Details of the Drug Combination

General Information of Drug Combination (ID: DCQEYCI)

• Drug Combination Name: Fluorouracil + Estramustine
• Indication: Breast carcinoma; Status: Investigative [1]
• Component Drugs:
  Fluorouracil (DMUM7HZ): Small molecular drug
  Estramustine (DMWTAOI): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: OCUBM
  Zero Interaction Potency (ZIP) Score: 3.36
  Bliss Independence Score: 7.08
  Loewe Additivity Score: 1.93
  LHighest Single Agent (HSA) Score: 9.16

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Fluorouracil

Disease Entry	ICD 11	Status	REF
Adenocarcinoma	2D40	Approved	[2]
Biliary tract cancer	2C17	Approved	[2]
Colon adenocarcinoma	N.A.	Approved	[2]
Esophageal squamous cell carcinoma	2E60.1	Approved	[2]
Gastric intestinal type adenocarcinoma	N.A.	Approved	[2]
Gastroesophageal junction adenocarcinoma	2B71	Approved	[2]
Metastasis from malignant tumor of colon	N.A.	Approved	[2]
Pancreatic adenocarcinoma	N.A.	Approved	[2]
Rectal adenocarcinoma	2B92	Approved	[2]
Rectum mucinous adenocarcinoma	N.A.	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Colon cancer	2B90.Z	Investigative	[2]
Colon mucinous adenocarcinoma	N.A.	Investigative	[2]
Colorectal cancer	2B91.Z	Investigative	[4]
Gastric cancer	2B72	Investigative	[2]
Tumour	2A00-2F9Z	Investigative	[5]

Fluorouracil Interacts with 4 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
TERT messenger RNA (TERT mRNA)	TTQY2EJ	TERT_HUMAN	.	[5]
Candida Thymidylate synthase (Candi TMP1)	TTU6BFZ	TYSY_CANAL	Inhibitor	[38]
Dihydrothymine dehydrogenase (DPYD)	TTZPS91	DPYD_HUMAN	Inhibitor	[39]
Thymidylate synthase messenger RNA (TYMS mRNA)	TTP1UKZ	TYSY_HUMAN	.	[5]

Fluorouracil Interacts with 8 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[40]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[41]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[42]
Organic anion transporter 2 (SLC22A7)	DT0OC1Q	S22A7_HUMAN	Substrate	[43]
Multidrug resistance-associated protein 3 (ABCC3)	DTQ3ZHF	MRP3_HUMAN	Substrate	[44]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[44]
Multidrug resistance-associated protein 5 (ABCC5)	DTYVM24	MRP5_HUMAN	Substrate	[44]
Equilibrative nucleoside transporter 1 (SLC29A1)	DTXD1TQ	S29A1_HUMAN	Substrate	[45]

Fluorouracil Interacts with 12 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[46]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Metabolism	[46]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[46]
Dihydrothymine dehydrogenase (DPYD)	DESOEW1	DPYD_HUMAN	Metabolism	[47]
Methylenetetrahydrofolate reductase (MTHFR)	DEOXTPZ	MTHR_HUMAN	Metabolism	[48]
Thymidine phosphorylase (TYMP)	DE4HCYL	TYPH_HUMAN	Metabolism	[48]
Amidophosphoribosyltransferase (GPAT)	DEMJ7R2	PUR1_HUMAN	Metabolism	[49]
Thymidylate synthase (TYMS)	DEASG0Q	TYSY_HUMAN	Metabolism	[48]
Uridine 5'-monophosphate synthase (UMPS)	DEWJYTE	UMPS_HUMAN	Metabolism	[50]
Uridine phosphorylase 1 (UPP1)	DEFZWAX	UPP1_HUMAN	Metabolism	[51]
Uridine phosphorylase 2 (UPP2)	DEBQ2WU	UPP2_HUMAN	Metabolism	[51]
Uracil phosphoribosyltransferase (UPRT)	DE20ETR	UPP_HUMAN	Metabolism	[52]

Fluorouracil Interacts with 1026 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Increases Chemical Synthesis	[53]
Methylenetetrahydrofolate reductase (MTHFR)	OTUBJSR7	MTHR_HUMAN	Increases Response To Substance	[54]
Dihydropyrimidine dehydrogenase (DPYD)	OTWRF2NR	DPYD_HUMAN	Increases Response To Substance	[55]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Expression	[56]
Equilibrative nucleoside transporter 1 (SLC29A1)	OTLOOZZS	S29A1_HUMAN	Increases Expression	[57]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Affects Response To Substance	[33]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Decreases Response To Substance	[44]
Solute carrier family 22 member 7 (SLC22A7)	OTKTNH1W	S22A7_HUMAN	Increases Transport	[43]
Glutathione S-transferase P (GSTP1)	OTLP0A0Y	GSTP1_HUMAN	Increases Expression	[10]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Increases Expression	[58]
Fanconi anemia group G protein (FANCG)	OT7MC8TZ	FANCG_HUMAN	Increases Expression	[7]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)	OTJKOMXE	BNI3L_HUMAN	Decreases Expression	[7]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Increases Expression	[7]
Annexin A4 (ANXA4)	OTUCRYXL	ANXA4_HUMAN	Decreases Expression	[7]
Thymidylate kinase (DTYMK)	OTJXYQYK	KTHY_HUMAN	Increases Expression	[7]
Flap endonuclease 1 (FEN1)	OT6QGG7O	FEN1_HUMAN	Increases Expression	[7]
Interleukin-1 receptor-associated kinase 1 (IRAK1)	OT133G8J	IRAK1_HUMAN	Increases Expression	[7]
UV excision repair protein RAD23 homolog B (RAD23B)	OT0PGOG3	RD23B_HUMAN	Increases Expression	[7]
Programmed cell death protein 4 (PDCD4)	OTZ6NXUX	PDCD4_HUMAN	Decreases Expression	[7]
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)	OTM3H5OA	MALT1_HUMAN	Increases Expression	[7]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Increases Expression	[59]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Increases Expression	[59]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[59]
Enoyl-CoA hydratase, mitochondrial (ECHS1)	OTS0593S	ECHM_HUMAN	Increases Expression	[59]
Spermine synthase (SMS)	OT8JYKNH	SPSY_HUMAN	Increases Expression	[59]
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Increases Expression	[59]
Thymosin beta-4 (TMSB4X)	OT9HPLP3	TYB4_HUMAN	Increases Expression	[59]
Large ribosomal subunit protein uL14 (RPL23)	OTXI1YLM	RL23_HUMAN	Increases Expression	[59]
Small ribosomal subunit protein eS28 (RPS28)	OT12IES1	RS28_HUMAN	Increases Expression	[59]
Thymosin beta-10 (TMSB10)	OTLVZ13T	TYB10_HUMAN	Increases Expression	[59]
FXYD domain-containing ion transport regulator 3 (FXYD3)	OT9PPRHE	FXYD3_HUMAN	Increases Expression	[59]
Cocaine esterase (CES2)	OTC647SQ	EST2_HUMAN	Increases Expression	[10]
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Decreases Expression	[10]
Regulator of G-protein signaling 16 (RGS16)	OTBKZASI	RGS16_HUMAN	Affects Expression	[10]
Securin (PTTG1)	OTIMYS4W	PTTG1_HUMAN	Decreases Expression	[10]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[10]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Increases Expression	[10]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[10]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[10]
Elastin (ELN)	OTFSO7PG	ELN_HUMAN	Affects Expression	[10]
Integrin beta-4 (ITGB4)	OT28UK84	ITB4_HUMAN	Decreases Expression	[10]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[10]
NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR)	OTPDCK1F	ADRO_HUMAN	Increases Expression	[10]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)	OTGP6GA4	NR4A1_HUMAN	Affects Expression	[10]
Corticotropin-releasing factor-binding protein (CRHBP)	OT9AB48G	CRHBP_HUMAN	Affects Expression	[10]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[10]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Affects Expression	[10]
DNA replication licensing factor MCM4 (MCM4)	OT19PNNG	MCM4_HUMAN	Affects Expression	[10]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Decreases Expression	[10]
Chitinase-3-like protein 1 (CHI3L1)	OT2Z7VJH	CH3L1_HUMAN	Increases Expression	[10]
L-dopachrome tautomerase (DCT)	OTYVNTBG	TYRP2_HUMAN	Affects Expression	[10]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[10]
Serine/threonine-protein kinase PLK1 (PLK1)	OTRZX45T	PLK1_HUMAN	Decreases Expression	[10]
GTP-binding protein GEM (GEM)	OT6SK8ZV	GEM_HUMAN	Affects Expression	[10]
DNA-binding protein inhibitor ID-3 (ID3)	OTUULW5Z	ID3_HUMAN	Increases Expression	[10]
Regulator of G-protein signaling 1 (RGS1)	OTGXJYMG	RGS1_HUMAN	Affects Expression	[10]
Dihydropyrimidinase-related protein 3 (DPYSL3)	OTINJV20	DPYL3_HUMAN	Affects Expression	[10]
Elongin-A (ELOA)	OTOQTF5K	ELOA1_HUMAN	Affects Expression	[10]
Squalene monooxygenase (SQLE)	OT0GGRDO	ERG1_HUMAN	Decreases Expression	[10]
Cyclin-dependent kinase 5 activator 1 (CDK5R1)	OTJELWK0	CD5R1_HUMAN	Affects Expression	[10]
Quinone oxidoreductase PIG3 (TP53I3)	OTSCM68G	QORX_HUMAN	Increases Expression	[10]
Probable carboxypeptidase X1 (CPXM1)	OTRCSQPG	CPXM1_HUMAN	Affects Expression	[10]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Decreases Expression	[10]
Epiphycan (EPYC)	OTTRI5WO	EPYC_HUMAN	Affects Expression	[10]
Collagen alpha-1(XII) chain (COL12A1)	OTHLTV53	COCA1_HUMAN	Decreases Expression	[10]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[10]
Spondin-1 (SPON1)	OTC06MY4	SPON1_HUMAN	Affects Expression	[10]
Ras-related protein Rab-21 (RAB21)	OTH3WGLG	RAB21_HUMAN	Affects Expression	[10]
Homeobox protein Hox-C11 (HOXC11)	OT8NMHM6	HXC11_HUMAN	Affects Expression	[11]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[11]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Increases Expression	[11]
Ribonucleoside-diphosphate reductase large subunit (RRM1)	OTXGQOR9	RIR1_HUMAN	Increases Expression	[11]
Serine/arginine-rich splicing factor 11 (SRSF11)	OTZSV6CZ	SRS11_HUMAN	Increases Expression	[11]
Unconventional myosin-Ie (MYO1E)	OTM9YSIZ	MYO1E_HUMAN	Increases Expression	[11]
Cleavage stimulation factor subunit 3 (CSTF3)	OT1Y7B5U	CSTF3_HUMAN	Increases Expression	[11]
Centromere protein Q (CENPQ)	OT3M6WAI	CENPQ_HUMAN	Increases Expression	[11]
Arginine/serine-rich coiled-coil protein 2 (RSRC2)	OTLE0KQM	RSRC2_HUMAN	Increases Expression	[11]
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1)	OTM3KHIE	ARFG1_HUMAN	Increases Expression	[11]
DNA damage-binding protein 2 (DDB2)	OTO8HVVB	DDB2_HUMAN	Increases Expression	[11]
Spermatogenesis-associated protein 25 (SPATA25)	OTJMFF0A	SPT25_HUMAN	Increases Expression	[11]
G-protein coupled receptor 35 (GPR35)	OTO23NRK	GPR35_HUMAN	Increases Expression	[11]
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B)	OTB41D5K	RPR1B_HUMAN	Increases Expression	[11]
Transcription factor 19 (TCF19)	OT7NKLF9	TCF19_HUMAN	Increases Expression	[11]
Mitogen-activated protein kinase 13 (MAPK13)	OT0W9GE7	MK13_HUMAN	Increases Expression	[12]
Eukaryotic translation initiation factor 3 subunit H (EIF3H)	OT61RBF5	EIF3H_HUMAN	Increases Expression	[12]
Mitotic checkpoint protein BUB3 (BUB3)	OTU91HAU	BUB3_HUMAN	Decreases Expression	[12]
Cytohesin-3 (CYTH3)	OTBXAT3Z	CYH3_HUMAN	Decreases Expression	[12]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10)	OTBURQ3A	NDUAA_HUMAN	Increases Expression	[12]
GTPase KRas (KRAS)	OT78QCN8	RASK_HUMAN	Decreases Expression	[12]
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)	OT47AK4C	HNRPC_HUMAN	Increases Expression	[12]
Histone H1.3 (H1-3)	OTT7VPRB	H13_HUMAN	Increases Expression	[12]
Cation-dependent mannose-6-phosphate receptor (M6PR)	OTFEWOSB	MPRD_HUMAN	Increases Expression	[12]
Long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADL)	OTP7Y0UF	ACADL_HUMAN	Increases Expression	[12]
Endoplasmic reticulum resident protein 29 (ERP29)	OTNKANMH	ERP29_HUMAN	Decreases Expression	[12]
Glutathione S-transferase theta-1 (GSTT1)	OTRFMWBK	GSTT1_HUMAN	Increases Expression	[12]
Large ribosomal subunit protein uL3 (RPL3)	OTX6VXLB	RL3_HUMAN	Decreases Expression	[12]
Aminomethyltransferase, mitochondrial (AMT)	OTQYEWZQ	GCST_HUMAN	Increases Expression	[12]
Translation initiation factor eIF2B subunit beta (EIF2B2)	OTQQMHM1	EI2BB_HUMAN	Decreases Expression	[12]
Adenosine 5'-monophosphoramidase HINT1 (HINT1)	OTQIR8LF	HINT1_HUMAN	Increases Expression	[12]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1)	OT62RL5P	BDH_HUMAN	Decreases Expression	[12]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA)	OT58PUEN	PP2BA_HUMAN	Increases Expression	[12]
Src substrate cortactin (CTTN)	OTJRG4ES	SRC8_HUMAN	Decreases Expression	[12]
Prostaglandin reductase 1 (PTGR1)	OTMAR351	PTGR1_HUMAN	Increases Expression	[12]
Eukaryotic translation initiation factor 4H (EIF4H)	OTGZI072	IF4H_HUMAN	Increases Expression	[12]
Telomeric repeat-binding factor 2 (TERF2)	OTBSAS0V	TERF2_HUMAN	Increases Expression	[12]
snRNA-activating protein complex subunit 1 (SNAPC1)	OTAPN1NI	SNPC1_HUMAN	Decreases Expression	[12]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)	OTL4VJC5	NUCKS_HUMAN	Decreases Expression	[12]
Lipid transferase CIDEB (CIDEB)	OT873IYM	CIDEB_HUMAN	Increases Expression	[12]
Homeobox protein BarH-like 2 (BARX2)	OT0R3QD3	BARX2_HUMAN	Increases Expression	[12]
Protocadherin alpha-5 (PCDHA5)	OTHZT1GR	PCDA5_HUMAN	Decreases Expression	[12]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Decreases Expression	[60]
Solute carrier family 15 member 1 (SLC15A1)	OT1P16B5	S15A1_HUMAN	Decreases Expression	[60]
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1)	OTBV52DR	SMHD1_HUMAN	Increases Expression	[13]
Ankyrin repeat domain-containing protein 36A (ANKRD36)	OT3XEYKG	AN36A_HUMAN	Increases Expression	[13]
Pyridoxal kinase (PDXK)	OT40AJ5J	PDXK_HUMAN	Decreases Expression	[13]
Inositol monophosphatase 2 (IMPA2)	OTNFB9YN	IMPA2_HUMAN	Increases Expression	[13]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Decreases Expression	[13]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4)	OT3LOE2J	MAST4_HUMAN	Increases Expression	[13]
Monocarboxylate transporter 7 (SLC16A6)	OT7BIIZX	MOT7_HUMAN	Increases Expression	[13]
Nucleoplasmin-3 (NPM3)	OTIAM1A3	NPM3_HUMAN	Decreases Expression	[13]
Ubiquitin-like protein ATG12 (ATG12)	OTJRO09Y	ATG12_HUMAN	Decreases Expression	[13]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Decreases Expression	[13]
Microtubule-associated protein 2 (MAP2)	OT6UYT3X	MTAP2_HUMAN	Increases Expression	[13]
Ribose-phosphate pyrophosphokinase 2 (PRPS2)	OTCY1B1O	PRPS2_HUMAN	Decreases Expression	[13]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[13]
Folate receptor alpha (FOLR1)	OT0QZ0H6	FOLR1_HUMAN	Decreases Expression	[13]
Calretinin (CALB2)	OTSNMCG9	CALB2_HUMAN	Increases Expression	[13]
Signal transducer CD24 (CD24)	OT7CODJ4	CD24_HUMAN	Increases Expression	[13]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Decreases Expression	[13]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1)	OT6LIGJP	MA1A1_HUMAN	Increases Expression	[13]
Proteasome subunit beta type-10 (PSMB10)	OTURUR9B	PSB10_HUMAN	Decreases Expression	[13]
Regulator of G-protein signaling 2 (RGS2)	OT0FSRW7	RGS2_HUMAN	Decreases Expression	[13]
Nuclear receptor-interacting protein 1 (NRIP1)	OTIZOJQV	NRIP1_HUMAN	Decreases Expression	[13]
CCN family member 3 (CCN3)	OTOW5YL4	CCN3_HUMAN	Increases Expression	[13]
Caveolin-2 (CAV2)	OT1FGRQX	CAV2_HUMAN	Decreases Expression	[13]
ADP-ribosylation factor-like protein 4C (ARL4C)	OTQ3QNNU	ARL4C_HUMAN	Increases Expression	[13]
Transmembrane protein 33 (TMEM33)	OTRG1DOY	TMM33_HUMAN	Decreases Expression	[13]
Epiplakin (EPPK1)	OT7BAU8C	EPIPL_HUMAN	Increases Expression	[13]
Triosephosphate isomerase (TPI1)	OT14KP4B	TPIS_HUMAN	Decreases Expression	[13]
Protein jagged-1 (JAG1)	OT3LGT6K	JAG1_HUMAN	Increases Expression	[13]
High mobility group nucleosome-binding domain-containing protein 5 (HMGN5)	OTUUAHVQ	HMGN5_HUMAN	Increases Expression	[13]
Small EDRK-rich factor 2 (SERF2)	OTZQDYCZ	SERF2_HUMAN	Decreases Expression	[13]
Transcription factor SOX-4 (SOX4)	OTSS40SS	SOX4_HUMAN	Increases Expression	[13]
Proline-rich nuclear receptor coactivator 1 (PNRC1)	OTQMLEE1	PNRC1_HUMAN	Increases Expression	[13]
S-methyl-5'-thioadenosine phosphorylase (MTAP)	OTOWN2K9	MTAP_HUMAN	Decreases Expression	[13]
Spliceosome RNA helicase DDX39B (DDX39B)	OTEVCFVU	DX39B_HUMAN	Increases Expression	[13]
Beta-1-syntrophin (SNTB1)	OTSRBECI	SNTB1_HUMAN	Increases Expression	[13]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Decreases Expression	[13]
Semaphorin-3A (SEMA3A)	OTQJSV7W	SEM3A_HUMAN	Increases Expression	[13]
Uncharacterized protein KIAA0040 (KIAA0040)	OT27EBY3	K0040_HUMAN	Increases Expression	[13]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[13]
Dual specificity protein phosphatase 6 (DUSP6)	OT4H6RKW	DUS6_HUMAN	Increases Expression	[13]
Pre-rRNA-processing protein TSR1 homolog (TSR1)	OTCVZFL9	TSR1_HUMAN	Decreases Expression	[13]
Fibronectin type III domain-containing protein 3B (FNDC3B)	OTBILGDR	FND3B_HUMAN	Decreases Expression	[13]
Nucleolar MIF4G domain-containing protein 1 (NOM1)	OTWZSJJC	NOM1_HUMAN	Decreases Expression	[13]
Protein FAM76B (FAM76B)	OT4RG5U7	FA76B_HUMAN	Decreases Expression	[13]
MAGUK p55 subfamily member 7 (MPP7)	OT3G3HTZ	MPP7_HUMAN	Decreases Expression	[13]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48)	OTSR6DEJ	SNR48_HUMAN	Decreases Expression	[13]
Parafibromin (CDC73)	OT6JASZ1	CDC73_HUMAN	Decreases Expression	[13]
Neuroblastoma breakpoint family member 10 (NBPF10)	OTGOCELY	NBPFA_HUMAN	Increases Expression	[13]
Kelch-like protein 24 (KLHL24)	OTWZSX5C	KLH24_HUMAN	Increases Expression	[13]
Ankyrin repeat domain-containing protein 11 (ANKRD11)	OTV0V70M	ANR11_HUMAN	Increases Expression	[13]
MAM domain-containing protein 2 (MAMDC2)	OT4GICNY	MAMC2_HUMAN	Increases Expression	[13]
Coiled-coil domain-containing protein 186 (CCDC186)	OTONSQAD	CC186_HUMAN	Increases Expression	[13]
Serologically defined colon cancer antigen 8 (SDCCAG8)	OTV2ZGV9	SDCG8_HUMAN	Increases Expression	[13]
Liprin-beta-1 (PPFIBP1)	OTRA2S7B	LIPB1_HUMAN	Increases Expression	[13]
Homeobox protein Mohawk (MKX)	OT7H7Z50	MKX_HUMAN	Decreases Expression	[13]
Mastermind-like protein 2 (MAML2)	OT1TSVAR	MAML2_HUMAN	Increases Expression	[13]
Delta and Notch-like epidermal growth factor-related receptor (DNER)	OT2GH2E5	DNER_HUMAN	Increases Expression	[13]
Ribosome biogenesis protein BRX1 homolog (BRIX1)	OTQ5F1D1	BRX1_HUMAN	Decreases Expression	[13]
Tribbles homolog 2 (TRIB2)	OTHSX3MX	TRIB2_HUMAN	Increases Expression	[13]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1)	OT2363Z9	T53I1_HUMAN	Increases Expression	[13]
Alkylated DNA repair protein alkB homolog 8 (ALKBH8)	OTXN70DV	ALKB8_HUMAN	Decreases Expression	[13]
EF-hand domain-containing protein D2 (EFHD2)	OTM9VMN3	EFHD2_HUMAN	Decreases Expression	[13]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1)	OTMJKJAK	NAF1_HUMAN	Decreases Expression	[13]
Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST2)	OT8A3H9Y	H6ST2_HUMAN	Decreases Expression	[13]
Transmembrane protein 74 (TMEM74)	OT3IZBM0	TMM74_HUMAN	Increases Expression	[13]
Small integral membrane protein 14 (SMIM14)	OT47IF19	SIM14_HUMAN	Increases Expression	[13]
Peptide deformylase, mitochondrial (PDF)	OTZ75ZK5	DEFM_HUMAN	Increases Expression	[13]
Synaptotagmin-like protein 2 (SYTL2)	OTUIOWKL	SYTL2_HUMAN	Increases Expression	[13]
Uncharacterized protein C14orf132 (C14ORF132)	OTBVC3AO	CN132_HUMAN	Increases Expression	[13]
Cell death regulator Aven (AVEN)	OTGIN5YK	AVEN_HUMAN	Decreases Expression	[13]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)	OTPL0AI1	ABC3C_HUMAN	Increases Expression	[13]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Increases Expression	[13]
Cysteine-rich motor neuron 1 protein (CRIM1)	OTTZNV6Y	CRIM1_HUMAN	Decreases Expression	[13]
Protein DBF4 homolog A (DBF4)	OTBL7JHQ	DBF4A_HUMAN	Decreases Expression	[13]
Pleckstrin homology domain-containing family B member 1 (PLEKHB1)	OTC7TNAX	PKHB1_HUMAN	Increases Expression	[13]
Switch-associated protein 70 (SWAP70)	OTPHT2QD	SWP70_HUMAN	Decreases Expression	[13]
Carboxypeptidase A4 (CPA4)	OT66MP0F	CBPA4_HUMAN	Decreases Expression	[13]
Endoribonuclease Dicer (DICER1)	OTTVSEY0	DICER_HUMAN	Decreases Expression	[13]
RRP15-like protein (RRP15)	OTE8CQ7K	RRP15_HUMAN	Decreases Expression	[13]
AP-4 complex subunit sigma-1 (AP4S1)	OTM3QBU8	AP4S1_HUMAN	Decreases Expression	[13]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Increases Expression	[14]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)	OTKOZRZP	PLOD2_HUMAN	Decreases Expression	[14]
Nuclear factor 1 B-type (NFIB)	OTX94PD0	NFIB_HUMAN	Decreases Expression	[14]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Increases Expression	[14]
Suppressor of cytokine signaling 1 (SOCS1)	OTWA9KFU	SOCS1_HUMAN	Increases Expression	[14]
Krueppel-like factor 4 (KLF4)	OT4O9RQW	KLF4_HUMAN	Increases Expression	[14]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Decreases Expression	[14]
Cell division control protein 45 homolog (CDC45)	OT6NNLOD	CDC45_HUMAN	Affects Expression	[14]
Transcription factor Maf (MAF)	OT1GR3IZ	MAF_HUMAN	Increases Expression	[14]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Decreases Expression	[14]
Fibrinogen silencer-binding protein (RAD54B)	OTMWB2P2	FSBP_HUMAN	Decreases Expression	[14]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[14]
GTPase HRas (HRAS)	OTWQN0DP	RASH_HUMAN	Increases Expression	[14]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Increases Expression	[14]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Affects Expression	[14]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[14]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Decreases Expression	[14]
Myb-related protein B (MYBL2)	OTZ3JX8Q	MYBB_HUMAN	Increases Expression	[14]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Increases Expression	[14]
Transcription factor JunB (JUNB)	OTG2JXV5	JUNB_HUMAN	Increases Expression	[14]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Increases Expression	[14]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[14]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Increases Expression	[14]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[14]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Increases Expression	[14]
Lysine-specific demethylase 5A (KDM5A)	OTLYFX8A	KDM5A_HUMAN	Decreases Expression	[14]
2'-5'-oligoadenylate synthase 2 (OAS2)	OT64CCTM	OAS2_HUMAN	Increases Expression	[14]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Decreases Expression	[14]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Expression	[14]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT)	OT0THBVA	DUT_HUMAN	Decreases Expression	[14]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Increases Expression	[14]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Increases Expression	[14]
Protein phosphatase inhibitor 2 (PPP1R2)	OTNLOUQR	IPP2_HUMAN	Decreases Expression	[14]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C)	OTCLOV90	CDN2C_HUMAN	Decreases Expression	[14]
DNA mismatch repair protein Msh2 (MSH2)	OT10H1AB	MSH2_HUMAN	Decreases Expression	[14]
Histone deacetylase 4 (HDAC4)	OTQNGD32	HDAC4_HUMAN	Decreases Expression	[14]
Protein S100-A10 (S100A10)	OTI71243	S10AA_HUMAN	Increases Expression	[14]
Large ribosomal subunit protein eL37 (RPL37)	OTB6SDZ1	RL37_HUMAN	Decreases Expression	[14]
Fanconi anemia group C protein (FANCC)	OTTIDM3P	FANCC_HUMAN	Decreases Expression	[14]
DNA-binding protein inhibitor ID-2 (ID2)	OT0U1D53	ID2_HUMAN	Increases Expression	[14]
Transforming growth factor beta receptor type 3 (TGFBR3)	OTQOOUC4	TGBR3_HUMAN	Increases Expression	[14]
Histone-binding protein RBBP4 (RBBP4)	OTG3BT3M	RBBP4_HUMAN	Decreases Expression	[14]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Increases Expression	[14]
Ribosomal protein eS27-like (RPS27L)	OTZWHU0N	RS27L_HUMAN	Increases Expression	[14]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)	OTE8GBUR	RIR2B_HUMAN	Increases Expression	[14]
Pantothenate kinase 1 (PANK1)	OT2CZVRT	PANK1_HUMAN	Increases Expression	[14]
Cullin-5 (CUL5)	OTMTZD47	CUL5_HUMAN	Increases Expression	[14]
RNA-binding protein 14 (RBM14)	OTO9GMBD	RBM14_HUMAN	Increases Expression	[14]
Endothelial PAS domain-containing protein 1 (EPAS1)	OTRE3O8U	EPAS1_HUMAN	Increases Expression	[14]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1)	OTYKB9G3	SIN1_HUMAN	Increases Expression	[14]
E3 ubiquitin-protein ligase SMURF1 (SMURF1)	OT5UIZR8	SMUF1_HUMAN	Increases Expression	[14]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Increases Expression	[14]
SERTA domain-containing protein 1 (SERTAD1)	OTBHKZQP	SRTD1_HUMAN	Increases Expression	[14]
Heat shock protein beta-8 (HSPB8)	OT0I83YS	HSPB8_HUMAN	Increases Expression	[14]
F-box only protein 5 (FBXO5)	OTTR957W	FBX5_HUMAN	Decreases Expression	[14]
Pleckstrin homology-like domain family A member 3 (PHLDA3)	OTXFUDO2	PHLA3_HUMAN	Increases Expression	[14]
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18)	OTCW8HT6	TNR18_HUMAN	Increases Expression	[14]
Regulator of G-protein signaling 13 (RGS13)	OTPAMQ18	RGS13_HUMAN	Decreases Expression	[15]
Pre-mRNA-processing factor 17 (CDC40)	OTOYUNHN	PRP17_HUMAN	Increases Expression	[15]
Synaptosomal-associated protein 29 (SNAP29)	OTT30ZON	SNP29_HUMAN	Increases Expression	[15]
Protein phosphatase 1 regulatory subunit 17 (PPP1R17)	OT19635T	PPR17_HUMAN	Increases Expression	[15]
RAC-beta serine/threonine-protein kinase (AKT2)	OTBB632K	AKT2_HUMAN	Increases Expression	[15]
Serpin B4 (SERPINB4)	OT88LHZ8	SPB4_HUMAN	Decreases Expression	[15]
Cullin-4B (CUL4B)	OT2QX4DO	CUL4B_HUMAN	Increases Expression	[15]
TRAF family member-associated NF-kappa-B activator (TANK)	OTZSGFIK	TANK_HUMAN	Increases Expression	[15]
Engulfment and cell motility protein 2 (ELMO2)	OTKDOC2M	ELMO2_HUMAN	Increases Expression	[15]
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2)	OT24ZO59	MD2L2_HUMAN	Decreases Expression	[15]
Peptidyl-prolyl cis-trans isomerase E (PPIE)	OTIE5OAD	PPIE_HUMAN	Increases Expression	[15]
Transmembrane gamma-carboxyglutamic acid protein 1 (PRRG1)	OTMH6OWG	TMG1_HUMAN	Decreases Expression	[16]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Increases Expression	[16]
Protein sprouty homolog 1 (SPRY1)	OT764FXI	SPY1_HUMAN	Increases Expression	[16]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)	OTRNDZXB	HNRPQ_HUMAN	Decreases Expression	[16]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[16]
Fibrinogen gamma chain (FGG)	OT5BJSEX	FIBG_HUMAN	Decreases Expression	[16]
Plasma serine protease inhibitor (SERPINA5)	OTTZXPGD	IPSP_HUMAN	Increases Expression	[16]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Increases Expression	[16]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)	OTXOQDSG	IFIT1_HUMAN	Increases Expression	[16]
Annexin A3 (ANXA3)	OTDD8OI7	ANXA3_HUMAN	Increases Expression	[16]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Decreases Expression	[16]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Increases Expression	[16]
Myristoylated alanine-rich C-kinase substrate (MARCKS)	OT7N056G	MARCS_HUMAN	Decreases Expression	[16]
Lysophosphatidic acid receptor 6 (LPAR6)	OT4BY3W4	LPAR6_HUMAN	Decreases Expression	[16]
Eukaryotic translation initiation factor 5 (EIF5)	OT79PQUN	IF5_HUMAN	Increases Expression	[16]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Decreases Expression	[16]
Ras-related protein Rab-11A (RAB11A)	OTC4FW0J	RB11A_HUMAN	Decreases Expression	[16]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[16]
Metallothionein-1X (MT1X)	OT9AKFVS	MT1X_HUMAN	Decreases Expression	[16]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[16]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Increases Expression	[16]
Four and a half LIM domains protein 3 (FHL3)	OTMPRLZ5	FHL3_HUMAN	Increases Expression	[16]
PCNA-associated factor (PCLAF)	OTMVIOUU	PAF15_HUMAN	Decreases Expression	[16]
Ankyrin repeat domain-containing protein 1 (ANKRD1)	OTHJ7JV9	ANKR1_HUMAN	Increases Expression	[16]
Adipogenesis regulatory factor (ADIRF)	OTTJP8D4	ADIRF_HUMAN	Increases Expression	[16]
Protein mono-ADP-ribosyltransferase PARP14 (PARP14)	OTFXJAKK	PAR14_HUMAN	Increases Expression	[16]
Centrosomal protein of 55 kDa (CEP55)	OTGSG2PA	CEP55_HUMAN	Decreases Expression	[16]
ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1)	OT416O2G	SUV3_HUMAN	Decreases Expression	[16]
Membrane progestin receptor beta (PAQR8)	OTGZ8W9F	PAQR8_HUMAN	Decreases Expression	[16]
Programmed cell death 6-interacting protein (PDCD6IP)	OTS8T6A7	PDC6I_HUMAN	Decreases Expression	[16]
BTB/POZ domain-containing protein KCTD12 (KCTD12)	OTPYKT4Z	KCD12_HUMAN	Decreases Expression	[16]
Cytoplasmic FMR1-interacting protein 2 (CYFIP2)	OTCAY35T	CYFP2_HUMAN	Increases Expression	[16]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Decreases Expression	[16]
Mini-chromosome maintenance complex-binding protein (MCMBP)	OTQ6WO7A	MCMBP_HUMAN	Increases Expression	[16]
Netrin-4 (NTN4)	OTDRRMP3	NET4_HUMAN	Increases Expression	[16]
Serine/threonine-protein kinase Nek6 (NEK6)	OT8PQSO1	NEK6_HUMAN	Decreases Expression	[16]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Decreases Expression	[17]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[17]
Protein phosphatase 1D (PPM1D)	OT8NLZ9D	PPM1D_HUMAN	Increases Expression	[17]
TP53-regulated inhibitor of apoptosis 1 (TRIAP1)	OTEAUJXN	TRIA1_HUMAN	Increases Expression	[17]
Glutathione peroxidase 1 (GPX1)	OTE2O72Q	GPX1_HUMAN	Increases Expression	[17]
Protein S100-A2 (S100A2)	OTTGHJ1H	S10A2_HUMAN	Increases Expression	[17]
Serpin B5 (SERPINB5)	OTSMXQRJ	SPB5_HUMAN	Increases Expression	[17]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Decreases Expression	[17]
Elongation factor 1-alpha 1 (EEF1A1)	OT00THXS	EF1A1_HUMAN	Increases Expression	[17]
Protein BTG2 (BTG2)	OTZF6K1H	BTG2_HUMAN	Increases Expression	[17]
Antigen peptide transporter 1 (TAP1)	OTJL27PW	TAP1_HUMAN	Increases Expression	[17]
Quinone oxidoreductase (CRYZ)	OTD2F4C8	QOR_HUMAN	Decreases Expression	[17]
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP)	OTVFQEPA	IKIP_HUMAN	Increases Expression	[17]
DNA damage-regulated autophagy modulator protein 1 (DRAM1)	OTIJTXEN	DRAM1_HUMAN	Increases Expression	[17]
Protein ECT2 (ECT2)	OTQDUCT6	ECT2_HUMAN	Decreases Expression	[17]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Decreases Expression	[17]
Serine/threonine-protein kinase PLK2 (PLK2)	OTKMJXJ8	PLK2_HUMAN	Increases Expression	[17]
Sestrin-1 (SESN1)	OTSFDZWL	SESN1_HUMAN	Increases Expression	[17]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Increases Phosphorylation	[61]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Increases Phosphorylation	[61]
Thymidine kinase 2, mitochondrial (TK2)	OTS1V4XB	KITM_HUMAN	Increases Expression	[18]
Adenylate cyclase type 9 (ADCY9)	OT1IZT5K	ADCY9_HUMAN	Decreases Expression	[18]
DNA polymerase alpha catalytic subunit (POLA1)	OT1WXFVY	DPOLA_HUMAN	Decreases Expression	[18]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)	OTPG0K7E	IMDH2_HUMAN	Increases Expression	[18]
CTP synthase 1 (CTPS1)	OTZ9J6ZG	PYRG1_HUMAN	Decreases Expression	[18]
Trifunctional purine biosynthetic protein adenosine-3 (GART)	OT01JWJB	PUR2_HUMAN	Increases Expression	[18]
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)	OTMZN747	PUR6_HUMAN	Increases Expression	[18]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)	OT6E2OW6	ENTP1_HUMAN	Decreases Expression	[18]
AMP deaminase 2 (AMPD2)	OTBS30JU	AMPD2_HUMAN	Decreases Expression	[18]
Guanylate cyclase soluble subunit beta-1 (GUCY1B1)	OTSHPHVB	GCYB1_HUMAN	Decreases Expression	[18]
5'(3')-deoxyribonucleotidase, mitochondrial (NT5M)	OTJF73BA	NT5M_HUMAN	Increases Expression	[18]
Protein shisa-9 (SHISA9)	OTZI2V0J	SHSA9_HUMAN	Increases Expression	[19]
Transmembrane protein 150C (TMEM150C)	OTUNPHV7	T150C_HUMAN	Decreases Expression	[19]
Left-right determination factor 2 (LEFTY2)	OT3RX4QF	LFTY2_HUMAN	Decreases Expression	[19]
Fatty acid-binding protein, brain (FABP7)	OTRE2H4G	FABP7_HUMAN	Decreases Expression	[19]
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5)	OTMVHF9E	LGR5_HUMAN	Decreases Expression	[19]
Cerberus (CER1)	OTTAJJ63	CER1_HUMAN	Decreases Expression	[19]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Increases Expression	[19]
Collagen alpha-1(II) chain (COL2A1)	OT5E59C8	CO2A1_HUMAN	Decreases Expression	[19]
Proto-oncogene DBL (MCF2)	OTB9N93T	MCF2_HUMAN	Increases Expression	[19]
Myosin light chain 4 (MYL4)	OTURFCSE	MYL4_HUMAN	Decreases Expression	[19]
Protein Cripto (CRIPTO)	OT46DZXJ	TDGF1_HUMAN	Decreases Expression	[19]
Secretogranin-2 (SCG2)	OTUHXX8U	SCG2_HUMAN	Increases Expression	[19]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Increases Expression	[19]
Homeobox protein Hox-B3 (HOXB3)	OT9UC5PE	HXB3_HUMAN	Decreases Expression	[19]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Increases Expression	[19]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Decreases Expression	[19]
Stomatin (STOM)	OTC8R6EH	STOM_HUMAN	Decreases Expression	[19]
Metalloproteinase inhibitor 3 (TIMP3)	OTDGQAD1	TIMP3_HUMAN	Increases Expression	[19]
Glioma pathogenesis-related protein 1 (GLIPR1)	OT0FGQK7	GLIP1_HUMAN	Increases Expression	[19]
LIM/homeobox protein Lhx1 (LHX1)	OT6WI2XS	LHX1_HUMAN	Decreases Expression	[19]
Homeobox protein Hox-A1 (HOXA1)	OTMSOJ7D	HXA1_HUMAN	Decreases Expression	[19]
Paired mesoderm homeobox protein 1 (PRRX1)	OTTZK5G8	PRRX1_HUMAN	Decreases Expression	[19]
Cadherin-6 (CDH6)	OT81Y80S	CADH6_HUMAN	Decreases Expression	[19]
Heart- and neural crest derivatives-expressed protein 2 (HAND2)	OTCXYW4Y	HAND2_HUMAN	Increases Expression	[19]
Protein delta homolog 1 (DLK1)	OTE1VLNB	DLK1_HUMAN	Increases Expression	[19]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Decreases Expression	[19]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Increases Expression	[19]
Testican-1 (SPOCK1)	OTLTDGK7	TICN1_HUMAN	Increases Expression	[19]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)	OTZVUOOB	FBLN3_HUMAN	Increases Expression	[19]
Protein ABHD12B (ABHD12B)	OTBHGWTF	AB12B_HUMAN	Decreases Expression	[19]
Secreted frizzled-related protein 2 (SFRP2)	OT8GZ0CA	SFRP2_HUMAN	Decreases Expression	[19]
Protein LRATD1 (LRATD1)	OT65IL83	LRAT1_HUMAN	Increases Expression	[19]
Neuroserpin (SERPINI1)	OTUJHIJW	NEUS_HUMAN	Increases Expression	[19]
Homeobox protein CDX-2 (CDX2)	OTCG4TSY	CDX2_HUMAN	Decreases Expression	[19]
G-protein coupled receptor 87 (GPR87)	OTQX45UM	GPR87_HUMAN	Increases Expression	[19]
Homeobox protein Hox-D1 (HOXD1)	OTN4V9ZF	HXD1_HUMAN	Decreases Expression	[19]
Transcription factor SOX-17 (SOX17)	OT9H4WWE	SOX17_HUMAN	Decreases Expression	[19]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Decreases Expression	[19]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)	OTTVT4MB	TNR19_HUMAN	Decreases Expression	[19]
Dynein axonemal heavy chain 2 (DNAH2)	OT7J5LDI	DYH2_HUMAN	Decreases Expression	[19]
Histone deacetylase 9 (HDAC9)	OTO8O0LF	HDAC9_HUMAN	Increases Expression	[19]
Thrombospondin type-1 domain-containing protein 7A (THSD7A)	OT7249HH	THS7A_HUMAN	Increases Expression	[19]
Nuclear factor erythroid 2-related factor 3 (NFE2L3)	OT1MGXT0	NF2L3_HUMAN	Increases Expression	[19]
Transcription factor E2F8 (E2F8)	OTQKZGFP	E2F8_HUMAN	Affects Expression	[21]
Aquaporin-12B (AQP12B)	OTNU5Z4K	AQ12B_HUMAN	Decreases Expression	[20]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Increases Expression	[62]
DNA fragmentation factor subunit alpha (DFFA)	OTFPFMT8	DFFA_HUMAN	Decreases Expression	[20]
Forkhead box protein N3 (FOXN3)	OTOJYJZP	FOXN3_HUMAN	Decreases Expression	[22]
Butyrophilin subfamily 3 member A3 (BTN3A3)	OTKMSJRA	BT3A3_HUMAN	Increases Expression	[30]
Cytochrome c oxidase subunit NDUFA4 (NDUFA4)	OTDVH3QG	NDUA4_HUMAN	Affects Expression	[20]
Importin subunit alpha-4 (KPNA3)	OTLI3TM2	IMA4_HUMAN	Decreases Expression	[26]
CCN family member 1 (CCN1)	OTKJBEMD	CCN1_HUMAN	Increases Expression	[63]
Pirin (PIR)	OT8ALXHU	PIR_HUMAN	Decreases Expression	[22]
Claudin-4 (CLDN4)	OT9C4PZ4	CLD4_HUMAN	Decreases Expression	[22]
Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD)	OTYZ8XRH	DHSD_HUMAN	Affects Expression	[20]
Acyl carrier protein, mitochondrial (NDUFAB1)	OTF906UR	ACPM_HUMAN	Affects Expression	[20]
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT)	OTZX703K	CDIPT_HUMAN	Affects Expression	[21]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Increases Expression	[64]
Tripeptidyl-peptidase 1 (TPP1)	OT2LQ771	TPP1_HUMAN	Affects Expression	[21]
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C)	OTVHOL9B	TR10C_HUMAN	Increases Expression	[65]
Ras-related protein M-Ras (MRAS)	OTNCVCQW	RASM_HUMAN	Affects Expression	[21]
Tax1-binding protein 3 (TAX1BP3)	OTQ6IB4T	TX1B3_HUMAN	Increases Expression	[26]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)	OT9RDS3H	IKKB_HUMAN	Decreases Expression	[66]
Angiopoietin-2 (ANGPT2)	OTEQK65P	ANGP2_HUMAN	Decreases Expression	[67]
Actin-related protein 2/3 complex subunit 3 (ARPC3)	OTKWVF8P	ARPC3_HUMAN	Decreases Expression	[26]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[26]
Toll-like receptor 3 (TLR3)	OT8QPYXZ	TLR3_HUMAN	Increases Expression	[68]
Melanoma-associated antigen B2 (MAGEB2)	OTAGUVU5	MAGB2_HUMAN	Decreases Expression	[22]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Decreases Expression	[69]
ATP-dependent RNA helicase DHX15 (DHX15)	OT4F98TK	DHX15_HUMAN	Increases Expression	[21]
Prominin-1 (PROM1)	OTBHV8NX	PROM1_HUMAN	Increases Expression	[22]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Expression	[70]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Increases Expression	[23]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[71]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1)	OTJ5TNHB	NDUC1_HUMAN	Affects Expression	[20]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[26]
Keratin, type II cuticular Hb6 (KRT86)	OT93MMAK	KRT86_HUMAN	Decreases Expression	[22]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Affects Expression	[21]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Affects Expression	[21]
Serine protease inhibitor Kazal-type 4 (SPINK4)	OTHTCW94	ISK4_HUMAN	Affects Expression	[21]
Cystatin-8 (CST8)	OTT2FRCJ	CST8_HUMAN	Affects Expression	[21]
Histone H2B type 1-K (H2BC12)	OTQ8V0KG	H2B1K_HUMAN	Decreases Expression	[30]
Receptor activity-modifying protein 1 (RAMP1)	OT7UT2XB	RAMP1_HUMAN	Decreases Expression	[22]
Sodium channel subunit beta-2 (SCN2B)	OTFAHJ38	SCN2B_HUMAN	Affects Expression	[21]
Probable phospholipid-transporting ATPase IIA (ATP9A)	OT328F1L	ATP9A_HUMAN	Decreases Expression	[22]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Increases Expression	[72]
Breast cancer anti-estrogen resistance protein 3 (BCAR3)	OTPJ17M8	BCAR3_HUMAN	Decreases Expression	[22]
Tumor necrosis factor ligand superfamily member 13 (TNFSF13)	OT90OWIO	TNF13_HUMAN	Increases Expression	[73]
Signal recognition particle subunit SRP72 (SRP72)	OTPV73W7	SRP72_HUMAN	Increases Expression	[21]
Cystatin-F (CST7)	OTQWZUVQ	CYTF_HUMAN	Decreases Expression	[22]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Decreases Expression	[22]
Tight junction protein ZO-3 (TJP3)	OTC1K8HC	ZO3_HUMAN	Affects Expression	[21]
Mitofusin-2 (MFN2)	OTPYN8A3	MFN2_HUMAN	Increases Expression	[74]
NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2)	OT4717TF	NDUB2_HUMAN	Increases Expression	[20]
RCC1 and BTB domain-containing protein 2 (RCBTB2)	OTECBF4R	RCBT2_HUMAN	Affects Expression	[21]
ATP-binding cassette sub-family C member 6 (ABCC6)	OTZT0LKT	MRP6_HUMAN	Increases Expression	[22]
Phenylalanine--tRNA ligase, mitochondrial (FARS2)	OTXAK6F0	SYFM_HUMAN	Decreases Expression	[30]
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1)	OTTR5311	STAU1_HUMAN	Decreases Expression	[26]
Mitochondrial uncoupling protein 4 (SLC25A27)	OTSBOPGD	UCP4_HUMAN	Decreases Expression	[20]
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10)	OTFLILEO	NDUBA_HUMAN	Affects Expression	[20]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Decreases Activity	[75]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Decreases Expression	[26]
Coagulation factor XII (F12)	OTBFD2FU	FA12_HUMAN	Decreases Expression	[22]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Increases Expression	[30]
Thyrotropin subunit beta (TSHB)	OTFDI39D	TSHB_HUMAN	Affects Expression	[76]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[77]
Hemoglobin subunit epsilon (HBE1)	OTJPKMX4	HBE_HUMAN	Decreases Expression	[22]
Keratin, type II cytoskeletal 6A (KRT6A)	OT392M5T	K2C6A_HUMAN	Affects Expression	[21]
Prelamin-A/C (LMNA)	OT3SG7ZR	LMNA_HUMAN	Increases Cleavage	[78]
Apolipoprotein C-III (APOC3)	OTW3520C	APOC3_HUMAN	Decreases Expression	[72]
Metallothionein-2 (MT2A)	OTHOACHD	MT2_HUMAN	Decreases Expression	[29]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Increases Expression	[77]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Decreases Activity	[75]
Vitamin K-dependent protein C (PROC)	OTGVH484	PROC_HUMAN	Decreases Activity	[79]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Decreases Expression	[22]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Decreases Expression	[72]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	OTBPMIMW	G3P_HUMAN	Affects Splicing	[80]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[26]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Increases Expression	[22]
Integrin beta-2 (ITGB2)	OTEKPEPR	ITB2_HUMAN	Decreases Expression	[81]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Increases Expression	[26]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Increases Expression	[30]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Phosphorylation	[82]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[83]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Increases Expression	[84]
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Affects Expression	[20]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Increases Phosphorylation	[85]
Progesterone receptor (PGR)	OT0FZ3QE	PRGR_HUMAN	Affects Expression	[20]
Eukaryotic translation initiation factor 4E (EIF4E)	OTDAWNLA	IF4E_HUMAN	Increases Expression	[21]
Protein disulfide-isomerase (P4HB)	OTTYNYPF	PDIA1_HUMAN	Decreases Expression	[72]
Trypsin-2 (PRSS2)	OTOMVUWL	TRY2_HUMAN	Affects Expression	[21]
Bifunctional glutamate/proline--tRNA ligase (EPRS1)	OTXK0FLB	SYEP_HUMAN	Decreases Expression	[26]
Cathepsin B (CTSB)	OTP9G5QB	CATB_HUMAN	Increases Cleavage	[86]
DNA excision repair protein ERCC-1 (ERCC1)	OTNPYQHI	ERCC1_HUMAN	Decreases Expression	[87]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Increases Expression	[88]
Zinc finger protein GLI1 (GLI1)	OT1BTAJO	GLI1_HUMAN	Decreases Expression	[89]
Collagen alpha-2(IV) chain (COL4A2)	OTJK1LKN	CO4A2_HUMAN	Decreases Expression	[22]
Nuclear factor 1 C-type (NFIC)	OTLMCUIB	NFIC_HUMAN	Increases Expression	[21]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Affects Expression	[21]
Keratin, type I cytoskeletal 16 (KRT16)	OTGA0EQN	K1C16_HUMAN	Increases Expression	[77]
CD63 antigen (CD63)	OT2UGZA9	CD63_HUMAN	Decreases Expression	[81]
Retinol-binding protein 1 (RBP1)	OTRP1MFC	RET1_HUMAN	Decreases Expression	[22]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)	OTIRPN6B	ROA1_HUMAN	Decreases Expression	[30]
Pro-cathepsin H (CTSH)	OTLFL0DG	CATH_HUMAN	Increases Expression	[22]
Cytochrome c oxidase subunit 6C (COX6C)	OT3V7JE5	COX6C_HUMAN	Affects Expression	[20]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Expression	[27]
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2)	OTI4EOAR	IFIT2_HUMAN	Increases Expression	[30]
Serum amyloid A-1 protein (SAA1)	OTO2D8S0	SAA1_HUMAN	Increases Expression	[30]
Heat shock 70 kDa protein 1A (HSPA1A)	OTKGIE76	HS71A_HUMAN	Decreases Expression	[22]
Small integral membrane protein 10-like protein 2A (SMIM10L2B)	OT04IG2N	SIL2A_HUMAN	Decreases Expression	[20]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[83]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[90]
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B)	OTDP94F3	COX5B_HUMAN	Affects Expression	[20]
T-cell surface glycoprotein CD8 beta chain (CD8B)	OTMZ1T7J	CD8B_HUMAN	Decreases Expression	[22]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Decreases Expression	[72]
DNA topoisomerase 1 (TOP1)	OT51O0CF	TOP1_HUMAN	Decreases Expression	[26]
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA)	OT0LHOZB	ODBA_HUMAN	Affects Expression	[21]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Decreases Expression	[22]
Interferon-induced transmembrane protein 1 (IFITM1)	OTECO1G8	IFM1_HUMAN	Increases Expression	[30]
Platelet glycoprotein Ib beta chain (GP1BB)	OTD7XNLL	GP1BB_HUMAN	Affects Expression	[21]
Keratin, type II cytoskeletal 5 (KRT5)	OTVGI9HT	K2C5_HUMAN	Decreases Expression	[22]
Protein disulfide-isomerase A4 (PDIA4)	OTVFUJ13	PDIA4_HUMAN	Decreases Expression	[26]
Troponin T, slow skeletal muscle (TNNT1)	OT8PBOAR	TNNT1_HUMAN	Decreases Expression	[22]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Increases Expression	[23]
Aspartate--tRNA ligase, cytoplasmic (DARS1)	OT0WGC2T	SYDC_HUMAN	Affects Expression	[21]
Protein C-ets-1 (ETS1)	OT4LVGDN	ETS1_HUMAN	Increases Expression	[66]
Fos-related antigen 1 (FOSL1)	OT9YTYMB	FOSL1_HUMAN	Affects Expression	[20]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Increases Expression	[26]
Transcription factor E2-alpha (TCF3)	OTW6FR32	TFE2_HUMAN	Affects Expression	[20]
Cytochrome c oxidase subunit 7C, mitochondrial (COX7C)	OTREWSBF	COX7C_HUMAN	Affects Expression	[20]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Phosphorylation	[62]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Decreases Expression	[91]
Carboxypeptidase E (CPE)	OTXNTV79	CBPE_HUMAN	Increases Expression	[22]
Interferon alpha/beta receptor 1 (IFNAR1)	OTD4OOFK	INAR1_HUMAN	Increases Expression	[92]
HLA class I histocompatibility antigen, alpha chain G (HLA-G)	OTMLK1KN	HLAG_HUMAN	Increases Expression	[30]
Regulator of chromosome condensation (RCC1)	OT25AGMB	RCC1_HUMAN	Decreases Expression	[26]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[82]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)	OTAFHAVI	ATF6A_HUMAN	Affects Expression	[20]
ATP synthase-coupling factor 6, mitochondrial (ATP5PF)	OTDAE8FP	ATP5J_HUMAN	Increases Expression	[20]
Nucleolin (NCL)	OTBXPKMP	NUCL_HUMAN	Affects Splicing	[80]
Troponin I, cardiac muscle (TNNI3)	OT65E12V	TNNI3_HUMAN	Decreases Expression	[22]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Affects Expression	[20]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Phosphorylation	[23]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Decreases Expression	[20]
Hepatocyte nuclear factor 1-alpha (HNF1A)	OT9DOUKL	HNF1A_HUMAN	Affects Expression	[20]
C4b-binding protein beta chain (C4BPB)	OTJ70B0K	C4BPB_HUMAN	Affects Expression	[21]
Kit ligand (KITLG)	OTB9AVQ4	SCF_HUMAN	Increases Expression	[84]
Lactoperoxidase (LPO)	OTJ9QKX9	PERL_HUMAN	Decreases Expression	[93]
Cornifin-B (SPRR1B)	OTXNW3P6	SPR1B_HUMAN	Affects Expression	[21]
Paired box protein Pax-3 (PAX3)	OTN5PJZV	PAX3_HUMAN	Decreases Expression	[25]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[94]
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB)	OTPOAAUW	AT5F1_HUMAN	Affects Expression	[20]
Insulin-like growth factor-binding protein 6 (IGFBP6)	OTW878VI	IBP6_HUMAN	Decreases Expression	[22]
Cyclin-C (CCNC)	OTMVK4K4	CCNC_HUMAN	Decreases Expression	[26]
G1/S-specific cyclin-E1 (CCNE1)	OTLD7UID	CCNE1_HUMAN	Decreases Expression	[31]
Cytochrome P450 2F1 (CYP2F1)	OTY3HJH1	CP2F1_HUMAN	Affects Expression	[21]
DNA replication licensing factor MCM3 (MCM3)	OTOOHQPM	MCM3_HUMAN	Decreases Expression	[26]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Decreases Expression	[22]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Decreases Degradation	[95]
Paired box protein Pax-6 (PAX6)	OTOC9876	PAX6_HUMAN	Decreases Expression	[74]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Decreases Expression	[22]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[96]
G0/G1 switch protein 2 (G0S2)	OT8FL49L	G0S2_HUMAN	Increases Expression	[22]
Probable global transcription activator SNF2L1 (SMARCA1)	OT0Y6PTU	SMCA1_HUMAN	Increases Expression	[22]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[96]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Affects Expression	[21]
Tripeptidyl-peptidase 2 (TPP2)	OT91OVAU	TPP2_HUMAN	Affects Localization	[97]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Increases Cleavage	[98]
Cellular retinoic acid-binding protein 1 (CRABP1)	OTISDG5X	RABP1_HUMAN	Increases Expression	[22]
ATP synthase subunit delta, mitochondrial (ATP5F1D)	OTXTAG2V	ATPD_HUMAN	Affects Expression	[20]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Increases Expression	[22]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Increases Expression	[26]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Decreases Expression	[26]
HLA class I histocompatibility antigen, alpha chain F (HLA-F)	OT76CM19	HLAF_HUMAN	Increases Expression	[30]
Adenylosuccinate synthetase isozyme 2 (ADSS2)	OTW26XXB	PURA2_HUMAN	Decreases Expression	[26]
Neurotensin receptor type 1 (NTSR1)	OTTJUTE3	NTR1_HUMAN	Decreases Expression	[22]
CAMPATH-1 antigen (CD52)	OT02LDQN	CD52_HUMAN	Affects Expression	[21]
Neural cell adhesion molecule L1 (L1CAM)	OTNWAQ4Y	L1CAM_HUMAN	Decreases Expression	[22]
Homeobox protein OTX2 (OTX2)	OTTV05B1	OTX2_HUMAN	Decreases Expression	[74]
Cyclin-dependent kinases regulatory subunit 2 (CKS2)	OTPTMHIV	CKS2_HUMAN	Decreases Expression	[71]
Protein S100-A3 (S100A3)	OTVIZJ2R	S10A3_HUMAN	Decreases Expression	[22]
Heat shock 70 kDa protein 4 (HSPA4)	OT5HR0AR	HSP74_HUMAN	Decreases Expression	[22]
5-hydroxytryptamine receptor 7 (HTR7)	OT44DEWB	5HT7R_HUMAN	Affects Expression	[21]
Profilin-2 (PFN2)	OT5SSSA7	PROF2_HUMAN	Increases Expression	[22]
Radixin (RDX)	OTNSYUN6	RADI_HUMAN	Affects Expression	[21]
Cornifin-A (SPRR1A)	OTJMI34A	SPR1A_HUMAN	Increases Expression	[21]
Homeobox protein MSX-2 (MSX2)	OT1WDKE1	MSX2_HUMAN	Decreases Expression	[22]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[99]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Affects Expression	[20]
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Affects Expression	[21]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A)	OTE2KVZV	SCNNA_HUMAN	Decreases Expression	[22]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Decreases Expression	[22]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[100]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[101]
Hepatocyte nuclear factor 4-alpha (HNF4A)	OTY1TOAB	HNF4A_HUMAN	Affects Expression	[20]
Neuroblastoma suppressor of tumorigenicity 1 (NBL1)	OTT37U4O	NBL1_HUMAN	Decreases Expression	[26]
Signal transducer and activator of transcription 1-alpha/beta (STAT1)	OTLMBUZ6	STAT1_HUMAN	Increases Expression	[20]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Affects Expression	[21]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Decreases Expression	[93]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[102]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Decreases Expression	[20]
Melanoma-associated antigen 2 (MAGEA2)	OTQ0YOTY	MAGA2_HUMAN	Decreases Expression	[22]
Melanoma-associated antigen 6 (MAGEA6)	OTI8S0O2	MAGA6_HUMAN	Decreases Expression	[22]
Melanoma-associated antigen 12 (MAGEA12)	OT8ULELL	MAGAC_HUMAN	Decreases Expression	[22]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Decreases Expression	[31]
Retinaldehyde dehydrogenase 3 (ALDH1A3)	OT1C9NKQ	AL1A3_HUMAN	Decreases Expression	[22]
Galectin-7 (LGALS7)	OTMSVI7R	LEG7_HUMAN	Decreases Expression	[22]
Iron-responsive element-binding protein 2 (IREB2)	OT747D24	IREB2_HUMAN	Increases Expression	[21]
Interferon alpha/beta receptor 2 (IFNAR2)	OTBIRNIJ	INAR2_HUMAN	Increases Expression	[30]
Sodium/hydrogen exchanger 3 (SLC9A3)	OTZ7PFVT	SL9A3_HUMAN	Decreases Expression	[20]
Caspase-4 (CASP4)	OTVQTV1L	CASP4_HUMAN	Increases Expression	[22]
Casein kinase I isoform epsilon (CSNK1E)	OTF0UXX6	KC1E_HUMAN	Affects Expression	[21]
Tuberin (TSC2)	OT47LWI9	TSC2_HUMAN	Increases Expression	[21]
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1)	OTEVK4WW	NDUV1_HUMAN	Affects Expression	[20]
Ketohexokinase (KHK)	OT153922	KHK_HUMAN	Increases Expression	[22]
Homeobox protein MOX-1 (MEOX1)	OTJEMT2D	MEOX1_HUMAN	Increases Expression	[25]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Expression	[103]
Amiloride-sensitive sodium channel subunit beta (SCNN1B)	OT61QQTL	SCNNB_HUMAN	Affects Expression	[21]
Serine/threonine-protein kinase Nek4 (NEK4)	OTOB8366	NEK4_HUMAN	Decreases Expression	[26]
Cyclin-G1 (CCNG1)	OT17IA9L	CCNG1_HUMAN	Decreases Expression	[26]
Rho-related GTP-binding protein RhoN (RND2)	OT98M6UI	RND2_HUMAN	Increases Expression	[30]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Decreases Expression	[71]
Rho GDP-dissociation inhibitor 2 (ARHGDIB)	OT9PD6CS	GDIR2_HUMAN	Affects Expression	[20]
Hexokinase-2 (HK2)	OTC0GCQO	HXK2_HUMAN	Decreases Expression	[104]
Ephrin-B2 (EFNB2)	OT0DCUOM	EFNB2_HUMAN	Decreases Expression	[22]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Increases Expression	[66]
LIM domain kinase 1 (LIMK1)	OTFZ8MZ0	LIMK1_HUMAN	Affects Expression	[20]
Monocarboxylate transporter 1 (SLC16A1)	OTW1UTZ7	MOT1_HUMAN	Decreases Expression	[26]
Heat shock-related 70 kDa protein 2 (HSPA2)	OTSDET7B	HSP72_HUMAN	Increases Expression	[30]
Microsomal triglyceride transfer protein large subunit (MTTP)	OTNUVSDT	MTP_HUMAN	Decreases Expression	[72]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Expression	[20]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Decreases Expression	[105]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Affects Expression	[20]
Forkhead box protein G1 (FOXG1)	OTAW57J4	FOXG1_HUMAN	Decreases Expression	[74]
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3)	OTSCYB9P	NDUV3_HUMAN	Increases Expression	[20]
NADH dehydrogenase 1 alpha subcomplex subunit 6 (NDUFA6)	OTEOIIOL	NDUA6_HUMAN	Affects Expression	[20]
Claudin-2 (CLDN2)	OTRF3D6Y	CLD2_HUMAN	Decreases Expression	[23]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Increases Expression	[106]
Forkhead box protein L2 (FOXL2)	OTFRQUYL	FOXL2_HUMAN	Increases Expression	[20]
Ribose-phosphate pyrophosphokinase 1 (PRPS1)	OTN3A6CN	PRPS1_HUMAN	Increases Expression	[21]
Ras-related protein Rab-8A (RAB8A)	OTPB54Y3	RAB8A_HUMAN	Decreases Expression	[26]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Affects Expression	[21]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB)	OT24GMCM	PP2AB_HUMAN	Increases Expression	[26]
Small ribosomal subunit protein eS26 (RPS26)	OTBYTA6A	RS26_HUMAN	Affects Expression	[21]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2)	OT3JPRCQ	GBB2_HUMAN	Decreases Expression	[26]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Decreases Expression	[26]
Hemoglobin subunit beta (HBB)	OT514IKQ	HBB_HUMAN	Affects Splicing	[80]
E3 ubiquitin-protein ligase RNF4 (RNF4)	OTCMXQRE	RNF4_HUMAN	Decreases Expression	[26]
Cyclin-A1 (CCNA1)	OTX4HD45	CCNA1_HUMAN	Affects Expression	[105]
Interferon-induced 35 kDa protein (IFI35)	OTV9RZ53	IN35_HUMAN	Increases Expression	[30]
Transcriptional activator protein Pur-alpha (PURA)	OT975ELW	PURA_HUMAN	Affects Expression	[21]
Interferon regulatory factor 9 (IRF9)	OTK4MYQJ	IRF9_HUMAN	Increases Expression	[30]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Increases Expression	[101]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Decreases Expression	[20]
Exosome complex component 10 (EXOSC10)	OTH8Z0AL	EXOSX_HUMAN	Increases Metabolism	[107]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Decreases Expression	[22]
Myocyte-specific enhancer factor 2B (MEF2B)	OT880SE6	MEF2B_HUMAN	Affects Expression	[21]
A-kinase anchor protein 12 (AKAP12)	OTCVRDDX	AKA12_HUMAN	Affects Expression	[21]
Lamin-B2 (LMNB2)	OTXRDUOS	LMNB2_HUMAN	Decreases Expression	[20]
Antigen peptide transporter 2 (TAP2)	OTWSYFI7	TAP2_HUMAN	Increases Expression	[108]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Expression	[109]
Keratin, type I cytoskeletal 17 (KRT17)	OT6Y1DPK	K1C17_HUMAN	Affects Expression	[21]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Affects Expression	[21]
Protein kinase C zeta type (PRKCZ)	OTN2FE42	KPCZ_HUMAN	Affects Expression	[21]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[110]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[69]
Forkhead box protein M1 (FOXM1)	OT5887KR	FOXM1_HUMAN	Decreases Expression	[20]
Neuroblast differentiation-associated protein AHNAK (AHNAK)	OT6KH1WG	AHNK_HUMAN	Decreases Expression	[22]
Mesoderm posterior protein 2 (MESP2)	OT7H4LYA	MESP2_HUMAN	Increases Expression	[25]
Sterol regulatory element-binding protein 2 (SREBF2)	OTBXUNPL	SRBP2_HUMAN	Decreases Expression	[20]
Transcription factor 15 (TCF15)	OTA6UCWC	TCF15_HUMAN	Increases Expression	[25]
Heat shock protein 75 kDa, mitochondrial (TRAP1)	OTNG0L8J	TRAP1_HUMAN	Affects Expression	[20]
TNF receptor-associated factor 2 (TRAF2)	OT1MEZZN	TRAF2_HUMAN	Decreases Expression	[95]
Forkhead box protein C1 (FOXC1)	OTOWZGYO	FOXC1_HUMAN	Affects Expression	[21]
Vesicle transport protein SEC20 (BNIP1)	OT7USYCY	SEC20_HUMAN	Increases Expression	[28]
Baculoviral IAP repeat-containing protein 1 (NAIP)	OTLA925F	BIRC1_HUMAN	Decreases Expression	[30]
RE1-silencing transcription factor (REST)	OTLL92LQ	REST_HUMAN	Affects Expression	[21]
FAS-associated death domain protein (FADD)	OTV7GFHH	FADD_HUMAN	Decreases Expression	[20]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)	OTS3FVTY	M3K1_HUMAN	Affects Expression	[20]
28 kDa heat- and acid-stable phosphoprotein (PDAP1)	OTJSWMOD	HAP28_HUMAN	Decreases Expression	[26]
Aquaporin-6 (AQP6)	OTXS6UYY	AQP6_HUMAN	Decreases Expression	[20]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)	OTC41R1E	RIPK1_HUMAN	Increases Expression	[20]
Neurogenic differentiation factor 1 (NEUROD1)	OTZQ7QJ2	NDF1_HUMAN	Affects Expression	[21]
Protein patched homolog 1 (PTCH1)	OTMG07H5	PTC1_HUMAN	Decreases Expression	[89]
CD166 antigen (ALCAM)	OTCO4LP7	CD166_HUMAN	Decreases Expression	[22]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)	OT6VY3A3	SPTN1_HUMAN	Increases Expression	[20]
Low-density lipoprotein receptor-related protein 8 (LRP8)	OTZ71YV2	LRP8_HUMAN	Decreases Expression	[30]
Transcription factor E2F2 (E2F2)	OTO75RM7	E2F2_HUMAN	Decreases Expression	[20]
Fas-activated serine/threonine kinase (FASTK)	OTTHFZMP	FASTK_HUMAN	Decreases Expression	[20]
Guanidinoacetate N-methyltransferase (GAMT)	OTVC87ES	GAMT_HUMAN	Increases Expression	[22]
Transcription factor HES-1 (HES1)	OT8P19W2	HES1_HUMAN	Increases Activity	[111]
Indian hedgehog protein (IHH)	OT1DWGXC	IHH_HUMAN	Decreases Expression	[112]
Transmembrane protein 187 (TMEM187)	OTOE4G8T	TM187_HUMAN	Decreases Expression	[20]
Pumilio homolog 1 (PUM1)	OTTMWP8L	PUM1_HUMAN	Affects Expression	[21]
Major vault protein (MVP)	OTJGHJRB	MVP_HUMAN	Increases Expression	[113]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Decreases Expression	[105]
Kinesin-like protein KIF14 (KIF14)	OTXHT4JM	KIF14_HUMAN	Decreases Expression	[20]
Angiopoietin-1 (ANGPT1)	OTVZ1NG3	ANGP1_HUMAN	Increases Expression	[67]
Sonic hedgehog protein (SHH)	OTOG2BXF	SHH_HUMAN	Decreases Expression	[89]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)	OTBOSJHO	TRADD_HUMAN	Affects Expression	[20]
Heat shock protein beta-2 (HSPB2)	OTS01646	HSPB2_HUMAN	Increases Phosphorylation	[88]
Transcription factor E2F4 (E2F4)	OTB3JFH4	E2F4_HUMAN	Decreases Expression	[20]
BDNF/NT-3 growth factors receptor (NTRK2)	OTD557PU	NTRK2_HUMAN	Decreases Expression	[22]
Survival motor neuron protein (SMN2)	OT54RLO1	SMN_HUMAN	Decreases Expression	[30]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Expression	[114]
Kinesin-like protein KIF26B (KIF26B)	OTVHWIKR	KI26B_HUMAN	Decreases Expression	[20]
Protein BEAN1 (BEAN1)	OT0WLH27	BEAN1_HUMAN	Increases Expression	[22]
Filamin A-interacting protein 1-like (FILIP1L)	OTPY8IMS	FIL1L_HUMAN	Increases Expression	[22]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Decreases Expression	[71]
Early estrogen-induced gene 1 protein (EEIG1)	OT2BMEAE	EEIG1_HUMAN	Affects Expression	[21]
Transcription initiation factor TFIID subunit 3 (TAF3)	OTVMULE9	TAF3_HUMAN	Affects Expression	[21]
GRAM domain-containing protein 4 (GRAMD4)	OT1HXEPM	GRAM4_HUMAN	Increases Expression	[115]
Heme transporter HRG1 (SLC48A1)	OTPFHZLO	HRG1_HUMAN	Affects Expression	[21]
Proline/serine-rich coiled-coil protein 1 (PSRC1)	OT7MDJMN	PSRC1_HUMAN	Decreases Expression	[71]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Decreases Expression	[71]
Teashirt homolog 1 (TSHZ1)	OTYQ9ECW	TSH1_HUMAN	Increases Expression	[21]
Protein MCM10 homolog (MCM10)	OTV0O3JN	MCM10_HUMAN	Affects Expression	[21]
Oligodendrocyte transcription factor 3 (OLIG3)	OTU8XLAF	OLIG3_HUMAN	Decreases Expression	[25]
Protein lifeguard 1 (GRINA)	OTMC1O66	LFG1_HUMAN	Affects Expression	[21]
Cyclin-J-like protein (CCNJL)	OTU0SRTC	CCNJL_HUMAN	Affects Expression	[21]
Mitofusin-1 (MFN1)	OTCBXQZF	MFN1_HUMAN	Increases Expression	[74]
Protein NOXP20 (FAM114A1)	OT0208Y4	NXP20_HUMAN	Affects Expression	[21]
Extracellular serine/threonine protein kinase FAM20C (FAM20C)	OTW5YZ7X	FA20C_HUMAN	Affects Expression	[21]
Serine/arginine repetitive matrix protein 1 (SRRM1)	OTAY2IP6	SRRM1_HUMAN	Decreases Expression	[26]
Ankyrin repeat domain-containing protein 36B (ANKRD36B)	OT3MW415	AN36B_HUMAN	Affects Expression	[21]
Metallothionein-1M (MT1M)	OTVT8PLU	MT1M_HUMAN	Increases Expression	[22]
Integral membrane protein GPR137C (GPR137C)	OTMEB9QG	G137C_HUMAN	Affects Expression	[21]
Fibrinogen C domain-containing protein 1 (FIBCD1)	OTSVT07B	FBCD1_HUMAN	Decreases Expression	[20]
tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1)	OT95QT6P	DTWD1_HUMAN	Increases Expression	[28]
ER membrane protein complex subunit 1 (EMC1)	OTYAH4LX	EMC1_HUMAN	Affects Expression	[21]
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH)	OTBIN5IP	SCPDL_HUMAN	Increases Expression	[30]
Minor histocompatibility antigen H13 (HM13)	OTGEO1LP	HM13_HUMAN	Affects Expression	[21]
Serine/threonine-protein kinase Nek9 (NEK9)	OT4VQCL5	NEK9_HUMAN	Decreases Expression	[26]
Grainyhead-like protein 3 homolog (GRHL3)	OT1V4ZEH	GRHL3_HUMAN	Affects Expression	[21]
Transmembrane protein 40 (TMEM40)	OTSJKKNA	TMM40_HUMAN	Affects Expression	[21]
Lipase member H (LIPH)	OTRGYLKL	LIPH_HUMAN	Decreases Expression	[26]
MAP kinase-activating death domain protein (MADD)	OTUFYVGG	MADD_HUMAN	Affects Expression	[20]
E3 ubiquitin-protein ligase MYLIP (MYLIP)	OTL0PFGV	MYLIP_HUMAN	Affects Expression	[21]
Serine protease HTRA1 (HTRA1)	OTR8ACBF	HTRA1_HUMAN	Increases Expression	[22]
Symplekin (SYMPK)	OTYAUDXV	SYMPK_HUMAN	Decreases Expression	[26]
Caspase-10 (CASP10)	OTE6J88E	CASPA_HUMAN	Increases Expression	[20]
Kallikrein-6 (KLK6)	OTIEA234	KLK6_HUMAN	Decreases Expression	[22]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1)	OT3062CA	SO2A1_HUMAN	Affects Expression	[21]
Major histocompatibility complex class I-related gene protein (MR1)	OTZU3XX7	HMR1_HUMAN	Increases Expression	[30]
Optineurin (OPTN)	OT2UXWH9	OPTN_HUMAN	Increases Expression	[30]
Sororin (CDCA5)	OTZLCQ5U	CDCA5_HUMAN	Increases Expression	[26]
THO complex subunit 1 (THOC1)	OTVABJ4Z	THOC1_HUMAN	Decreases Expression	[26]
Chronophin (PDXP)	OTZ7GN95	PLPP_HUMAN	Decreases Expression	[26]
Cytochrome c oxidase assembly protein COX14 (COX14)	OTQ378WN	COX14_HUMAN	Affects Expression	[20]
Retina and anterior neural fold homeobox protein 2 (RAX2)	OT1HD6CF	RAX2_HUMAN	Affects Expression	[21]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3)	OT8C6PKL	AGAP3_HUMAN	Decreases Expression	[26]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Increases Expression	[116]
Serine/threonine-protein kinase Nek1 (NEK1)	OTBUCUW6	NEK1_HUMAN	Decreases Expression	[26]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Affects Expression	[21]
Transcription factor ATOH8 (ATOH8)	OT7SY3BN	ATOH8_HUMAN	Affects Expression	[21]
Pre-mRNA-splicing factor 18 (PRPF18)	OTX4VZ4R	PRP18_HUMAN	Decreases Expression	[30]
MyoD family inhibitor (MDFI)	OTIA6YUG	MDFI_HUMAN	Decreases Expression	[22]
Noelin (OLFM1)	OTOYPEWW	NOE1_HUMAN	Increases Expression	[22]
Protein smoothened (SMO)	OTXXE208	SMO_HUMAN	Decreases Expression	[89]
Retinoic acid receptor responder protein 2 (RARRES2)	OT1BJE8K	RARR2_HUMAN	Decreases Expression	[26]
NADH dehydrogenase 1 alpha subcomplex assembly factor 3 (NDUFAF3)	OT4MCB6W	NDUF3_HUMAN	Decreases Expression	[20]
Multiple myeloma tumor-associated protein 2 (C1ORF35)	OTK6PUYF	MMTA2_HUMAN	Affects Expression	[21]
Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23)	OTG0B7RM	SCMC3_HUMAN	Affects Expression	[21]
Histone-lysine N-methyltransferase SETD5 (SETD5)	OTRPAVEO	SETD5_HUMAN	Affects Expression	[21]
Hyaluronan and proteoglycan link protein 2 (HAPLN2)	OT0G3KEQ	HPLN2_HUMAN	Affects Expression	[21]
PR domain zinc finger protein 14 (PRDM14)	OTWZKY4L	PRD14_HUMAN	Affects Expression	[20]
Neurogenin-2 (NEUROG2)	OTAEMIGT	NGN2_HUMAN	Decreases Expression	[25]
Kallikrein-15 (KLK15)	OT7BVG17	KLK15_HUMAN	Affects Expression	[21]
Serine/threonine-protein kinase PLK3 (PLK3)	OT19CT2Z	PLK3_HUMAN	Increases Expression	[101]
Complex I assembly factor ACAD9, mitochondrial (ACAD9)	OT4HITJ6	ACAD9_HUMAN	Decreases Expression	[20]
2-oxoglutarate and iron-dependent oxygenase JMJD4 (JMJD4)	OTYZGH63	JMJD4_HUMAN	Decreases Expression	[20]
ATP-binding cassette sub-family B member 6 (ABCB6)	OTPGZFES	ABCB6_HUMAN	Decreases Expression	[108]
StAR-related lipid transfer protein 7, mitochondrial (STARD7)	OTDUZ296	STAR7_HUMAN	Affects Expression	[21]
Muscleblind-like protein 1 (MBNL1)	OTOV7J85	MBNL1_HUMAN	Decreases Expression	[26]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)	OT0ALMEG	M3K20_HUMAN	Affects Expression	[21]
NF-kappa-B inhibitor-interacting Ras-like protein 1 (NKIRAS1)	OTWETJTL	KBRS1_HUMAN	Affects Expression	[21]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Expression	[72]
Myoferlin (MYOF)	OTRFC3IJ	MYOF_HUMAN	Decreases Expression	[22]
Programmed cell death 1 ligand 1 (CD274)	OTJ0VFDL	PD1L1_HUMAN	Increases Expression	[117]
NADH dehydrogenase 1 alpha subcomplex assembly factor 4 (NDUFAF4)	OTWJ5B9M	NDUF4_HUMAN	Affects Expression	[20]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B)	OTY94WRA	HM20B_HUMAN	Decreases Expression	[26]
MyoD family inhibitor domain-containing protein (MDFIC)	OTSRYBWZ	MDFIC_HUMAN	Affects Expression	[21]
Ribosome-binding protein 1 (RRBP1)	OT4ZTPTM	RRBP1_HUMAN	Decreases Expression	[22]
Small proline-rich protein 3 (SPRR3)	OTN9QJKG	SPRR3_HUMAN	Affects Expression	[21]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)	OTOSRDJT	TR10D_HUMAN	Increases Expression	[65]
Dickkopf-related protein 4 (DKK4)	OTWCCVF6	DKK4_HUMAN	Increases Expression	[21]
DNA repair protein REV1 (REV1)	OTHIKICX	REV1_HUMAN	Affects Expression	[21]
Hydroxyproline dehydrogenase (PRODH2)	OTHO2TO0	HYPDH_HUMAN	Decreases Expression	[22]
FK506-binding protein-like (FKBPL)	OTR9ND6K	FKBPL_HUMAN	Increases Expression	[102]
Suppressor of fused homolog (SUFU)	OT0IRYG1	SUFU_HUMAN	Decreases Expression	[89]
Probable G-protein coupled receptor 132 (GPR132)	OTJ5WHHX	GP132_HUMAN	Increases Expression	[21]
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE)	OTNONPMB	GLCNE_HUMAN	Decreases Expression	[22]
C-type lectin domain family 11 member A (CLEC11A)	OT9KBH7C	CLC11_HUMAN	Decreases Expression	[22]
DNA replication complex GINS protein PSF2 (GINS2)	OT974IYI	PSF2_HUMAN	Affects Expression	[21]
R3H domain-containing protein 2 (R3HDM2)	OTMJ3S6J	R3HD2_HUMAN	Affects Expression	[21]
Complex I intermediate-associated protein 30, mitochondrial (NDUFAF1)	OTYK9JU6	CIA30_HUMAN	Increases Expression	[20]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1)	OTBCIBC7	SAMH1_HUMAN	Affects Expression	[21]
Angiopoietin-related protein 3 (ANGPTL3)	OTCD5Z9W	ANGL3_HUMAN	Decreases Expression	[72]
Origin recognition complex subunit 6 (ORC6)	OTKQN3KP	ORC6_HUMAN	Increases Expression	[21]
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9)	OTO3WI7S	NDUB9_HUMAN	Affects Expression	[20]
Soluble TNF receptor II (CRMB1)	OT06I7G2	CRMB_CAMPM	Increases ADR	[118]
Mitochondrial pyruvate carrier 2 (MPC2)	OT0GHXGG	MPC2_HUMAN	Affects Response To Substance	[33]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Decreases Response To Substance	[119]
Tumor protein p73 (TP73)	OT0LUO47	P73_HUMAN	Affects Response To Substance	[120]
Nucleoside diphosphate kinase A (NME1)	OT0NELQ1	NDKA_HUMAN	Affects Response To Substance	[34]
Four and a half LIM domains protein 2 (FHL2)	OT0OAYWT	FHL2_HUMAN	Affects Response To Substance	[33]
Tripartite motif-containing protein 2 (TRIM2)	OT0V1YVC	TRIM2_HUMAN	Affects Response To Substance	[33]
Neuropilin and tolloid-like protein 2 (NETO2)	OT0YAMC0	NETO2_HUMAN	Affects Response To Substance	[33]
Sperm protein associated with the nucleus on the X chromosome C (SPANXC)	OT1033B9	SPNXC_HUMAN	Affects Response To Substance	[33]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Affects Response To Substance	[33]
Solute carrier family 35 member F5 (SLC35F5)	OT1FX2QO	S35F5_HUMAN	Affects Response To Substance	[121]
Replication factor C subunit 3 (RFC3)	OT1MS7AO	RFC3_HUMAN	Affects Response To Substance	[34]
Amyloid beta precursor protein binding family B member 2 (APBB2)	OT1VD51B	APBB2_HUMAN	Affects Response To Substance	[33]
Carboxypeptidase D (CPD)	OT2CS64Y	CBPD_HUMAN	Affects Response To Substance	[33]
Uncharacterized protein C11orf24 (C11ORF24)	OT2DOJ6E	CK024_HUMAN	Affects Response To Substance	[33]
La-related protein 4B (LARP4B)	OT2HI0QE	LAR4B_HUMAN	Affects Response To Substance	[33]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)	OT2HZK5M	GTR3_HUMAN	Affects Response To Substance	[33]
Nucleoside diphosphate kinase, mitochondrial (NME4)	OT2JTT42	NDKM_HUMAN	Affects Response To Substance	[33]
Chromobox protein homolog 1 (CBX1)	OT2L4XZX	CBX1_HUMAN	Affects Response To Substance	[33]
Kelch-like protein 7 (KLHL7)	OT2OF1O8	KLHL7_HUMAN	Affects Response To Substance	[33]
LIM and SH3 domain protein 1 (LASP1)	OT2QIDCL	LASP1_HUMAN	Affects Response To Substance	[33]
Protein transport protein Sec31A (SEC31A)	OT2U42AC	SC31A_HUMAN	Affects Response To Substance	[33]
Protein-tyrosine sulfotransferase 2 (TPST2)	OT2XKFCE	TPST2_HUMAN	Affects Response To Substance	[33]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Response To Substance	[122]
Protein FAM171A1 (FAM171A1)	OT33BHEP	F1711_HUMAN	Affects Response To Substance	[33]
Very long chain fatty acid elongase 5 (ELOVL5)	OT375W1Z	ELOV5_HUMAN	Affects Response To Substance	[33]
Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)	OT37FKH0	CYLD_HUMAN	Increases Response To Substance	[123]
Angiogenin (ANG)	OT3ECS6P	ANGI_HUMAN	Affects Response To Substance	[33]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Response To Substance	[124]
Hypermethylated in cancer 2 protein (HIC2)	OT3VP1D9	HIC2_HUMAN	Affects Response To Substance	[33]
Sorcin (SRI)	OT4R3EAC	SORCN_HUMAN	Decreases Response To Substance	[125]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Affects Response To Substance	[126]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1)	OT536PE7	SCOT1_HUMAN	Affects Response To Substance	[33]
DNA repair nuclease/redox regulator APEX1 (APEX1)	OT53OI14	APEX1_HUMAN	Increases Response To Substance	[127]
Breast carcinoma-amplified sequence 4 (BCAS4)	OT596N5E	BCAS4_HUMAN	Affects Response To Substance	[33]
Myosin phosphatase Rho-interacting protein (MPRIP)	OT5FV5NS	MPRIP_HUMAN	Affects Response To Substance	[33]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Affects Response To Substance	[33]
Tumor necrosis factor receptor superfamily member 5 (CD40)	OT5YU2XB	TNR5_HUMAN	Decreases Response To Substance	[128]
Mitochondrial enolase superfamily member 1 (ENOSF1)	OT65D3ZK	ENOF1_HUMAN	Decreases Response To Substance	[129]
Macrophage colony-stimulating factor 1 (CSF1)	OT68M7RD	CSF1_HUMAN	Affects Response To Substance	[33]
Myosin regulatory light polypeptide 9 (MYL9)	OT6B22JB	MYL9_HUMAN	Affects Response To Substance	[33]
Glutamate--cysteine ligase regulatory subunit (GCLM)	OT6CP234	GSH0_HUMAN	Affects Response To Substance	[33]
Melanoma-associated antigen D1 (MAGED1)	OT6EOLFC	MAGD1_HUMAN	Affects Response To Substance	[34]
DNA replication licensing factor MCM7 (MCM7)	OT6FXC6K	MCM7_HUMAN	Affects Response To Substance	[34]
Electron transfer flavoprotein subunit beta (ETFB)	OT6Q6FBD	ETFB_HUMAN	Affects Response To Substance	[34]
Opioid growth factor receptor-like protein 1 (OGFRL1)	OT6QGBYE	OGRL1_HUMAN	Affects Response To Substance	[33]
DNA topoisomerase 2-binding protein 1 (TOPBP1)	OT6UPZPD	TOPB1_HUMAN	Affects Response To Substance	[34]
Transforming protein RhoA (RHOA)	OT6YOJ9N	RHOA_HUMAN	Decreases Response To Substance	[130]
GTP-binding protein 4 (GTPBP4)	OT6ZHAWC	GTPB4_HUMAN	Affects Response To Substance	[33]
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2)	OT714BUO	AL3A2_HUMAN	Affects Response To Substance	[33]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)	OT7C68YV	BACH_HUMAN	Affects Response To Substance	[34]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)	OT7M67WT	GALT3_HUMAN	Affects Response To Substance	[33]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Affects Response To Substance	[33]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)	OT7Y43A1	PP1A_HUMAN	Affects Response To Substance	[33]
CDKN2A-interacting protein (CDKN2AIP)	OT80RRQJ	CARF_HUMAN	Affects Response To Substance	[33]
Cbp/p300-interacting transactivator 2 (CITED2)	OT812TV7	CITE2_HUMAN	Affects Response To Substance	[34]
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B)	OT8CMPB2	FKB1B_HUMAN	Affects Response To Substance	[33]
Mortality factor 4-like protein 2 (MORF4L2)	OT8OI3EC	MO4L2_HUMAN	Decreases Response To Substance	[131]
Putative hydrolase DDAH2 (DDAH2)	OT8Q40G2	DDAH2_HUMAN	Affects Response To Substance	[33]
Pre-B-cell leukemia transcription factor 3 (PBX3)	OT8WMVM4	PBX3_HUMAN	Affects Response To Substance	[33]
Intersectin-1 (ITSN1)	OT8YF3S5	ITSN1_HUMAN	Affects Response To Substance	[33]
Frizzled-2 (FZD2)	OT952ML1	FZD2_HUMAN	Affects Response To Substance	[33]
Galectin-3-binding protein (LGALS3BP)	OT9AGQKH	LG3BP_HUMAN	Affects Response To Substance	[33]
L-lactate dehydrogenase B chain (LDHB)	OT9B1CT3	LDHB_HUMAN	Affects Response To Substance	[33]
Transcription factor MafF (MAFF)	OT9B7MX0	MAFF_HUMAN	Affects Response To Substance	[33]
Epsilon-sarcoglycan (SGCE)	OT9F17JB	SGCE_HUMAN	Affects Response To Substance	[33]
Carbohydrate sulfotransferase 7 (CHST7)	OT9HCUST	CHST7_HUMAN	Affects Response To Substance	[33]
Adapter molecule crk (CRK)	OT9Q5YSN	CRK_HUMAN	Affects Response To Substance	[33]
Dysbindin domain-containing protein 2 (DBNDD2)	OT9RI580	DBND2_HUMAN	Affects Response To Substance	[33]
Lanosterol synthase (LSS)	OT9W2SFH	LSS_HUMAN	Affects Response To Substance	[33]
Perilipin-3 (PLIN3)	OT9ZA7MR	PLIN3_HUMAN	Affects Response To Substance	[33]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Affects Response To Substance	[33]
Apolipoprotein C-I (APOC1)	OTA58CED	APOC1_HUMAN	Affects Response To Substance	[33]
Ribonuclease 4 (RNASE4)	OTA5SZLC	RNAS4_HUMAN	Affects Response To Substance	[33]
SEC14-like protein 1 (SEC14L1)	OTA75FET	S14L1_HUMAN	Affects Response To Substance	[33]
DNA polymerase epsilon subunit 2 (POLE2)	OTAC9V6L	DPOE2_HUMAN	Affects Response To Substance	[33]
Integrin alpha-V (ITGAV)	OTAM7JTR	ITAV_HUMAN	Affects Response To Substance	[33]
Receptor-type tyrosine-protein phosphatase kappa (PTPRK)	OTAP5AT3	PTPRK_HUMAN	Affects Response To Substance	[33]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Response To Substance	[132]
Collagen alpha-3(VI) chain (COL6A3)	OTAS6R6I	CO6A3_HUMAN	Affects Response To Substance	[33]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Affects Response To Substance	[126]
Lanosterol 14-alpha demethylase (CYP51A1)	OTAYHG9C	CP51A_HUMAN	Affects Response To Substance	[33]
Sterol O-acyltransferase 1 (SOAT1)	OTB4Y5RJ	SOAT1_HUMAN	Affects Response To Substance	[33]
Ras-related protein R-Ras (RRAS)	OTBBF28C	RRAS_HUMAN	Affects Response To Substance	[33]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Affects Response To Substance	[126]
Cochlin (COCH)	OTBEHD89	COCH_HUMAN	Affects Response To Substance	[33]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14)	OTBFIOVY	GTR14_HUMAN	Affects Response To Substance	[33]
Protein transport protein Sec23A (SEC23A)	OTBRNIJ3	SC23A_HUMAN	Affects Response To Substance	[33]
Alpha-galactosidase A (GLA)	OTBSR6DT	AGAL_HUMAN	Affects Response To Substance	[33]
Regenerating islet-derived protein 4 (REG4)	OTBWIKOA	REG4_HUMAN	Decreases Response To Substance	[133]
Transmembrane protein 184B (TMEM184B)	OTBZY7E9	T184B_HUMAN	Affects Response To Substance	[33]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Affects Response To Substance	[33]
Adenylyl cyclase-associated protein 2 (CAP2)	OTC1WFNO	CAP2_HUMAN	Affects Response To Substance	[33]
RNA-binding protein 5 (RBM5)	OTCBWHHV	RBM5_HUMAN	Affects Response To Substance	[34]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Decreases Response To Substance	[134]
Baculoviral IAP repeat-containing protein 6 (BIRC6)	OTCQJAB0	BIRC6_HUMAN	Decreases Response To Substance	[135]
Probable cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1)	OTCU8PFI	CIAO1_HUMAN	Affects Response To Substance	[34]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Affects Response To Substance	[33]
Adhesion G protein-coupled receptor L2 (ADGRL2)	OTCXD2YR	AGRL2_HUMAN	Affects Response To Substance	[33]
Large ribosomal subunit protein eL24 (RPL24)	OTCY9DEB	RL24_HUMAN	Affects Response To Substance	[34]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Affects Response To Substance	[33]
Protein timeless homolog (TIMELESS)	OTD8DCBJ	TIM_HUMAN	Affects Response To Substance	[34]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Response To Substance	[131]
Gamma-adducin (ADD3)	OTDRSHAZ	ADDG_HUMAN	Affects Response To Substance	[33]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)	OTDS2EAR	TNR1B_HUMAN	Affects Response To Substance	[121]
DNA polymerase subunit gamma-1 (POLG)	OTDUCT04	DPOG1_HUMAN	Affects Response To Substance	[34]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)	OTDVVNS0	EDIL3_HUMAN	Affects Response To Substance	[33]
Cytosolic phospholipase A2 (PLA2G4A)	OTE70SOT	PA24A_HUMAN	Affects Response To Substance	[33]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Decreases Response To Substance	[136]
Very-long-chain (HACD1)	OTEC7EP7	HACD1_HUMAN	Affects Response To Substance	[33]
DNA ligase 1 (LIG1)	OTEEQS43	DNLI1_HUMAN	Affects Response To Substance	[34]
H(+)/Cl(-) exchange transporter 3 (CLCN3)	OTEEXNMU	CLCN3_HUMAN	Affects Response To Substance	[33]
Maternal embryonic leucine zipper kinase (MELK)	OTEY2UQA	MELK_HUMAN	Affects Response To Substance	[34]
Proteolipid protein 2 (PLP2)	OTEZ4LOV	PLP2_HUMAN	Affects Response To Substance	[33]
Paraneoplastic antigen Ma2 (PNMA2)	OTF5YBQG	PNMA2_HUMAN	Affects Response To Substance	[33]
Mitogen-activated protein kinase 7 (MAPK7)	OTF7H7L7	MK07_HUMAN	Decreases Response To Substance	[137]
Kelch-like ECH-associated protein 1 (KEAP1)	OTFHOD0C	KEAP1_HUMAN	Affects Response To Substance	[138]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Decreases Response To Substance	[59]
E3 ubiquitin-protein ligase NEDD4 (NEDD4)	OTFPXLXT	NEDD4_HUMAN	Affects Response To Substance	[33]
SOSS complex subunit B2 (NABP1)	OTFTNFHW	SOSB2_HUMAN	Increases ADR	[139]
Centromere protein X (CENPX)	OTG1RAKJ	CENPX_HUMAN	Affects Response To Substance	[33]
Protein AF1q (MLLT11)	OTG5RVHC	AF1Q_HUMAN	Affects Response To Substance	[33]
DNA mismatch repair protein Mlh1 (MLH1)	OTG5XDD8	MLH1_HUMAN	Increases Response To Substance	[140]
Lymphocyte antigen 6 complex locus protein G6d (LY6G6D)	OTG75QOC	LY66D_HUMAN	Affects Response To Substance	[33]
Regulator of G-protein signaling 4 (RGS4)	OTG94HHL	RGS4_HUMAN	Affects Response To Substance	[33]
TRIO and F-actin-binding protein (TRIOBP)	OTGB5WHC	TARA_HUMAN	Affects Response To Substance	[33]
Tubulin-specific chaperone E (TBCE)	OTGBSTKS	TBCE_HUMAN	Affects Response To Substance	[33]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)	OTGD8TID	FLRT2_HUMAN	Affects Response To Substance	[33]
DNA replication licensing factor MCM2 (MCM2)	OTGGORIQ	MCM2_HUMAN	Affects Response To Substance	[34]
Fibroblast growth factor 7 (FGF7)	OTGK6ANL	FGF7_HUMAN	Decreases Response To Substance	[141]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	OTGM06VJ	IDI1_HUMAN	Affects Response To Substance	[33]
Melanoma-associated antigen 4 (MAGEA4)	OTGP9SD0	MAGA4_HUMAN	Affects Response To Substance	[33]
Phospholipid scramblase 1 (PLSCR1)	OTGY9B5T	PLS1_HUMAN	Affects Response To Substance	[33]
Partitioning defective 3 homolog (PARD3)	OTH5BPLO	PARD3_HUMAN	Affects Response To Substance	[33]
Flavin reductase (BLVRB)	OTHCFN2C	BLVRB_HUMAN	Affects Response To Substance	[33]
Heat shock protein beta-1 (HSPB1)	OTHFZ8ED	HSPB1_HUMAN	Decreases Response To Substance	[142]
Potassium voltage-gated channel subfamily A member 5 (KCNA5)	OTHI2N71	KCNA5_HUMAN	Increases Response To Substance	[143]
Translationally-controlled tumor protein (TPT1)	OTHMTRJU	TCTP_HUMAN	Decreases Response To Substance	[122]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Affects Response To Substance	[126]
Dystonin (DST)	OTHZBM4X	DYST_HUMAN	Affects Response To Substance	[33]
FYVE, RhoGEF and PH domain-containing protein 6 (FGD6)	OTI0T62C	FGD6_HUMAN	Affects Response To Substance	[33]
Protein S100-A11 (S100A11)	OTI57KDN	S10AB_HUMAN	Increases Response To Substance	[144]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Affects Response To Substance	[34]
Laminin subunit gamma-1 (LAMC1)	OTIG527N	LAMC1_HUMAN	Affects Response To Substance	[33]
Baculoviral IAP repeat-containing protein 7 (BIRC7)	OTITCGHB	BIRC7_HUMAN	Decreases Response To Substance	[145]
Kinesin-like protein KIF2C (KIF2C)	OTJ8G3NP	KIF2C_HUMAN	Affects Response To Substance	[34]
Replication factor C subunit 2 (RFC2)	OTJ9N6BD	RFC2_HUMAN	Affects Response To Substance	[34]
Retrotransposon Gag-like protein 8C (RTL8C)	OTJA37NU	RTL8C_HUMAN	Affects Response To Substance	[33]
Cyclin-F (CCNF)	OTJFVU43	CCNF_HUMAN	Affects Response To Substance	[126]
Heat shock cognate 71 kDa protein (HSPA8)	OTJI2RCI	HSP7C_HUMAN	Affects Response To Substance	[33]
Rhomboid-related protein 2 (RHBDL2)	OTJPJ8N6	RHBL2_HUMAN	Affects Response To Substance	[33]
Unconventional myosin-VI (MYO6)	OTJQYRC7	MYO6_HUMAN	Affects Response To Substance	[33]
Endothelin-1 receptor (EDNRA)	OTK9T5O3	EDNRA_HUMAN	Affects Response To Substance	[146]
Serine/threonine-protein kinase 38 (STK38)	OTKMYCYR	STK38_HUMAN	Affects Response To Substance	[33]
Starch-binding domain-containing protein 1 (STBD1)	OTKPS9AM	STBD1_HUMAN	Affects Response To Substance	[33]
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial (ECHDC3)	OTKU2RMC	ECHD3_HUMAN	Affects Response To Substance	[33]
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT2)	OTKXMSM7	MGAT2_HUMAN	Affects Response To Substance	[33]
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR)	OTKYMT99	CABYR_HUMAN	Affects Response To Substance	[33]
EF-hand domain-containing protein D1 (EFHD1)	OTL5INE4	EFHD1_HUMAN	Affects Response To Substance	[33]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)	OTL9I7LO	GA45B_HUMAN	Decreases Response To Substance	[147]
Sorting nexin-6 (SNX6)	OTLKQYJU	SNX6_HUMAN	Affects Response To Substance	[33]
PDZ and LIM domain protein 5 (PDLIM5)	OTLQVV22	PDLI5_HUMAN	Affects Response To Substance	[33]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Affects Response To Substance	[33]
Separin (ESPL1)	OTMGEVOK	ESPL1_HUMAN	Affects Response To Substance	[34]
Sperm protein associated with the nucleus on the X chromosome A (SPANXA1)	OTMK3QIS	SPNXA_HUMAN	Affects Response To Substance	[33]
Pleckstrin homology domain-containing family O member 1 (PLEKHO1)	OTMVUQ9W	PKHO1_HUMAN	Affects Response To Substance	[33]
Ubiquitin-conjugating enzyme E2 R1 (CDC34)	OTNBK390	UB2R1_HUMAN	Affects Response To Substance	[33]
Protein ENTREP3 (ENTREP3)	OTNJB3FP	EREP3_HUMAN	Affects Response To Substance	[33]
HMG box transcription factor BBX (BBX)	OTNQ3QUC	BBX_HUMAN	Affects Response To Substance	[33]
Melanoma-associated antigen D4 (MAGED4B)	OTO37U7W	MAGD4_HUMAN	Affects Response To Substance	[33]
Purine nucleoside phosphorylase (PNP)	OTO5NIJ2	PNPH_HUMAN	Affects Response To Substance	[34]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Response To Substance	[148]
Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1)	OTODG57A	FUT1_HUMAN	Affects Response To Substance	[149]
Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA)	OTOJ8QFF	SDHA_HUMAN	Affects Response To Substance	[34]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Decreases Response To Substance	[150]
Copper homeostasis protein cutC homolog (CUTC)	OTOVHLU9	CUTC_HUMAN	Affects Response To Substance	[33]
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD)	OTP9COQT	PISD_HUMAN	Affects Response To Substance	[34]
Ras-related protein Rab-20 (RAB20)	OTP9OOVS	RAB20_HUMAN	Affects Response To Substance	[33]
MHC class I polypeptide-related sequence A (MICA)	OTPEIEAR	MICA_HUMAN	Affects Response To Substance	[33]
Tensin-3 (TNS3)	OTPG2D8Z	TENS3_HUMAN	Affects Response To Substance	[33]
Neurotensin/neuromedin N (NTS)	OTPGDNQS	NEUT_HUMAN	Affects Response To Substance	[33]
Na(+)/citrate cotransporter (SLC13A5)	OTPH1TA7	S13A5_HUMAN	Decreases Response To Substance	[151]
Interferon alpha-1/13 (IFNA1)	OTPMKY0L	IFNA1_HUMAN	Increases Abundance	[6]
SPARC (SPARC)	OTPN90H0	SPRC_HUMAN	Increases Response To Substance	[152]
M-phase inducer phosphatase 3 (CDC25C)	OTPQI71S	MPIP3_HUMAN	Affects Response To Substance	[34]
Protein C-mannosyl-transferase DPY19L1 (DPY19L1)	OTPULBDX	D19L1_HUMAN	Affects Response To Substance	[33]
Transcription factor SOX-18 (SOX18)	OTPUMHWA	SOX18_HUMAN	Affects Response To Substance	[33]
Copper-transporting ATPase 2 (ATP7B)	OTPWLNCO	ATP7B_HUMAN	Increases Response To Substance	[131]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Affects Response To Substance	[33]
Centromere protein U (CENPU)	OTQ4TZRS	CENPU_HUMAN	Affects Response To Substance	[34]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Affects Response To Substance	[33]
Angiopoietin-related protein 4 (ANGPTL4)	OTQL5SPX	ANGL4_HUMAN	Affects Response To Substance	[33]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Decreases Response To Substance	[153]
E3 ubiquitin-protein ligase RNF34 (RNF34)	OTQY58LU	RNF34_HUMAN	Decreases Response To Substance	[154]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI)	OTR443C5	BGH3_HUMAN	Affects Response To Substance	[33]
Kelch-like protein 9 (KLHL9)	OTRGEG3Z	KLHL9_HUMAN	Affects Response To Substance	[33]
LIM domain kinase 2 (LIMK2)	OTRJD7VZ	LIMK2_HUMAN	Affects Response To Substance	[33]
Large ribosomal subunit protein eL6 (RPL6)	OTRU71O4	RL6_HUMAN	Decreases Response To Substance	[155]
Perilipin-2 (PLIN2)	OTRXJ9UN	PLIN2_HUMAN	Affects Response To Substance	[33]
MHC class I polypeptide-related sequence B (MICB)	OTS2DVDW	MICB_HUMAN	Affects Response To Substance	[33]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)	OTSBQR6D	PLCG1_HUMAN	Decreases Response To Substance	[156]
Thymosin beta-15A (TMSB15A)	OTSBWCES	TB15A_HUMAN	Affects Response To Substance	[126]
Protein phosphatase 1 regulatory subunit 1B (PPP1R1B)	OTSIJMQ9	PPR1B_HUMAN	Increases Response To Substance	[157]
Formin-binding protein 1 (FNBP1)	OTSJ5KKA	FNBP1_HUMAN	Affects Response To Substance	[33]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)	OTSMGKXQ	EBP_HUMAN	Affects Response To Substance	[34]
Interleukin-27 receptor subunit alpha (IL27RA)	OTSQBAKI	I27RA_HUMAN	Affects Response To Substance	[33]
Rhotekin (RTKN)	OTSS8XR6	RTKN_HUMAN	Decreases Response To Substance	[158]
Procollagen C-endopeptidase enhancer 2 (PCOLCE2)	OTSUEQZ1	PCOC2_HUMAN	Affects Response To Substance	[33]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Affects Response To Substance	[33]
Cdc42 effector protein 1 (CDC42EP1)	OTT525WA	BORG5_HUMAN	Affects Response To Substance	[33]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Affects Response To Substance	[33]
Nucleophosmin (NPM1)	OTTBYYT0	NPM_HUMAN	Decreases Response To Substance	[159]
Selenide, water dikinase 2 (SEPHS2)	OTTFXROR	SPS2_HUMAN	Affects Response To Substance	[33]
DNA polymerase alpha subunit B (POLA2)	OTTWQ73N	DPOA2_HUMAN	Affects Response To Substance	[34]
EH domain-containing protein 2 (EHD2)	OTTX391J	EHD2_HUMAN	Affects Response To Substance	[33]
Protein enabled homolog (ENAH)	OTU49OK5	ENAH_HUMAN	Affects Response To Substance	[33]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Affects Response To Substance	[33]
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)	OTUG4BWA	PAHX_HUMAN	Affects Response To Substance	[33]
Leupaxin (LPXN)	OTUNV3CK	LPXN_HUMAN	Affects Response To Substance	[34]
AT-rich interactive domain-containing protein 5B (ARID5B)	OTUQ4CQY	ARI5B_HUMAN	Affects Response To Substance	[33]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Affects Response To Substance	[33]
Cysteine and glycine-rich protein 1 (CSRP1)	OTUS7RM2	CSRP1_HUMAN	Affects Response To Substance	[33]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Affects Response To Substance	[34]
Acyl-CoA (FADS1)	OTUYOYHX	FADS1_HUMAN	Affects Response To Substance	[33]
Histone deacetylase 2 (HDAC2)	OTUYVFKN	HDAC2_HUMAN	Increases Response To Substance	[153]
Nucleolysin TIAR (TIAL1)	OTV2KFZH	TIAR_HUMAN	Affects Response To Substance	[34]
Lymphocyte antigen 6 complex locus protein G6c (LY6G6C)	OTV7F59X	LY66C_HUMAN	Affects Response To Substance	[33]
ATP-binding cassette sub-family C member 11 (ABCC11)	OTVHL7OR	MRP8_HUMAN	Decreases Response To Substance	[160]
Megakaryocyte and platelet inhibitory receptor G6b (MPIG6B)	OTVNKQWA	G6B_HUMAN	Affects Response To Substance	[33]
GTP-binding protein Rit1 (RIT1)	OTVNOGOH	RIT1_HUMAN	Affects Response To Substance	[33]
Abasic site processing protein HMCES (HMCES)	OTVRDL6U	HMCES_HUMAN	Affects Response To Substance	[34]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Affects Response To Substance	[33]
Folylpolyglutamate synthase, mitochondrial (FPGS)	OTW3F1ZE	FOLC_HUMAN	Increases Response To Substance	[161]
Fanconi anemia group I protein (FANCI)	OTW8E3SC	FANCI_HUMAN	Affects Response To Substance	[34]
Retrotransposon-derived protein PEG10 (PEG10)	OTWD2278	PEG10_HUMAN	Affects Response To Substance	[33]
Periostin (POSTN)	OTWP62UA	POSTN_HUMAN	Decreases Response To Substance	[162]
Acyl-coenzyme A thioesterase 13 (ACOT13)	OTWRUST1	ACO13_HUMAN	Affects Response To Substance	[33]
DNA primase small subunit (PRIM1)	OTWWP8Y6	PRI1_HUMAN	Affects Response To Substance	[34]
Amyloid-beta A4 precursor protein-binding family A member 2 (APBA2)	OTXD8ID1	APBA2_HUMAN	Affects Response To Substance	[33]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Affects Response To Substance	[33]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Increases Abundance	[6]
Peptidyl-prolyl cis-trans isomerase FKBP11 (FKBP11)	OTY2GC67	FKB11_HUMAN	Affects Response To Substance	[33]
Adhesion G-protein coupled receptor G6 (ADGRG6)	OTY2UBXO	AGRG6_HUMAN	Affects Response To Substance	[33]
Class E basic helix-loop-helix protein 41 (BHLHE41)	OTY9GJ1Y	BHE41_HUMAN	Affects Response To Substance	[33]
Serine/threonine-protein kinase TAO3 (TAOK3)	OTYBATSH	TAOK3_HUMAN	Affects Response To Substance	[34]
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1)	OTYEJAGZ	GPT_HUMAN	Affects Response To Substance	[33]
Glia-derived nexin (SERPINE2)	OTYF5340	GDN_HUMAN	Increases ADR	[139]
Chloride intracellular channel protein 1 (CLIC1)	OTYLFWNG	CLIC1_HUMAN	Affects Response To Substance	[33]
Interferon beta (IFNB1)	OTYQGUB5	IFNB_HUMAN	Increases Response To Substance	[163]
Galectin-3 (LGALS3)	OTYQT0ZI	LEG3_HUMAN	Decreases Response To Substance	[164]
ADP-ribosylation factor 3 (ARF3)	OTYYQX85	ARF3_HUMAN	Affects Response To Substance	[34]
Selenide, water dikinase 1 (SEPHS1)	OTZ19I59	SPS1_HUMAN	Affects Response To Substance	[33]
Glutathione S-transferase A4 (GSTA4)	OTZ1USIA	GSTA4_HUMAN	Affects Response To Substance	[33]
Thiosulfate sulfurtransferase (TST)	OTZ4F5LK	THTR_HUMAN	Affects Response To Substance	[34]
Erythropoietin (EPO)	OTZ90CN4	EPO_HUMAN	Increases Response To Substance	[165]
Fermitin family homolog 2 (FERMT2)	OTZNPWWX	FERM2_HUMAN	Affects Response To Substance	[33]
Pro-neuregulin-1, membrane-bound isoform (NRG1)	OTZO6F1X	NRG1_HUMAN	Affects Response To Substance	[33]
Latexin (LXN)	OTZQ2M6Y	LXN_HUMAN	Affects Response To Substance	[33]
Multidrug and toxin extrusion protein 1 (SLC47A1)	OTZX0U5Q	S47A1_HUMAN	Affects Response To Substance	[33]

Indication(s) of Estramustine

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Approved	[3]

Estramustine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Estramustine binding protein (EMBP)	TTSBFYK	NOUNIPROTAC	Binder	[166]

Estramustine Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[167]

Estramustine Interacts with 2 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Increases Expression	[168]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Increases Phosphorylation	[169]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Ewing sarcoma-peripheral primitive neuroectodermal tumour	DC6EJAY	ES2	Investigative	[170]
Breast and ovarian cancer syndrome	DC3391I	UWB1289	Investigative	[1]
Rectal adenocarcinoma	DC45OUK	SW837	Investigative	[1]
Adenocarcinoma	DCNMZTZ	A427	Investigative	[171]
Adenocarcinoma	DCQAC7B	NCIH23	Investigative	[171]
Adenocarcinoma	DC1HNM3	COLO320DM	Investigative	[171]
Amelanotic melanoma	DCKS94D	A2058	Investigative	[171]
Germ cell tumour	DCEXSZU	PA1	Investigative	[171]
Malignant melanoma	DCDL0QH	A375	Investigative	[171]
Malignant melanoma	DCLG5ZV	SKMEL30	Investigative	[171]
Malignant melanoma	DCQ1IC9	UACC62	Investigative	[171]
Mesothelioma	DCQOS6W	MSTO	Investigative	[171]
Ovarian endometrioid adenocarcinoma	DCHKTGK	A2780	Investigative	[171]
Ovarian serous cystadenocarcinoma	DCN500T	SK-OV-3	Investigative	[171]

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