma suppressor of tumorigenicity 1 (NBL1)	OTT37U4O	NBL1_HUMAN	Decreases Expression	[28]
Signal transducer and activator of transcription 1-alpha/beta (STAT1)	OTLMBUZ6	STAT1_HUMAN	Increases Expression	[22]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Affects Expression	[23]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Decreases Expression	[95]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[104]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Decreases Expression	[22]
Melanoma-associated antigen 2 (MAGEA2)	OTQ0YOTY	MAGA2_HUMAN	Decreases Expression	[24]
Melanoma-associated antigen 6 (MAGEA6)	OTI8S0O2	MAGA6_HUMAN	Decreases Expression	[24]
Melanoma-associated antigen 12 (MAGEA12)	OT8ULELL	MAGAC_HUMAN	Decreases Expression	[24]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Decreases Expression	[33]
Retinaldehyde dehydrogenase 3 (ALDH1A3)	OT1C9NKQ	AL1A3_HUMAN	Decreases Expression	[24]
Galectin-7 (LGALS7)	OTMSVI7R	LEG7_HUMAN	Decreases Expression	[24]
Iron-responsive element-binding protein 2 (IREB2)	OT747D24	IREB2_HUMAN	Increases Expression	[23]
Interferon alpha/beta receptor 2 (IFNAR2)	OTBIRNIJ	INAR2_HUMAN	Increases Expression	[32]
Sodium/hydrogen exchanger 3 (SLC9A3)	OTZ7PFVT	SL9A3_HUMAN	Decreases Expression	[22]
Caspase-4 (CASP4)	OTVQTV1L	CASP4_HUMAN	Increases Expression	[24]
Casein kinase I isoform epsilon (CSNK1E)	OTF0UXX6	KC1E_HUMAN	Affects Expression	[23]
Tuberin (TSC2)	OT47LWI9	TSC2_HUMAN	Increases Expression	[23]
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1)	OTEVK4WW	NDUV1_HUMAN	Affects Expression	[22]
Ketohexokinase (KHK)	OT153922	KHK_HUMAN	Increases Expression	[24]
Homeobox protein MOX-1 (MEOX1)	OTJEMT2D	MEOX1_HUMAN	Increases Expression	[27]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Expression	[105]
Amiloride-sensitive sodium channel subunit beta (SCNN1B)	OT61QQTL	SCNNB_HUMAN	Affects Expression	[23]
Serine/threonine-protein kinase Nek4 (NEK4)	OTOB8366	NEK4_HUMAN	Decreases Expression	[28]
Cyclin-G1 (CCNG1)	OT17IA9L	CCNG1_HUMAN	Decreases Expression	[28]
Rho-related GTP-binding protein RhoN (RND2)	OT98M6UI	RND2_HUMAN	Increases Expression	[32]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Decreases Expression	[73]
Rho GDP-dissociation inhibitor 2 (ARHGDIB)	OT9PD6CS	GDIR2_HUMAN	Affects Expression	[22]
Hexokinase-2 (HK2)	OTC0GCQO	HXK2_HUMAN	Decreases Expression	[106]
Ephrin-B2 (EFNB2)	OT0DCUOM	EFNB2_HUMAN	Decreases Expression	[24]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Increases Expression	[68]
LIM domain kinase 1 (LIMK1)	OTFZ8MZ0	LIMK1_HUMAN	Affects Expression	[22]
Monocarboxylate transporter 1 (SLC16A1)	OTW1UTZ7	MOT1_HUMAN	Decreases Expression	[28]
Heat shock-related 70 kDa protein 2 (HSPA2)	OTSDET7B	HSP72_HUMAN	Increases Expression	[32]
Microsomal triglyceride transfer protein large subunit (MTTP)	OTNUVSDT	MTP_HUMAN	Decreases Expression	[74]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Expression	[22]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Decreases Expression	[107]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Affects Expression	[22]
Forkhead box protein G1 (FOXG1)	OTAW57J4	FOXG1_HUMAN	Decreases Expression	[76]
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3)	OTSCYB9P	NDUV3_HUMAN	Increases Expression	[22]
NADH dehydrogenase 1 alpha subcomplex subunit 6 (NDUFA6)	OTEOIIOL	NDUA6_HUMAN	Affects Expression	[22]
Claudin-2 (CLDN2)	OTRF3D6Y	CLD2_HUMAN	Decreases Expression	[25]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Increases Expression	[108]
Forkhead box protein L2 (FOXL2)	OTFRQUYL	FOXL2_HUMAN	Increases Expression	[22]
Ribose-phosphate pyrophosphokinase 1 (PRPS1)	OTN3A6CN	PRPS1_HUMAN	Increases Expression	[23]
Ras-related protein Rab-8A (RAB8A)	OTPB54Y3	RAB8A_HUMAN	Decreases Expression	[28]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Affects Expression	[23]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB)	OT24GMCM	PP2AB_HUMAN	Increases Expression	[28]
Small ribosomal subunit protein eS26 (RPS26)	OTBYTA6A	RS26_HUMAN	Affects Expression	[23]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2)	OT3JPRCQ	GBB2_HUMAN	Decreases Expression	[28]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Decreases Expression	[28]
Hemoglobin subunit beta (HBB)	OT514IKQ	HBB_HUMAN	Affects Splicing	[82]
E3 ubiquitin-protein ligase RNF4 (RNF4)	OTCMXQRE	RNF4_HUMAN	Decreases Expression	[28]
Cyclin-A1 (CCNA1)	OTX4HD45	CCNA1_HUMAN	Affects Expression	[107]
Interferon-induced 35 kDa protein (IFI35)	OTV9RZ53	IN35_HUMAN	Increases Expression	[32]
Transcriptional activator protein Pur-alpha (PURA)	OT975ELW	PURA_HUMAN	Affects Expression	[23]
Interferon regulatory factor 9 (IRF9)	OTK4MYQJ	IRF9_HUMAN	Increases Expression	[32]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Increases Expression	[103]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Decreases Expression	[22]
Exosome complex component 10 (EXOSC10)	OTH8Z0AL	EXOSX_HUMAN	Increases Metabolism	[109]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Decreases Expression	[24]
Myocyte-specific enhancer factor 2B (MEF2B)	OT880SE6	MEF2B_HUMAN	Affects Expression	[23]
A-kinase anchor protein 12 (AKAP12)	OTCVRDDX	AKA12_HUMAN	Affects Expression	[23]
Lamin-B2 (LMNB2)	OTXRDUOS	LMNB2_HUMAN	Decreases Expression	[22]
Antigen peptide transporter 2 (TAP2)	OTWSYFI7	TAP2_HUMAN	Increases Expression	[110]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Expression	[111]
Keratin, type I cytoskeletal 17 (KRT17)	OT6Y1DPK	K1C17_HUMAN	Affects Expression	[23]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Affects Expression	[23]
Protein kinase C zeta type (PRKCZ)	OTN2FE42	KPCZ_HUMAN	Affects Expression	[23]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[112]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[71]
Forkhead box protein M1 (FOXM1)	OT5887KR	FOXM1_HUMAN	Decreases Expression	[22]
Neuroblast differentiation-associated protein AHNAK (AHNAK)	OT6KH1WG	AHNK_HUMAN	Decreases Expression	[24]
Mesoderm posterior protein 2 (MESP2)	OT7H4LYA	MESP2_HUMAN	Increases Expression	[27]
Sterol regulatory element-binding protein 2 (SREBF2)	OTBXUNPL	SRBP2_HUMAN	Decreases Expression	[22]
Transcription factor 15 (TCF15)	OTA6UCWC	TCF15_HUMAN	Increases Expression	[27]
Heat shock protein 75 kDa, mitochondrial (TRAP1)	OTNG0L8J	TRAP1_HUMAN	Affects Expression	[22]
TNF receptor-associated factor 2 (TRAF2)	OT1MEZZN	TRAF2_HUMAN	Decreases Expression	[97]
Forkhead box protein C1 (FOXC1)	OTOWZGYO	FOXC1_HUMAN	Affects Expression	[23]
Vesicle transport protein SEC20 (BNIP1)	OT7USYCY	SEC20_HUMAN	Increases Expression	[30]
Baculoviral IAP repeat-containing protein 1 (NAIP)	OTLA925F	BIRC1_HUMAN	Decreases Expression	[32]
RE1-silencing transcription factor (REST)	OTLL92LQ	REST_HUMAN	Affects Expression	[23]
FAS-associated death domain protein (FADD)	OTV7GFHH	FADD_HUMAN	Decreases Expression	[22]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)	OTS3FVTY	M3K1_HUMAN	Affects Expression	[22]
28 kDa heat- and acid-stable phosphoprotein (PDAP1)	OTJSWMOD	HAP28_HUMAN	Decreases Expression	[28]
Aquaporin-6 (AQP6)	OTXS6UYY	AQP6_HUMAN	Decreases Expression	[22]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)	OTC41R1E	RIPK1_HUMAN	Increases Expression	[22]
Neurogenic differentiation factor 1 (NEUROD1)	OTZQ7QJ2	NDF1_HUMAN	Affects Expression	[23]
Protein patched homolog 1 (PTCH1)	OTMG07H5	PTC1_HUMAN	Decreases Expression	[91]
CD166 antigen (ALCAM)	OTCO4LP7	CD166_HUMAN	Decreases Expression	[24]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)	OT6VY3A3	SPTN1_HUMAN	Increases Expression	[22]
Low-density lipoprotein receptor-related protein 8 (LRP8)	OTZ71YV2	LRP8_HUMAN	Decreases Expression	[32]
Transcription factor E2F2 (E2F2)	OTO75RM7	E2F2_HUMAN	Decreases Expression	[22]
Fas-activated serine/threonine kinase (FASTK)	OTTHFZMP	FASTK_HUMAN	Decreases Expression	[22]
Guanidinoacetate N-methyltransferase (GAMT)	OTVC87ES	GAMT_HUMAN	Increases Expression	[24]
Transcription factor HES-1 (HES1)	OT8P19W2	HES1_HUMAN	Increases Activity	[113]
Indian hedgehog protein (IHH)	OT1DWGXC	IHH_HUMAN	Decreases Expression	[114]
Transmembrane protein 187 (TMEM187)	OTOE4G8T	TM187_HUMAN	Decreases Expression	[22]
Pumilio homolog 1 (PUM1)	OTTMWP8L	PUM1_HUMAN	Affects Expression	[23]
Major vault protein (MVP)	OTJGHJRB	MVP_HUMAN	Increases Expression	[115]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Decreases Expression	[107]
Kinesin-like protein KIF14 (KIF14)	OTXHT4JM	KIF14_HUMAN	Decreases Expression	[22]
Angiopoietin-1 (ANGPT1)	OTVZ1NG3	ANGP1_HUMAN	Increases Expression	[69]
Sonic hedgehog protein (SHH)	OTOG2BXF	SHH_HUMAN	Decreases Expression	[91]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)	OTBOSJHO	TRADD_HUMAN	Affects Expression	[22]
Heat shock protein beta-2 (HSPB2)	OTS01646	HSPB2_HUMAN	Increases Phosphorylation	[90]
Transcription factor E2F4 (E2F4)	OTB3JFH4	E2F4_HUMAN	Decreases Expression	[22]
BDNF/NT-3 growth factors receptor (NTRK2)	OTD557PU	NTRK2_HUMAN	Decreases Expression	[24]
Survival motor neuron protein (SMN2)	OT54RLO1	SMN_HUMAN	Decreases Expression	[32]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Expression	[116]
Kinesin-like protein KIF26B (KIF26B)	OTVHWIKR	KI26B_HUMAN	Decreases Expression	[22]
Protein BEAN1 (BEAN1)	OT0WLH27	BEAN1_HUMAN	Increases Expression	[24]
Filamin A-interacting protein 1-like (FILIP1L)	OTPY8IMS	FIL1L_HUMAN	Increases Expression	[24]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Decreases Expression	[73]
Early estrogen-induced gene 1 protein (EEIG1)	OT2BMEAE	EEIG1_HUMAN	Affects Expression	[23]
Transcription initiation factor TFIID subunit 3 (TAF3)	OTVMULE9	TAF3_HUMAN	Affects Expression	[23]
GRAM domain-containing protein 4 (GRAMD4)	OT1HXEPM	GRAM4_HUMAN	Increases Expression	[117]
Heme transporter HRG1 (SLC48A1)	OTPFHZLO	HRG1_HUMAN	Affects Expression	[23]
Proline/serine-rich coiled-coil protein 1 (PSRC1)	OT7MDJMN	PSRC1_HUMAN	Decreases Expression	[73]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Decreases Expression	[73]
Teashirt homolog 1 (TSHZ1)	OTYQ9ECW	TSH1_HUMAN	Increases Expression	[23]
Protein MCM10 homolog (MCM10)	OTV0O3JN	MCM10_HUMAN	Affects Expression	[23]
Oligodendrocyte transcription factor 3 (OLIG3)	OTU8XLAF	OLIG3_HUMAN	Decreases Expression	[27]
Protein lifeguard 1 (GRINA)	OTMC1O66	LFG1_HUMAN	Affects Expression	[23]
Cyclin-J-like protein (CCNJL)	OTU0SRTC	CCNJL_HUMAN	Affects Expression	[23]
Mitofusin-1 (MFN1)	OTCBXQZF	MFN1_HUMAN	Increases Expression	[76]
Protein NOXP20 (FAM114A1)	OT0208Y4	NXP20_HUMAN	Affects Expression	[23]
Extracellular serine/threonine protein kinase FAM20C (FAM20C)	OTW5YZ7X	FA20C_HUMAN	Affects Expression	[23]
Serine/arginine repetitive matrix protein 1 (SRRM1)	OTAY2IP6	SRRM1_HUMAN	Decreases Expression	[28]
Ankyrin repeat domain-containing protein 36B (ANKRD36B)	OT3MW415	AN36B_HUMAN	Affects Expression	[23]
Metallothionein-1M (MT1M)	OTVT8PLU	MT1M_HUMAN	Increases Expression	[24]
Integral membrane protein GPR137C (GPR137C)	OTMEB9QG	G137C_HUMAN	Affects Expression	[23]
Fibrinogen C domain-containing protein 1 (FIBCD1)	OTSVT07B	FBCD1_HUMAN	Decreases Expression	[22]
tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1)	OT95QT6P	DTWD1_HUMAN	Increases Expression	[30]
ER membrane protein complex subunit 1 (EMC1)	OTYAH4LX	EMC1_HUMAN	Affects Expression	[23]
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH)	OTBIN5IP	SCPDL_HUMAN	Increases Expression	[32]
Minor histocompatibility antigen H13 (HM13)	OTGEO1LP	HM13_HUMAN	Affects Expression	[23]
Serine/threonine-protein kinase Nek9 (NEK9)	OT4VQCL5	NEK9_HUMAN	Decreases Expression	[28]
Grainyhead-like protein 3 homolog (GRHL3)	OT1V4ZEH	GRHL3_HUMAN	Affects Expression	[23]
Transmembrane protein 40 (TMEM40)	OTSJKKNA	TMM40_HUMAN	Affects Expression	[23]
Lipase member H (LIPH)	OTRGYLKL	LIPH_HUMAN	Decreases Expression	[28]
MAP kinase-activating death domain protein (MADD)	OTUFYVGG	MADD_HUMAN	Affects Expression	[22]
E3 ubiquitin-protein ligase MYLIP (MYLIP)	OTL0PFGV	MYLIP_HUMAN	Affects Expression	[23]
Serine protease HTRA1 (HTRA1)	OTR8ACBF	HTRA1_HUMAN	Increases Expression	[24]
Symplekin (SYMPK)	OTYAUDXV	SYMPK_HUMAN	Decreases Expression	[28]
Caspase-10 (CASP10)	OTE6J88E	CASPA_HUMAN	Increases Expression	[22]
Kallikrein-6 (KLK6)	OTIEA234	KLK6_HUMAN	Decreases Expression	[24]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1)	OT3062CA	SO2A1_HUMAN	Affects Expression	[23]
Major histocompatibility complex class I-related gene protein (MR1)	OTZU3XX7	HMR1_HUMAN	Increases Expression	[32]
Optineurin (OPTN)	OT2UXWH9	OPTN_HUMAN	Increases Expression	[32]
Sororin (CDCA5)	OTZLCQ5U	CDCA5_HUMAN	Increases Expression	[28]
THO complex subunit 1 (THOC1)	OTVABJ4Z	THOC1_HUMAN	Decreases Expression	[28]
Chronophin (PDXP)	OTZ7GN95	PLPP_HUMAN	Decreases Expression	[28]
Cytochrome c oxidase assembly protein COX14 (COX14)	OTQ378WN	COX14_HUMAN	Affects Expression	[22]
Retina and anterior neural fold homeobox protein 2 (RAX2)	OT1HD6CF	RAX2_HUMAN	Affects Expression	[23]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3)	OT8C6PKL	AGAP3_HUMAN	Decreases Expression	[28]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Increases Expression	[118]
Serine/threonine-protein kinase Nek1 (NEK1)	OTBUCUW6	NEK1_HUMAN	Decreases Expression	[28]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Affects Expression	[23]
Transcription factor ATOH8 (ATOH8)	OT7SY3BN	ATOH8_HUMAN	Affects Expression	[23]
Pre-mRNA-splicing factor 18 (PRPF18)	OTX4VZ4R	PRP18_HUMAN	Decreases Expression	[32]
MyoD family inhibitor (MDFI)	OTIA6YUG	MDFI_HUMAN	Decreases Expression	[24]
Noelin (OLFM1)	OTOYPEWW	NOE1_HUMAN	Increases Expression	[24]
Protein smoothened (SMO)	OTXXE208	SMO_HUMAN	Decreases Expression	[91]
Retinoic acid receptor responder protein 2 (RARRES2)	OT1BJE8K	RARR2_HUMAN	Decreases Expression	[28]
NADH dehydrogenase 1 alpha subcomplex assembly factor 3 (NDUFAF3)	OT4MCB6W	NDUF3_HUMAN	Decreases Expression	[22]
Multiple myeloma tumor-associated protein 2 (C1ORF35)	OTK6PUYF	MMTA2_HUMAN	Affects Expression	[23]
Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23)	OTG0B7RM	SCMC3_HUMAN	Affects Expression	[23]
Histone-lysine N-methyltransferase SETD5 (SETD5)	OTRPAVEO	SETD5_HUMAN	Affects Expression	[23]
Hyaluronan and proteoglycan link protein 2 (HAPLN2)	OT0G3KEQ	HPLN2_HUMAN	Affects Expression	[23]
PR domain zinc finger protein 14 (PRDM14)	OTWZKY4L	PRD14_HUMAN	Affects Expression	[22]
Neurogenin-2 (NEUROG2)	OTAEMIGT	NGN2_HUMAN	Decreases Expression	[27]
Kallikrein-15 (KLK15)	OT7BVG17	KLK15_HUMAN	Affects Expression	[23]
Serine/threonine-protein kinase PLK3 (PLK3)	OT19CT2Z	PLK3_HUMAN	Increases Expression	[103]
Complex I assembly factor ACAD9, mitochondrial (ACAD9)	OT4HITJ6	ACAD9_HUMAN	Decreases Expression	[22]
2-oxoglutarate and iron-dependent oxygenase JMJD4 (JMJD4)	OTYZGH63	JMJD4_HUMAN	Decreases Expression	[22]
ATP-binding cassette sub-family B member 6 (ABCB6)	OTPGZFES	ABCB6_HUMAN	Decreases Expression	[110]
StAR-related lipid transfer protein 7, mitochondrial (STARD7)	OTDUZ296	STAR7_HUMAN	Affects Expression	[23]
Muscleblind-like protein 1 (MBNL1)	OTOV7J85	MBNL1_HUMAN	Decreases Expression	[28]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)	OT0ALMEG	M3K20_HUMAN	Affects Expression	[23]
NF-kappa-B inhibitor-interacting Ras-like protein 1 (NKIRAS1)	OTWETJTL	KBRS1_HUMAN	Affects Expression	[23]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Expression	[74]
Myoferlin (MYOF)	OTRFC3IJ	MYOF_HUMAN	Decreases Expression	[24]
Programmed cell death 1 ligand 1 (CD274)	OTJ0VFDL	PD1L1_HUMAN	Increases Expression	[119]
NADH dehydrogenase 1 alpha subcomplex assembly factor 4 (NDUFAF4)	OTWJ5B9M	NDUF4_HUMAN	Affects Expression	[22]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B)	OTY94WRA	HM20B_HUMAN	Decreases Expression	[28]
MyoD family inhibitor domain-containing protein (MDFIC)	OTSRYBWZ	MDFIC_HUMAN	Affects Expression	[23]
Ribosome-binding protein 1 (RRBP1)	OT4ZTPTM	RRBP1_HUMAN	Decreases Expression	[24]
Small proline-rich protein 3 (SPRR3)	OTN9QJKG	SPRR3_HUMAN	Affects Expression	[23]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)	OTOSRDJT	TR10D_HUMAN	Increases Expression	[67]
Dickkopf-related protein 4 (DKK4)	OTWCCVF6	DKK4_HUMAN	Increases Expression	[23]
DNA repair protein REV1 (REV1)	OTHIKICX	REV1_HUMAN	Affects Expression	[23]
Hydroxyproline dehydrogenase (PRODH2)	OTHO2TO0	HYPDH_HUMAN	Decreases Expression	[24]
FK506-binding protein-like (FKBPL)	OTR9ND6K	FKBPL_HUMAN	Increases Expression	[104]
Suppressor of fused homolog (SUFU)	OT0IRYG1	SUFU_HUMAN	Decreases Expression	[91]
Probable G-protein coupled receptor 132 (GPR132)	OTJ5WHHX	GP132_HUMAN	Increases Expression	[23]
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE)	OTNONPMB	GLCNE_HUMAN	Decreases Expression	[24]
C-type lectin domain family 11 member A (CLEC11A)	OT9KBH7C	CLC11_HUMAN	Decreases Expression	[24]
DNA replication complex GINS protein PSF2 (GINS2)	OT974IYI	PSF2_HUMAN	Affects Expression	[23]
R3H domain-containing protein 2 (R3HDM2)	OTMJ3S6J	R3HD2_HUMAN	Affects Expression	[23]
Complex I intermediate-associated protein 30, mitochondrial (NDUFAF1)	OTYK9JU6	CIA30_HUMAN	Increases Expression	[22]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1)	OTBCIBC7	SAMH1_HUMAN	Affects Expression	[23]
Angiopoietin-related protein 3 (ANGPTL3)	OTCD5Z9W	ANGL3_HUMAN	Decreases Expression	[74]
Origin recognition complex subunit 6 (ORC6)	OTKQN3KP	ORC6_HUMAN	Increases Expression	[23]
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9)	OTO3WI7S	NDUB9_HUMAN	Affects Expression	[22]
Soluble TNF receptor II (CRMB1)	OT06I7G2	CRMB_CAMPM	Increases ADR	[120]
Mitochondrial pyruvate carrier 2 (MPC2)	OT0GHXGG	MPC2_HUMAN	Affects Response To Substance	[35]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Decreases Response To Substance	[121]
Tumor protein p73 (TP73)	OT0LUO47	P73_HUMAN	Affects Response To Substance	[122]
Nucleoside diphosphate kinase A (NME1)	OT0NELQ1	NDKA_HUMAN	Affects Response To Substance	[36]
Four and a half LIM domains protein 2 (FHL2)	OT0OAYWT	FHL2_HUMAN	Affects Response To Substance	[35]
Tripartite motif-containing protein 2 (TRIM2)	OT0V1YVC	TRIM2_HUMAN	Affects Response To Substance	[35]
Neuropilin and tolloid-like protein 2 (NETO2)	OT0YAMC0	NETO2_HUMAN	Affects Response To Substance	[35]
Sperm protein associated with the nucleus on the X chromosome C (SPANXC)	OT1033B9	SPNXC_HUMAN	Affects Response To Substance	[35]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Affects Response To Substance	[35]
Solute carrier family 35 member F5 (SLC35F5)	OT1FX2QO	S35F5_HUMAN	Affects Response To Substance	[123]
Replication factor C subunit 3 (RFC3)	OT1MS7AO	RFC3_HUMAN	Affects Response To Substance	[36]
Amyloid beta precursor protein binding family B member 2 (APBB2)	OT1VD51B	APBB2_HUMAN	Affects Response To Substance	[35]
Carboxypeptidase D (CPD)	OT2CS64Y	CBPD_HUMAN	Affects Response To Substance	[35]
Uncharacterized protein C11orf24 (C11ORF24)	OT2DOJ6E	CK024_HUMAN	Affects Response To Substance	[35]
La-related protein 4B (LARP4B)	OT2HI0QE	LAR4B_HUMAN	Affects Response To Substance	[35]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)	OT2HZK5M	GTR3_HUMAN	Affects Response To Substance	[35]
Nucleoside diphosphate kinase, mitochondrial (NME4)	OT2JTT42	NDKM_HUMAN	Affects Response To Substance	[35]
Chromobox protein homolog 1 (CBX1)	OT2L4XZX	CBX1_HUMAN	Affects Response To Substance	[35]
Kelch-like protein 7 (KLHL7)	OT2OF1O8	KLHL7_HUMAN	Affects Response To Substance	[35]
LIM and SH3 domain protein 1 (LASP1)	OT2QIDCL	LASP1_HUMAN	Affects Response To Substance	[35]
Protein transport protein Sec31A (SEC31A)	OT2U42AC	SC31A_HUMAN	Affects Response To Substance	[35]
Protein-tyrosine sulfotransferase 2 (TPST2)	OT2XKFCE	TPST2_HUMAN	Affects Response To Substance	[35]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Response To Substance	[124]
Protein FAM171A1 (FAM171A1)	OT33BHEP	F1711_HUMAN	Affects Response To Substance	[35]
Very long chain fatty acid elongase 5 (ELOVL5)	OT375W1Z	ELOV5_HUMAN	Affects Response To Substance	[35]
Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)	OT37FKH0	CYLD_HUMAN	Increases Response To Substance	[125]
Angiogenin (ANG)	OT3ECS6P	ANGI_HUMAN	Affects Response To Substance	[35]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Response To Substance	[126]
Hypermethylated in cancer 2 protein (HIC2)	OT3VP1D9	HIC2_HUMAN	Affects Response To Substance	[35]
Sorcin (SRI)	OT4R3EAC	SORCN_HUMAN	Decreases Response To Substance	[127]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Affects Response To Substance	[128]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1)	OT536PE7	SCOT1_HUMAN	Affects Response To Substance	[35]
DNA repair nuclease/redox regulator APEX1 (APEX1)	OT53OI14	APEX1_HUMAN	Increases Response To Substance	[129]
Breast carcinoma-amplified sequence 4 (BCAS4)	OT596N5E	BCAS4_HUMAN	Affects Response To Substance	[35]
Myosin phosphatase Rho-interacting protein (MPRIP)	OT5FV5NS	MPRIP_HUMAN	Affects Response To Substance	[35]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Affects Response To Substance	[35]
Tumor necrosis factor receptor superfamily member 5 (CD40)	OT5YU2XB	TNR5_HUMAN	Decreases Response To Substance	[130]
Mitochondrial enolase superfamily member 1 (ENOSF1)	OT65D3ZK	ENOF1_HUMAN	Decreases Response To Substance	[131]
Macrophage colony-stimulating factor 1 (CSF1)	OT68M7RD	CSF1_HUMAN	Affects Response To Substance	[35]
Myosin regulatory light polypeptide 9 (MYL9)	OT6B22JB	MYL9_HUMAN	Affects Response To Substance	[35]
Glutamate--cysteine ligase regulatory subunit (GCLM)	OT6CP234	GSH0_HUMAN	Affects Response To Substance	[35]
Melanoma-associated antigen D1 (MAGED1)	OT6EOLFC	MAGD1_HUMAN	Affects Response To Substance	[36]
DNA replication licensing factor MCM7 (MCM7)	OT6FXC6K	MCM7_HUMAN	Affects Response To Substance	[36]
Electron transfer flavoprotein subunit beta (ETFB)	OT6Q6FBD	ETFB_HUMAN	Affects Response To Substance	[36]
Opioid growth factor receptor-like protein 1 (OGFRL1)	OT6QGBYE	OGRL1_HUMAN	Affects Response To Substance	[35]
DNA topoisomerase 2-binding protein 1 (TOPBP1)	OT6UPZPD	TOPB1_HUMAN	Affects Response To Substance	[36]
Transforming protein RhoA (RHOA)	OT6YOJ9N	RHOA_HUMAN	Decreases Response To Substance	[132]
GTP-binding protein 4 (GTPBP4)	OT6ZHAWC	GTPB4_HUMAN	Affects Response To Substance	[35]
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2)	OT714BUO	AL3A2_HUMAN	Affects Response To Substance	[35]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)	OT7C68YV	BACH_HUMAN	Affects Response To Substance	[36]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)	OT7M67WT	GALT3_HUMAN	Affects Response To Substance	[35]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Affects Response To Substance	[35]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)	OT7Y43A1	PP1A_HUMAN	Affects Response To Substance	[35]
CDKN2A-interacting protein (CDKN2AIP)	OT80RRQJ	CARF_HUMAN	Affects Response To Substance	[35]
Cbp/p300-interacting transactivator 2 (CITED2)	OT812TV7	CITE2_HUMAN	Affects Response To Substance	[36]
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B)	OT8CMPB2	FKB1B_HUMAN	Affects Response To Substance	[35]
Mortality factor 4-like protein 2 (MORF4L2)	OT8OI3EC	MO4L2_HUMAN	Decreases Response To Substance	[133]
Putative hydrolase DDAH2 (DDAH2)	OT8Q40G2	DDAH2_HUMAN	Affects Response To Substance	[35]
Pre-B-cell leukemia transcription factor 3 (PBX3)	OT8WMVM4	PBX3_HUMAN	Affects Response To Substance	[35]
Intersectin-1 (ITSN1)	OT8YF3S5	ITSN1_HUMAN	Affects Response To Substance	[35]
Frizzled-2 (FZD2)	OT952ML1	FZD2_HUMAN	Affects Response To Substance	[35]
Galectin-3-binding protein (LGALS3BP)	OT9AGQKH	LG3BP_HUMAN	Affects Response To Substance	[35]
L-lactate dehydrogenase B chain (LDHB)	OT9B1CT3	LDHB_HUMAN	Affects Response To Substance	[35]
Transcription factor MafF (MAFF)	OT9B7MX0	MAFF_HUMAN	Affects Response To Substance	[35]
Epsilon-sarcoglycan (SGCE)	OT9F17JB	SGCE_HUMAN	Affects Response To Substance	[35]
Carbohydrate sulfotransferase 7 (CHST7)	OT9HCUST	CHST7_HUMAN	Affects Response To Substance	[35]
Adapter molecule crk (CRK)	OT9Q5YSN	CRK_HUMAN	Affects Response To Substance	[35]
Dysbindin domain-containing protein 2 (DBNDD2)	OT9RI580	DBND2_HUMAN	Affects Response To Substance	[35]
Lanosterol synthase (LSS)	OT9W2SFH	LSS_HUMAN	Affects Response To Substance	[35]
Perilipin-3 (PLIN3)	OT9ZA7MR	PLIN3_HUMAN	Affects Response To Substance	[35]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Affects Response To Substance	[35]
Apolipoprotein C-I (APOC1)	OTA58CED	APOC1_HUMAN	Affects Response To Substance	[35]
Ribonuclease 4 (RNASE4)	OTA5SZLC	RNAS4_HUMAN	Affects Response To Substance	[35]
SEC14-like protein 1 (SEC14L1)	OTA75FET	S14L1_HUMAN	Affects Response To Substance	[35]
DNA polymerase epsilon subunit 2 (POLE2)	OTAC9V6L	DPOE2_HUMAN	Affects Response To Substance	[35]
Integrin alpha-V (ITGAV)	OTAM7JTR	ITAV_HUMAN	Affects Response To Substance	[35]
Receptor-type tyrosine-protein phosphatase kappa (PTPRK)	OTAP5AT3	PTPRK_HUMAN	Affects Response To Substance	[35]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Response To Substance	[134]
Collagen alpha-3(VI) chain (COL6A3)	OTAS6R6I	CO6A3_HUMAN	Affects Response To Substance	[35]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Affects Response To Substance	[128]
Lanosterol 14-alpha demethylase (CYP51A1)	OTAYHG9C	CP51A_HUMAN	Affects Response To Substance	[35]
Sterol O-acyltransferase 1 (SOAT1)	OTB4Y5RJ	SOAT1_HUMAN	Affects Response To Substance	[35]
Ras-related protein R-Ras (RRAS)	OTBBF28C	RRAS_HUMAN	Affects Response To Substance	[35]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Affects Response To Substance	[128]
Cochlin (COCH)	OTBEHD89	COCH_HUMAN	Affects Response To Substance	[35]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14)	OTBFIOVY	GTR14_HUMAN	Affects Response To Substance	[35]
Protein transport protein Sec23A (SEC23A)	OTBRNIJ3	SC23A_HUMAN	Affects Response To Substance	[35]
Alpha-galactosidase A (GLA)	OTBSR6DT	AGAL_HUMAN	Affects Response To Substance	[35]
Regenerating islet-derived protein 4 (REG4)	OTBWIKOA	REG4_HUMAN	Decreases Response To Substance	[135]
Transmembrane protein 184B (TMEM184B)	OTBZY7E9	T184B_HUMAN	Affects Response To Substance	[35]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Affects Response To Substance	[35]
Adenylyl cyclase-associated protein 2 (CAP2)	OTC1WFNO	CAP2_HUMAN	Affects Response To Substance	[35]
RNA-binding protein 5 (RBM5)	OTCBWHHV	RBM5_HUMAN	Affects Response To Substance	[36]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Decreases Response To Substance	[136]
Baculoviral IAP repeat-containing protein 6 (BIRC6)	OTCQJAB0	BIRC6_HUMAN	Decreases Response To Substance	[137]
Probable cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1)	OTCU8PFI	CIAO1_HUMAN	Affects Response To Substance	[36]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Affects Response To Substance	[35]
Adhesion G protein-coupled receptor L2 (ADGRL2)	OTCXD2YR	AGRL2_HUMAN	Affects Response To Substance	[35]
Large ribosomal subunit protein eL24 (RPL24)	OTCY9DEB	RL24_HUMAN	Affects Response To Substance	[36]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Affects Response To Substance	[35]
Protein timeless homolog (TIMELESS)	OTD8DCBJ	TIM_HUMAN	Affects Response To Substance	[36]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Response To Substance	[133]
Gamma-adducin (ADD3)	OTDRSHAZ	ADDG_HUMAN	Affects Response To Substance	[35]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)	OTDS2EAR	TNR1B_HUMAN	Affects Response To Substance	[123]
DNA polymerase subunit gamma-1 (POLG)	OTDUCT04	DPOG1_HUMAN	Affects Response To Substance	[36]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)	OTDVVNS0	EDIL3_HUMAN	Affects Response To Substance	[35]
Cytosolic phospholipase A2 (PLA2G4A)	OTE70SOT	PA24A_HUMAN	Affects Response To Substance	[35]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Decreases Response To Substance	[138]
Very-long-chain (HACD1)	OTEC7EP7	HACD1_HUMAN	Affects Response To Substance	[35]
DNA ligase 1 (LIG1)	OTEEQS43	DNLI1_HUMAN	Affects Response To Substance	[36]
H(+)/Cl(-) exchange transporter 3 (CLCN3)	OTEEXNMU	CLCN3_HUMAN	Affects Response To Substance	[35]
Maternal embryonic leucine zipper kinase (MELK)	OTEY2UQA	MELK_HUMAN	Affects Response To Substance	[36]
Proteolipid protein 2 (PLP2)	OTEZ4LOV	PLP2_HUMAN	Affects Response To Substance	[35]
Paraneoplastic antigen Ma2 (PNMA2)	OTF5YBQG	PNMA2_HUMAN	Affects Response To Substance	[35]
Mitogen-activated protein kinase 7 (MAPK7)	OTF7H7L7	MK07_HUMAN	Decreases Response To Substance	[139]
Kelch-like ECH-associated protein 1 (KEAP1)	OTFHOD0C	KEAP1_HUMAN	Affects Response To Substance	[140]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Decreases Response To Substance	[61]
E3 ubiquitin-protein ligase NEDD4 (NEDD4)	OTFPXLXT	NEDD4_HUMAN	Affects Response To Substance	[35]
SOSS complex subunit B2 (NABP1)	OTFTNFHW	SOSB2_HUMAN	Increases ADR	[141]
Centromere protein X (CENPX)	OTG1RAKJ	CENPX_HUMAN	Affects Response To Substance	[35]
Protein AF1q (MLLT11)	OTG5RVHC	AF1Q_HUMAN	Affects Response To Substance	[35]
DNA mismatch repair protein Mlh1 (MLH1)	OTG5XDD8	MLH1_HUMAN	Increases Response To Substance	[142]
Lymphocyte antigen 6 complex locus protein G6d (LY6G6D)	OTG75QOC	LY66D_HUMAN	Affects Response To Substance	[35]
Regulator of G-protein signaling 4 (RGS4)	OTG94HHL	RGS4_HUMAN	Affects Response To Substance	[35]
TRIO and F-actin-binding protein (TRIOBP)	OTGB5WHC	TARA_HUMAN	Affects Response To Substance	[35]
Tubulin-specific chaperone E (TBCE)	OTGBSTKS	TBCE_HUMAN	Affects Response To Substance	[35]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)	OTGD8TID	FLRT2_HUMAN	Affects Response To Substance	[35]
DNA replication licensing factor MCM2 (MCM2)	OTGGORIQ	MCM2_HUMAN	Affects Response To Substance	[36]
Fibroblast growth factor 7 (FGF7)	OTGK6ANL	FGF7_HUMAN	Decreases Response To Substance	[143]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	OTGM06VJ	IDI1_HUMAN	Affects Response To Substance	[35]
Melanoma-associated antigen 4 (MAGEA4)	OTGP9SD0	MAGA4_HUMAN	Affects Response To Substance	[35]
Phospholipid scramblase 1 (PLSCR1)	OTGY9B5T	PLS1_HUMAN	Affects Response To Substance	[35]
Partitioning defective 3 homolog (PARD3)	OTH5BPLO	PARD3_HUMAN	Affects Response To Substance	[35]
Flavin reductase (BLVRB)	OTHCFN2C	BLVRB_HUMAN	Affects Response To Substance	[35]
Heat shock protein beta-1 (HSPB1)	OTHFZ8ED	HSPB1_HUMAN	Decreases Response To Substance	[144]
Potassium voltage-gated channel subfamily A member 5 (KCNA5)	OTHI2N71	KCNA5_HUMAN	Increases Response To Substance	[145]
Translationally-controlled tumor protein (TPT1)	OTHMTRJU	TCTP_HUMAN	Decreases Response To Substance	[124]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Affects Response To Substance	[128]
Dystonin (DST)	OTHZBM4X	DYST_HUMAN	Affects Response To Substance	[35]
FYVE, RhoGEF and PH domain-containing protein 6 (FGD6)	OTI0T62C	FGD6_HUMAN	Affects Response To Substance	[35]
Protein S100-A11 (S100A11)	OTI57KDN	S10AB_HUMAN	Increases Response To Substance	[146]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Affects Response To Substance	[36]
Laminin subunit gamma-1 (LAMC1)	OTIG527N	LAMC1_HUMAN	Affects Response To Substance	[35]
Baculoviral IAP repeat-containing protein 7 (BIRC7)	OTITCGHB	BIRC7_HUMAN	Decreases Response To Substance	[147]
Kinesin-like protein KIF2C (KIF2C)	OTJ8G3NP	KIF2C_HUMAN	Affects Response To Substance	[36]
Replication factor C subunit 2 (RFC2)	OTJ9N6BD	RFC2_HUMAN	Affects Response To Substance	[36]
Retrotransposon Gag-like protein 8C (RTL8C)	OTJA37NU	RTL8C_HUMAN	Affects Response To Substance	[35]
Cyclin-F (CCNF)	OTJFVU43	CCNF_HUMAN	Affects Response To Substance	[128]
Heat shock cognate 71 kDa protein (HSPA8)	OTJI2RCI	HSP7C_HUMAN	Affects Response To Substance	[35]
Rhomboid-related protein 2 (RHBDL2)	OTJPJ8N6	RHBL2_HUMAN	Affects Response To Substance	[35]
Unconventional myosin-VI (MYO6)	OTJQYRC7	MYO6_HUMAN	Affects Response To Substance	[35]
Endothelin-1 receptor (EDNRA)	OTK9T5O3	EDNRA_HUMAN	Affects Response To Substance	[148]
Serine/threonine-protein kinase 38 (STK38)	OTKMYCYR	STK38_HUMAN	Affects Response To Substance	[35]
Starch-binding domain-containing protein 1 (STBD1)	OTKPS9AM	STBD1_HUMAN	Affects Response To Substance	[35]
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial (ECHDC3)	OTKU2RMC	ECHD3_HUMAN	Affects Response To Substance	[35]
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT2)	OTKXMSM7	MGAT2_HUMAN	Affects Response To Substance	[35]
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR)	OTKYMT99	CABYR_HUMAN	Affects Response To Substance	[35]
EF-hand domain-containing protein D1 (EFHD1)	OTL5INE4	EFHD1_HUMAN	Affects Response To Substance	[35]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)	OTL9I7LO	GA45B_HUMAN	Decreases Response To Substance	[149]
Sorting nexin-6 (SNX6)	OTLKQYJU	SNX6_HUMAN	Affects Response To Substance	[35]
PDZ and LIM domain protein 5 (PDLIM5)	OTLQVV22	PDLI5_HUMAN	Affects Response To Substance	[35]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Affects Response To Substance	[35]
Separin (ESPL1)	OTMGEVOK	ESPL1_HUMAN	Affects Response To Substance	[36]
Sperm protein associated with the nucleus on the X chromosome A (SPANXA1)	OTMK3QIS	SPNXA_HUMAN	Affects Response To Substance	[35]
Pleckstrin homology domain-containing family O member 1 (PLEKHO1)	OTMVUQ9W	PKHO1_HUMAN	Affects Response To Substance	[35]
Ubiquitin-conjugating enzyme E2 R1 (CDC34)	OTNBK390	UB2R1_HUMAN	Affects Response To Substance	[35]
Protein ENTREP3 (ENTREP3)	OTNJB3FP	EREP3_HUMAN	Affects Response To Substance	[35]
HMG box transcription factor BBX (BBX)	OTNQ3QUC	BBX_HUMAN	Affects Response To Substance	[35]
Melanoma-associated antigen D4 (MAGED4B)	OTO37U7W	MAGD4_HUMAN	Affects Response To Substance	[35]
Purine nucleoside phosphorylase (PNP)	OTO5NIJ2	PNPH_HUMAN	Affects Response To Substance	[36]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Response To Substance	[150]
Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1)	OTODG57A	FUT1_HUMAN	Affects Response To Substance	[151]
Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA)	OTOJ8QFF	SDHA_HUMAN	Affects Response To Substance	[36]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Decreases Response To Substance	[152]
Copper homeostasis protein cutC homolog (CUTC)	OTOVHLU9	CUTC_HUMAN	Affects Response To Substance	[35]
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD)	OTP9COQT	PISD_HUMAN	Affects Response To Substance	[36]
Ras-related protein Rab-20 (RAB20)	OTP9OOVS	RAB20_HUMAN	Affects Response To Substance	[35]
MHC class I polypeptide-related sequence A (MICA)	OTPEIEAR	MICA_HUMAN	Affects Response To Substance	[35]
Tensin-3 (TNS3)	OTPG2D8Z	TENS3_HUMAN	Affects Response To Substance	[35]
Neurotensin/neuromedin N (NTS)	OTPGDNQS	NEUT_HUMAN	Affects Response To Substance	[35]
Na(+)/citrate cotransporter (SLC13A5)	OTPH1TA7	S13A5_HUMAN	Decreases Response To Substance	[153]
Interferon alpha-1/13 (IFNA1)	OTPMKY0L	IFNA1_HUMAN	Increases Abundance	[8]
SPARC (SPARC)	OTPN90H0	SPRC_HUMAN	Increases Response To Substance	[154]
M-phase inducer phosphatase 3 (CDC25C)	OTPQI71S	MPIP3_HUMAN	Affects Response To Substance	[36]
Protein C-mannosyl-transferase DPY19L1 (DPY19L1)	OTPULBDX	D19L1_HUMAN	Affects Response To Substance	[35]
Transcription factor SOX-18 (SOX18)	OTPUMHWA	SOX18_HUMAN	Affects Response To Substance	[35]
Copper-transporting ATPase 2 (ATP7B)	OTPWLNCO	ATP7B_HUMAN	Increases Response To Substance	[133]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Affects Response To Substance	[35]
Centromere protein U (CENPU)	OTQ4TZRS	CENPU_HUMAN	Affects Response To Substance	[36]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Affects Response To Substance	[35]
Angiopoietin-related protein 4 (ANGPTL4)	OTQL5SPX	ANGL4_HUMAN	Affects Response To Substance	[35]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Decreases Response To Substance	[155]
E3 ubiquitin-protein ligase RNF34 (RNF34)	OTQY58LU	RNF34_HUMAN	Decreases Response To Substance	[156]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI)	OTR443C5	BGH3_HUMAN	Affects Response To Substance	[35]
Kelch-like protein 9 (KLHL9)	OTRGEG3Z	KLHL9_HUMAN	Affects Response To Substance	[35]
LIM domain kinase 2 (LIMK2)	OTRJD7VZ	LIMK2_HUMAN	Affects Response To Substance	[35]
Large ribosomal subunit protein eL6 (RPL6)	OTRU71O4	RL6_HUMAN	Decreases Response To Substance	[157]
Perilipin-2 (PLIN2)	OTRXJ9UN	PLIN2_HUMAN	Affects Response To Substance	[35]
MHC class I polypeptide-related sequence B (MICB)	OTS2DVDW	MICB_HUMAN	Affects Response To Substance	[35]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)	OTSBQR6D	PLCG1_HUMAN	Decreases Response To Substance	[158]
Thymosin beta-15A (TMSB15A)	OTSBWCES	TB15A_HUMAN	Affects Response To Substance	[128]
Protein phosphatase 1 regulatory subunit 1B (PPP1R1B)	OTSIJMQ9	PPR1B_HUMAN	Increases Response To Substance	[159]
Formin-binding protein 1 (FNBP1)	OTSJ5KKA	FNBP1_HUMAN	Affects Response To Substance	[35]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)	OTSMGKXQ	EBP_HUMAN	Affects Response To Substance	[36]
Interleukin-27 receptor subunit alpha (IL27RA)	OTSQBAKI	I27RA_HUMAN	Affects Response To Substance	[35]
Rhotekin (RTKN)	OTSS8XR6	RTKN_HUMAN	Decreases Response To Substance	[160]
Procollagen C-endopeptidase enhancer 2 (PCOLCE2)	OTSUEQZ1	PCOC2_HUMAN	Affects Response To Substance	[35]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Affects Response To Substance	[35]
Cdc42 effector protein 1 (CDC42EP1)	OTT525WA	BORG5_HUMAN	Affects Response To Substance	[35]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Affects Response To Substance	[35]
Nucleophosmin (NPM1)	OTTBYYT0	NPM_HUMAN	Decreases Response To Substance	[161]
Selenide, water dikinase 2 (SEPHS2)	OTTFXROR	SPS2_HUMAN	Affects Response To Substance	[35]
DNA polymerase alpha subunit B (POLA2)	OTTWQ73N	DPOA2_HUMAN	Affects Response To Substance	[36]
EH domain-containing protein 2 (EHD2)	OTTX391J	EHD2_HUMAN	Affects Response To Substance	[35]
Protein enabled homolog (ENAH)	OTU49OK5	ENAH_HUMAN	Affects Response To Substance	[35]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Affects Response To Substance	[35]
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)	OTUG4BWA	PAHX_HUMAN	Affects Response To Substance	[35]
Leupaxin (LPXN)	OTUNV3CK	LPXN_HUMAN	Affects Response To Substance	[36]
AT-rich interactive domain-containing protein 5B (ARID5B)	OTUQ4CQY	ARI5B_HUMAN	Affects Response To Substance	[35]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Affects Response To Substance	[35]
Cysteine and glycine-rich protein 1 (CSRP1)	OTUS7RM2	CSRP1_HUMAN	Affects Response To Substance	[35]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Affects Response To Substance	[36]
Acyl-CoA (FADS1)	OTUYOYHX	FADS1_HUMAN	Affects Response To Substance	[35]
Histone deacetylase 2 (HDAC2)	OTUYVFKN	HDAC2_HUMAN	Increases Response To Substance	[155]
Nucleolysin TIAR (TIAL1)	OTV2KFZH	TIAR_HUMAN	Affects Response To Substance	[36]
Lymphocyte antigen 6 complex locus protein G6c (LY6G6C)	OTV7F59X	LY66C_HUMAN	Affects Response To Substance	[35]
ATP-binding cassette sub-family C member 11 (ABCC11)	OTVHL7OR	MRP8_HUMAN	Decreases Response To Substance	[162]
Megakaryocyte and platelet inhibitory receptor G6b (MPIG6B)	OTVNKQWA	G6B_HUMAN	Affects Response To Substance	[35]
GTP-binding protein Rit1 (RIT1)	OTVNOGOH	RIT1_HUMAN	Affects Response To Substance	[35]
Abasic site processing protein HMCES (HMCES)	OTVRDL6U	HMCES_HUMAN	Affects Response To Substance	[36]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Affects Response To Substance	[35]
Folylpolyglutamate synthase, mitochondrial (FPGS)	OTW3F1ZE	FOLC_HUMAN	Increases Response To Substance	[163]
Fanconi anemia group I protein (FANCI)	OTW8E3SC	FANCI_HUMAN	Affects Response To Substance	[36]
Retrotransposon-derived protein PEG10 (PEG10)	OTWD2278	PEG10_HUMAN	Affects Response To Substance	[35]
Periostin (POSTN)	OTWP62UA	POSTN_HUMAN	Decreases Response To Substance	[164]
Acyl-coenzyme A thioesterase 13 (ACOT13)	OTWRUST1	ACO13_HUMAN	Affects Response To Substance	[35]
DNA primase small subunit (PRIM1)	OTWWP8Y6	PRI1_HUMAN	Affects Response To Substance	[36]
Amyloid-beta A4 precursor protein-binding family A member 2 (APBA2)	OTXD8ID1	APBA2_HUMAN	Affects Response To Substance	[35]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Affects Response To Substance	[35]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Increases Abundance	[8]
Peptidyl-prolyl cis-trans isomerase FKBP11 (FKBP11)	OTY2GC67	FKB11_HUMAN	Affects Response To Substance	[35]
Adhesion G-protein coupled receptor G6 (ADGRG6)	OTY2UBXO	AGRG6_HUMAN	Affects Response To Substance	[35]
Class E basic helix-loop-helix protein 41 (BHLHE41)	OTY9GJ1Y	BHE41_HUMAN	Affects Response To Substance	[35]
Serine/threonine-protein kinase TAO3 (TAOK3)	OTYBATSH	TAOK3_HUMAN	Affects Response To Substance	[36]
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1)	OTYEJAGZ	GPT_HUMAN	Affects Response To Substance	[35]
Glia-derived nexin (SERPINE2)	OTYF5340	GDN_HUMAN	Increases ADR	[141]
Chloride intracellular channel protein 1 (CLIC1)	OTYLFWNG	CLIC1_HUMAN	Affects Response To Substance	[35]
Interferon beta (IFNB1)	OTYQGUB5	IFNB_HUMAN	Increases Response To Substance	[165]
Galectin-3 (LGALS3)	OTYQT0ZI	LEG3_HUMAN	Decreases Response To Substance	[166]
ADP-ribosylation factor 3 (ARF3)	OTYYQX85	ARF3_HUMAN	Affects Response To Substance	[36]
Selenide, water dikinase 1 (SEPHS1)	OTZ19I59	SPS1_HUMAN	Affects Response To Substance	[35]
Glutathione S-transferase A4 (GSTA4)	OTZ1USIA	GSTA4_HUMAN	Affects Response To Substance	[35]
Thiosulfate sulfurtransferase (TST)	OTZ4F5LK	THTR_HUMAN	Affects Response To Substance	[36]
Erythropoietin (EPO)	OTZ90CN4	EPO_HUMAN	Increases Response To Substance	[167]
Fermitin family homolog 2 (FERMT2)	OTZNPWWX	FERM2_HUMAN	Affects Response To Substance	[35]
Pro-neuregulin-1, membrane-bound isoform (NRG1)	OTZO6F1X	NRG1_HUMAN	Affects Response To Substance	[35]
Latexin (LXN)	OTZQ2M6Y	LXN_HUMAN	Affects Response To Substance	[35]
Multidrug and toxin extrusion protein 1 (SLC47A1)	OTZX0U5Q	S47A1_HUMAN	Affects Response To Substance	[35]

Indication(s) of Erlotinib

Disease Entry	ICD 11	Status	REF
Adrenal gland neoplasm	N.A.	Approved	[6]
Adult hepatocellular carcinoma	N.A.	Approved	[6]
Brain cancer	2A00	Approved	[6]
Esophageal disorder	N.A.	Approved	[6]
Lung cancer	2C25.0	Approved	[6]
Non-small-cell lung cancer	2C25.Y	Approved	[7]
Pancreatic adenocarcinoma	N.A.	Approved	[6]
Psoriasis	EA90	Approved	[6]
Salivary gland squamous cell carcinoma	N.A.	Approved	[6]
Pancreatic cancer	2C10	Phase 3	[7]
Colon cancer	2B90.Z	Phase 2	[7]
Ependymoma	2A00.0Y	Investigative	[6]
Neoplastic meningitis	N.A.	Investigative	[6]
Neuroblastoma	2D11.2	Investigative	[6]

Erlotinib Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Epidermal growth factor receptor (EGFR)	TTGKNB4	EGFR_HUMAN	Inhibitor	[168]

Erlotinib Interacts with 2 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[169]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[170]

Erlotinib Interacts with 4 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[171]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[172]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[172]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[172]

Erlotinib Interacts with 1 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Increases Response	[173]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adenocarcinoma	DC0PXP4	DLD1	Investigative	[174]
Ewing sarcoma-peripheral primitive neuroectodermal tumour	DC6GJ5O	ES2	Investigative	[174]
Breast and ovarian cancer syndrome	DCW2L30	UWB1289	Investigative	[175]
Breast and ovarian cancer syndrome	DCMSHKT	UWB1289+BRCA1	Investigative	[175]
Breast carcinoma	DCWW9WK	KPL1	Investigative	[175]
Breast carcinoma	DCISOID	OCUBM	Investigative	[175]
Colon adenocarcinoma	DCW622Q	LOVO	Investigative	[175]
Colon carcinoma	DCPS2ZQ	RKO	Investigative	[175]
Invasive ductal carcinoma	DCTZ8JI	T-47D	Investigative	[175]
Rectal adenocarcinoma	DCGU6MD	SW837	Investigative	[175]
Adenocarcinoma	DCRDQ10	CAOV3	Investigative	[1]
Adenocarcinoma	DCVWULN	OVCAR3	Investigative	[1]
Adenocarcinoma	DCYAQ85	A427	Investigative	[1]
Adenocarcinoma	DC1FKDB	NCIH1650	Investigative	[1]
Adenocarcinoma	DCQLUV5	NCIH2122	Investigative	[1]
Adenocarcinoma	DC3DZHV	NCIH23	Investigative	[1]
Adenocarcinoma	DCGPT6R	NCIH520	Investigative	[1]
Adenocarcinoma	DCZZ5XF	COLO320DM	Investigative	[1]
Adenocarcinoma	DCQVIX9	HCT116	Investigative	[1]
Adenocarcinoma	DCA04XA	SW-620	Investigative	[1]
Germ cell tumour	DC48752	PA1	Investigative	[1]
Malignant melanoma	DCJUCAV	A375	Investigative	[1]
Malignant melanoma	DC3I5GN	RPMI7951	Investigative	[1]
Malignant melanoma	DC3GSPS	SKMEL30	Investigative	[1]
Malignant melanoma	DCSUB9D	UACC62	Investigative	[1]
Mesothelioma	DCEYIS9	MSTO	Investigative	[1]
Non small cell carcinoma	DCSC54Z	SKMES1	Investigative	[1]
Ovarian endometrioid adenocarcinoma	DCFE5XZ	A2780	Investigative	[1]
Ovarian serous cystadenocarcinoma	DCDM2MA	SK-OV-3	Investigative	[1]

References

• [1] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [2] Fluorouracil FDA Label
• [3] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [4] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [5] Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
• [6] Erlotinib FDA Label
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4920).
• [8] Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines. J Gastroenterol. 2006 Feb;41(2):140-50.
• [9] Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols. Mol Cancer. 2004 Apr 26;3:11.
• [10] Thymidylate synthase pharmacogenetics. Invest New Drugs. 2005 Dec;23(6):533-7. doi: 10.1007/s10637-005-4021-7.
• [11] Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil. Biochem Biophys Res Commun. 2007 Nov 9;363(1):216-22. doi: 10.1016/j.bbrc.2007.08.164. Epub 2007 Sep 6.
• [12] Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
• [13] Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray. Cancer Lett. 2004 Oct 8;214(1):19-33.
• [14] Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
• [15] Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
• [16] Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Int J Cancer. 2006 Sep 1;119(5):1164-75.
• [17] Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
• [18] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [19] Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. Int J Oncol. 2007 Dec;31(6):1491-500.
• [20] Expression profiling of nucleotide metabolism-related genes in human breast cancer cells after treatment with 5-fluorouracil. Cancer Invest. 2009 Jun;27(5):561-7.
• [21] Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
• [22] New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20.
• [23] Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
• [24] Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
• [25] Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. Biochem Pharmacol. 2015 Nov 1;98(1):51-68. doi: 10.1016/j.bcp.2015.08.105. Epub 2015 Aug 24.
• [26] Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase. Cancer Res. 2006 Sep 1;66(17):8829-37. doi: 10.1158/0008-5472.CAN-06-0540.
• [27] Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reprod Toxicol. 2020 Jan;91:74-91. doi: 10.1016/j.reprotox.2019.10.004. Epub 2019 Nov 8.
• [28] Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
• [29] Novel proapoptotic agent SM-1 enhances the inhibitory effect of 5-fluorouracil on colorectal cancer cells in vitro and in vivo. Oncol Lett. 2017 Jun;13(6):4762-4768. doi: 10.3892/ol.2017.6043. Epub 2017 Apr 19.
• [30] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [31] Identification of XAF1-MT2A mutual antagonism as a molecular switch in cell-fate decisions under stressful conditions. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5683-5688. doi: 10.1073/pnas.1700861114. Epub 2017 May 15.
• [32] 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Anticancer Res. 2005 Sep-Oct;25(5):3271-8.
• [33] Rare sugar D-allose enhances anti-tumor effect of 5-fluorouracil on the human hepatocellular carcinoma cell line HuH-7. J Biosci Bioeng. 2008 Sep;106(3):248-52. doi: 10.1263/jbb.106.248.
• [34] The previously undescribed ZKSCAN3 (ZNF306) is a novel "driver" of colorectal cancer progression. Cancer Res. 2008 Jun 1;68(11):4321-30. doi: 10.1158/0008-5472.CAN-08-0407.
• [35] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [36] Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells. Cancer Res. 2004 Nov 15;64(22):8167-76. doi: 10.1158/0008-5472.CAN-04-0970.
• [37] Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14-3-3/NF-B feedback loop. J Exp Clin Cancer Res. 2018 Dec 20;37(1):321. doi: 10.1186/s13046-018-1005-y.
• [38] Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer. Sci Transl Med. 2011 Jan 26;3(67):67ra7. doi: 10.1126/scitranslmed.3001922.
• [39] HCRP1 inhibits cell proliferation and invasion and promotes chemosensitivity in esophageal squamous cell carcinoma. Chem Biol Interact. 2019 Aug 1;308:357-363. doi: 10.1016/j.cbi.2019.05.032. Epub 2019 May 29.
• [40] The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors. Cancer Chemother Pharmacol. 2004 Apr;53(4):296-304.
• [41] Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells. Eur J Cancer. 2002 Jun;38(9):1271-7.
• [42] Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
• [43] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [44] Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
• [45] Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8.
• [46] ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
• [47] Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 2007 Jul-Aug;27(4B):2241-9.
• [48] Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
• [49] 5-Fluorouracil toxicity-attributable IVS14 + 1G > A mutation of the dihydropyrimidine dehydrogenase gene in Polish colorectal cancer patients. Pharmacol Rep. 2008 Mar-Apr;60(2):238-42.
• [50] 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65.
• [51] PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150653776)
• [52] Orotate phosphoribosyltransferase is overexpressed in malignant pleural mesothelioma: Dramatically responds one case in high OPRT expression. Rare Dis. 2016 Apr 5;4(1):e1165909.
• [53] Uridine phosphorylase in breast cancer: a new prognostic factor? Front Biosci. 2006 Sep 1;11:2759-66.
• [54] Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine. Cancer Gene Ther. 2000 Jul;7(7):1015-22.
• [55] Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur. Jpn J Cancer Res. 2001 May;92(5):524-8. doi: 10.1111/j.1349-7006.2001.tb01125.x.
• [56] Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol. 2005 Mar 1;23(7):1365-9. doi: 10.1200/JCO.2005.06.219.
• [57] Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity. Eur J Cancer. 1997 Nov;33(13):2258-64. doi: 10.1016/s0959-8049(97)00261-x.
• [58] Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in a colon cancer cell line. J Gastroenterol. 2006 Dec;41(12):1149-57.
• [59] Schedule-dependent therapeutic effects of gemcitabine combined with uracil-tegafur in a human pancreatic cancer xenograft model. Pancreas. 2006 Aug;33(2):142-7. doi: 10.1097/01.mpa.0000226882.48204.26.
• [60] Mechanism of apoptotic effects induced by 5-fluorouracil on human liver carcinoma Bel7402 cell line. Chin Med J (Engl). 2002 Jul;115(7):968-71.
• [61] 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
• [62] Regulation of human peptide transporter 1 (PEPT1) in gastric cancer cells by anticancer drugs. Cancer Lett. 2005 Dec 8;230(1):72-80.
• [63] Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling. Oncogene. 2008 Dec 4;27(57):7212-22.
• [64] 5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53. Oncotarget. 2015 Dec 22;6(41):43679-97. doi: 10.18632/oncotarget.6030.
• [65] Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors. Cancer Res. 2007 Aug 15;67(16):7917-22. doi: 10.1158/0008-5472.CAN-07-0133.
• [66] p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. J Biol Chem. 2004 May 14;279(20):21183-92. doi: 10.1074/jbc.M311912200. Epub 2004 Mar 11.
• [67] Partial contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferon-alpha/5-fluorouracil against Hepatocellular Carcinoma. Clin Cancer Res. 2004 Dec 1;10(23):7884-95. doi: 10.1158/1078-0432.CCR-04-0794.
• [68] Transcriptional repression of IKK by p53 in arsenite-induced GADD45 accumulation and apoptosis. Oncogene. 2019 Jan;38(5):731-746. doi: 10.1038/s41388-018-0478-7. Epub 2018 Sep 3.
• [69] Combination therapy of interferon-alpha and 5-fluorouracil inhibits tumor angiogenesis in human hepatocellular carcinoma cells by regulating vascular endothelial growth factor and angiopoietins. Oncol Rep. 2007 Oct;18(4):801-9.
• [70] p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines. Mol Cell Biol. 2008 Nov;28(21):6557-67. doi: 10.1128/MCB.01202-08. Epub 2008 Sep 8.
• [71] Role of the Fas/FasL pathway in combination therapy with interferon-alpha and fluorouracil against hepatocellular carcinoma in vitro. J Hepatol. 2007 Jan;46(1):77-88. doi: 10.1016/j.jhep.2006.07.032. Epub 2006 Sep 25.
• [72] Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins. Toxicol In Vitro. 2018 Feb;46:284-293. doi: 10.1016/j.tiv.2017.10.019. Epub 2017 Oct 17.
• [73] Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
• [74] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [75] [Expression of APRIL in colorectal carcinoma tissues and effects of chemotherapeutic agents on APRIL expression in colorectal carcinoma SW480 cells]. Ai Zheng. 2008 Apr;27(4):369-73.
• [76] 5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells. J Toxicol Sci. 2018;43(12):727-734. doi: 10.2131/jts.43.727.
• [77] Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
• [78] Dynamic monitoring of cardio-specific markers and markers of thyroid gland function in cancer patients--a pilot study. Anticancer Res. 2007 Jul-Aug;27(4A):1883-6.
• [79] Topical fluorouracil for actinic keratoses and photoaging: a clinical and molecular analysis. Arch Dermatol. 2009 Jun;145(6):659-66. doi: 10.1001/archdermatol.2009.97.
• [80] Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53. Cancer Biol Ther. 2008 Aug;7(8):1305-12. doi: 10.4161/cbt.7.8.6302. Epub 2008 Aug 16.
• [81] Thrombogenicity of intravenous 5-fluorouracil alone or in combination with cisplatin. Cancer. 1990 Feb 15;65(4):885-9. doi: 10.1002/1097-0142(19900215)65:4<885::aid-cncr2820650410>3.0.co;2-h.
• [82] Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo. Nucleic Acids Res. 2007;35(2):550-8. doi: 10.1093/nar/gkl1084. Epub 2006 Dec 14.
• [83] Fluorouracil induces apoptosis and surface molecule modulation of peripheral blood leukocytes. Clin Lab Haematol. 2004 Oct;26(5):327-33. doi: 10.1111/j.1365-2257.2004.00629.x.
• [84] Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer. Chem Biol Interact. 2018 Aug 1;291:16-28. doi: 10.1016/j.cbi.2018.06.001. Epub 2018 Jun 5.
• [85] P38 MAPK, NF-B, and JAK-STAT3 Signaling Pathways Involved in Capecitabine-Induced Hand-Foot Syndrome via Interleukin 6 or Interleukin 8 Abnormal Expression. Chem Res Toxicol. 2022 Mar 21;35(3):422-430. doi: 10.1021/acs.chemrestox.1c00317. Epub 2022 Feb 11.
• [86] The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling. J Biol Chem. 2009 Feb 13;284(7):4343-53. doi: 10.1074/jbc.M805570200. Epub 2008 Dec 18.
• [87] p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation. Oral Oncol. 1998 Nov;34(6):529-37. doi: 10.1016/s1368-8375(98)00036-0.
• [88] Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells. Int J Cancer. 2010 May 15;126(10):2457-68. doi: 10.1002/ijc.24943.
• [89] The optimal schedule for 5-fluorouracil radiosensitization in colon cancer cell lines. Oncol Rep. 2006 Nov;16(5):1085-91.
• [90] Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil. Cancer Res. 2008 Sep 1;68(17):7035-41. doi: 10.1158/0008-5472.CAN-07-6496.
• [91] Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells. Acta Biochim Biophys Sin (Shanghai). 2008 Sep;40(9):819-29.
• [92] DNA damaging drugs-induced down-regulation of Bcl-2 is essential for induction of apoptosis in high-risk HPV-positive HEp-2 and KB cells. Cancer Lett. 2006 May 18;236(2):213-21. doi: 10.1016/j.canlet.2005.05.024. Epub 2005 Jul 5.
• [93] Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines. Oncol Rep. 2007 Jun;17(6):1461-7.
• [94] The up-regulation of type I interferon receptor gene plays a key role in hepatocellular carcinoma cells in the synergistic antiproliferative effect by 5-fluorouracil and interferon-alpha. Int J Oncol. 2006 Dec;29(6):1469-78.
• [95] Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
• [96] Adjuvant therapy with -tocopherol-induce apoptosis in HT-29 colon cancer via cyclin-dependent cell cycle arrest mechanism. J Biochem Mol Toxicol. 2019 Nov;33(11):e22399. doi: 10.1002/jbt.22399. Epub 2019 Oct 6.
• [97] 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells. Biochem Biophys Res Commun. 2000 Jul 14;273(3):1168-74. doi: 10.1006/bbrc.2000.3072.
• [98] Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs. Toxicol In Vitro. 2013 Dec;27(8):2256-63. doi: 10.1016/j.tiv.2013.09.020. Epub 2013 Oct 2.
• [99] MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress. Biochem Biophys Res Commun. 2010 Aug 27;399(3):324-30. doi: 10.1016/j.bbrc.2010.06.133. Epub 2010 Jul 17.
• [100] Constitutive expression of interleukin-18 in head and neck squamous carcinoma cells. Head Neck. 2004 Jun;26(6):494-503. doi: 10.1002/hed.20011.
• [101] Predictive value of GADD153, p21 and c-Jun for chemotherapy response in gastric cancer. Cancer Sci. 2007 May;98(5):707-15. doi: 10.1111/j.1349-7006.2007.00435.x. Epub 2007 Mar 9.
• [102] Development and applications of a real-time quantitative RT-PCR method (QRT-PCR) for BRCA1 mRNA. Clin Biochem. 2005 Jan;38(1):50-7. doi: 10.1016/j.clinbiochem.2004.09.012.
• [103] Regulation of p53 stability and function in HCT116 colon cancer cells. J Biol Chem. 2004 Feb 27;279(9):7598-605. doi: 10.1074/jbc.M311732200. Epub 2003 Dec 9.
• [104] The differential effects of cyclophosphamide, epirubicin and 5-fluorouracil on apoptotic marker (CPP-32), pro-apoptotic protein (p21(WAF-1)) and anti-apoptotic protein (bcl-2) in breast cancer cells. Breast Cancer Res Treat. 2003 Aug;80(3):239-44. doi: 10.1023/A:1024995202135.
• [105] TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther. 2008 Dec;7(12):2034-8. doi: 10.4161/cbt.7.12.7460.
• [106] Stunning and its effect on 3H-FDG uptake and key gene expression in breast cancer cells undergoing chemotherapy. J Nucl Med. 2006 Apr;47(4):603-8.
• [107] Cadmium modifies the cell cycle and apoptotic profiles of human breast cancer cells treated with 5-fluorouracil. Int J Mol Sci. 2013 Aug 12;14(8):16600-16. doi: 10.3390/ijms140816600.
• [108] Different responses to 5-fluoraouracil in mutagenicity and gene expression between two human lymphoblastoid cell lines with or without TP53 mutation. Acta Med Okayama. 2012;66(2):119-29. doi: 10.18926/AMO/48262.
• [109] The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells. Mol Cancer Res. 2008 Jun;6(6):990-5. doi: 10.1158/1541-7786.MCR-07-2217.
• [110] Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
• [111] Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell. J Gene Med. 2009 Jan;11(1):3-13. doi: 10.1002/jgm.1270.
• [112] Enhanced Bax in oral SCC in relation to antitumor effects of chemotherapy. J Oral Pathol Med. 2005 Feb;34(2):93-9. doi: 10.1111/j.1600-0714.2004.00257.x.
• [113] gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res. 2009 Jan 15;69(2):573-82. doi: 10.1158/0008-5472.CAN-08-2088.
• [114] Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may?involve inhibition of the Hedgehog signaling pathway. Mol Med Rep. 2014 Nov;10(5):2563-7. doi: 10.3892/mmr.2014.2511. Epub 2014 Aug 21.
• [115] YB-1 facilitates basal and 5-fluorouracil-inducible expression of the human major vault protein (MVP) gene. Oncogene. 2005 May 19;24(22):3606-18. doi: 10.1038/sj.onc.1208386.
• [116] An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC?inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells. Chem Biol Interact. 2016 Jun 25;253:112-24. doi: 10.1016/j.cbi.2016.05.008. Epub 2016 May 6.
• [117] GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria. Cell Death Differ. 2011 May;18(5):874-86. doi: 10.1038/cdd.2010.153. Epub 2010 Dec 3.
• [118] Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs. Cancer Biol Ther. 2006 Apr;5(4):380-5. doi: 10.4161/cbt.5.4.2477. Epub 2006 Apr 4.
• [119] Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis. Mol Immunol. 2008 Mar;45(5):1470-6. doi: 10.1016/j.molimm.2007.08.013. Epub 2007 Oct 24.
• [120] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [121] Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. Mol Cancer. 2011 Apr 13;10:37. doi: 10.1186/1476-4598-10-37.
• [122] Characterization of 5-fluorouracil-resistant cholangiocarcinoma cell lines. Chemotherapy. 2008;54(5):343-51. doi: 10.1159/000151541. Epub 2008 Aug 21.
• [123] Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response. Int J Cancer. 2006 Jul 15;119(2):406-13. doi: 10.1002/ijc.21843.
• [124] Antiapoptotic protein partners fortilin and MCL1 independently protect cells from 5-fluorouracil-induced cytotoxicity. J Biol Chem. 2004 Sep 24;279(39):40868-75. doi: 10.1074/jbc.M401454200. Epub 2004 Jul 15.
• [125] Down-regulation of CYLD as a trigger for NF-B activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells. Int J Oncol. 2011 Jan;38(1):121-31.
• [126] Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma Res. 2005 Oct;15(5):357-62. doi: 10.1097/00008390-200510000-00003.
• [127] [Correlation of sorcin overexpression to multidrug resistance of human gastric cancer cell line SGC7901]. Ai Zheng. 2008 Apr;27(4):337-42.
• [128] Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil. Int J Oncol. 2004 May;24(5):1279-88.
• [129] Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites. Mol Cancer Res. 2009 Jun;7(6):897-906. doi: 10.1158/1541-7786.MCR-08-0519. Epub 2009 May 26.
• [130] CD40 signaling activated by agonistic anti-CD40 monoclonal antibody 5C11 has different effects on biological behavior of gastric carcinoma cells. Immunol Lett. 2010 Jul 8;131(2):120-5. doi: 10.1016/j.imlet.2010.02.007. Epub 2010 Feb 25.
• [131] Expression of rTSbeta as a 5-fluorouracil resistance marker in patients with primary breast cancer. Oncol Rep. 2008 Apr;19(4):881-8.
• [132] Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6239-47. doi: 10.1158/1078-0432.CCR-04-0242.
• [133] Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors. Cancer Res. 2008 Jul 1;68(13):4977-82. doi: 10.1158/0008-5472.CAN-07-6770.
• [134] Epidermal growth factor receptor vIII enhances tumorigenicity and resistance to 5-fluorouracil in human hepatocellular carcinoma. Cancer Lett. 2009 Jun 28;279(1):30-8. doi: 10.1016/j.canlet.2009.01.019. Epub 2009 Feb 12.
• [135] Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene. 2007 Jun 28;26(30):4383-93. doi: 10.1038/sj.onc.1210215. Epub 2007 Jan 22.
• [136] Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells. Br J Cancer. 2005 Jul 25;93(2):233-41. doi: 10.1038/sj.bjc.6602663.
• [137] [Knock-down of apollon gene by antisense oligodeoxynucleotide inhibits the proliferation of Lovo cells and enhances chemo-sensitivity]. Yao Xue Xue Bao. 2011 Feb;46(2):138-45.
• [138] Overexpression and significance of prion protein in gastric cancer and multidrug-resistant gastric carcinoma cell line SGC7901/ADR. Int J Cancer. 2005 Jan 10;113(2):213-20. doi: 10.1002/ijc.20570.
• [139] A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants. J Microbiol Methods. 2011 Dec;87(3):363-7. doi: 10.1016/j.mimet.2011.10.003. Epub 2011 Oct 8.
• [140] Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology. 2008 Oct;135(4):1358-1368, 1368.e1-4. doi: 10.1053/j.gastro.2008.06.082. Epub 2008 Jul 3.
• [141] Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Cancer Sci. 2013 Aug;104(8):1074-82. doi: 10.1111/cas.12186. Epub 2013 Jun 10.
• [142] Decreased expression of hMLH1 correlates with reduced 5-fluorouracil-mediated apoptosis in colon cancer cells. Oncol Rep. 2007 Nov;18(5):1129-37.
• [143] Silencing of keratinocyte growth factor receptor restores 5-fluorouracil and tamoxifen efficacy on responsive cancer cells. PLoS One. 2008 Jun 25;3(6):e2528. doi: 10.1371/journal.pone.0002528.
• [144] Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer. Oncol Rep. 2008 Nov;20(5):1165-72.
• [145] Detection of potassium currents and regulation of multidrug resistance by potassium channels in human gastric cancer cells. Cell Biol Int. 2007 Jul;31(7):741-7. doi: 10.1016/j.cellbi.2007.01.008. Epub 2007 Jan 21.
• [146] Tudor staphylococcal nuclease drives chemoresistance of non-small cell lung carcinoma cells by regulating S100A11. Oncotarget. 2015 May 20;6(14):12156-73. doi: 10.18632/oncotarget.3495.
• [147] Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis. Cell Mol Life Sci. 2007 May;64(9):1137-44. doi: 10.1007/s00018-007-6510-7.
• [148] Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma. Cancer Sci. 2006 Dec;97(12):1388-95. doi: 10.1111/j.1349-7006.2006.00333.x. Epub 2006 Oct 9.
• [149] Interferon-gamma sensitizes hepatitis B virus-expressing hepatocarcinoma cells to 5-fluorouracil through inhibition of hepatitis B virus-mediated nuclear factor-kappaB activation. Cancer Sci. 2007 Nov;98(11):1758-66. doi: 10.1111/j.1349-7006.2007.00591.x. Epub 2007 Aug 16.
• [150] Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
• [151] Alterations in the glycolipid composition and cellular properties of ovarian carcinoma-derived RMG-1 cells on transfection of the alpha1,2-fucosyltransferase gene. Cancer Sci. 2005 Jan;96(1):26-30. doi: 10.1111/j.1349-7006.2005.00005.x.
• [152] Inactivating mutation of the pro-apoptotic gene BID in gastric cancer. J Pathol. 2004 Apr;202(4):439-45. doi: 10.1002/path.1532.
• [153] Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells. Toxicol Appl Pharmacol. 2020 Sep 1;402:115117. doi: 10.1016/j.taap.2020.115117. Epub 2020 Jul 4.
• [154] Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy. J Clin Invest. 2005 Jun;115(6):1492-502. doi: 10.1172/JCI23002. Epub 2005 May 12.
• [155] The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil. Cell Biol Toxicol. 2023 Oct;39(5):2401-2419. doi: 10.1007/s10565-022-09731-3. Epub 2022 May 24.
• [156] Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells. Anticancer Res. 2005 Jul-Aug;25(4):2737-41.
• [157] Regulation of multidrug resistance by ribosomal protein l6 in gastric cancer cells. Cancer Biol Ther. 2005 Feb;4(2):242-7. doi: 10.4161/cbt.4.2.1477. Epub 2005 Feb 20.
• [158] Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA. Chin Med J (Engl). 2007 May 5;120(9):749-54.
• [159] Reversal of multidrug resistance of vincristine-resistant gastric adenocarcinoma cells through up-regulation of DARPP-32. Cell Biol Int. 2007 Sep;31(9):1010-5. doi: 10.1016/j.cellbi.2007.03.020. Epub 2007 Mar 21.
• [160] Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. Oncogene. 2004 Nov 18;23(54):8731-42. doi: 10.1038/sj.onc.1208106.
• [161] Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
• [162] ABCC11 expression is regulated by estrogen in MCF7 cells, correlated with estrogen receptor alpha expression in postmenopausal breast tumors and overexpressed in tamoxifen-resistant breast cancer cells. Endocr Relat Cancer. 2008 Mar;15(1):125-38. doi: 10.1677/ERC-07-0189.
• [163] Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate. Gut. 2004 Dec;53(12):1825-31. doi: 10.1136/gut.2004.042713.
• [164] Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies. Carcinogenesis. 2005 May;26(5):908-15. doi: 10.1093/carcin/bgi034. Epub 2005 Feb 24.
• [165] Interferons upregulate thymidine phosphorylase expression via JAK-STAT-dependent transcriptional activation and mRNA stabilization in human glioblastoma cells. J Neurooncol. 2005 May;72(3):217-23. doi: 10.1007/s11060-004-3012-4.
• [166] Galectin-3 germline variant at position 191 enhances nuclear accumulation and activation of -catenin in gastric cancer. Clin Exp Metastasis. 2011 Dec;28(8):743-50. doi: 10.1007/s10585-011-9406-8. Epub 2011 Jul 13.
• [167] Recombinant human erythropoietin alpha targets intratumoral blood vessels, improving chemotherapy in human xenograft models. Cancer Res. 2005 Aug 15;65(16):7186-93. doi: 10.1158/0008-5472.CAN-04-2498.
• [168] Quantitative prediction of fold resistance for inhibitors of EGFR. Biochemistry. 2009 Sep 8;48(35):8435-48.
• [169] Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice. Mol Cancer Ther. 2008 Aug;7(8):2280-7.
• [170] Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy. Adv Drug Deliv Rev. 2009 Jan 31;61(1):26-33.
• [171] In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors. Drug Metab Dispos. 2014 Jul;42(7):1202-9.
• [172] Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.
• [173] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
• [174] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [175] Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.