Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ8JIK)

• Drug Name: Chenodiol Drug Info
• Synonyms: 474-25-9; Chenix; Chenic acid; Chenodeoxycholate; Gallodesoxycholic acid; Chendol; Chenodesoxycholic acid; Cdca; Chenofalk; Anthropodeoxycholic acid; Anthropodesoxycholic acid; Anthropododesoxycholic acid; Chenodesoxycholsaeure; Xenbilox; Henohol; Chenique Acid; Chenodiol [USAN]; 3alpha,7alpha-Dihydroxy-5beta-cholan-24-oic acid; Sodium chenodeoxycholate; Acido chenodeoxicholico; Chenodesoxycholsaeure [German]; Acide chenodeoxycholique; 7-alpha-Hydroxylithocholic acid; Acidum chenodeoxycholicum

Indication

Disease Entry	ICD 11	Status	REF
Cholelithiasis	DC11	Approved	[1]

• Cross-matching ID:
  PubChem CID: 10133
  ChEBI ID: CHEMBL240597
  CAS Number: CAS 474-25-9
  TTD Drug ID: DMQ8JIK
  VARIDT Drug ID: DR00524
  INTEDE Drug ID: DR0295
  ACDINA Drug ID: D00118

Molecule-Related Drug Atlas

Drug(s) Targeting Farnesoid X-activated receptor (FXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Guggulsterone	DMP7LK1	Osteoarthritis	FA00-FA05	Approved	[10]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[11]
GS-9674	DM936V7	Primary sclerosing cholangitis	DB96.2	Phase 3	[12]
Apomine	DM6B9HP	Osteopetrosis	LD24.10	Phase 2	[13]
LJN452	DM3XRUH	Primary biliary cholangitis	DB96.1	Phase 2	[14]
EYP001	DM5PBLM	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[15]
EDP-305	DMGJYZ8	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[16]
LMB763	DMQOXNL	Diabetic nephropathy	GB61.Z	Phase 2	[17]
MET409	DM89QXT	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[18]
Turofexorate isopropyl	DM36ONA	Hyperlipidaemia	5C80	Phase 1	[19]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[20]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[21]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[26]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[27]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[28]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[31]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[32]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[35]
Metronidazole	DMTIVEN	Abscess		Approved	[36]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[37]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[38]

Drug(s) Affected By 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[39]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[41]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[6]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[45]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[46]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[47]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[47]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[53]

Drug(s) Affected By Gastrotropin (FABP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[58]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[61]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[64]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[69]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[74]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]

Drug(s) Affected By Solute carrier family 22 member 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[81]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[82]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[83]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[84]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[85]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[88]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[86]

Drug(s) Affected By Fatty acid-binding protein, brain (FABP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[91]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[92]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[93]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[42]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[98]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[99]
7-hydroxycoumarin	DMTMNO7	Discovery agent	N.A.	Investigative	[100]

Drug(s) Affected By Apolipoprotein M (APOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[104]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[105]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[106]

Drug(s) Affected By Aldo-keto reductase family 1 member C4 (AKR1C4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[107]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[108]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[48]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[48]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[109]
Indomethacin	DMSC4A7	Bursitis		Approved	[108]

Drug(s) Affected By Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Haloperidol	DM96SE0	Delirium		Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[113]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[91]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[114]

Drug(s) Affected By Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ACADSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[119]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[117]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[87]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]

Drug(s) Affected By Apolipoprotein C-IV (APOC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[124]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[125]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[126]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[127]
GW7647	DM9RD0C	Discovery agent	N.A.	Investigative	[128]
Farnesol	DMV2X1B	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Peroxisomal biogenesis factor 3 (PEX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[132]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[47]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[47]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[47]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[134]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[135]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[133]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[47]

Drug(s) Affected By Bile acid-CoA:amino acid N-acyltransferase (BAAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[138]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[140]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[141]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[77]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[144]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[145]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By Acyl-CoA dehydrogenase family member 11 (ACAD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]

Drug(s) Affected By ATP-binding cassette sub-family G member 8 (ABCG8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[123]

Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[154]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[155]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[155]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[155]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[155]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[155]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[155]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[156]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[157]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[158]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[159]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[162]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[163]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[163]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[164]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[165]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[166]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[166]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[167]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[168]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[169]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[166]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[166]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[170]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[171]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[172]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[172]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[159]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[171]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[172]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[173]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[171]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[174]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[171]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[178]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[179]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[180]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[179]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[181]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[191]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[193]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 1 (NR1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[195]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[196]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[198]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[199]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[200]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[201]
Methysergide	DM1EF73	Migraine	8A80	Approved	[173]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[141]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[202]

Drug(s) Affected By Coronin-1A (CORO1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[45]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[190]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[205]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[207]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[210]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[212]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[213]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[215]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[217]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[218]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[217]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]

Drug(s) Affected By Hematopoietically-expressed homeobox protein HHEX (HHEX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[220]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[222]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[223]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 2 (NR1D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[225]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[224]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[195]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[226]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[65]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[227]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[39]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[227]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[230]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[227]

Drug(s) Affected By Organic solute transporter subunit alpha (SLC51A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[150]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[6]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]

Drug(s) Affected By Organic solute transporter subunit beta (SLC51B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[41]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[150]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[233]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[6]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[151]

Drug(s) Affected By Homeobox protein CDX-2 (CDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[236]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[93]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[126]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[237]
OXYRESVERATROL	DMN7S4L	Discovery agent	N.A.	Investigative	[238]

Drug(s) Affected By ATP-binding cassette sub-family G member 5 (ABCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[39]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[6]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[159]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[239]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[240]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[164]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[83]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[6]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[41]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[150]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[6]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Farnesoid X-activated receptor (FXR)	TTS4UGC	NR1H4_HUMAN	Modulator	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[3]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[4]
Cytochrome P450 8B1 (CYP8B1)	DETL4WB	CP8B1_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)	OTRI4UR1	CP8B1_HUMAN	Gene/Protein Processing	[6]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)	OTJC60Q7	THIL_HUMAN	Gene/Protein Processing	[7]
Acyl-CoA dehydrogenase family member 11 (ACAD11)	OT3T9HAX	ACD11_HUMAN	Gene/Protein Processing	[7]
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)	OTW3GO4Y	ARK73_HUMAN	Gene/Protein Processing	[7]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[7]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[8]
Aldo-keto reductase family 1 member C4 (AKR1C4)	OTW2MMOF	AK1C4_HUMAN	Gene/Protein Processing	[7]
Apolipoprotein C-IV (APOC4)	OTE8ZUXY	APOC4_HUMAN	Gene/Protein Processing	[7]
Apolipoprotein M (APOM)	OTI3FQQC	APOM_HUMAN	Gene/Protein Processing	[7]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Gene/Protein Processing	[9]

References

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