Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTWRQI)

• Drug Name: crotylaldehyde Drug Info
• Synonyms: Crotonaldehyde; CROTONALDEHYDE; 2-Butenal; Crotylaldehyde; Crotonal; (2E)-but-2-enal; trans-Crotonaldehyde; 123-73-9; Crotonic aldehyde; (E)-Crotonaldehyde; (E)-but-2-enal; trans-2-Butenal; Methylpropenal; Propylene aldehyde; 1-Formylpropene; beta-Methylacrolein; 4170-30-3; 2-Butenal, (2E)-; Aldehyde crotonique; 2-Butenaldehyde; but-2-enal; Topanel; trans- Crotonal; 2-Butenal, (E)-; Topanel CA; trans-but-2-enal; RCRA waste number U053; E-2-Butenal; beta-Methyl acrolein; trans-2-butenaldehyde; Krotonaldehyd [Czech]; (E)-2-Butenal; CROTONALDEHYDE, (E)-; 2-butenal; crotonal; trans-crotonaldehyde

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 447466
  ChEBI ID: CHEBI:41607
  CAS Number: CAS 4170-30-3
  TTD Drug ID: DMTWRQI

Molecule-Related Drug Atlas

Drug(s) Targeting Mitochondrial aldehyde dehydrogenase (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALD-401	DM2U530	Cerebrovascular ischaemia	8B1Z	Phase 2	[7]
GS-6637	DMXG3T1	Substance use disorder	6C4Z	Phase 1	[8]
ANS-6637	DM39QWN	Substance use disorder	6C4Z	Phase 1	[9]
FP-045	DMV9FTH	Cardiovascular disease	BA00-BE2Z	Phase 1	[10]
Daidzin	DMFCMPS	N. A.	N. A.	Terminated	[2]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[2]
ISOFORMONENTIN	DM5CMA8	Discovery agent	N.A.	Investigative	[11]
prunetin	DMPD41Q	Discovery agent	N.A.	Investigative	[11]
CVT-10216	DMDH6PJ	Alcohol dependence	6C40.2	Investigative	[12]

Drug(s) Targeting Transformation-sensitive protein p120 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[13]
LY3526318	DMFXNQM	Chronic low-back pain	MG30	Phase 2	[14]
HX-100	DMFRM15	Diabetic neuropathy	8C0Z	Phase 1	[15]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[16]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[17]
[3H]resolvin D1	DMFT0HU	Discovery agent	N.A.	Investigative	[18]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[19]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[20]
4-oxo-nonenal	DMPX1J9	Discovery agent	N.A.	Investigative	[21]
dibutyl phthalate	DMEDGKO	Discovery agent	N.A.	Investigative	[22]

Drug(s) Affected By Transcription factor E2F8 (E2F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM38 (TRIM38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]

Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[42]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[43]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]

Drug(s) Affected By C-C motif chemokine 25 (CCL25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]

Drug(s) Affected By C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[61]

Drug(s) Affected By NEDD4-binding protein 1 (N4BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[65]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]

Drug(s) Affected By Microtubule cross-linking factor 2 (MTCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[77]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[81]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[82]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[85]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[86]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[89]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[90]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[94]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[95]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[99]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[100]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[103]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[104]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[106]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[109]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[110]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[112]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[114]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[115]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[92]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]

Drug(s) Affected By Thrombomodulin (THBD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[118]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[123]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[125]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[126]
Terbutaline	DMD4381	Asthma	CA23	Approved	[127]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[128]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[131]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[132]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[133]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[133]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[133]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[133]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[137]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[138]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[140]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[118]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[141]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[142]

Drug(s) Affected By Nuclear factor 1 C-type (NFIC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[147]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[148]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[149]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[114]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[154]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]

Drug(s) Affected By Macrophage colony-stimulating factor 1 (CSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]

Drug(s) Affected By Granulocyte colony-stimulating factor (CSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[100]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[161]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[109]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[164]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[69]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]

Drug(s) Affected By Zinc finger protein GLI2 (GLI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[118]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[171]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[172]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[173]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[174]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[114]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[175]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[176]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[90]

Drug(s) Affected By RNA-binding protein RO60 (RO60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[177]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[177]

Drug(s) Affected By Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (DBT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[178]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[181]

Drug(s) Affected By Interleukin-7 (IL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[149]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[161]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[183]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[184]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[185]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[115]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[188]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[189]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]

Drug(s) Affected By POU domain, class 2, transcription factor 1 (POU2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[178]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[194]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[192]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[178]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[200]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[201]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[82]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[206]

Drug(s) Affected By C-X-C motif chemokine 3 (CXCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[207]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[118]

Drug(s) Affected By Interleukin-11 (IL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[209]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[210]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[210]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[214]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[210]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[215]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[217]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[218]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[219]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[222]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[223]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[225]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[82]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[160]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[226]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[227]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[133]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[228]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[229]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[230]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[231]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[234]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[235]
Bortezomib	DMNO38U	Leukemia		Approved	[236]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[237]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[77]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By ETS domain-containing protein Elk-4 (ELK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[177]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[177]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[177]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[239]

Drug(s) Affected By S-adenosylmethionine synthase isoform type-2 (MAT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[242]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[241]

Drug(s) Affected By Heat shock 70 kDa protein 1-like (HSPA1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[165]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[196]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[185]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[245]

Drug(s) Affected By Prostaglandin E2 receptor EP4 subtype (PTGER4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[246]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[184]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[247]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[248]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[249]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[69]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[250]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[252]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[254]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[258]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[259]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[260]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[260]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[258]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[258]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[133]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[177]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[177]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[265]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[266]

Drug(s) Affected By Trafficking protein particle complex subunit 10 (TRAPPC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[267]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[268]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[269]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[270]

Drug(s) Affected By Dual specificity protein kinase CLK1 (CLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[271]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]

Drug(s) Affected By High mobility group protein HMGI-C (HMGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[234]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[272]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]

Drug(s) Affected By Growth arrest-specific protein 1 (GAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[272]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[273]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[274]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]

Drug(s) Affected By GTP-binding protein GEM (GEM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]

Drug(s) Affected By Serine protease HTRA3 (HTRA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[276]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[279]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[280]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[281]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[282]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[283]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[258]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[258]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[258]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[201]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[285]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[284]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[258]

Drug(s) Affected By Max dimerization protein 1 (MXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]

Drug(s) Affected By Protein CBFA2T1 (RUNX1T1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[272]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[61]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[37]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[37]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]

Drug(s) Affected By Nucleosome-remodeling factor subunit BPTF (BPTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[282]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[90]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[90]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[90]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[290]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[148]

Drug(s) Affected By Bone morphogenetic protein receptor type-2 (BMPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[293]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[294]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[61]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 8 (LRP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[296]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]

Drug(s) Affected By Translocating chain-associated membrane protein 2 (TRAM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[297]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[298]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[61]

Drug(s) Affected By ELAV-like protein 1 (ELAVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[299]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[300]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[301]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[302]

Drug(s) Affected By Lymphocyte antigen 6K (LY6K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[303]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[305]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[307]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[308]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[270]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[309]

Drug(s) Affected By Guanine nucleotide exchange factor subunit RIC1 (RIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[307]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[312]

Drug(s) Affected By Glucoside xylosyltransferase 1 (GXYLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[306]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]

Drug(s) Affected By Complex III assembly factor LYRM7 (LYRM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[239]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[313]

Drug(s) Affected By Terminal nucleotidyltransferase 4A (TENT4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[282]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[314]
Brilinta	DMBR01X	Acute coronary syndrome	BA41	Approved	[315]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]

Drug(s) Affected By Growth/differentiation factor 6 (GDF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Indomethacin	DMSC4A7	Bursitis		Approved	[316]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[274]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[317]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
Nitrobenzanthrone	DMN6L70	N. A.	N. A.	Investigative	[318]

Drug(s) Affected By Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[248]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[246]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[319]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[320]

Drug(s) Affected By Rho GTPase-activating protein 11A (ARHGAP11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[234]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]

Drug(s) Affected By Aspartate-rich protein 1 (DRICH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]

Drug(s) Affected By Mitotic deacetylase-associated SANT domain protein (MIDEAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[296]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[322]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[67]

Drug(s) Affected By Myosin phosphatase Rho-interacting protein (MPRIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[323]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[324]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]

Drug(s) Affected By Protein MMS22-like (MMS22L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[234]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[272]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[325]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[305]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]

Drug(s) Affected By Coiled-coil domain-containing protein 121 (CCDC121)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Haloperidol	DM96SE0	Delirium		Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[240]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[322]

Drug(s) Affected By Coiled-coil domain-containing protein 9B (CCDC9B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[239]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By Docking protein 3 (DOK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[327]

Drug(s) Affected By MOB kinase activator 1B (MOB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[328]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[329]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[330]

Drug(s) Affected By Charged multivesicular body protein 1b (CHMP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[307]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[312]

Drug(s) Affected By Leucine-rich repeat-containing protein 70 (LRRC70)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[332]

Drug(s) Affected By Treslin (TICRR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[234]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Prickle-like protein 2 (PRICKLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[333]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[334]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]

Drug(s) Affected By Ankyrin repeat domain-containing protein 37 (ANKRD37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[61]

Drug(s) Affected By Neuroblastoma breakpoint family member 11 (NBPF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Inactive tyrosine-protein kinase PRAG1 (PRAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[282]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]

Drug(s) Affected By CREB3 regulatory factor (CREBRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[247]

Drug(s) Affected By Armadillo repeat-containing protein 8 (ARMC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]

Drug(s) Affected By EP300-interacting inhibitor of differentiation 3 (EID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]

Drug(s) Affected By Ankyrin repeat domain-containing protein 36B (ANKRD36B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[335]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[61]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[313]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[304]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[270]

Drug(s) Affected By Testis-expressed protein 19 (TEX19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[336]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[337]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[31]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[270]

Drug(s) Affected By NHL repeat-containing protein 2 (NHLRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[338]

Drug(s) Affected By Folliculin (FLCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[239]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[340]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[145]
Bortezomib	DMNO38U	Leukemia		Approved	[293]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Olfactory receptor 5T2 (OR5T2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]

Drug(s) Affected By Checkpoint protein HUS1B (HUS1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]

Drug(s) Affected By TRAF3-interacting protein 1 (TRAF3IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[341]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By DNA-binding death effector domain-containing protein 2 (DEDD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[82]
Bortezomib	DMNO38U	Leukemia		Approved	[342]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[343]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]

Drug(s) Affected By Lipoma-preferred partner (LPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[306]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[344]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[344]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Leucine-rich repeat-containing protein 58 (LRRC58)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[345]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[296]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By RNA-binding protein 33 (RBM33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]

Drug(s) Affected By CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[296]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[296]

Drug(s) Affected By FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[118]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[145]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[272]

Drug(s) Affected By PWWP domain-containing protein 2A (PWWP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[322]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[269]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[270]

Drug(s) Affected By Germ cell nuclear acidic protein (GCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[225]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[346]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[181]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[225]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[82]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[347]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[225]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[348]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[349]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[266]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[348]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[350]

Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[351]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[177]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[352]

Drug(s) Affected By NF-kappa-B inhibitor zeta (NFKBIZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[353]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[354]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[184]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Neuroblastoma breakpoint family member 3 (NBPF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[355]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]

Drug(s) Affected By Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[356]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[177]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[357]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[184]

Drug(s) Affected By Rab3 GTPase-activating protein non-catalytic subunit (RAB3GAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]

Drug(s) Affected By Zinc finger protein Eos (IKZF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]

Drug(s) Affected By Homeodomain-interacting protein kinase 2 (HIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[357]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]

Drug(s) Affected By Protein FAM217B (FAM217B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[203]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[200]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[269]

Drug(s) Affected By Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[353]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[240]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[272]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[282]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]

Drug(s) Affected By Ankyrin repeat domain-containing protein 10 (ANKRD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[140]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[293]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[358]

Drug(s) Affected By REST corepressor 3 (RCOR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[359]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[359]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[322]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[67]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[360]

Drug(s) Affected By FERM domain-containing protein 4A (FRMD4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[361]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[272]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[362]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]

Drug(s) Affected By Rabankyrin-5 (ANKFY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[341]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[298]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[225]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[363]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]

Drug(s) Affected By Leucyl-cystinyl aminopeptidase (LNPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[239]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[293]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]

Drug(s) Affected By A-kinase anchor protein 11 (AKAP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[328]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[282]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[355]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]

Drug(s) Affected By TRAF2 and NCK-interacting protein kinase (TNIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[364]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[267]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[297]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[37]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[52]

Drug(s) Affected By General transcription factor 3C polypeptide 4 (GTF3C4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[293]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[296]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[365]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[305]

Drug(s) Affected By F-box only protein 5 (FBXO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[366]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[367]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]

Drug(s) Affected By Ras-related protein Rab-22A (RAB22A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[298]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]

Drug(s) Affected By Myocardin-related transcription factor B (MRTFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[368]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[272]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[311]

Drug(s) Affected By Nuclear pore complex-interacting protein family member A1 (NPIPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[242]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[248]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[242]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[369]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[307]

Drug(s) Affected By C-C motif chemokine 26 (CCL26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[370]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[364]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[371]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[298]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[372]

Drug(s) Affected By UDP-N-acetylglucosamine transporter (SLC35A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[306]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[373]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[65]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[374]

Drug(s) Affected By RRP15-like protein (RRP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[364]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[282]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[375]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[296]

Drug(s) Affected By Nuclear receptor corepressor 2 (NCOR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[306]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[376]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[377]

Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[378]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[225]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[148]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[379]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[380]
Fructose	DM43AN2	Vomiting	MD90	Approved	[133]
Ketoprofen	DMRKXPT	Bursitis		Approved	[133]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[381]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[382]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[383]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[384]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[141]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[386]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[387]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[388]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[391]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[392]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[393]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[394]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[384]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Selenium	DM25CGV	N. A.	N. A.	Approved	[395]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[396]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[397]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[398]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[399]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[150]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[400]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[69]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[401]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[402]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[403]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[404]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[405]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[406]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[386]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[407]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[378]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[408]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[409]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[410]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[391]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[149]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[411]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[133]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[188]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[407]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[412]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[413]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[414]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[415]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[416]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[417]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[418]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[151]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[419]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[420]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[421]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[422]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[423]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[424]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[424]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[425]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[426]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[167]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[427]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[359]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[428]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[429]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[411]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[430]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[206]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[431]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[432]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[431]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[57]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[184]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[431]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mitochondrial aldehyde dehydrogenase (ALDH2)	TTFLN4T	ALDH2_HUMAN	Inhibitor	[2]
Transformation-sensitive protein p120 (TRPA1)	TTELV3W	TRPA1_HUMAN	Activator	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
A-kinase anchor protein 11 (AKAP11)	OT7E2FVD	AKA11_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Biotransformations	[5]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Drug Response	[6]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[4]
Alpha-tocopherol transfer protein-like	OTODDR21	TTPAL_HUMAN	Gene/Protein Processing	[4]
AN1-type zinc finger protein 2A	OTTG7P8R	ZFN2A_HUMAN	Gene/Protein Processing	[4]
Angiopoietin-related protein 4 (ANGPTL4)	OTQL5SPX	ANGL4_HUMAN	Gene/Protein Processing	[4]
Ankyrin repeat domain-containing protein 10 (ANKRD10)	OTIZ2VK8	ANR10_HUMAN	Gene/Protein Processing	[4]
Ankyrin repeat domain-containing protein 36B (ANKRD36B)	OT3MW415	AN36B_HUMAN	Gene/Protein Processing	[4]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6288).
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest. 2008 Jul;118(7):2574-82.
• [4] Gene expression profile and cytotoxicity of human bronchial epithelial cells exposed to crotonaldehyde. Toxicol Lett. 2010 Aug 16;197(2):113-22.
• [5] Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds. Chem Biol Interact. 2011 May 30;191(1-3):192-8. doi: 10.1016/j.cbi.2011.02.004. Epub 2011 Feb 15.
• [6] Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. Int J Cancer. 2007 Nov 15;121(10):2301-6. doi: 10.1002/ijc.22933.
• [7] A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo. Clin Cancer Res. 2011 Dec 1;17(23):7265-72.
• [8] Clinical pipeline report, company report or official report of Gilead.
• [9] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [10] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [11] Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. J Med Chem. 2008 Aug 14;51(15):4482-7.
• [12] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2595).
• [13] TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10.
• [14] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
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