Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0YOXQ)

• Drug Name: SB-431542 Drug Info
• Synonyms: 301836-41-9; SB-431542; SB 431542; 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide; SB431542; UNII-E1557V1V0N; CHEMBL440084; E1557V1V0N; 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE; 4-(4-(1,3-Benzodioxole-5-yl)-5-(2-pyridyl)-1H-imidazole-2-yl)benzamide; SB 431542 hydrate; C22H16N4O3; 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide; 4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary fibrosis	CB03.4	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 4521392
  ChEBI ID: CHEMBL440084
  CAS Number: CAS 301836-41-9
  TTD Drug ID: DM0YOXQ

Molecule-Related Drug Atlas

Drug(s) Targeting TGF-beta receptor type I (TGFBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY2157299	DMP8HW1	Arteriosclerosis	BD40	Phase 2/3	[4]
TEW-7197	DM2LBC3	Myeloproliferative neoplasm	2A20	Phase 2	[5]
Metelimumab	DMENFD6	Scleroderma	4A42	Phase 1/2	[6]
TP-0184	DMJVZBC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
P-2745	DMJ3PNS	Chronic myelogenous leukaemia	2A20.0	Phase 1	[8]
LY3200882	DMQP6VB	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
PF-06952229	DMDQJEZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
SM-16	DMHXJV2	Fibrosis	GA14-GC01	Terminated	[11]
LF-984	DMIYMS2	Fibrosis	GA14-GC01	Terminated	[12]
PMID23639540C13d	DMSTQGH	Discovery agent	N.A.	Investigative	[13]

Drug(s) Affected By Membrane-associated progesterone receptor component 1 (PGRMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[23]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[24]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[30]

Drug(s) Affected By Protein lin-7 homolog A (LIN7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]

Drug(s) Affected By RNA-binding protein Musashi homolog 1 (MSI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[40]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[45]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]

Drug(s) Affected By Catenin delta-1 (CTNND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]

Drug(s) Affected By AP-2 complex subunit alpha-2 (AP2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[58]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[55]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[59]

Drug(s) Affected By Tight junction protein ZO-3 (TJP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[63]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]

Drug(s) Affected By AP-2 complex subunit alpha-1 (AP2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Bortezomib	DMNO38U	Leukemia		Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[65]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By Serine/threonine-protein kinase PAK 4 (PAK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[68]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[59]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[14]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[14]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Selenium	DM25CGV	N. A.	N. A.	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[74]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[77]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]

Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[85]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[89]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[89]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[101]

Drug(s) Affected By Tyrosine-protein kinase HCK (HCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[103]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[106]

Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[89]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Bortezomib	DMNO38U	Leukemia		Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Chorionic somatomammotropin hormone 1 (CSH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[113]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[114]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[115]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[116]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[119]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[120]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[121]

Drug(s) Affected By Laminin subunit gamma-1 (LAMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Indomethacin	DMSC4A7	Bursitis		Approved	[124]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[125]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[128]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[129]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]

Drug(s) Affected By Keratin, type I cytoskeletal 13 (KRT13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[135]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[136]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[137]

Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[83]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[140]

Drug(s) Affected By CD59 glycoprotein (CD59)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[144]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[145]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[146]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[147]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[148]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[58]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[150]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[152]
Haloperidol	DM96SE0	Delirium		Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[112]

Drug(s) Affected By Desmoplakin (DSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]

Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[156]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[159]

Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[161]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[162]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[163]

Drug(s) Affected By Cadherin-3 (CDH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[166]

Drug(s) Affected By Sterol carrier protein 2 (SCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[112]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[168]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[167]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[171]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[173]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[174]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[176]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[177]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[180]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[171]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[181]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[182]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[173]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[174]

Drug(s) Affected By Peroxiredoxin-6 (PRDX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[112]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[186]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[162]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[187]

Drug(s) Affected By Enoyl-CoA hydratase, mitochondrial (ECHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[191]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[193]

Drug(s) Affected By Catenin alpha-1 (CTNNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[100]
Haloperidol	DM96SE0	Delirium		Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]

Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[169]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[88]
Bortezomib	DMNO38U	Leukemia		Approved	[64]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[55]

Drug(s) Affected By Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Haloperidol	DM96SE0	Delirium		Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[191]

Drug(s) Affected By Basal cell adhesion molecule (BCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[199]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]

Drug(s) Affected By Ras-related protein Rab-13 (RAB13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[201]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[201]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[202]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[199]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[59]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[203]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[115]

Drug(s) Affected By Tyrosine-protein kinase Blk (BLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[152]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[204]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Bortezomib	DMNO38U	Leukemia		Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[205]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[206]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[113]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[207]

Drug(s) Affected By Ephrin-B2 (EFNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]

Drug(s) Affected By Trifunctional enzyme subunit beta, mitochondrial (HADHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[153]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[153]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[191]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[210]

Drug(s) Affected By T-box transcription factor TBX4 (TBX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[38]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[46]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[46]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[46]

Drug(s) Affected By Cell division control protein 42 homolog (CDC42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[157]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[213]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[214]
Bortezomib	DMNO38U	Leukemia		Approved	[64]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[216]

Drug(s) Affected By Coxsackievirus and adenovirus receptor (CXADR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[217]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]

Drug(s) Affected By Dermcidin (DCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[153]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]

Drug(s) Affected By Pregnancy-specific beta-1-glycoprotein 9 (PSG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]

Drug(s) Affected By 3-ketodihydrosphingosine reductase (KDSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[220]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[195]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[135]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[221]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[59]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[223]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[224]

Drug(s) Affected By AP-1 complex subunit beta-1 (AP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[202]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[65]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[226]

Drug(s) Affected By Interleukin enhancer-binding factor 3 (ILF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[125]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[143]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[40]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[228]

Drug(s) Affected By CD166 antigen (ALCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]

Drug(s) Affected By Desmoglein-2 (DSG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[202]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]

Drug(s) Affected By Malectin (MLEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]

Drug(s) Affected By Oligodendrocyte transcription factor 3 (OLIG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[232]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[232]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[232]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[232]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[232]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[234]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[232]

Drug(s) Affected By Keratin, type II cytoskeletal 1b (KRT77)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[230]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[152]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[235]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[235]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[85]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]

Drug(s) Affected By Protein PALS1 (PALS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[59]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[14]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[238]

Drug(s) Affected By SERPINE1 mRNA-binding protein 1 (SERBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]

Drug(s) Affected By Glutathione peroxidase 7 (GPX7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[143]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[221]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[143]

Drug(s) Affected By Plakophilin-4 (PKP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[101]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Indomethacin	DMSC4A7	Bursitis		Approved	[240]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]

Drug(s) Affected By Homeobox protein CDX-2 (CDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[242]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[243]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[244]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
OXYRESVERATROL	DMN7S4L	Discovery agent	N.A.	Investigative	[245]

Drug(s) Affected By Plakophilin-2 (PKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Cell adhesion molecule 1 (CADM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[247]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[248]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By Semaphorin-4C (SEMA4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[143]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[230]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[250]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[251]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[252]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[253]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[254]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Band 4.1-like protein 5 (EPB41L5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[255]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]

Drug(s) Affected By Adipocyte plasma membrane-associated protein (APMAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[256]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[257]

Drug(s) Affected By Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[258]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[221]

Drug(s) Affected By ORM1-like protein 1 (ORMDL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By Cingulin (CGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[259]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[169]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[101]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[50]

Drug(s) Affected By Cathepsin Z (CTSZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[59]

Drug(s) Affected By Tight junction protein ZO-2 (TJP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[263]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[162]

Drug(s) Affected By ETS-related transcription factor Elf-5 (ELF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[264]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[265]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[266]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[267]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[47]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[115]
ORG2058	DMH1M6N	Discovery agent	N.A.	Investigative	[265]

Drug(s) Affected By Glutathione S-transferase kappa 1 (GSTK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[268]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[269]

Drug(s) Affected By Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[270]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[271]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[268]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[55]

Drug(s) Affected By Gremlin-1 (GREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[274]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[277]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[278]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[278]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]

Drug(s) Affected By Transcription factor SOX-17 (SOX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[279]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[279]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[279]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[280]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[101]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[279]
Ziprasidone	DMM58JY	Bipolar disorder	6A60	Approved	[279]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TGF-beta receptor type I (TGFBR1)	TTP4520	TGFR1_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Gene/Protein Processing	[3]
3-ketodihydrosphingosine reductase (KDSR)	OTCIES3H	KDSR_HUMAN	Gene/Protein Processing	[3]
Adipocyte plasma membrane-associated protein (APMAP)	OT1P2GJA	APMAP_HUMAN	Gene/Protein Processing	[3]
AP-1 complex subunit beta-1 (AP1B1)	OTY0K84R	AP1B1_HUMAN	Gene/Protein Processing	[3]
AP-2 complex subunit alpha-1 (AP2A1)	OTEFZB21	AP2A1_HUMAN	Gene/Protein Processing	[3]
AP-2 complex subunit alpha-2 (AP2A2)	OTD1UGUN	AP2A2_HUMAN	Gene/Protein Processing	[3]
Band 4.1-like protein 5 (EPB41L5)	OTPPQPLU	E41L5_HUMAN	Gene/Protein Processing	[3]
Basal cell adhesion molecule (BCAM)	OTHZOPSD	BCAM_HUMAN	Gene/Protein Processing	[3]
Cadherin-3 (CDH3)	OTKNLQU7	CADH3_HUMAN	Gene/Protein Processing	[3]
Catenin alpha-1 (CTNNA1)	OTFC725Z	CTNA1_HUMAN	Gene/Protein Processing	[3]

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