Details of the Drug Combination

General Information of Drug Combination (ID: DCTQ3GZ)

Drug Combination Name
Fluorouracil Sorafenib
Indication
Disease Entry Status REF
Breast and ovarian cancer syndrome Investigative [1]
Component Drugs Fluorouracil   DMUM7HZ Sorafenib   DMS8IFC
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: UWB1289+BRCA1
Zero Interaction Potency (ZIP) Score: 3.43
Bliss Independence Score: 2.84
Loewe Additivity Score: 1.17
LHighest Single Agent (HSA) Score: 8.01

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Fluorouracil
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [2]
Biliary tract cancer 2C17 Approved [2]
Colon adenocarcinoma N.A. Approved [2]
Esophageal squamous cell carcinoma 2E60.1 Approved [2]
Gastric intestinal type adenocarcinoma N.A. Approved [2]
Gastroesophageal junction adenocarcinoma 2B71 Approved [2]
Metastasis from malignant tumor of colon N.A. Approved [2]
Pancreatic adenocarcinoma N.A. Approved [2]
Rectal adenocarcinoma 2B92 Approved [2]
Rectum mucinous adenocarcinoma N.A. Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Colon cancer 2B90.Z Investigative [2]
Colon mucinous adenocarcinoma N.A. Investigative [2]
Colorectal cancer 2B91.Z Investigative [4]
Gastric cancer 2B72 Investigative [2]
Tumour 2A00-2F9Z Investigative [5]
Fluorouracil Interacts with 4 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
TERT messenger RNA (TERT mRNA) TTQY2EJ TERT_HUMAN . [5]
Candida Thymidylate synthase (Candi TMP1) TTU6BFZ TYSY_CANAL Inhibitor [40]
Dihydrothymine dehydrogenase (DPYD) TTZPS91 DPYD_HUMAN Inhibitor [41]
Thymidylate synthase messenger RNA (TYMS mRNA) TTP1UKZ TYSY_HUMAN . [5]
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Fluorouracil Interacts with 8 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [42]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [43]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [44]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [45]
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [46]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [46]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [46]
Equilibrative nucleoside transporter 1 (SLC29A1) DTXD1TQ S29A1_HUMAN Substrate [47]
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⏷ Show the Full List of 8 DTP(s)
Fluorouracil Interacts with 12 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [48]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Metabolism [48]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [48]
Dihydrothymine dehydrogenase (DPYD) DESOEW1 DPYD_HUMAN Metabolism [49]
Methylenetetrahydrofolate reductase (MTHFR) DEOXTPZ MTHR_HUMAN Metabolism [50]
Thymidine phosphorylase (TYMP) DE4HCYL TYPH_HUMAN Metabolism [50]
Amidophosphoribosyltransferase (GPAT) DEMJ7R2 PUR1_HUMAN Metabolism [51]
Thymidylate synthase (TYMS) DEASG0Q TYSY_HUMAN Metabolism [50]
Uridine 5'-monophosphate synthase (UMPS) DEWJYTE UMPS_HUMAN Metabolism [52]
Uridine phosphorylase 1 (UPP1) DEFZWAX UPP1_HUMAN Metabolism [53]
Uridine phosphorylase 2 (UPP2) DEBQ2WU UPP2_HUMAN Metabolism [53]
Uracil phosphoribosyltransferase (UPRT) DE20ETR UPP_HUMAN Metabolism [54]
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⏷ Show the Full List of 12 DME(s)
Fluorouracil Interacts with 1026 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Increases Chemical Synthesis [55]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Increases Response To Substance [56]
Dihydropyrimidine dehydrogenase (DPYD) OTWRF2NR DPYD_HUMAN Increases Response To Substance [57]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [58]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Increases Expression [59]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Affects Response To Substance [35]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Decreases Response To Substance [46]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Increases Transport [45]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Increases Expression [12]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [60]
Fanconi anemia group G protein (FANCG) OT7MC8TZ FANCG_HUMAN Increases Expression [9]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Decreases Expression [9]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Increases Expression [9]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Decreases Expression [9]
Thymidylate kinase (DTYMK) OTJXYQYK KTHY_HUMAN Increases Expression [9]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Increases Expression [9]
Interleukin-1 receptor-associated kinase 1 (IRAK1) OT133G8J IRAK1_HUMAN Increases Expression [9]
UV excision repair protein RAD23 homolog B (RAD23B) OT0PGOG3 RD23B_HUMAN Increases Expression [9]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Decreases Expression [9]
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) OTM3H5OA MALT1_HUMAN Increases Expression [9]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Increases Expression [61]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [61]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [61]
Enoyl-CoA hydratase, mitochondrial (ECHS1) OTS0593S ECHM_HUMAN Increases Expression [61]
Spermine synthase (SMS) OT8JYKNH SPSY_HUMAN Increases Expression [61]
10 kDa heat shock protein, mitochondrial (HSPE1) OT7JSZLB CH10_HUMAN Increases Expression [61]
Thymosin beta-4 (TMSB4X) OT9HPLP3 TYB4_HUMAN Increases Expression [61]
Large ribosomal subunit protein uL14 (RPL23) OTXI1YLM RL23_HUMAN Increases Expression [61]
Small ribosomal subunit protein eS28 (RPS28) OT12IES1 RS28_HUMAN Increases Expression [61]
Thymosin beta-10 (TMSB10) OTLVZ13T TYB10_HUMAN Increases Expression [61]
FXYD domain-containing ion transport regulator 3 (FXYD3) OT9PPRHE FXYD3_HUMAN Increases Expression [61]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Expression [12]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [12]
Regulator of G-protein signaling 16 (RGS16) OTBKZASI RGS16_HUMAN Affects Expression [12]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Expression [12]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [12]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Increases Expression [12]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [12]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [12]
Elastin (ELN) OTFSO7PG ELN_HUMAN Affects Expression [12]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Decreases Expression [12]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [12]
NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) OTPDCK1F ADRO_HUMAN Increases Expression [12]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) OTGP6GA4 NR4A1_HUMAN Affects Expression [12]
Corticotropin-releasing factor-binding protein (CRHBP) OT9AB48G CRHBP_HUMAN Affects Expression [12]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [12]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Affects Expression [12]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Affects Expression [12]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [12]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Increases Expression [12]
L-dopachrome tautomerase (DCT) OTYVNTBG TYRP2_HUMAN Affects Expression [12]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [12]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [12]
GTP-binding protein GEM (GEM) OT6SK8ZV GEM_HUMAN Affects Expression [12]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Increases Expression [12]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Affects Expression [12]
Dihydropyrimidinase-related protein 3 (DPYSL3) OTINJV20 DPYL3_HUMAN Affects Expression [12]
Elongin-A (ELOA) OTOQTF5K ELOA1_HUMAN Affects Expression [12]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Decreases Expression [12]
Cyclin-dependent kinase 5 activator 1 (CDK5R1) OTJELWK0 CD5R1_HUMAN Affects Expression [12]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Increases Expression [12]
Probable carboxypeptidase X1 (CPXM1) OTRCSQPG CPXM1_HUMAN Affects Expression [12]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Decreases Expression [12]
Epiphycan (EPYC) OTTRI5WO EPYC_HUMAN Affects Expression [12]
Collagen alpha-1(XII) chain (COL12A1) OTHLTV53 COCA1_HUMAN Decreases Expression [12]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [12]
Spondin-1 (SPON1) OTC06MY4 SPON1_HUMAN Affects Expression [12]
Ras-related protein Rab-21 (RAB21) OTH3WGLG RAB21_HUMAN Affects Expression [12]
Homeobox protein Hox-C11 (HOXC11) OT8NMHM6 HXC11_HUMAN Affects Expression [13]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [13]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [13]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Increases Expression [13]
Serine/arginine-rich splicing factor 11 (SRSF11) OTZSV6CZ SRS11_HUMAN Increases Expression [13]
Unconventional myosin-Ie (MYO1E) OTM9YSIZ MYO1E_HUMAN Increases Expression [13]
Cleavage stimulation factor subunit 3 (CSTF3) OT1Y7B5U CSTF3_HUMAN Increases Expression [13]
Centromere protein Q (CENPQ) OT3M6WAI CENPQ_HUMAN Increases Expression [13]
Arginine/serine-rich coiled-coil protein 2 (RSRC2) OTLE0KQM RSRC2_HUMAN Increases Expression [13]
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) OTM3KHIE ARFG1_HUMAN Increases Expression [13]
DNA damage-binding protein 2 (DDB2) OTO8HVVB DDB2_HUMAN Increases Expression [13]
Spermatogenesis-associated protein 25 (SPATA25) OTJMFF0A SPT25_HUMAN Increases Expression [13]
G-protein coupled receptor 35 (GPR35) OTO23NRK GPR35_HUMAN Increases Expression [13]
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) OTB41D5K RPR1B_HUMAN Increases Expression [13]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Increases Expression [13]
Mitogen-activated protein kinase 13 (MAPK13) OT0W9GE7 MK13_HUMAN Increases Expression [14]
Eukaryotic translation initiation factor 3 subunit H (EIF3H) OT61RBF5 EIF3H_HUMAN Increases Expression [14]
Mitotic checkpoint protein BUB3 (BUB3) OTU91HAU BUB3_HUMAN Decreases Expression [14]
Cytohesin-3 (CYTH3) OTBXAT3Z CYH3_HUMAN Decreases Expression [14]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) OTBURQ3A NDUAA_HUMAN Increases Expression [14]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Decreases Expression [14]
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) OT47AK4C HNRPC_HUMAN Increases Expression [14]
Histone H1.3 (H1-3) OTT7VPRB H13_HUMAN Increases Expression [14]
Cation-dependent mannose-6-phosphate receptor (M6PR) OTFEWOSB MPRD_HUMAN Increases Expression [14]
Long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADL) OTP7Y0UF ACADL_HUMAN Increases Expression [14]
Endoplasmic reticulum resident protein 29 (ERP29) OTNKANMH ERP29_HUMAN Decreases Expression [14]
Glutathione S-transferase theta-1 (GSTT1) OTRFMWBK GSTT1_HUMAN Increases Expression [14]
Large ribosomal subunit protein uL3 (RPL3) OTX6VXLB RL3_HUMAN Decreases Expression [14]
Aminomethyltransferase, mitochondrial (AMT) OTQYEWZQ GCST_HUMAN Increases Expression [14]
Translation initiation factor eIF2B subunit beta (EIF2B2) OTQQMHM1 EI2BB_HUMAN Decreases Expression [14]
Adenosine 5'-monophosphoramidase HINT1 (HINT1) OTQIR8LF HINT1_HUMAN Increases Expression [14]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1) OT62RL5P BDH_HUMAN Decreases Expression [14]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA) OT58PUEN PP2BA_HUMAN Increases Expression [14]
Src substrate cortactin (CTTN) OTJRG4ES SRC8_HUMAN Decreases Expression [14]
Prostaglandin reductase 1 (PTGR1) OTMAR351 PTGR1_HUMAN Increases Expression [14]
Eukaryotic translation initiation factor 4H (EIF4H) OTGZI072 IF4H_HUMAN Increases Expression [14]
Telomeric repeat-binding factor 2 (TERF2) OTBSAS0V TERF2_HUMAN Increases Expression [14]
snRNA-activating protein complex subunit 1 (SNAPC1) OTAPN1NI SNPC1_HUMAN Decreases Expression [14]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) OTL4VJC5 NUCKS_HUMAN Decreases Expression [14]
Lipid transferase CIDEB (CIDEB) OT873IYM CIDEB_HUMAN Increases Expression [14]
Homeobox protein BarH-like 2 (BARX2) OT0R3QD3 BARX2_HUMAN Increases Expression [14]
Protocadherin alpha-5 (PCDHA5) OTHZT1GR PCDA5_HUMAN Decreases Expression [14]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [62]
Solute carrier family 15 member 1 (SLC15A1) OT1P16B5 S15A1_HUMAN Decreases Expression [62]
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1) OTBV52DR SMHD1_HUMAN Increases Expression [15]
Ankyrin repeat domain-containing protein 36A (ANKRD36) OT3XEYKG AN36A_HUMAN Increases Expression [15]
Pyridoxal kinase (PDXK) OT40AJ5J PDXK_HUMAN Decreases Expression [15]
Inositol monophosphatase 2 (IMPA2) OTNFB9YN IMPA2_HUMAN Increases Expression [15]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Decreases Expression [15]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4) OT3LOE2J MAST4_HUMAN Increases Expression [15]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [15]
Nucleoplasmin-3 (NPM3) OTIAM1A3 NPM3_HUMAN Decreases Expression [15]
Ubiquitin-like protein ATG12 (ATG12) OTJRO09Y ATG12_HUMAN Decreases Expression [15]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Expression [15]
Microtubule-associated protein 2 (MAP2) OT6UYT3X MTAP2_HUMAN Increases Expression [15]
Ribose-phosphate pyrophosphokinase 2 (PRPS2) OTCY1B1O PRPS2_HUMAN Decreases Expression [15]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [15]
Folate receptor alpha (FOLR1) OT0QZ0H6 FOLR1_HUMAN Decreases Expression [15]
Calretinin (CALB2) OTSNMCG9 CALB2_HUMAN Increases Expression [15]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [15]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [15]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) OT6LIGJP MA1A1_HUMAN Increases Expression [15]
Proteasome subunit beta type-10 (PSMB10) OTURUR9B PSB10_HUMAN Decreases Expression [15]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Decreases Expression [15]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Decreases Expression [15]
CCN family member 3 (CCN3) OTOW5YL4 CCN3_HUMAN Increases Expression [15]
Caveolin-2 (CAV2) OT1FGRQX CAV2_HUMAN Decreases Expression [15]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Increases Expression [15]
Transmembrane protein 33 (TMEM33) OTRG1DOY TMM33_HUMAN Decreases Expression [15]
Epiplakin (EPPK1) OT7BAU8C EPIPL_HUMAN Increases Expression [15]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Decreases Expression [15]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Increases Expression [15]
High mobility group nucleosome-binding domain-containing protein 5 (HMGN5) OTUUAHVQ HMGN5_HUMAN Increases Expression [15]
Small EDRK-rich factor 2 (SERF2) OTZQDYCZ SERF2_HUMAN Decreases Expression [15]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Increases Expression [15]
Proline-rich nuclear receptor coactivator 1 (PNRC1) OTQMLEE1 PNRC1_HUMAN Increases Expression [15]
S-methyl-5'-thioadenosine phosphorylase (MTAP) OTOWN2K9 MTAP_HUMAN Decreases Expression [15]
Spliceosome RNA helicase DDX39B (DDX39B) OTEVCFVU DX39B_HUMAN Increases Expression [15]
Beta-1-syntrophin (SNTB1) OTSRBECI SNTB1_HUMAN Increases Expression [15]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [15]
Semaphorin-3A (SEMA3A) OTQJSV7W SEM3A_HUMAN Increases Expression [15]
Uncharacterized protein KIAA0040 (KIAA0040) OT27EBY3 K0040_HUMAN Increases Expression [15]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [15]
Dual specificity protein phosphatase 6 (DUSP6) OT4H6RKW DUS6_HUMAN Increases Expression [15]
Pre-rRNA-processing protein TSR1 homolog (TSR1) OTCVZFL9 TSR1_HUMAN Decreases Expression [15]
Fibronectin type III domain-containing protein 3B (FNDC3B) OTBILGDR FND3B_HUMAN Decreases Expression [15]
Nucleolar MIF4G domain-containing protein 1 (NOM1) OTWZSJJC NOM1_HUMAN Decreases Expression [15]
Protein FAM76B (FAM76B) OT4RG5U7 FA76B_HUMAN Decreases Expression [15]
MAGUK p55 subfamily member 7 (MPP7) OT3G3HTZ MPP7_HUMAN Decreases Expression [15]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48) OTSR6DEJ SNR48_HUMAN Decreases Expression [15]
Parafibromin (CDC73) OT6JASZ1 CDC73_HUMAN Decreases Expression [15]
Neuroblastoma breakpoint family member 10 (NBPF10) OTGOCELY NBPFA_HUMAN Increases Expression [15]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [15]
Ankyrin repeat domain-containing protein 11 (ANKRD11) OTV0V70M ANR11_HUMAN Increases Expression [15]
MAM domain-containing protein 2 (MAMDC2) OT4GICNY MAMC2_HUMAN Increases Expression [15]
Coiled-coil domain-containing protein 186 (CCDC186) OTONSQAD CC186_HUMAN Increases Expression [15]
Serologically defined colon cancer antigen 8 (SDCCAG8) OTV2ZGV9 SDCG8_HUMAN Increases Expression [15]
Liprin-beta-1 (PPFIBP1) OTRA2S7B LIPB1_HUMAN Increases Expression [15]
Homeobox protein Mohawk (MKX) OT7H7Z50 MKX_HUMAN Decreases Expression [15]
Mastermind-like protein 2 (MAML2) OT1TSVAR MAML2_HUMAN Increases Expression [15]
Delta and Notch-like epidermal growth factor-related receptor (DNER) OT2GH2E5 DNER_HUMAN Increases Expression [15]
Ribosome biogenesis protein BRX1 homolog (BRIX1) OTQ5F1D1 BRX1_HUMAN Decreases Expression [15]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Increases Expression [15]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [15]
Alkylated DNA repair protein alkB homolog 8 (ALKBH8) OTXN70DV ALKB8_HUMAN Decreases Expression [15]
EF-hand domain-containing protein D2 (EFHD2) OTM9VMN3 EFHD2_HUMAN Decreases Expression [15]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) OTMJKJAK NAF1_HUMAN Decreases Expression [15]
Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST2) OT8A3H9Y H6ST2_HUMAN Decreases Expression [15]
Transmembrane protein 74 (TMEM74) OT3IZBM0 TMM74_HUMAN Increases Expression [15]
Small integral membrane protein 14 (SMIM14) OT47IF19 SIM14_HUMAN Increases Expression [15]
Peptide deformylase, mitochondrial (PDF) OTZ75ZK5 DEFM_HUMAN Increases Expression [15]
Synaptotagmin-like protein 2 (SYTL2) OTUIOWKL SYTL2_HUMAN Increases Expression [15]
Uncharacterized protein C14orf132 (C14ORF132) OTBVC3AO CN132_HUMAN Increases Expression [15]
Cell death regulator Aven (AVEN) OTGIN5YK AVEN_HUMAN Decreases Expression [15]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) OTPL0AI1 ABC3C_HUMAN Increases Expression [15]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [15]
Cysteine-rich motor neuron 1 protein (CRIM1) OTTZNV6Y CRIM1_HUMAN Decreases Expression [15]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Decreases Expression [15]
Pleckstrin homology domain-containing family B member 1 (PLEKHB1) OTC7TNAX PKHB1_HUMAN Increases Expression [15]
Switch-associated protein 70 (SWAP70) OTPHT2QD SWP70_HUMAN Decreases Expression [15]
Carboxypeptidase A4 (CPA4) OT66MP0F CBPA4_HUMAN Decreases Expression [15]
Endoribonuclease Dicer (DICER1) OTTVSEY0 DICER_HUMAN Decreases Expression [15]
RRP15-like protein (RRP15) OTE8CQ7K RRP15_HUMAN Decreases Expression [15]
AP-4 complex subunit sigma-1 (AP4S1) OTM3QBU8 AP4S1_HUMAN Decreases Expression [15]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Expression [16]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) OTKOZRZP PLOD2_HUMAN Decreases Expression [16]
Nuclear factor 1 B-type (NFIB) OTX94PD0 NFIB_HUMAN Decreases Expression [16]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Increases Expression [16]
Suppressor of cytokine signaling 1 (SOCS1) OTWA9KFU SOCS1_HUMAN Increases Expression [16]
Krueppel-like factor 4 (KLF4) OT4O9RQW KLF4_HUMAN Increases Expression [16]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [16]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Affects Expression [16]
Transcription factor Maf (MAF) OT1GR3IZ MAF_HUMAN Increases Expression [16]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [16]
Fibrinogen silencer-binding protein (RAD54B) OTMWB2P2 FSBP_HUMAN Decreases Expression [16]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [16]
GTPase HRas (HRAS) OTWQN0DP RASH_HUMAN Increases Expression [16]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [16]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Affects Expression [16]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [16]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Decreases Expression [16]
Myb-related protein B (MYBL2) OTZ3JX8Q MYBB_HUMAN Increases Expression [16]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Increases Expression [16]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Increases Expression [16]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [16]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [16]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Expression [16]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [16]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Increases Expression [16]
Lysine-specific demethylase 5A (KDM5A) OTLYFX8A KDM5A_HUMAN Decreases Expression [16]
2'-5'-oligoadenylate synthase 2 (OAS2) OT64CCTM OAS2_HUMAN Increases Expression [16]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [16]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [16]
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) OT0THBVA DUT_HUMAN Decreases Expression [16]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Increases Expression [16]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Increases Expression [16]
Protein phosphatase inhibitor 2 (PPP1R2) OTNLOUQR IPP2_HUMAN Decreases Expression [16]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) OTCLOV90 CDN2C_HUMAN Decreases Expression [16]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [16]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Decreases Expression [16]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Increases Expression [16]
Large ribosomal subunit protein eL37 (RPL37) OTB6SDZ1 RL37_HUMAN Decreases Expression [16]
Fanconi anemia group C protein (FANCC) OTTIDM3P FANCC_HUMAN Decreases Expression [16]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Increases Expression [16]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Increases Expression [16]
Histone-binding protein RBBP4 (RBBP4) OTG3BT3M RBBP4_HUMAN Decreases Expression [16]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [16]
Ribosomal protein eS27-like (RPS27L) OTZWHU0N RS27L_HUMAN Increases Expression [16]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [16]
Pantothenate kinase 1 (PANK1) OT2CZVRT PANK1_HUMAN Increases Expression [16]
Cullin-5 (CUL5) OTMTZD47 CUL5_HUMAN Increases Expression [16]
RNA-binding protein 14 (RBM14) OTO9GMBD RBM14_HUMAN Increases Expression [16]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Increases Expression [16]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1) OTYKB9G3 SIN1_HUMAN Increases Expression [16]
E3 ubiquitin-protein ligase SMURF1 (SMURF1) OT5UIZR8 SMUF1_HUMAN Increases Expression [16]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Increases Expression [16]
SERTA domain-containing protein 1 (SERTAD1) OTBHKZQP SRTD1_HUMAN Increases Expression [16]
Heat shock protein beta-8 (HSPB8) OT0I83YS HSPB8_HUMAN Increases Expression [16]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [16]
Pleckstrin homology-like domain family A member 3 (PHLDA3) OTXFUDO2 PHLA3_HUMAN Increases Expression [16]
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) OTCW8HT6 TNR18_HUMAN Increases Expression [16]
Regulator of G-protein signaling 13 (RGS13) OTPAMQ18 RGS13_HUMAN Decreases Expression [17]
Pre-mRNA-processing factor 17 (CDC40) OTOYUNHN PRP17_HUMAN Increases Expression [17]
Synaptosomal-associated protein 29 (SNAP29) OTT30ZON SNP29_HUMAN Increases Expression [17]
Protein phosphatase 1 regulatory subunit 17 (PPP1R17) OT19635T PPR17_HUMAN Increases Expression [17]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Increases Expression [17]
Serpin B4 (SERPINB4) OT88LHZ8 SPB4_HUMAN Decreases Expression [17]
Cullin-4B (CUL4B) OT2QX4DO CUL4B_HUMAN Increases Expression [17]
TRAF family member-associated NF-kappa-B activator (TANK) OTZSGFIK TANK_HUMAN Increases Expression [17]
Engulfment and cell motility protein 2 (ELMO2) OTKDOC2M ELMO2_HUMAN Increases Expression [17]
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) OT24ZO59 MD2L2_HUMAN Decreases Expression [17]
Peptidyl-prolyl cis-trans isomerase E (PPIE) OTIE5OAD PPIE_HUMAN Increases Expression [17]
Transmembrane gamma-carboxyglutamic acid protein 1 (PRRG1) OTMH6OWG TMG1_HUMAN Decreases Expression [18]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [18]
Protein sprouty homolog 1 (SPRY1) OT764FXI SPY1_HUMAN Increases Expression [18]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) OTRNDZXB HNRPQ_HUMAN Decreases Expression [18]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [18]
Fibrinogen gamma chain (FGG) OT5BJSEX FIBG_HUMAN Decreases Expression [18]
Plasma serine protease inhibitor (SERPINA5) OTTZXPGD IPSP_HUMAN Increases Expression [18]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Increases Expression [18]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Increases Expression [18]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Increases Expression [18]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Decreases Expression [18]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [18]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Decreases Expression [18]
Lysophosphatidic acid receptor 6 (LPAR6) OT4BY3W4 LPAR6_HUMAN Decreases Expression [18]
Eukaryotic translation initiation factor 5 (EIF5) OT79PQUN IF5_HUMAN Increases Expression [18]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Decreases Expression [18]
Ras-related protein Rab-11A (RAB11A) OTC4FW0J RB11A_HUMAN Decreases Expression [18]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [18]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Decreases Expression [18]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [18]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Increases Expression [18]
Four and a half LIM domains protein 3 (FHL3) OTMPRLZ5 FHL3_HUMAN Increases Expression [18]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [18]
Ankyrin repeat domain-containing protein 1 (ANKRD1) OTHJ7JV9 ANKR1_HUMAN Increases Expression [18]
Adipogenesis regulatory factor (ADIRF) OTTJP8D4 ADIRF_HUMAN Increases Expression [18]
Protein mono-ADP-ribosyltransferase PARP14 (PARP14) OTFXJAKK PAR14_HUMAN Increases Expression [18]
Centrosomal protein of 55 kDa (CEP55) OTGSG2PA CEP55_HUMAN Decreases Expression [18]
ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1) OT416O2G SUV3_HUMAN Decreases Expression [18]
Membrane progestin receptor beta (PAQR8) OTGZ8W9F PAQR8_HUMAN Decreases Expression [18]
Programmed cell death 6-interacting protein (PDCD6IP) OTS8T6A7 PDC6I_HUMAN Decreases Expression [18]
BTB/POZ domain-containing protein KCTD12 (KCTD12) OTPYKT4Z KCD12_HUMAN Decreases Expression [18]
Cytoplasmic FMR1-interacting protein 2 (CYFIP2) OTCAY35T CYFP2_HUMAN Increases Expression [18]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [18]
Mini-chromosome maintenance complex-binding protein (MCMBP) OTQ6WO7A MCMBP_HUMAN Increases Expression [18]
Netrin-4 (NTN4) OTDRRMP3 NET4_HUMAN Increases Expression [18]
Serine/threonine-protein kinase Nek6 (NEK6) OT8PQSO1 NEK6_HUMAN Decreases Expression [18]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Decreases Expression [19]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [19]
Protein phosphatase 1D (PPM1D) OT8NLZ9D PPM1D_HUMAN Increases Expression [19]
TP53-regulated inhibitor of apoptosis 1 (TRIAP1) OTEAUJXN TRIA1_HUMAN Increases Expression [19]
Glutathione peroxidase 1 (GPX1) OTE2O72Q GPX1_HUMAN Increases Expression [19]
Protein S100-A2 (S100A2) OTTGHJ1H S10A2_HUMAN Increases Expression [19]
Serpin B5 (SERPINB5) OTSMXQRJ SPB5_HUMAN Increases Expression [19]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Expression [19]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Increases Expression [19]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [19]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Increases Expression [19]
Quinone oxidoreductase (CRYZ) OTD2F4C8 QOR_HUMAN Decreases Expression [19]
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) OTVFQEPA IKIP_HUMAN Increases Expression [19]
DNA damage-regulated autophagy modulator protein 1 (DRAM1) OTIJTXEN DRAM1_HUMAN Increases Expression [19]
Protein ECT2 (ECT2) OTQDUCT6 ECT2_HUMAN Decreases Expression [19]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [19]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Increases Expression [19]
Sestrin-1 (SESN1) OTSFDZWL SESN1_HUMAN Increases Expression [19]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Increases Phosphorylation [63]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Phosphorylation [63]
Thymidine kinase 2, mitochondrial (TK2) OTS1V4XB KITM_HUMAN Increases Expression [20]
Adenylate cyclase type 9 (ADCY9) OT1IZT5K ADCY9_HUMAN Decreases Expression [20]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Decreases Expression [20]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) OTPG0K7E IMDH2_HUMAN Increases Expression [20]
CTP synthase 1 (CTPS1) OTZ9J6ZG PYRG1_HUMAN Decreases Expression [20]
Trifunctional purine biosynthetic protein adenosine-3 (GART) OT01JWJB PUR2_HUMAN Increases Expression [20]
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) OTMZN747 PUR6_HUMAN Increases Expression [20]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) OT6E2OW6 ENTP1_HUMAN Decreases Expression [20]
AMP deaminase 2 (AMPD2) OTBS30JU AMPD2_HUMAN Decreases Expression [20]
Guanylate cyclase soluble subunit beta-1 (GUCY1B1) OTSHPHVB GCYB1_HUMAN Decreases Expression [20]
5'(3')-deoxyribonucleotidase, mitochondrial (NT5M) OTJF73BA NT5M_HUMAN Increases Expression [20]
Protein shisa-9 (SHISA9) OTZI2V0J SHSA9_HUMAN Increases Expression [21]
Transmembrane protein 150C (TMEM150C) OTUNPHV7 T150C_HUMAN Decreases Expression [21]
Left-right determination factor 2 (LEFTY2) OT3RX4QF LFTY2_HUMAN Decreases Expression [21]
Fatty acid-binding protein, brain (FABP7) OTRE2H4G FABP7_HUMAN Decreases Expression [21]
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) OTMVHF9E LGR5_HUMAN Decreases Expression [21]
Cerberus (CER1) OTTAJJ63 CER1_HUMAN Decreases Expression [21]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [21]
Collagen alpha-1(II) chain (COL2A1) OT5E59C8 CO2A1_HUMAN Decreases Expression [21]
Proto-oncogene DBL (MCF2) OTB9N93T MCF2_HUMAN Increases Expression [21]
Myosin light chain 4 (MYL4) OTURFCSE MYL4_HUMAN Decreases Expression [21]
Protein Cripto (CRIPTO) OT46DZXJ TDGF1_HUMAN Decreases Expression [21]
Secretogranin-2 (SCG2) OTUHXX8U SCG2_HUMAN Increases Expression [21]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Increases Expression [21]
Homeobox protein Hox-B3 (HOXB3) OT9UC5PE HXB3_HUMAN Decreases Expression [21]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Increases Expression [21]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Decreases Expression [21]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Decreases Expression [21]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Increases Expression [21]
Glioma pathogenesis-related protein 1 (GLIPR1) OT0FGQK7 GLIP1_HUMAN Increases Expression [21]
LIM/homeobox protein Lhx1 (LHX1) OT6WI2XS LHX1_HUMAN Decreases Expression [21]
Homeobox protein Hox-A1 (HOXA1) OTMSOJ7D HXA1_HUMAN Decreases Expression [21]
Paired mesoderm homeobox protein 1 (PRRX1) OTTZK5G8 PRRX1_HUMAN Decreases Expression [21]
Cadherin-6 (CDH6) OT81Y80S CADH6_HUMAN Decreases Expression [21]
Heart- and neural crest derivatives-expressed protein 2 (HAND2) OTCXYW4Y HAND2_HUMAN Increases Expression [21]
Protein delta homolog 1 (DLK1) OTE1VLNB DLK1_HUMAN Increases Expression [21]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Expression [21]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Increases Expression [21]
Testican-1 (SPOCK1) OTLTDGK7 TICN1_HUMAN Increases Expression [21]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Increases Expression [21]
Protein ABHD12B (ABHD12B) OTBHGWTF AB12B_HUMAN Decreases Expression [21]
Secreted frizzled-related protein 2 (SFRP2) OT8GZ0CA SFRP2_HUMAN Decreases Expression [21]
Protein LRATD1 (LRATD1) OT65IL83 LRAT1_HUMAN Increases Expression [21]
Neuroserpin (SERPINI1) OTUJHIJW NEUS_HUMAN Increases Expression [21]
Homeobox protein CDX-2 (CDX2) OTCG4TSY CDX2_HUMAN Decreases Expression [21]
G-protein coupled receptor 87 (GPR87) OTQX45UM GPR87_HUMAN Increases Expression [21]
Homeobox protein Hox-D1 (HOXD1) OTN4V9ZF HXD1_HUMAN Decreases Expression [21]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Expression [21]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Decreases Expression [21]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Decreases Expression [21]
Dynein axonemal heavy chain 2 (DNAH2) OT7J5LDI DYH2_HUMAN Decreases Expression [21]
Histone deacetylase 9 (HDAC9) OTO8O0LF HDAC9_HUMAN Increases Expression [21]
Thrombospondin type-1 domain-containing protein 7A (THSD7A) OT7249HH THS7A_HUMAN Increases Expression [21]
Nuclear factor erythroid 2-related factor 3 (NFE2L3) OT1MGXT0 NF2L3_HUMAN Increases Expression [21]
Transcription factor E2F8 (E2F8) OTQKZGFP E2F8_HUMAN Affects Expression [23]
Aquaporin-12B (AQP12B) OTNU5Z4K AQ12B_HUMAN Decreases Expression [22]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [64]
DNA fragmentation factor subunit alpha (DFFA) OTFPFMT8 DFFA_HUMAN Decreases Expression [22]
Forkhead box protein N3 (FOXN3) OTOJYJZP FOXN3_HUMAN Decreases Expression [24]
Butyrophilin subfamily 3 member A3 (BTN3A3) OTKMSJRA BT3A3_HUMAN Increases Expression [32]
Cytochrome c oxidase subunit NDUFA4 (NDUFA4) OTDVH3QG NDUA4_HUMAN Affects Expression [22]
Importin subunit alpha-4 (KPNA3) OTLI3TM2 IMA4_HUMAN Decreases Expression [28]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [65]
Pirin (PIR) OT8ALXHU PIR_HUMAN Decreases Expression [24]
Claudin-4 (CLDN4) OT9C4PZ4 CLD4_HUMAN Decreases Expression [24]
Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD) OTYZ8XRH DHSD_HUMAN Affects Expression [22]
Acyl carrier protein, mitochondrial (NDUFAB1) OTF906UR ACPM_HUMAN Affects Expression [22]
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) OTZX703K CDIPT_HUMAN Affects Expression [23]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Increases Expression [66]
Tripeptidyl-peptidase 1 (TPP1) OT2LQ771 TPP1_HUMAN Affects Expression [23]
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) OTVHOL9B TR10C_HUMAN Increases Expression [67]
Ras-related protein M-Ras (MRAS) OTNCVCQW RASM_HUMAN Affects Expression [23]
Tax1-binding protein 3 (TAX1BP3) OTQ6IB4T TX1B3_HUMAN Increases Expression [28]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Expression [68]
Angiopoietin-2 (ANGPT2) OTEQK65P ANGP2_HUMAN Decreases Expression [69]
Actin-related protein 2/3 complex subunit 3 (ARPC3) OTKWVF8P ARPC3_HUMAN Decreases Expression [28]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [28]
Toll-like receptor 3 (TLR3) OT8QPYXZ TLR3_HUMAN Increases Expression [70]
Melanoma-associated antigen B2 (MAGEB2) OTAGUVU5 MAGB2_HUMAN Decreases Expression [24]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [71]
ATP-dependent RNA helicase DHX15 (DHX15) OT4F98TK DHX15_HUMAN Increases Expression [23]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Increases Expression [24]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [72]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Increases Expression [25]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [73]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1) OTJ5TNHB NDUC1_HUMAN Affects Expression [22]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [28]
Keratin, type II cuticular Hb6 (KRT86) OT93MMAK KRT86_HUMAN Decreases Expression [24]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Affects Expression [23]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Affects Expression [23]
Serine protease inhibitor Kazal-type 4 (SPINK4) OTHTCW94 ISK4_HUMAN Affects Expression [23]
Cystatin-8 (CST8) OTT2FRCJ CST8_HUMAN Affects Expression [23]
Histone H2B type 1-K (H2BC12) OTQ8V0KG H2B1K_HUMAN Decreases Expression [32]
Receptor activity-modifying protein 1 (RAMP1) OT7UT2XB RAMP1_HUMAN Decreases Expression [24]
Sodium channel subunit beta-2 (SCN2B) OTFAHJ38 SCN2B_HUMAN Affects Expression [23]
Probable phospholipid-transporting ATPase IIA (ATP9A) OT328F1L ATP9A_HUMAN Decreases Expression [24]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Increases Expression [74]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Decreases Expression [24]
Tumor necrosis factor ligand superfamily member 13 (TNFSF13) OT90OWIO TNF13_HUMAN Increases Expression [75]
Signal recognition particle subunit SRP72 (SRP72) OTPV73W7 SRP72_HUMAN Increases Expression [23]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Decreases Expression [24]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Decreases Expression [24]
Tight junction protein ZO-3 (TJP3) OTC1K8HC ZO3_HUMAN Affects Expression [23]
Mitofusin-2 (MFN2) OTPYN8A3 MFN2_HUMAN Increases Expression [76]
NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2) OT4717TF NDUB2_HUMAN Increases Expression [22]
RCC1 and BTB domain-containing protein 2 (RCBTB2) OTECBF4R RCBT2_HUMAN Affects Expression [23]
ATP-binding cassette sub-family C member 6 (ABCC6) OTZT0LKT MRP6_HUMAN Increases Expression [24]
Phenylalanine--tRNA ligase, mitochondrial (FARS2) OTXAK6F0 SYFM_HUMAN Decreases Expression [32]
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) OTTR5311 STAU1_HUMAN Decreases Expression [28]
Mitochondrial uncoupling protein 4 (SLC25A27) OTSBOPGD UCP4_HUMAN Decreases Expression [22]
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) OTFLILEO NDUBA_HUMAN Affects Expression [22]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Decreases Activity [77]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Decreases Expression [28]
Coagulation factor XII (F12) OTBFD2FU FA12_HUMAN Decreases Expression [24]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Increases Expression [32]
Thyrotropin subunit beta (TSHB) OTFDI39D TSHB_HUMAN Affects Expression [78]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [79]
Hemoglobin subunit epsilon (HBE1) OTJPKMX4 HBE_HUMAN Decreases Expression [24]
Keratin, type II cytoskeletal 6A (KRT6A) OT392M5T K2C6A_HUMAN Affects Expression [23]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Increases Cleavage [80]
Apolipoprotein C-III (APOC3) OTW3520C APOC3_HUMAN Decreases Expression [74]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Decreases Expression [31]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [79]
Catalase (CAT) OTHEBX9R CATA_HUMAN Decreases Activity [77]
Vitamin K-dependent protein C (PROC) OTGVH484 PROC_HUMAN Decreases Activity [81]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Decreases Expression [24]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Decreases Expression [74]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Affects Splicing [82]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [28]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Increases Expression [24]
Integrin beta-2 (ITGB2) OTEKPEPR ITB2_HUMAN Decreases Expression [83]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Increases Expression [28]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Increases Expression [32]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [84]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [85]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Increases Expression [86]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Affects Expression [22]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Phosphorylation [87]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Affects Expression [22]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Increases Expression [23]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Decreases Expression [74]
Trypsin-2 (PRSS2) OTOMVUWL TRY2_HUMAN Affects Expression [23]
Bifunctional glutamate/proline--tRNA ligase (EPRS1) OTXK0FLB SYEP_HUMAN Decreases Expression [28]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Increases Cleavage [88]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Decreases Expression [89]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [90]
Zinc finger protein GLI1 (GLI1) OT1BTAJO GLI1_HUMAN Decreases Expression [91]
Collagen alpha-2(IV) chain (COL4A2) OTJK1LKN CO4A2_HUMAN Decreases Expression [24]
Nuclear factor 1 C-type (NFIC) OTLMCUIB NFIC_HUMAN Increases Expression [23]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Affects Expression [23]
Keratin, type I cytoskeletal 16 (KRT16) OTGA0EQN K1C16_HUMAN Increases Expression [79]
CD63 antigen (CD63) OT2UGZA9 CD63_HUMAN Decreases Expression [83]
Retinol-binding protein 1 (RBP1) OTRP1MFC RET1_HUMAN Decreases Expression [24]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Decreases Expression [32]
Pro-cathepsin H (CTSH) OTLFL0DG CATH_HUMAN Increases Expression [24]
Cytochrome c oxidase subunit 6C (COX6C) OT3V7JE5 COX6C_HUMAN Affects Expression [22]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Expression [29]
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) OTI4EOAR IFIT2_HUMAN Increases Expression [32]
Serum amyloid A-1 protein (SAA1) OTO2D8S0 SAA1_HUMAN Increases Expression [32]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Decreases Expression [24]
Small integral membrane protein 10-like protein 2A (SMIM10L2B) OT04IG2N SIL2A_HUMAN Decreases Expression [22]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [85]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [92]
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) OTDP94F3 COX5B_HUMAN Affects Expression [22]
T-cell surface glycoprotein CD8 beta chain (CD8B) OTMZ1T7J CD8B_HUMAN Decreases Expression [24]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [74]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Decreases Expression [28]
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA) OT0LHOZB ODBA_HUMAN Affects Expression [23]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Decreases Expression [24]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Increases Expression [32]
Platelet glycoprotein Ib beta chain (GP1BB) OTD7XNLL GP1BB_HUMAN Affects Expression [23]
Keratin, type II cytoskeletal 5 (KRT5) OTVGI9HT K2C5_HUMAN Decreases Expression [24]
Protein disulfide-isomerase A4 (PDIA4) OTVFUJ13 PDIA4_HUMAN Decreases Expression [28]
Troponin T, slow skeletal muscle (TNNT1) OT8PBOAR TNNT1_HUMAN Decreases Expression [24]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [25]
Aspartate--tRNA ligase, cytoplasmic (DARS1) OT0WGC2T SYDC_HUMAN Affects Expression [23]
Protein C-ets-1 (ETS1) OT4LVGDN ETS1_HUMAN Increases Expression [68]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Affects Expression [22]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Increases Expression [28]
Transcription factor E2-alpha (TCF3) OTW6FR32 TFE2_HUMAN Affects Expression [22]
Cytochrome c oxidase subunit 7C, mitochondrial (COX7C) OTREWSBF COX7C_HUMAN Affects Expression [22]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [64]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [93]
Carboxypeptidase E (CPE) OTXNTV79 CBPE_HUMAN Increases Expression [24]
Interferon alpha/beta receptor 1 (IFNAR1) OTD4OOFK INAR1_HUMAN Increases Expression [94]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Increases Expression [32]
Regulator of chromosome condensation (RCC1) OT25AGMB RCC1_HUMAN Decreases Expression [28]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [84]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Affects Expression [22]
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) OTDAE8FP ATP5J_HUMAN Increases Expression [22]
Nucleolin (NCL) OTBXPKMP NUCL_HUMAN Affects Splicing [82]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Decreases Expression [24]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Affects Expression [22]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Phosphorylation [25]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [22]
Hepatocyte nuclear factor 1-alpha (HNF1A) OT9DOUKL HNF1A_HUMAN Affects Expression [22]
C4b-binding protein beta chain (C4BPB) OTJ70B0K C4BPB_HUMAN Affects Expression [23]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Increases Expression [86]
Lactoperoxidase (LPO) OTJ9QKX9 PERL_HUMAN Decreases Expression [95]
Cornifin-B (SPRR1B) OTXNW3P6 SPR1B_HUMAN Affects Expression [23]
Paired box protein Pax-3 (PAX3) OTN5PJZV PAX3_HUMAN Decreases Expression [27]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [96]
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) OTPOAAUW AT5F1_HUMAN Affects Expression [22]
Insulin-like growth factor-binding protein 6 (IGFBP6) OTW878VI IBP6_HUMAN Decreases Expression [24]
Cyclin-C (CCNC) OTMVK4K4 CCNC_HUMAN Decreases Expression [28]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [33]
Cytochrome P450 2F1 (CYP2F1) OTY3HJH1 CP2F1_HUMAN Affects Expression [23]
DNA replication licensing factor MCM3 (MCM3) OTOOHQPM MCM3_HUMAN Decreases Expression [28]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Decreases Expression [24]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Degradation [97]
Paired box protein Pax-6 (PAX6) OTOC9876 PAX6_HUMAN Decreases Expression [76]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [24]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [98]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Increases Expression [24]
Probable global transcription activator SNF2L1 (SMARCA1) OT0Y6PTU SMCA1_HUMAN Increases Expression [24]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [98]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Affects Expression [23]
Tripeptidyl-peptidase 2 (TPP2) OT91OVAU TPP2_HUMAN Affects Localization [99]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Increases Cleavage [100]
Cellular retinoic acid-binding protein 1 (CRABP1) OTISDG5X RABP1_HUMAN Increases Expression [24]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Affects Expression [22]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Increases Expression [24]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Increases Expression [28]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Decreases Expression [28]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Increases Expression [32]
Adenylosuccinate synthetase isozyme 2 (ADSS2) OTW26XXB PURA2_HUMAN Decreases Expression [28]
Neurotensin receptor type 1 (NTSR1) OTTJUTE3 NTR1_HUMAN Decreases Expression [24]
CAMPATH-1 antigen (CD52) OT02LDQN CD52_HUMAN Affects Expression [23]
Neural cell adhesion molecule L1 (L1CAM) OTNWAQ4Y L1CAM_HUMAN Decreases Expression [24]
Homeobox protein OTX2 (OTX2) OTTV05B1 OTX2_HUMAN Decreases Expression [76]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Decreases Expression [73]
Protein S100-A3 (S100A3) OTVIZJ2R S10A3_HUMAN Decreases Expression [24]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Decreases Expression [24]
5-hydroxytryptamine receptor 7 (HTR7) OT44DEWB 5HT7R_HUMAN Affects Expression [23]
Profilin-2 (PFN2) OT5SSSA7 PROF2_HUMAN Increases Expression [24]
Radixin (RDX) OTNSYUN6 RADI_HUMAN Affects Expression [23]
Cornifin-A (SPRR1A) OTJMI34A SPR1A_HUMAN Increases Expression [23]
Homeobox protein MSX-2 (MSX2) OT1WDKE1 MSX2_HUMAN Decreases Expression [24]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [101]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Affects Expression [22]
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Affects Expression [23]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A) OTE2KVZV SCNNA_HUMAN Decreases Expression [24]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Decreases Expression [24]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [102]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [103]
Hepatocyte nuclear factor 4-alpha (HNF4A) OTY1TOAB HNF4A_HUMAN Affects Expression [22]
Neuroblastoma suppressor of tumorigenicity 1 (NBL1) OTT37U4O NBL1_HUMAN Decreases Expression [28]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Expression [22]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Affects Expression [23]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Expression [95]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [104]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Decreases Expression [22]
Melanoma-associated antigen 2 (MAGEA2) OTQ0YOTY MAGA2_HUMAN Decreases Expression [24]
Melanoma-associated antigen 6 (MAGEA6) OTI8S0O2 MAGA6_HUMAN Decreases Expression [24]
Melanoma-associated antigen 12 (MAGEA12) OT8ULELL MAGAC_HUMAN Decreases Expression [24]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Expression [33]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Decreases Expression [24]
Galectin-7 (LGALS7) OTMSVI7R LEG7_HUMAN Decreases Expression [24]
Iron-responsive element-binding protein 2 (IREB2) OT747D24 IREB2_HUMAN Increases Expression [23]
Interferon alpha/beta receptor 2 (IFNAR2) OTBIRNIJ INAR2_HUMAN Increases Expression [32]
Sodium/hydrogen exchanger 3 (SLC9A3) OTZ7PFVT SL9A3_HUMAN Decreases Expression [22]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Expression [24]
Casein kinase I isoform epsilon (CSNK1E) OTF0UXX6 KC1E_HUMAN Affects Expression [23]
Tuberin (TSC2) OT47LWI9 TSC2_HUMAN Increases Expression [23]
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) OTEVK4WW NDUV1_HUMAN Affects Expression [22]
Ketohexokinase (KHK) OT153922 KHK_HUMAN Increases Expression [24]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Increases Expression [27]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Expression [105]
Amiloride-sensitive sodium channel subunit beta (SCNN1B) OT61QQTL SCNNB_HUMAN Affects Expression [23]
Serine/threonine-protein kinase Nek4 (NEK4) OTOB8366 NEK4_HUMAN Decreases Expression [28]
Cyclin-G1 (CCNG1) OT17IA9L CCNG1_HUMAN Decreases Expression [28]
Rho-related GTP-binding protein RhoN (RND2) OT98M6UI RND2_HUMAN Increases Expression [32]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [73]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Affects Expression [22]
Hexokinase-2 (HK2) OTC0GCQO HXK2_HUMAN Decreases Expression [106]
Ephrin-B2 (EFNB2) OT0DCUOM EFNB2_HUMAN Decreases Expression [24]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Increases Expression [68]
LIM domain kinase 1 (LIMK1) OTFZ8MZ0 LIMK1_HUMAN Affects Expression [22]
Monocarboxylate transporter 1 (SLC16A1) OTW1UTZ7 MOT1_HUMAN Decreases Expression [28]
Heat shock-related 70 kDa protein 2 (HSPA2) OTSDET7B HSP72_HUMAN Increases Expression [32]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Decreases Expression [74]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Expression [22]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Decreases Expression [107]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Affects Expression [22]
Forkhead box protein G1 (FOXG1) OTAW57J4 FOXG1_HUMAN Decreases Expression [76]
NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3) OTSCYB9P NDUV3_HUMAN Increases Expression [22]
NADH dehydrogenase 1 alpha subcomplex subunit 6 (NDUFA6) OTEOIIOL NDUA6_HUMAN Affects Expression [22]
Claudin-2 (CLDN2) OTRF3D6Y CLD2_HUMAN Decreases Expression [25]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [108]
Forkhead box protein L2 (FOXL2) OTFRQUYL FOXL2_HUMAN Increases Expression [22]
Ribose-phosphate pyrophosphokinase 1 (PRPS1) OTN3A6CN PRPS1_HUMAN Increases Expression [23]
Ras-related protein Rab-8A (RAB8A) OTPB54Y3 RAB8A_HUMAN Decreases Expression [28]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Affects Expression [23]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) OT24GMCM PP2AB_HUMAN Increases Expression [28]
Small ribosomal subunit protein eS26 (RPS26) OTBYTA6A RS26_HUMAN Affects Expression [23]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) OT3JPRCQ GBB2_HUMAN Decreases Expression [28]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Decreases Expression [28]
Hemoglobin subunit beta (HBB) OT514IKQ HBB_HUMAN Affects Splicing [82]
E3 ubiquitin-protein ligase RNF4 (RNF4) OTCMXQRE RNF4_HUMAN Decreases Expression [28]
Cyclin-A1 (CCNA1) OTX4HD45 CCNA1_HUMAN Affects Expression [107]
Interferon-induced 35 kDa protein (IFI35) OTV9RZ53 IN35_HUMAN Increases Expression [32]
Transcriptional activator protein Pur-alpha (PURA) OT975ELW PURA_HUMAN Affects Expression [23]
Interferon regulatory factor 9 (IRF9) OTK4MYQJ IRF9_HUMAN Increases Expression [32]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [103]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [22]
Exosome complex component 10 (EXOSC10) OTH8Z0AL EXOSX_HUMAN Increases Metabolism [109]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Decreases Expression [24]
Myocyte-specific enhancer factor 2B (MEF2B) OT880SE6 MEF2B_HUMAN Affects Expression [23]
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Affects Expression [23]
Lamin-B2 (LMNB2) OTXRDUOS LMNB2_HUMAN Decreases Expression [22]
Antigen peptide transporter 2 (TAP2) OTWSYFI7 TAP2_HUMAN Increases Expression [110]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [111]
Keratin, type I cytoskeletal 17 (KRT17) OT6Y1DPK K1C17_HUMAN Affects Expression [23]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Affects Expression [23]
Protein kinase C zeta type (PRKCZ) OTN2FE42 KPCZ_HUMAN Affects Expression [23]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [112]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [71]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [22]
Neuroblast differentiation-associated protein AHNAK (AHNAK) OT6KH1WG AHNK_HUMAN Decreases Expression [24]
Mesoderm posterior protein 2 (MESP2) OT7H4LYA MESP2_HUMAN Increases Expression [27]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Decreases Expression [22]
Transcription factor 15 (TCF15) OTA6UCWC TCF15_HUMAN Increases Expression [27]
Heat shock protein 75 kDa, mitochondrial (TRAP1) OTNG0L8J TRAP1_HUMAN Affects Expression [22]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Decreases Expression [97]
Forkhead box protein C1 (FOXC1) OTOWZGYO FOXC1_HUMAN Affects Expression [23]
Vesicle transport protein SEC20 (BNIP1) OT7USYCY SEC20_HUMAN Increases Expression [30]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Decreases Expression [32]
RE1-silencing transcription factor (REST) OTLL92LQ REST_HUMAN Affects Expression [23]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [22]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) OTS3FVTY M3K1_HUMAN Affects Expression [22]
28 kDa heat- and acid-stable phosphoprotein (PDAP1) OTJSWMOD HAP28_HUMAN Decreases Expression [28]
Aquaporin-6 (AQP6) OTXS6UYY AQP6_HUMAN Decreases Expression [22]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) OTC41R1E RIPK1_HUMAN Increases Expression [22]
Neurogenic differentiation factor 1 (NEUROD1) OTZQ7QJ2 NDF1_HUMAN Affects Expression [23]
Protein patched homolog 1 (PTCH1) OTMG07H5 PTC1_HUMAN Decreases Expression [91]
CD166 antigen (ALCAM) OTCO4LP7 CD166_HUMAN Decreases Expression [24]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Increases Expression [22]
Low-density lipoprotein receptor-related protein 8 (LRP8) OTZ71YV2 LRP8_HUMAN Decreases Expression [32]
Transcription factor E2F2 (E2F2) OTO75RM7 E2F2_HUMAN Decreases Expression [22]
Fas-activated serine/threonine kinase (FASTK) OTTHFZMP FASTK_HUMAN Decreases Expression [22]
Guanidinoacetate N-methyltransferase (GAMT) OTVC87ES GAMT_HUMAN Increases Expression [24]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Increases Activity [113]
Indian hedgehog protein (IHH) OT1DWGXC IHH_HUMAN Decreases Expression [114]
Transmembrane protein 187 (TMEM187) OTOE4G8T TM187_HUMAN Decreases Expression [22]
Pumilio homolog 1 (PUM1) OTTMWP8L PUM1_HUMAN Affects Expression [23]
Major vault protein (MVP) OTJGHJRB MVP_HUMAN Increases Expression [115]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Decreases Expression [107]
Kinesin-like protein KIF14 (KIF14) OTXHT4JM KIF14_HUMAN Decreases Expression [22]
Angiopoietin-1 (ANGPT1) OTVZ1NG3 ANGP1_HUMAN Increases Expression [69]
Sonic hedgehog protein (SHH) OTOG2BXF SHH_HUMAN Decreases Expression [91]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Affects Expression [22]
Heat shock protein beta-2 (HSPB2) OTS01646 HSPB2_HUMAN Increases Phosphorylation [90]
Transcription factor E2F4 (E2F4) OTB3JFH4 E2F4_HUMAN Decreases Expression [22]
BDNF/NT-3 growth factors receptor (NTRK2) OTD557PU NTRK2_HUMAN Decreases Expression [24]
Survival motor neuron protein (SMN2) OT54RLO1 SMN_HUMAN Decreases Expression [32]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [116]
Kinesin-like protein KIF26B (KIF26B) OTVHWIKR KI26B_HUMAN Decreases Expression [22]
Protein BEAN1 (BEAN1) OT0WLH27 BEAN1_HUMAN Increases Expression [24]
Filamin A-interacting protein 1-like (FILIP1L) OTPY8IMS FIL1L_HUMAN Increases Expression [24]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [73]
Early estrogen-induced gene 1 protein (EEIG1) OT2BMEAE EEIG1_HUMAN Affects Expression [23]
Transcription initiation factor TFIID subunit 3 (TAF3) OTVMULE9 TAF3_HUMAN Affects Expression [23]
GRAM domain-containing protein 4 (GRAMD4) OT1HXEPM GRAM4_HUMAN Increases Expression [117]
Heme transporter HRG1 (SLC48A1) OTPFHZLO HRG1_HUMAN Affects Expression [23]
Proline/serine-rich coiled-coil protein 1 (PSRC1) OT7MDJMN PSRC1_HUMAN Decreases Expression [73]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [73]
Teashirt homolog 1 (TSHZ1) OTYQ9ECW TSH1_HUMAN Increases Expression [23]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Affects Expression [23]
Oligodendrocyte transcription factor 3 (OLIG3) OTU8XLAF OLIG3_HUMAN Decreases Expression [27]
Protein lifeguard 1 (GRINA) OTMC1O66 LFG1_HUMAN Affects Expression [23]
Cyclin-J-like protein (CCNJL) OTU0SRTC CCNJL_HUMAN Affects Expression [23]
Mitofusin-1 (MFN1) OTCBXQZF MFN1_HUMAN Increases Expression [76]
Protein NOXP20 (FAM114A1) OT0208Y4 NXP20_HUMAN Affects Expression [23]
Extracellular serine/threonine protein kinase FAM20C (FAM20C) OTW5YZ7X FA20C_HUMAN Affects Expression [23]
Serine/arginine repetitive matrix protein 1 (SRRM1) OTAY2IP6 SRRM1_HUMAN Decreases Expression [28]
Ankyrin repeat domain-containing protein 36B (ANKRD36B) OT3MW415 AN36B_HUMAN Affects Expression [23]
Metallothionein-1M (MT1M) OTVT8PLU MT1M_HUMAN Increases Expression [24]
Integral membrane protein GPR137C (GPR137C) OTMEB9QG G137C_HUMAN Affects Expression [23]
Fibrinogen C domain-containing protein 1 (FIBCD1) OTSVT07B FBCD1_HUMAN Decreases Expression [22]
tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1) OT95QT6P DTWD1_HUMAN Increases Expression [30]
ER membrane protein complex subunit 1 (EMC1) OTYAH4LX EMC1_HUMAN Affects Expression [23]
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) OTBIN5IP SCPDL_HUMAN Increases Expression [32]
Minor histocompatibility antigen H13 (HM13) OTGEO1LP HM13_HUMAN Affects Expression [23]
Serine/threonine-protein kinase Nek9 (NEK9) OT4VQCL5 NEK9_HUMAN Decreases Expression [28]
Grainyhead-like protein 3 homolog (GRHL3) OT1V4ZEH GRHL3_HUMAN Affects Expression [23]
Transmembrane protein 40 (TMEM40) OTSJKKNA TMM40_HUMAN Affects Expression [23]
Lipase member H (LIPH) OTRGYLKL LIPH_HUMAN Decreases Expression [28]
MAP kinase-activating death domain protein (MADD) OTUFYVGG MADD_HUMAN Affects Expression [22]
E3 ubiquitin-protein ligase MYLIP (MYLIP) OTL0PFGV MYLIP_HUMAN Affects Expression [23]
Serine protease HTRA1 (HTRA1) OTR8ACBF HTRA1_HUMAN Increases Expression [24]
Symplekin (SYMPK) OTYAUDXV SYMPK_HUMAN Decreases Expression [28]
Caspase-10 (CASP10) OTE6J88E CASPA_HUMAN Increases Expression [22]
Kallikrein-6 (KLK6) OTIEA234 KLK6_HUMAN Decreases Expression [24]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) OT3062CA SO2A1_HUMAN Affects Expression [23]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Increases Expression [32]
Optineurin (OPTN) OT2UXWH9 OPTN_HUMAN Increases Expression [32]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Increases Expression [28]
THO complex subunit 1 (THOC1) OTVABJ4Z THOC1_HUMAN Decreases Expression [28]
Chronophin (PDXP) OTZ7GN95 PLPP_HUMAN Decreases Expression [28]
Cytochrome c oxidase assembly protein COX14 (COX14) OTQ378WN COX14_HUMAN Affects Expression [22]
Retina and anterior neural fold homeobox protein 2 (RAX2) OT1HD6CF RAX2_HUMAN Affects Expression [23]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3) OT8C6PKL AGAP3_HUMAN Decreases Expression [28]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [118]
Serine/threonine-protein kinase Nek1 (NEK1) OTBUCUW6 NEK1_HUMAN Decreases Expression [28]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Affects Expression [23]
Transcription factor ATOH8 (ATOH8) OT7SY3BN ATOH8_HUMAN Affects Expression [23]
Pre-mRNA-splicing factor 18 (PRPF18) OTX4VZ4R PRP18_HUMAN Decreases Expression [32]
MyoD family inhibitor (MDFI) OTIA6YUG MDFI_HUMAN Decreases Expression [24]
Noelin (OLFM1) OTOYPEWW NOE1_HUMAN Increases Expression [24]
Protein smoothened (SMO) OTXXE208 SMO_HUMAN Decreases Expression [91]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Decreases Expression [28]
NADH dehydrogenase 1 alpha subcomplex assembly factor 3 (NDUFAF3) OT4MCB6W NDUF3_HUMAN Decreases Expression [22]
Multiple myeloma tumor-associated protein 2 (C1ORF35) OTK6PUYF MMTA2_HUMAN Affects Expression [23]
Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23) OTG0B7RM SCMC3_HUMAN Affects Expression [23]
Histone-lysine N-methyltransferase SETD5 (SETD5) OTRPAVEO SETD5_HUMAN Affects Expression [23]
Hyaluronan and proteoglycan link protein 2 (HAPLN2) OT0G3KEQ HPLN2_HUMAN Affects Expression [23]
PR domain zinc finger protein 14 (PRDM14) OTWZKY4L PRD14_HUMAN Affects Expression [22]
Neurogenin-2 (NEUROG2) OTAEMIGT NGN2_HUMAN Decreases Expression [27]
Kallikrein-15 (KLK15) OT7BVG17 KLK15_HUMAN Affects Expression [23]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [103]
Complex I assembly factor ACAD9, mitochondrial (ACAD9) OT4HITJ6 ACAD9_HUMAN Decreases Expression [22]
2-oxoglutarate and iron-dependent oxygenase JMJD4 (JMJD4) OTYZGH63 JMJD4_HUMAN Decreases Expression [22]
ATP-binding cassette sub-family B member 6 (ABCB6) OTPGZFES ABCB6_HUMAN Decreases Expression [110]
StAR-related lipid transfer protein 7, mitochondrial (STARD7) OTDUZ296 STAR7_HUMAN Affects Expression [23]
Muscleblind-like protein 1 (MBNL1) OTOV7J85 MBNL1_HUMAN Decreases Expression [28]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) OT0ALMEG M3K20_HUMAN Affects Expression [23]
NF-kappa-B inhibitor-interacting Ras-like protein 1 (NKIRAS1) OTWETJTL KBRS1_HUMAN Affects Expression [23]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Expression [74]
Myoferlin (MYOF) OTRFC3IJ MYOF_HUMAN Decreases Expression [24]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Increases Expression [119]
NADH dehydrogenase 1 alpha subcomplex assembly factor 4 (NDUFAF4) OTWJ5B9M NDUF4_HUMAN Affects Expression [22]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) OTY94WRA HM20B_HUMAN Decreases Expression [28]
MyoD family inhibitor domain-containing protein (MDFIC) OTSRYBWZ MDFIC_HUMAN Affects Expression [23]
Ribosome-binding protein 1 (RRBP1) OT4ZTPTM RRBP1_HUMAN Decreases Expression [24]
Small proline-rich protein 3 (SPRR3) OTN9QJKG SPRR3_HUMAN Affects Expression [23]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) OTOSRDJT TR10D_HUMAN Increases Expression [67]
Dickkopf-related protein 4 (DKK4) OTWCCVF6 DKK4_HUMAN Increases Expression [23]
DNA repair protein REV1 (REV1) OTHIKICX REV1_HUMAN Affects Expression [23]
Hydroxyproline dehydrogenase (PRODH2) OTHO2TO0 HYPDH_HUMAN Decreases Expression [24]
FK506-binding protein-like (FKBPL) OTR9ND6K FKBPL_HUMAN Increases Expression [104]
Suppressor of fused homolog (SUFU) OT0IRYG1 SUFU_HUMAN Decreases Expression [91]
Probable G-protein coupled receptor 132 (GPR132) OTJ5WHHX GP132_HUMAN Increases Expression [23]
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) OTNONPMB GLCNE_HUMAN Decreases Expression [24]
C-type lectin domain family 11 member A (CLEC11A) OT9KBH7C CLC11_HUMAN Decreases Expression [24]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Affects Expression [23]
R3H domain-containing protein 2 (R3HDM2) OTMJ3S6J R3HD2_HUMAN Affects Expression [23]
Complex I intermediate-associated protein 30, mitochondrial (NDUFAF1) OTYK9JU6 CIA30_HUMAN Increases Expression [22]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) OTBCIBC7 SAMH1_HUMAN Affects Expression [23]
Angiopoietin-related protein 3 (ANGPTL3) OTCD5Z9W ANGL3_HUMAN Decreases Expression [74]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Increases Expression [23]
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) OTO3WI7S NDUB9_HUMAN Affects Expression [22]
Soluble TNF receptor II (CRMB1) OT06I7G2 CRMB_CAMPM Increases ADR [120]
Mitochondrial pyruvate carrier 2 (MPC2) OT0GHXGG MPC2_HUMAN Affects Response To Substance [35]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Decreases Response To Substance [121]
Tumor protein p73 (TP73) OT0LUO47 P73_HUMAN Affects Response To Substance [122]
Nucleoside diphosphate kinase A (NME1) OT0NELQ1 NDKA_HUMAN Affects Response To Substance [36]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Affects Response To Substance [35]
Tripartite motif-containing protein 2 (TRIM2) OT0V1YVC TRIM2_HUMAN Affects Response To Substance [35]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Affects Response To Substance [35]
Sperm protein associated with the nucleus on the X chromosome C (SPANXC) OT1033B9 SPNXC_HUMAN Affects Response To Substance [35]
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Affects Response To Substance [35]
Solute carrier family 35 member F5 (SLC35F5) OT1FX2QO S35F5_HUMAN Affects Response To Substance [123]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Affects Response To Substance [36]
Amyloid beta precursor protein binding family B member 2 (APBB2) OT1VD51B APBB2_HUMAN Affects Response To Substance [35]
Carboxypeptidase D (CPD) OT2CS64Y CBPD_HUMAN Affects Response To Substance [35]
Uncharacterized protein C11orf24 (C11ORF24) OT2DOJ6E CK024_HUMAN Affects Response To Substance [35]
La-related protein 4B (LARP4B) OT2HI0QE LAR4B_HUMAN Affects Response To Substance [35]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Affects Response To Substance [35]
Nucleoside diphosphate kinase, mitochondrial (NME4) OT2JTT42 NDKM_HUMAN Affects Response To Substance [35]
Chromobox protein homolog 1 (CBX1) OT2L4XZX CBX1_HUMAN Affects Response To Substance [35]
Kelch-like protein 7 (KLHL7) OT2OF1O8 KLHL7_HUMAN Affects Response To Substance [35]
LIM and SH3 domain protein 1 (LASP1) OT2QIDCL LASP1_HUMAN Affects Response To Substance [35]
Protein transport protein Sec31A (SEC31A) OT2U42AC SC31A_HUMAN Affects Response To Substance [35]
Protein-tyrosine sulfotransferase 2 (TPST2) OT2XKFCE TPST2_HUMAN Affects Response To Substance [35]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Response To Substance [124]
Protein FAM171A1 (FAM171A1) OT33BHEP F1711_HUMAN Affects Response To Substance [35]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Affects Response To Substance [35]
Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD) OT37FKH0 CYLD_HUMAN Increases Response To Substance [125]
Angiogenin (ANG) OT3ECS6P ANGI_HUMAN Affects Response To Substance [35]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Response To Substance [126]
Hypermethylated in cancer 2 protein (HIC2) OT3VP1D9 HIC2_HUMAN Affects Response To Substance [35]
Sorcin (SRI) OT4R3EAC SORCN_HUMAN Decreases Response To Substance [127]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Affects Response To Substance [128]
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1) OT536PE7 SCOT1_HUMAN Affects Response To Substance [35]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Increases Response To Substance [129]
Breast carcinoma-amplified sequence 4 (BCAS4) OT596N5E BCAS4_HUMAN Affects Response To Substance [35]
Myosin phosphatase Rho-interacting protein (MPRIP) OT5FV5NS MPRIP_HUMAN Affects Response To Substance [35]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Affects Response To Substance [35]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Response To Substance [130]
Mitochondrial enolase superfamily member 1 (ENOSF1) OT65D3ZK ENOF1_HUMAN Decreases Response To Substance [131]
Macrophage colony-stimulating factor 1 (CSF1) OT68M7RD CSF1_HUMAN Affects Response To Substance [35]
Myosin regulatory light polypeptide 9 (MYL9) OT6B22JB MYL9_HUMAN Affects Response To Substance [35]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Affects Response To Substance [35]
Melanoma-associated antigen D1 (MAGED1) OT6EOLFC MAGD1_HUMAN Affects Response To Substance [36]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Affects Response To Substance [36]
Electron transfer flavoprotein subunit beta (ETFB) OT6Q6FBD ETFB_HUMAN Affects Response To Substance [36]
Opioid growth factor receptor-like protein 1 (OGFRL1) OT6QGBYE OGRL1_HUMAN Affects Response To Substance [35]
DNA topoisomerase 2-binding protein 1 (TOPBP1) OT6UPZPD TOPB1_HUMAN Affects Response To Substance [36]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Decreases Response To Substance [132]
GTP-binding protein 4 (GTPBP4) OT6ZHAWC GTPB4_HUMAN Affects Response To Substance [35]
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) OT714BUO AL3A2_HUMAN Affects Response To Substance [35]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) OT7C68YV BACH_HUMAN Affects Response To Substance [36]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) OT7M67WT GALT3_HUMAN Affects Response To Substance [35]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Affects Response To Substance [35]
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) OT7Y43A1 PP1A_HUMAN Affects Response To Substance [35]
CDKN2A-interacting protein (CDKN2AIP) OT80RRQJ CARF_HUMAN Affects Response To Substance [35]
Cbp/p300-interacting transactivator 2 (CITED2) OT812TV7 CITE2_HUMAN Affects Response To Substance [36]
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) OT8CMPB2 FKB1B_HUMAN Affects Response To Substance [35]
Mortality factor 4-like protein 2 (MORF4L2) OT8OI3EC MO4L2_HUMAN Decreases Response To Substance [133]
Putative hydrolase DDAH2 (DDAH2) OT8Q40G2 DDAH2_HUMAN Affects Response To Substance [35]
Pre-B-cell leukemia transcription factor 3 (PBX3) OT8WMVM4 PBX3_HUMAN Affects Response To Substance [35]
Intersectin-1 (ITSN1) OT8YF3S5 ITSN1_HUMAN Affects Response To Substance [35]
Frizzled-2 (FZD2) OT952ML1 FZD2_HUMAN Affects Response To Substance [35]
Galectin-3-binding protein (LGALS3BP) OT9AGQKH LG3BP_HUMAN Affects Response To Substance [35]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Affects Response To Substance [35]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Affects Response To Substance [35]
Epsilon-sarcoglycan (SGCE) OT9F17JB SGCE_HUMAN Affects Response To Substance [35]
Carbohydrate sulfotransferase 7 (CHST7) OT9HCUST CHST7_HUMAN Affects Response To Substance [35]
Adapter molecule crk (CRK) OT9Q5YSN CRK_HUMAN Affects Response To Substance [35]
Dysbindin domain-containing protein 2 (DBNDD2) OT9RI580 DBND2_HUMAN Affects Response To Substance [35]
Lanosterol synthase (LSS) OT9W2SFH LSS_HUMAN Affects Response To Substance [35]
Perilipin-3 (PLIN3) OT9ZA7MR PLIN3_HUMAN Affects Response To Substance [35]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Affects Response To Substance [35]
Apolipoprotein C-I (APOC1) OTA58CED APOC1_HUMAN Affects Response To Substance [35]
Ribonuclease 4 (RNASE4) OTA5SZLC RNAS4_HUMAN Affects Response To Substance [35]
SEC14-like protein 1 (SEC14L1) OTA75FET S14L1_HUMAN Affects Response To Substance [35]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Affects Response To Substance [35]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Affects Response To Substance [35]
Receptor-type tyrosine-protein phosphatase kappa (PTPRK) OTAP5AT3 PTPRK_HUMAN Affects Response To Substance [35]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Response To Substance [134]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Affects Response To Substance [35]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Affects Response To Substance [128]
Lanosterol 14-alpha demethylase (CYP51A1) OTAYHG9C CP51A_HUMAN Affects Response To Substance [35]
Sterol O-acyltransferase 1 (SOAT1) OTB4Y5RJ SOAT1_HUMAN Affects Response To Substance [35]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Affects Response To Substance [35]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Affects Response To Substance [128]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Affects Response To Substance [35]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14) OTBFIOVY GTR14_HUMAN Affects Response To Substance [35]
Protein transport protein Sec23A (SEC23A) OTBRNIJ3 SC23A_HUMAN Affects Response To Substance [35]
Alpha-galactosidase A (GLA) OTBSR6DT AGAL_HUMAN Affects Response To Substance [35]
Regenerating islet-derived protein 4 (REG4) OTBWIKOA REG4_HUMAN Decreases Response To Substance [135]
Transmembrane protein 184B (TMEM184B) OTBZY7E9 T184B_HUMAN Affects Response To Substance [35]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Affects Response To Substance [35]
Adenylyl cyclase-associated protein 2 (CAP2) OTC1WFNO CAP2_HUMAN Affects Response To Substance [35]
RNA-binding protein 5 (RBM5) OTCBWHHV RBM5_HUMAN Affects Response To Substance [36]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Decreases Response To Substance [136]
Baculoviral IAP repeat-containing protein 6 (BIRC6) OTCQJAB0 BIRC6_HUMAN Decreases Response To Substance [137]
Probable cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1) OTCU8PFI CIAO1_HUMAN Affects Response To Substance [36]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Affects Response To Substance [35]
Adhesion G protein-coupled receptor L2 (ADGRL2) OTCXD2YR AGRL2_HUMAN Affects Response To Substance [35]
Large ribosomal subunit protein eL24 (RPL24) OTCY9DEB RL24_HUMAN Affects Response To Substance [36]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Affects Response To Substance [35]
Protein timeless homolog (TIMELESS) OTD8DCBJ TIM_HUMAN Affects Response To Substance [36]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Response To Substance [133]
Gamma-adducin (ADD3) OTDRSHAZ ADDG_HUMAN Affects Response To Substance [35]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) OTDS2EAR TNR1B_HUMAN Affects Response To Substance [123]
DNA polymerase subunit gamma-1 (POLG) OTDUCT04 DPOG1_HUMAN Affects Response To Substance [36]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) OTDVVNS0 EDIL3_HUMAN Affects Response To Substance [35]
Cytosolic phospholipase A2 (PLA2G4A) OTE70SOT PA24A_HUMAN Affects Response To Substance [35]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Decreases Response To Substance [138]
Very-long-chain (HACD1) OTEC7EP7 HACD1_HUMAN Affects Response To Substance [35]
DNA ligase 1 (LIG1) OTEEQS43 DNLI1_HUMAN Affects Response To Substance [36]
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Affects Response To Substance [35]
Maternal embryonic leucine zipper kinase (MELK) OTEY2UQA MELK_HUMAN Affects Response To Substance [36]
Proteolipid protein 2 (PLP2) OTEZ4LOV PLP2_HUMAN Affects Response To Substance [35]
Paraneoplastic antigen Ma2 (PNMA2) OTF5YBQG PNMA2_HUMAN Affects Response To Substance [35]
Mitogen-activated protein kinase 7 (MAPK7) OTF7H7L7 MK07_HUMAN Decreases Response To Substance [139]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Affects Response To Substance [140]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Decreases Response To Substance [61]
E3 ubiquitin-protein ligase NEDD4 (NEDD4) OTFPXLXT NEDD4_HUMAN Affects Response To Substance [35]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases ADR [141]
Centromere protein X (CENPX) OTG1RAKJ CENPX_HUMAN Affects Response To Substance [35]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Affects Response To Substance [35]
DNA mismatch repair protein Mlh1 (MLH1) OTG5XDD8 MLH1_HUMAN Increases Response To Substance [142]
Lymphocyte antigen 6 complex locus protein G6d (LY6G6D) OTG75QOC LY66D_HUMAN Affects Response To Substance [35]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Affects Response To Substance [35]
TRIO and F-actin-binding protein (TRIOBP) OTGB5WHC TARA_HUMAN Affects Response To Substance [35]
Tubulin-specific chaperone E (TBCE) OTGBSTKS TBCE_HUMAN Affects Response To Substance [35]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Affects Response To Substance [35]
DNA replication licensing factor MCM2 (MCM2) OTGGORIQ MCM2_HUMAN Affects Response To Substance [36]
Fibroblast growth factor 7 (FGF7) OTGK6ANL FGF7_HUMAN Decreases Response To Substance [143]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Affects Response To Substance [35]
Melanoma-associated antigen 4 (MAGEA4) OTGP9SD0 MAGA4_HUMAN Affects Response To Substance [35]
Phospholipid scramblase 1 (PLSCR1) OTGY9B5T PLS1_HUMAN Affects Response To Substance [35]
Partitioning defective 3 homolog (PARD3) OTH5BPLO PARD3_HUMAN Affects Response To Substance [35]
Flavin reductase (BLVRB) OTHCFN2C BLVRB_HUMAN Affects Response To Substance [35]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Decreases Response To Substance [144]
Potassium voltage-gated channel subfamily A member 5 (KCNA5) OTHI2N71 KCNA5_HUMAN Increases Response To Substance [145]
Translationally-controlled tumor protein (TPT1) OTHMTRJU TCTP_HUMAN Decreases Response To Substance [124]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Affects Response To Substance [128]
Dystonin (DST) OTHZBM4X DYST_HUMAN Affects Response To Substance [35]
FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) OTI0T62C FGD6_HUMAN Affects Response To Substance [35]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Increases Response To Substance [146]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Affects Response To Substance [36]
Laminin subunit gamma-1 (LAMC1) OTIG527N LAMC1_HUMAN Affects Response To Substance [35]
Baculoviral IAP repeat-containing protein 7 (BIRC7) OTITCGHB BIRC7_HUMAN Decreases Response To Substance [147]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Affects Response To Substance [36]
Replication factor C subunit 2 (RFC2) OTJ9N6BD RFC2_HUMAN Affects Response To Substance [36]
Retrotransposon Gag-like protein 8C (RTL8C) OTJA37NU RTL8C_HUMAN Affects Response To Substance [35]
Cyclin-F (CCNF) OTJFVU43 CCNF_HUMAN Affects Response To Substance [128]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Affects Response To Substance [35]
Rhomboid-related protein 2 (RHBDL2) OTJPJ8N6 RHBL2_HUMAN Affects Response To Substance [35]
Unconventional myosin-VI (MYO6) OTJQYRC7 MYO6_HUMAN Affects Response To Substance [35]
Endothelin-1 receptor (EDNRA) OTK9T5O3 EDNRA_HUMAN Affects Response To Substance [148]
Serine/threonine-protein kinase 38 (STK38) OTKMYCYR STK38_HUMAN Affects Response To Substance [35]
Starch-binding domain-containing protein 1 (STBD1) OTKPS9AM STBD1_HUMAN Affects Response To Substance [35]
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial (ECHDC3) OTKU2RMC ECHD3_HUMAN Affects Response To Substance [35]
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT2) OTKXMSM7 MGAT2_HUMAN Affects Response To Substance [35]
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR) OTKYMT99 CABYR_HUMAN Affects Response To Substance [35]
EF-hand domain-containing protein D1 (EFHD1) OTL5INE4 EFHD1_HUMAN Affects Response To Substance [35]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Decreases Response To Substance [149]
Sorting nexin-6 (SNX6) OTLKQYJU SNX6_HUMAN Affects Response To Substance [35]
PDZ and LIM domain protein 5 (PDLIM5) OTLQVV22 PDLI5_HUMAN Affects Response To Substance [35]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Affects Response To Substance [35]
Separin (ESPL1) OTMGEVOK ESPL1_HUMAN Affects Response To Substance [36]
Sperm protein associated with the nucleus on the X chromosome A (SPANXA1) OTMK3QIS SPNXA_HUMAN Affects Response To Substance [35]
Pleckstrin homology domain-containing family O member 1 (PLEKHO1) OTMVUQ9W PKHO1_HUMAN Affects Response To Substance [35]
Ubiquitin-conjugating enzyme E2 R1 (CDC34) OTNBK390 UB2R1_HUMAN Affects Response To Substance [35]
Protein ENTREP3 (ENTREP3) OTNJB3FP EREP3_HUMAN Affects Response To Substance [35]
HMG box transcription factor BBX (BBX) OTNQ3QUC BBX_HUMAN Affects Response To Substance [35]
Melanoma-associated antigen D4 (MAGED4B) OTO37U7W MAGD4_HUMAN Affects Response To Substance [35]
Purine nucleoside phosphorylase (PNP) OTO5NIJ2 PNPH_HUMAN Affects Response To Substance [36]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Response To Substance [150]
Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1) OTODG57A FUT1_HUMAN Affects Response To Substance [151]
Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA) OTOJ8QFF SDHA_HUMAN Affects Response To Substance [36]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Decreases Response To Substance [152]
Copper homeostasis protein cutC homolog (CUTC) OTOVHLU9 CUTC_HUMAN Affects Response To Substance [35]
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) OTP9COQT PISD_HUMAN Affects Response To Substance [36]
Ras-related protein Rab-20 (RAB20) OTP9OOVS RAB20_HUMAN Affects Response To Substance [35]
MHC class I polypeptide-related sequence A (MICA) OTPEIEAR MICA_HUMAN Affects Response To Substance [35]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Affects Response To Substance [35]
Neurotensin/neuromedin N (NTS) OTPGDNQS NEUT_HUMAN Affects Response To Substance [35]
Na(+)/citrate cotransporter (SLC13A5) OTPH1TA7 S13A5_HUMAN Decreases Response To Substance [153]
Interferon alpha-1/13 (IFNA1) OTPMKY0L IFNA1_HUMAN Increases Abundance [8]
SPARC (SPARC) OTPN90H0 SPRC_HUMAN Increases Response To Substance [154]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Affects Response To Substance [36]
Protein C-mannosyl-transferase DPY19L1 (DPY19L1) OTPULBDX D19L1_HUMAN Affects Response To Substance [35]
Transcription factor SOX-18 (SOX18) OTPUMHWA SOX18_HUMAN Affects Response To Substance [35]
Copper-transporting ATPase 2 (ATP7B) OTPWLNCO ATP7B_HUMAN Increases Response To Substance [133]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Affects Response To Substance [35]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Affects Response To Substance [36]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Affects Response To Substance [35]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Affects Response To Substance [35]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Decreases Response To Substance [155]
E3 ubiquitin-protein ligase RNF34 (RNF34) OTQY58LU RNF34_HUMAN Decreases Response To Substance [156]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) OTR443C5 BGH3_HUMAN Affects Response To Substance [35]
Kelch-like protein 9 (KLHL9) OTRGEG3Z KLHL9_HUMAN Affects Response To Substance [35]
LIM domain kinase 2 (LIMK2) OTRJD7VZ LIMK2_HUMAN Affects Response To Substance [35]
Large ribosomal subunit protein eL6 (RPL6) OTRU71O4 RL6_HUMAN Decreases Response To Substance [157]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Affects Response To Substance [35]
MHC class I polypeptide-related sequence B (MICB) OTS2DVDW MICB_HUMAN Affects Response To Substance [35]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) OTSBQR6D PLCG1_HUMAN Decreases Response To Substance [158]
Thymosin beta-15A (TMSB15A) OTSBWCES TB15A_HUMAN Affects Response To Substance [128]
Protein phosphatase 1 regulatory subunit 1B (PPP1R1B) OTSIJMQ9 PPR1B_HUMAN Increases Response To Substance [159]
Formin-binding protein 1 (FNBP1) OTSJ5KKA FNBP1_HUMAN Affects Response To Substance [35]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) OTSMGKXQ EBP_HUMAN Affects Response To Substance [36]
Interleukin-27 receptor subunit alpha (IL27RA) OTSQBAKI I27RA_HUMAN Affects Response To Substance [35]
Rhotekin (RTKN) OTSS8XR6 RTKN_HUMAN Decreases Response To Substance [160]
Procollagen C-endopeptidase enhancer 2 (PCOLCE2) OTSUEQZ1 PCOC2_HUMAN Affects Response To Substance [35]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Affects Response To Substance [35]
Cdc42 effector protein 1 (CDC42EP1) OTT525WA BORG5_HUMAN Affects Response To Substance [35]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Affects Response To Substance [35]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Decreases Response To Substance [161]
Selenide, water dikinase 2 (SEPHS2) OTTFXROR SPS2_HUMAN Affects Response To Substance [35]
DNA polymerase alpha subunit B (POLA2) OTTWQ73N DPOA2_HUMAN Affects Response To Substance [36]
EH domain-containing protein 2 (EHD2) OTTX391J EHD2_HUMAN Affects Response To Substance [35]
Protein enabled homolog (ENAH) OTU49OK5 ENAH_HUMAN Affects Response To Substance [35]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Affects Response To Substance [35]
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) OTUG4BWA PAHX_HUMAN Affects Response To Substance [35]
Leupaxin (LPXN) OTUNV3CK LPXN_HUMAN Affects Response To Substance [36]
AT-rich interactive domain-containing protein 5B (ARID5B) OTUQ4CQY ARI5B_HUMAN Affects Response To Substance [35]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Affects Response To Substance [35]
Cysteine and glycine-rich protein 1 (CSRP1) OTUS7RM2 CSRP1_HUMAN Affects Response To Substance [35]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Affects Response To Substance [36]
Acyl-CoA (FADS1) OTUYOYHX FADS1_HUMAN Affects Response To Substance [35]
Histone deacetylase 2 (HDAC2) OTUYVFKN HDAC2_HUMAN Increases Response To Substance [155]
Nucleolysin TIAR (TIAL1) OTV2KFZH TIAR_HUMAN Affects Response To Substance [36]
Lymphocyte antigen 6 complex locus protein G6c (LY6G6C) OTV7F59X LY66C_HUMAN Affects Response To Substance [35]
ATP-binding cassette sub-family C member 11 (ABCC11) OTVHL7OR MRP8_HUMAN Decreases Response To Substance [162]
Megakaryocyte and platelet inhibitory receptor G6b (MPIG6B) OTVNKQWA G6B_HUMAN Affects Response To Substance [35]
GTP-binding protein Rit1 (RIT1) OTVNOGOH RIT1_HUMAN Affects Response To Substance [35]
Abasic site processing protein HMCES (HMCES) OTVRDL6U HMCES_HUMAN Affects Response To Substance [36]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Affects Response To Substance [35]
Folylpolyglutamate synthase, mitochondrial (FPGS) OTW3F1ZE FOLC_HUMAN Increases Response To Substance [163]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Affects Response To Substance [36]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Affects Response To Substance [35]
Periostin (POSTN) OTWP62UA POSTN_HUMAN Decreases Response To Substance [164]
Acyl-coenzyme A thioesterase 13 (ACOT13) OTWRUST1 ACO13_HUMAN Affects Response To Substance [35]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Affects Response To Substance [36]
Amyloid-beta A4 precursor protein-binding family A member 2 (APBA2) OTXD8ID1 APBA2_HUMAN Affects Response To Substance [35]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Affects Response To Substance [35]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Increases Abundance [8]
Peptidyl-prolyl cis-trans isomerase FKBP11 (FKBP11) OTY2GC67 FKB11_HUMAN Affects Response To Substance [35]
Adhesion G-protein coupled receptor G6 (ADGRG6) OTY2UBXO AGRG6_HUMAN Affects Response To Substance [35]
Class E basic helix-loop-helix protein 41 (BHLHE41) OTY9GJ1Y BHE41_HUMAN Affects Response To Substance [35]
Serine/threonine-protein kinase TAO3 (TAOK3) OTYBATSH TAOK3_HUMAN Affects Response To Substance [36]
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) OTYEJAGZ GPT_HUMAN Affects Response To Substance [35]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Increases ADR [141]
Chloride intracellular channel protein 1 (CLIC1) OTYLFWNG CLIC1_HUMAN Affects Response To Substance [35]
Interferon beta (IFNB1) OTYQGUB5 IFNB_HUMAN Increases Response To Substance [165]
Galectin-3 (LGALS3) OTYQT0ZI LEG3_HUMAN Decreases Response To Substance [166]
ADP-ribosylation factor 3 (ARF3) OTYYQX85 ARF3_HUMAN Affects Response To Substance [36]
Selenide, water dikinase 1 (SEPHS1) OTZ19I59 SPS1_HUMAN Affects Response To Substance [35]
Glutathione S-transferase A4 (GSTA4) OTZ1USIA GSTA4_HUMAN Affects Response To Substance [35]
Thiosulfate sulfurtransferase (TST) OTZ4F5LK THTR_HUMAN Affects Response To Substance [36]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Increases Response To Substance [167]
Fermitin family homolog 2 (FERMT2) OTZNPWWX FERM2_HUMAN Affects Response To Substance [35]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Affects Response To Substance [35]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Affects Response To Substance [35]
Multidrug and toxin extrusion protein 1 (SLC47A1) OTZX0U5Q S47A1_HUMAN Affects Response To Substance [35]
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⏷ Show the Full List of 1026 DOT(s)
Indication(s) of Sorafenib
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [6]
Carcinoma 2A00-2F9Z Approved [6]
Clear cell renal carcinoma N.A. Approved [6]
Lung cancer 2C25.0 Approved [6]
Medullary thyroid gland carcinoma N.A. Approved [6]
Non-small-cell lung cancer 2C25.Y Approved [6]
Renal cell carcinoma 2C90 Approved [7]
Thyroid cancer 2D10 Approved [6]
Hepatocellular carcinoma 2C12.02 Phase 3 [7]
Myelodysplastic syndrome 2A37 Phase 2 [7]
Sorafenib Interacts with 4 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Tyrosine-protein kinase Kit (KIT) TTX41N9 KIT_HUMAN Modulator [173]
Platelet-derived growth factor receptor beta (PDGFRB) TTI7421 PGFRB_HUMAN Modulator [173]
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [174]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Modulator [173]
------------------------------------------------------------------------------------
Sorafenib Interacts with 7 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [175]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [176]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [177]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [178]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [179]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [178]
RalBP1-associated Eps domain-containing protein 2 (RALBP1) DTYEM9B REPS2_HUMAN Substrate [180]
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⏷ Show the Full List of 7 DTP(s)
Sorafenib Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [181]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [182]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [183]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [183]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [181]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Metabolism [184]
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⏷ Show the Full List of 6 DME(s)
Sorafenib Interacts with 112 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Decreases Activity [185]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Affects Response To Substance [186]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Decreases Phosphorylation [187]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Expression [125]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [188]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [188]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [189]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [190]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [190]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) OTFBU4GD P3C2A_HUMAN Decreases Expression [168]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [168]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Expression [168]
GTPase NRas (NRAS) OTVQ1DG3 RASN_HUMAN Decreases Expression [168]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Decreases Expression [168]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [168]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Decreases Expression [168]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [168]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Decreases Expression [168]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Expression [168]
Cyclin-dependent kinase 9 (CDK9) OT2B7OGB CDK9_HUMAN Decreases Expression [168]
Growth factor receptor-bound protein 2 (GRB2) OTOP7LTE GRB2_HUMAN Decreases Expression [168]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [168]
Interferon regulatory factor 5 (IRF5) OT8SIIAP IRF5_HUMAN Increases Expression [168]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [168]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [168]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Increases Expression [168]
Histone deacetylase 6 (HDAC6) OT9W9MXQ HDAC6_HUMAN Decreases Expression [168]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [188]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [191]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Decreases Expression [192]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Decreases Expression [169]
E3 ubiquitin-protein ligase parkin (PRKN) OTJBN41W PRKN_HUMAN Increases Ubiquitination [193]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [194]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [170]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) OT8V1J4M GA45G_HUMAN Increases Expression [195]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Localization [192]
Tyrosine-protein kinase ABL1 (ABL1) OT09YVXH ABL1_HUMAN Decreases Activity [196]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Decreases Expression [197]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Activity [198]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Secretion [199]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Activity [187]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [200]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [194]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Decreases Phosphorylation [201]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [202]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Decreases Phosphorylation [192]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET) OTLU040A RET_HUMAN Decreases Activity [203]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Increases Expression [199]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [204]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Activity [196]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Activity [185]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [205]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [169]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Decreases Activity [206]
Serine/threonine-protein kinase B-raf (BRAF) OT7S81XQ BRAF_HUMAN Decreases Activity [207]
Platelet-derived growth factor receptor alpha (PDGFRA) OTDJXUCN PGFRA_HUMAN Decreases Phosphorylation [208]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [188]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Decreases Phosphorylation [209]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Increases Secretion [210]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [211]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [211]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [205]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Expression [212]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Decreases Phosphorylation [187]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Decreases Phosphorylation [207]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Phosphorylation [213]
Signal transducer and activator of transcription 5A (STAT5A) OTBSJGN3 STA5A_HUMAN Decreases Activity [214]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [215]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Decreases Phosphorylation [197]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Decreases Phosphorylation [197]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Decreases Phosphorylation [197]
Crk-like protein (CRKL) OTOYSD1R CRKL_HUMAN Decreases Phosphorylation [196]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [216]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Increases Expression [195]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Phosphorylation [215]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [217]
Stanniocalcin-1 (STC1) OTGVVXYF STC1_HUMAN Decreases Expression [218]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [219]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [201]
Gasdermin-D (GSDMD) OTH39BKI GSDMD_HUMAN Increases Expression [199]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [220]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [221]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [222]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Decreases Expression [205]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Decreases Phosphorylation [207]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Cleavage [192]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [192]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [223]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [224]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Decreases Expression [209]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Decreases Phosphorylation [225]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Decreases Expression [226]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Cleavage [171]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Decreases Expression [227]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Decreases Expression [192]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Activity [228]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Increases Expression [171]
Docking protein 1 (DOK1) OTGVRLW6 DOK1_HUMAN Decreases Phosphorylation [196]
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1) OT50NR57 PINK1_HUMAN Increases Expression [193]
Eukaryotic translation initiation factor 2A (EIF2A) OTWXELQP EIF2A_HUMAN Increases Phosphorylation [170]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Increases Expression [229]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [230]
Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD) OT37FKH0 CYLD_HUMAN Increases Expression [125]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Affects Localization [226]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Phosphorylation [170]
E3 ubiquitin-protein ligase TRIM62 (TRIM62) OT15YO6N TRI62_HUMAN Affects Response To Substance [231]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Response To Substance [192]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Affects Response To Substance [186]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Decreases Response To Substance [232]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Affects Response To Substance [186]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Increases Response To Substance [221]
Na(+)/citrate cotransporter (SLC13A5) OTPH1TA7 S13A5_HUMAN Decreases Response To Substance [153]
------------------------------------------------------------------------------------
⏷ Show the Full List of 112 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Ewing sarcoma-peripheral primitive neuroectodermal tumour DC1OA37 ES2 Investigative [233]
Breast and ovarian cancer syndrome DCFTSG6 UWB1289 Investigative [1]
Breast carcinoma DCIQXOM ZR751 Investigative [1]
Breast carcinoma DC7WUBU KPL1 Investigative [1]
Breast carcinoma DCDC8RI OCUBM Investigative [1]
Carcinoma DCHI12T OV90 Investigative [1]
Carcinoma DCNV46J MDAMB436 Investigative [1]
Colon carcinoma DC8LUK7 RKO Investigative [1]
Invasive ductal carcinoma DCOZXUJ T-47D Investigative [1]
Rectal adenocarcinoma DCLRWZY SW837 Investigative [1]
Adenocarcinoma DCD61BM CAOV3 Investigative [234]
Adenocarcinoma DCJ9YIM OVCAR3 Investigative [234]
Adenocarcinoma DC2A9B7 A427 Investigative [234]
Adenocarcinoma DC0942V NCIH1650 Investigative [234]
Adenocarcinoma DC0X6ZR NCIH2122 Investigative [234]
Adenocarcinoma DCJXFRZ NCIH23 Investigative [234]
Adenocarcinoma DCQNWMG NCIH520 Investigative [234]
Adenocarcinoma DCKPDOA COLO320DM Investigative [234]
Adenocarcinoma DC8L0XO DLD1 Investigative [234]
Adenocarcinoma DC37X0U HCT116 Investigative [234]
Adenocarcinoma DC23U0V HT29 Investigative [234]
Adenocarcinoma DCUCN2J SW-620 Investigative [234]
Amelanotic melanoma DC3RDB7 A2058 Investigative [234]
Germ cell tumour DCFIV0U PA1 Investigative [234]
Large cell lung carcinoma DCMUSHW NCI-H460 Investigative [234]
Malignant melanoma DCV48SI A375 Investigative [234]
Malignant melanoma DCRG3OY HT144 Investigative [234]
Malignant melanoma DCX3HRI RPMI7951 Investigative [234]
Malignant melanoma DC4R2WU SKMEL30 Investigative [234]
Malignant melanoma DC4FGYG UACC62 Investigative [234]
Mesothelioma DCM7XB1 MSTO Investigative [234]
Non small cell carcinoma DCGJ49J SKMES1 Investigative [234]
Ovarian endometrioid adenocarcinoma DC71C2M A2780 Investigative [234]
Ovarian serous cystadenocarcinoma DC08FW9 SK-OV-3 Investigative [234]
Prostate carcinoma DCV07OB LNCAP Investigative [234]
Prostate carcinoma DCEAFZX VCAP Investigative [234]
------------------------------------------------------------------------------------
⏷ Show the Full List of 36 DrugCom(s)

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143 Silencing of keratinocyte growth factor receptor restores 5-fluorouracil and tamoxifen efficacy on responsive cancer cells. PLoS One. 2008 Jun 25;3(6):e2528. doi: 10.1371/journal.pone.0002528.
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148 Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma. Cancer Sci. 2006 Dec;97(12):1388-95. doi: 10.1111/j.1349-7006.2006.00333.x. Epub 2006 Oct 9.
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161 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
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167 Recombinant human erythropoietin alpha targets intratumoral blood vessels, improving chemotherapy in human xenograft models. Cancer Res. 2005 Aug 15;65(16):7186-93. doi: 10.1158/0008-5472.CAN-04-2498.
168 Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015 Dec 5;242:107-22.
169 Destruxin B inhibits hepatocellular carcinoma cell growth through modulation of the Wnt/-catenin signaling pathway and epithelial-mesenchymal transition. Toxicol In Vitro. 2014 Jun;28(4):552-61. doi: 10.1016/j.tiv.2014.01.002. Epub 2014 Jan 13.
170 The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol. 2007 Aug;27(15):5499-513. doi: 10.1128/MCB.01080-06. Epub 2007 Jun 4.
171 Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway. Leukemia. 2008 Apr;22(4):808-18. doi: 10.1038/sj.leu.2405098. Epub 2008 Jan 17.
172 Ovatodiolide suppresses yes-associated protein 1-modulated cancer stem cell phenotypes in highly malignant hepatocellular carcinoma and sensitizes cancer cells to chemotherapy in vitro. Toxicol In Vitro. 2018 Sep;51:74-82. doi: 10.1016/j.tiv.2018.04.010. Epub 2018 Apr 24.
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174 Nasopharyngeal carcinoma: Current treatment options and future directions. J Nasopharyng Carcinoma, 2014, 1(16): e16.
175 Multidrug resistance protein 2 implicates anticancer drug-resistance to sorafenib. Biol Pharm Bull. 2011;34(3):433-5.
176 Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation. Mol Cancer Ther. 2010 Feb;9(2):319-26.
177 Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier. Mol Pharm. 2011 Apr 4;8(2):571-82.
178 Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
179 Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
180 Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. Int J Cancer. 2010 Mar 15;126(6):1327-38.
181 Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8.
182 Ontogeny and sorafenib metabolism. Clin Cancer Res. 2012 Oct 15;18(20):5788-95.
183 Drug Interactions Flockhart Table
184 Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma. Invest New Drugs. 2011 Dec;29(6):1511-4.
185 Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite. Chem Biol Interact. 2021 Apr 1;338:109401. doi: 10.1016/j.cbi.2021.109401. Epub 2021 Feb 5.
186 The Enhanced metastatic potential of hepatocellular carcinoma (HCC) cells with sorafenib resistance. PLoS One. 2013 Nov 11;8(11):e78675. doi: 10.1371/journal.pone.0078675. eCollection 2013.
187 Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor. Mol Cancer Ther. 2009 Jan;8(1):152-9. doi: 10.1158/1535-7163.MCT-08-0553.
188 Sorafenib induces apoptotic cell death in human non-small cell lung cancer cells by down-regulating mammalian target of rapamycin (mTOR)-dependent survivin expression. Biochem Pharmacol. 2011 Aug 1;82(3):216-26. doi: 10.1016/j.bcp.2011.04.011. Epub 2011 May 13.
189 Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
190 Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines. BMC Cancer. 2012 Sep 10;12:402.
191 The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation. Cancer Res. 2007 Oct 1;67(19):9490-500. doi: 10.1158/0008-5472.CAN-07-0598.
192 Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. J Biol Chem. 2005 Oct 21;280(42):35217-27. doi: 10.1074/jbc.M506551200. Epub 2005 Aug 18.
193 Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response. J Biol Chem. 2017 Sep 8;292(36):15105-15120. doi: 10.1074/jbc.M117.783175. Epub 2017 Jul 3.
194 Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells. Cancer Res. 2010 Nov 15;70(22):9309-18. doi: 10.1158/0008-5472.CAN-10-1033. Epub 2010 Nov 9.
195 Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma. Oncotarget. 2015 Sep 29;6(29):27953-65. doi: 10.18632/oncotarget.4446.
196 Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. Cancer Res. 2009 May 1;69(9):3927-36. doi: 10.1158/0008-5472.CAN-08-2978. Epub 2009 Apr 14.
197 Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of MKK4/JNK and uPA expression. Environ Toxicol. 2018 Dec;33(12):1237-1244. doi: 10.1002/tox.22630. Epub 2018 Sep 6.
198 Sorafenib inhibits transforming growth factor 1-mediated epithelial-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology. 2011 May;53(5):1708-18. doi: 10.1002/hep.24254.
199 Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events. Toxicol In Vitro. 2021 Mar;71:105063. doi: 10.1016/j.tiv.2020.105063. Epub 2020 Dec 1.
200 Sorafenib is an antagonist of the aryl hydrocarbon receptor. Toxicology. 2022 Mar 30;470:153118. doi: 10.1016/j.tox.2022.153118. Epub 2022 Feb 3.
201 Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia. 2011 May;25(5):838-47. doi: 10.1038/leu.2011.2. Epub 2011 Feb 4.
202 Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation. Cancer Res. 2007 Oct 1;67(19):9443-54. doi: 10.1158/0008-5472.CAN-07-1473.
203 Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. J Biol Chem. 2007 Oct 5;282(40):29230-40. doi: 10.1074/jbc.M703461200. Epub 2007 Jul 30.
204 Synergistic activity of letrozole and sorafenib on breast cancer cells. Breast Cancer Res Treat. 2010 Nov;124(1):79-88. doi: 10.1007/s10549-009-0714-5. Epub 2010 Jan 7.
205 Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. J Pharmacol Exp Ther. 2006 Dec;319(3):1070-80. doi: 10.1124/jpet.106.108621. Epub 2006 Sep 7.
206 Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anticancer Drugs. 2011 Jan;22(1):79-88. doi: 10.1097/CAD.0b013e32833f44fd.
207 Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target. Neuroendocrinology. 2007;85(1):45-53. doi: 10.1159/000100508. Epub 2007 Mar 5.
208 Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies. Mol Cancer Ther. 2011 Jun;10(6):1028-35. doi: 10.1158/1535-7163.MCT-10-1044. Epub 2011 Apr 11.
209 Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma. Int J Cancer. 2012 Aug 1;131(3):548-57. doi: 10.1002/ijc.26374. Epub 2011 Sep 12.
210 Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
211 Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas. Mol Cancer Ther. 2008 Nov;7(11):3519-26. doi: 10.1158/1535-7163.MCT-08-0138.
212 Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways. Chem Biol Interact. 2023 Jan 25;370:110329. doi: 10.1016/j.cbi.2022.110329. Epub 2022 Dec 22.
213 Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf. Eur J Med Chem. 2011 Jul;46(7):2845-51. doi: 10.1016/j.ejmech.2011.04.007. Epub 2011 Apr 14.
214 The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation. Mol Pharmacol. 2007 Sep;72(3):788-95. doi: 10.1124/mol.106.033308. Epub 2007 Jun 26.
215 Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation. Tumour Biol. 2015 Apr;36(4):2323-34. doi: 10.1007/s13277-014-2839-3. Epub 2014 Nov 22.
216 Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations. BMC Cancer. 2009 Oct 31;9:387. doi: 10.1186/1471-2407-9-387.
217 The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms. Eur J Cancer. 2010 Mar;46(4):836-50. doi: 10.1016/j.ejca.2009.12.025. Epub 2010 Jan 12.
218 Downregulation of stanniocalcin 1 is responsible for sorafenib-induced cardiotoxicity. Toxicol Sci. 2015 Feb;143(2):374-84. doi: 10.1093/toxsci/kfu235. Epub 2014 Nov 3.
219 Sorafenib induces preferential apoptotic killing of a drug- and radio-resistant Hep G2 cells through a mitochondria-dependent oxidative stress mechanism. Cancer Biol Ther. 2009 Oct;8(20):1904-13. doi: 10.4161/cbt.8.20.9436. Epub 2009 Oct 6.
220 Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury. Toxicol Appl Pharmacol. 2019 Sep 15;379:114665. doi: 10.1016/j.taap.2019.114665. Epub 2019 Jul 16.
221 Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment. Cancer Lett. 2013 Feb 1;329(1):45-58. doi: 10.1016/j.canlet.2012.09.020. Epub 2012 Oct 2.
222 The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006. Oncogene. 2005 Oct 20;24(46):6861-9. doi: 10.1038/sj.onc.1208841.
223 Why are most phospholipidosis inducers also hERG blockers?. Arch Toxicol. 2017 Dec;91(12):3885-3895. doi: 10.1007/s00204-017-1995-9. Epub 2017 May 27.
224 The multikinase inhibitor sorafenib induces caspase-dependent apoptosis in PC-3 prostate cancer cells. Asian J Androl. 2010 Jul;12(4):527-34. doi: 10.1038/aja.2010.21. Epub 2010 May 17.
225 Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin. J Transl Med. 2005 Oct 28;3:39. doi: 10.1186/1479-5876-3-39.
226 GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines. J Biol Chem. 2008 Jan 11;283(2):726-32. doi: 10.1074/jbc.M705343200. Epub 2007 Nov 8.
227 Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Mol Cancer Ther. 2006 Sep;5(9):2378-87. doi: 10.1158/1535-7163.MCT-06-0235.
228 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
229 Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol Ther. 2008 Oct;7(10):1648-62. doi: 10.4161/cbt.7.10.6623. Epub 2008 Oct 12.
230 A high-throughput screen for teratogens using human pluripotent stem cells. Toxicol Sci. 2014 Jan;137(1):76-90. doi: 10.1093/toxsci/kft239. Epub 2013 Oct 23.
231 TRIM62 silencing represses the proliferation and invasion and increases the chemosensitivity of hepatocellular carcinoma cells by affecting the NF-B pathway. Toxicol Appl Pharmacol. 2022 Jun 15;445:116035. doi: 10.1016/j.taap.2022.116035. Epub 2022 Apr 23.
232 Diospyros kaki leaves inhibit HGF/Met signaling-mediated EMT and stemness features in hepatocellular carcinoma. Food Chem Toxicol. 2020 Aug;142:111475. doi: 10.1016/j.fct.2020.111475. Epub 2020 Jun 6.
233 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
234 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.