Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM31OGF)

• Drug Name: U0126 Drug Info
• Synonyms: U0126; 109511-58-2; U-0126; U 0126; 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene; UNII-8027P94HLL; CHEBI:64208; 8027P94HLL; (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile; FT-1069-1; 218601-62-8; Succinonitrile, bis(amino(o-aminophenylthio)methylene)-; Butanedinitrile, bis(amino((2-aminophenyl)thio)methylene)-; C18H16N6S2; (2z)-Bis{amino[(2-Aminophenyl)sulfanyl]methylidene}butanedinitrile; (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylene}succinonitrile

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3006531
  ChEBI ID: CHEMBL34704
  CAS Number: CAS 218601-62-8
  TTD Drug ID: DM31OGF

Molecule-Related Drug Atlas

Drug(s) Targeting MAPK/ERK kinase kinase 1 (MAP3K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[2]
Ro092210	DM2DXHO	Discovery agent	N.A.	Investigative	[2]
LLZ16406	DMOGZLU	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Mitogen-activated protein kinase (MAPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GBL-310	DM2IFJQ	Keratosis	ED56	Phase 2	[14]
LTT462	DM94E6W	Solid tumour/cancer	2A00-2F9Z	Phase 1	[15]
PF-07799544	DMAO10K	Aggressive cancer	2A00-2F9Z	Phase 1	[16]
PMID25991433-Compound-L2	DM58UO9	N. A.	N. A.	Patented	[17]
PMID25991433-Compound-L3	DM3LWUR	N. A.	N. A.	Patented	[17]
Bidentate ligands of Markush derivative 2	DM2QNMC	N. A.	N. A.	Patented	[18]
Bidentate ligands of Markush derivative 1	DMB08D3	N. A.	N. A.	Patented	[18]
PMID25991433-Compound-Q1	DMEMSB2	N. A.	N. A.	Patented	[17]
PMID25991433-Compound-C3	DMSKWBE	N. A.	N. A.	Patented	[17]
PMID25991433-Compound-J6	DMOWULJ	N. A.	N. A.	Patented	[17]

Drug(s) Targeting MAPK/ERK kinase kinase 2 (MAP3K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[2]
URMC-099	DMCJXWK	Discovery agent	N.A.	Investigative	[19]
Ro092210	DM2DXHO	Discovery agent	N.A.	Investigative	[2]
LLZ16407	DM783BP	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[26]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[29]

Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[31]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[32]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[35]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[44]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[45]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[46]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[49]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[50]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[50]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[51]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[53]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[50]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[50]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[55]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[60]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[61]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[65]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[66]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[41]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[66]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[68]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[66]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[77]

Drug(s) Affected By Claudin-5 (CLDN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[79]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[80]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[81]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[82]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[83]
CS-600G	DM1PV4Y	N. A.	N. A.	Phase 3	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[85]
LY294002	DMY1AFS	Neuroblastoma	2D11.2	Phase 1	[86]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[81]

Drug(s) Affected By Forkhead box protein N1 (FOXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[89]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[90]

Drug(s) Affected By Claudin-3 (CLDN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[93]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[91]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]

Drug(s) Affected By CCN family member 4 (CCN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[12]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[12]
Indomethacin	DMSC4A7	Bursitis		Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[100]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[102]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[103]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[102]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[111]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[112]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[114]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[120]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[121]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[122]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]

Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[88]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[132]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[134]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[140]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[142]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[143]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[144]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[145]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[146]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[147]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[148]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[146]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Haloperidol	DM96SE0	Delirium		Approved	[153]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[156]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[157]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[158]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[157]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[159]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[162]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[163]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[165]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[170]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[168]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[173]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[174]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[177]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[77]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[178]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[181]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[182]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[185]

Drug(s) Affected By Keratin, type I cytoskeletal 10 (KRT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[127]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[187]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[188]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[187]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[5]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[5]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[192]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[193]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[196]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[197]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[198]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[199]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[100]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[25]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[204]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[205]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[207]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[208]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[210]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[211]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[215]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[219]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[220]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[221]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[205]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[222]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[223]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[224]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[204]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[225]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[207]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[208]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]

Drug(s) Affected By CD70 antigen (CD70)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[235]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[236]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[237]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[238]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[239]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[241]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[242]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[158]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[243]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[187]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[187]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[251]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[252]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[249]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[253]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[227]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[250]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[255]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[257]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[258]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[263]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[264]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[265]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[236]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[266]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[252]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[270]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[271]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[187]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[272]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[187]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[275]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[277]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[278]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[279]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[252]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[235]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[264]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[283]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[284]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[285]

Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[286]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[287]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[236]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[88]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[288]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[289]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[290]

Drug(s) Affected By Major vault protein (MVP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[291]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[277]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[187]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[292]

Drug(s) Affected By Sonic hedgehog protein (SHH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[268]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[295]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[296]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[293]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[297]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[298]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF187 (RNF187)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[299]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[300]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[301]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[302]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[303]
PMID28460551-Compound-3	DMA1FRM	N. A.	N. A.	Patented	[302]
H-89	DM4RVGO	Discovery agent	N.A.	Investigative	[302]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[304]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[305]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[306]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[219]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[312]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[313]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[60]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[314]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[315]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[316]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[317]

Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[252]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[319]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[321]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[322]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[60]

Drug(s) Affected By NADPH oxidase 1 (NOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[187]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[187]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[323]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[324]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[325]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[325]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[326]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[325]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[327]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[328]

Drug(s) Affected By Nuclear receptor corepressor 2 (NCOR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[220]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[247]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[297]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[91]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[300]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[203]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[330]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MAPK/ERK kinase kinase 1 (MAP3K1)	TTQBCEJ	M3K1_HUMAN	Inhibitor	[2]
MAPK/ERK kinase kinase 2 (MAP3K2)	TTK1N5G	M3K2_HUMAN	Inhibitor	[2]
Mitogen-activated protein kinase (MAPK)	TTVOE6D	NOUNIPROTAC	Inhibitor	[3]
Mitogen-activated protein kinase kinase (MAPKK)	TTCZO0Q	NOUNIPROTAC	Inhibitor	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[5]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Gene/Protein Processing	[7]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Gene/Protein Processing	[7]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[8]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[9]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[10]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[11]
CCN family member 4 (CCN4)	OT69BER9	CCN4_HUMAN	Gene/Protein Processing	[12]
CD70 antigen (CD70)	OTHB2AL1	CD70_HUMAN	Gene/Protein Processing	[13]

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