Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUN54G)

• Drug Name: AMINOHIPPURIC ACID Drug Info
• Synonyms: 4-Aminohippuric acid; aminohippuric acid; 61-78-9; P-AMINOHIPPURIC ACID; Paha; Glycine, N-(4-aminobenzoyl)-; N-(4-Aminobenzoyl)glycine; para-Aminohippuric acid; Nefrotest; 2-(4-aminobenzamido)acetic acid; N-(p-Aminobenzoyl)glycine; p-Aminohippurate; Aminohippurate; PAH (amino acid); 4-Amino hippuric acid; N-(para-aminobenzoyl)glycine; Hippuric acid, p-amino-; N-(p-Aminobenzoyl)aminoacetic acid; para-Aminohippurate; paraaminohippuric acid; PAH; UNII-Y79XT83BJ9; NSC 13064; HSDB 2139; 4-Aminobenzoyl Glycine; EINECS 200-518-9

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 2148
  ChEBI ID: CHEBI:104011
  CAS Number: CAS 61-78-9
  TTD Drug ID: DMUN54G
  VARIDT Drug ID: DR00067

Molecule-Related Drug Atlas

Drug(s) Targeting Solute carrier family 22 member 8 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[2]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[13]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[2]
GLUTARATE	DMPUFDS	Discovery agent	N.A.	Investigative	[2]
ADIPATE	DM2XI09	Discovery agent	N.A.	Investigative	[2]
HEPTANOATE	DMGEO8N	Discovery agent	N.A.	Investigative	[2]

Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[18]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[19]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[20]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[21]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[22]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[23]

Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[26]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[27]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[31]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[32]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[33]

Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[35]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[36]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[37]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[38]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[39]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[41]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[19]

Drug(s) Transported By Organic anion transporter 1 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[44]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[45]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[45]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[45]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[46]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[47]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[48]
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[49]

Drug(s) Transported By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[44]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[45]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[10]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[51]
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[52]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[53]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[54]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[55]
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[56]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[81]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[10]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[82]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[82]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[83]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[83]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[84]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[85]

Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[58]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[60]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[54]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[61]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[62]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[63]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[64]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[65]

Drug(s) Transported By ATP-binding cassette sub-family A member 8 (ABCA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[4]
Sodium taurocholate	DM3GO0J	Type-2 diabetes	5A11	Phase 1/2	[4]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[4]

Drug(s) Transported By Sodium-dependent phosphate transport protein 4 (SLC17A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[5]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[75]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[78]
uric acid	DMA1MKT	Discovery agent	N.A.	Investigative	[76]
[3H]estrone-3-sulphate	DMGPF0N	Discovery agent	N.A.	Investigative	[76]

Drug(s) Affected By ABC-type organic anion transporter ABCA8 (ABCA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[69]
Indomethacin	DMSC4A7	Bursitis		Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[73]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[74]

Drug(s) Affected By Aryl hydrocarbon receptor repressor (AHRR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[89]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[90]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[68]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[94]

Drug(s) Affected By Secretory carrier-associated membrane protein 3 (SCAMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[97]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[98]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[99]

Drug(s) Affected By Glutathione S-transferase A4 (GSTA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[104]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[100]

Drug(s) Affected By C-X-C motif chemokine 13 (CXCL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[108]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[68]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[67]
MG149	DM7V58G	Discovery agent	N.A.	Investigative	[112]

Drug(s) Affected By Pre-mRNA-processing factor 17 (CDC40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[114]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[115]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[116]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Ketoprofen	DMRKXPT	Bursitis		Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[127]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[128]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[129]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[130]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[135]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[136]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[137]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[138]
Fructose	DM43AN2	Vomiting	MD90	Approved	[118]
Ketoprofen	DMRKXPT	Bursitis		Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[140]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[141]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[142]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[145]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[146]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[147]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[153]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[154]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[156]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[160]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[161]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[130]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[163]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[167]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[174]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[175]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[178]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[179]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[180]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[181]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[183]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[185]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[186]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[187]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[188]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[190]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[192]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[193]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[195]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[196]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[197]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[198]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[199]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[150]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[200]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[201]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[201]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[201]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[202]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[203]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[204]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[205]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[206]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[207]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[118]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[208]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[209]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[210]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[213]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Fructose	DM43AN2	Vomiting	MD90	Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[218]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[223]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[227]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[228]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[230]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[232]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[235]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[236]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[239]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[242]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[243]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[244]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[245]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[246]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[248]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[171]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[249]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[242]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[252]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[253]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[256]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[257]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[258]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[258]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[259]

Drug(s) Affected By Glutathione S-transferase A2 (GSTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[260]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[262]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[263]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[240]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[264]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[265]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[266]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[267]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[210]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[268]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[269]
Selenium	DM25CGV	N. A.	N. A.	Approved	[270]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[271]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[272]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[274]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[275]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[210]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[218]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[278]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[156]

Drug(s) Affected By Fibroblast growth factor 6 (FGF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[280]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[282]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By Alcohol dehydrogenase class-3 (ADH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[283]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[289]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[290]
Bortezomib	DMNO38U	Leukemia		Approved	[291]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[293]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[294]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[296]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[298]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[225]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[299]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[300]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[301]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[302]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[303]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[304]

Drug(s) Affected By Integrin beta-5 (ITGB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[305]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[171]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[305]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[242]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[305]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Syndecan-1 (SDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[306]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[242]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[311]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[313]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[314]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[315]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[316]

Drug(s) Affected By Proteasome subunit beta type-1 (PSMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[317]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[318]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[319]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[319]

Drug(s) Affected By Interleukin-11 (IL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[320]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[321]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[324]

Drug(s) Affected By Amine oxidase A (MAOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[225]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[325]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[326]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[327]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[327]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[327]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[328]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[327]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[331]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[146]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[332]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[334]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[336]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[337]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[340]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[342]
Fructose	DM43AN2	Vomiting	MD90	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[284]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[344]

Drug(s) Affected By Proteasome subunit alpha type-1 (PSMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[345]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[347]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[348]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[349]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[350]

Drug(s) Affected By Protein S100-A4 (S100A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[248]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[352]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[353]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]

Drug(s) Affected By Amine oxidase B (MAOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[354]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[355]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
BENZYL BENZOATE	DMDPYI5	Infestations of lice and scabies	1G00.Z	Approved	[357]
Linezolid	DMGFPU2	Bacteremia	1A73	Approved	[358]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[359]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[360]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[361]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[140]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[362]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[364]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[365]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]

Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator (ARNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[369]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[370]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[371]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[131]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[372]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]

Drug(s) Affected By Proteasome subunit alpha type-5 (PSMA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[373]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[374]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[316]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[348]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[73]

Drug(s) Affected By Proteasome subunit beta type-5 (PSMB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Sibutramine	DMFJTDI	Obesity	5B81	Approved	[375]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[376]
Bortezomib	DMNO38U	Leukemia		Approved	[377]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[378]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[95]
WP-1066	DMUGHWR	Recurrent glioblastoma	2A00.00	Phase 1/2	[378]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[379]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[380]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[360]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[381]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[382]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[383]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[359]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[140]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[362]

Drug(s) Affected By Interleukin-12 subunit alpha (IL12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[337]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[386]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[387]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[105]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[388]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[389]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[390]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[320]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[258]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[258]

Drug(s) Affected By Fibroblast growth factor 9 (FGF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[392]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[242]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[393]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[394]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[395]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[396]

Drug(s) Affected By Interleukin-13 (IL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[398]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[399]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[400]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[402]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[400]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[154]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[403]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[404]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[405]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[408]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[409]

Drug(s) Affected By 26S proteasome regulatory subunit 7 (PSMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[410]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[411]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[374]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[412]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[413]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[414]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[415]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[416]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[417]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[418]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[306]

Drug(s) Affected By N-alpha-acetyltransferase 10 (NAA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[347]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[105]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[290]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[97]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[419]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[420]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[421]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[179]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[422]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[423]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[424]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[425]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[426]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[427]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[428]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[269]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[429]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[430]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[221]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[431]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[433]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[435]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[436]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[316]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[438]
Indomethacin	DMSC4A7	Bursitis		Approved	[439]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[440]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[269]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[214]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[121]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[442]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[443]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[444]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[446]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[248]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[447]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[449]

Drug(s) Affected By Proteasome subunit beta type-3 (PSMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[450]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[451]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[95]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[452]

Drug(s) Affected By Methionine aminopeptidase 2 (METAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[453]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[454]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[95]
PMID27998201-Compound-22	DMS9QA7	Alzheimer disease	8A20	Patented	[455]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 4 (PSMD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[456]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[97]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[98]

Drug(s) Affected By T-cell leukemia/lymphoma protein 1A (TCL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[457]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By 26S proteasome regulatory subunit 4 (PSMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[347]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[458]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[95]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[452]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[97]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[459]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[78]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[460]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[262]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[461]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[462]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[463]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[462]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[462]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[464]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[465]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[190]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[462]

Drug(s) Affected By Serine/arginine-rich splicing factor 1 (SRSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[466]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[467]
Bortezomib	DMNO38U	Leukemia		Approved	[291]

Drug(s) Affected By FAS-associated death domain protein (FADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Selenium	DM25CGV	N. A.	N. A.	Approved	[468]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[436]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[469]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[470]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[471]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[299]

Drug(s) Affected By Interleukin-27 subunit beta (EBI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[472]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[242]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[228]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[92]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[473]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[474]

Drug(s) Affected By Transmembrane glycoprotein NMB (GPNMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[475]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[259]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[476]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[242]

Drug(s) Affected By Splicing factor 3B subunit 3 (SF3B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[477]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[347]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[458]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[478]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[78]

Drug(s) Affected By Serine/arginine-rich splicing factor 7 (SRSF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[410]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[479]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[347]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[290]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[480]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[481]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[482]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[483]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[484]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[485]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[486]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[210]

Drug(s) Affected By Glutathione S-transferase A3 (GSTA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[107]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[240]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[293]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[264]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[487]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1-like 2 (HNRNPA1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[457]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[451]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[97]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[99]

Drug(s) Affected By PHD finger-like domain-containing protein 5A (PHF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[479]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[488]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[489]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[490]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[491]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[492]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[493]

Drug(s) Affected By Pre-mRNA-splicing factor 38A (PRPF38A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[258]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[258]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[452]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[494]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[476]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 1 (PSMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[105]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[290]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[495]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[452]

Drug(s) Affected By Forkhead box protein P3 (FOXP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[333]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[497]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[489]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[498]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
Dorsomorphin	DMKYXJW	Discovery agent	N.A.	Investigative	[499]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[500]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[501]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[502]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[501]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[504]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]

Drug(s) Affected By Solute carrier family 22 member 11 (SLC22A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[505]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[505]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[505]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[505]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[506]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[505]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[507]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[505]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[508]

Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[509]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[293]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[510]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[511]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[512]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Arylamine N-acetyltransferase 2 (NAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[513]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[514]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[515]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[516]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[517]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[518]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[258]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[506]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]

Drug(s) Affected By Arylamine N-acetyltransferase 1 (NAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[519]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[517]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[520]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[519]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[258]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[258]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[519]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[521]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[522]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[523]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[524]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[525]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[526]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[527]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[171]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[528]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[409]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[522]

Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[505]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[286]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[529]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[530]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[530]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[530]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[530]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[530]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[530]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[82]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[531]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[105]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[532]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[533]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[534]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[92]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[535]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[535]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[536]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[317]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[537]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[538]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[539]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[540]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[416]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[541]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[542]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[543]

Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[544]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[371]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[545]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[546]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[534]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[547]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[319]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[548]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[549]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[550]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[258]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[258]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[259]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[551]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[552]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[553]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[554]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[555]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[556]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[169]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Solute carrier family 22 member 8 (SLC22A8)	TTTQR47	S22A8_HUMAN	Inhibitor	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium-dependent phosphate transport protein 3 (SLC17A2)	DTRF4L3	NPT3_HUMAN	Substrate	[3]
ATP-binding cassette sub-family A member 8 (ABCA8)	DT9NXMV	ABCA8_HUMAN	Substrate	[4]
Sodium-dependent phosphate transport protein 4 (SLC17A3)	DTFOJL7	NPT4_HUMAN	Substrate	[5]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[6]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[7]
Organic anion transporting polypeptide 1A2 (SLCO1A2)	DTE2B1D	SO1A2_HUMAN	Substrate	[8]
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[6]
Organic anion transporter 1 (SLC22A6)	DTQ23VB	S22A6_HUMAN	Substrate	[9]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
26S proteasome non-ATPase regulatory subunit 1 (PSMD1)	OTW258OV	PSMD1_HUMAN	Gene/Protein Processing	[11]
26S proteasome non-ATPase regulatory subunit 4 (PSMD4)	OTH1VZTM	PSMD4_HUMAN	Gene/Protein Processing	[11]
26S proteasome regulatory subunit 4 (PSMC1)	OTLHD56E	PRS4_HUMAN	Gene/Protein Processing	[11]
26S proteasome regulatory subunit 7 (PSMC2)	OTJ4V337	PRS7_HUMAN	Gene/Protein Processing	[11]
ABC-type organic anion transporter ABCA8 (ABCA8)	OTCWLX6N	ABCA8_HUMAN	Regulation of Drug Effects	[4]
Alcohol dehydrogenase class-3 (ADH5)	OTSO67MI	ADHX_HUMAN	Gene/Protein Processing	[11]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[11]
Alpha-taxilin	OTO8XY5A	TXLNA_HUMAN	Gene/Protein Processing	[12]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Gene/Protein Processing	[11]
Amine oxidase B (MAOB)	OTTDFM1O	AOFB_HUMAN	Gene/Protein Processing	[11]

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