Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWQIJX)

• Drug Name: Celastrol Drug Info
• Synonyms: Tripterin; Tripterine; Celastrol, Celastrus scandens; (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid; (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid; 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid

Indication

Disease Entry	ICD 11	Status	REF
Motor neurone disease	8B60	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 122724
  ChEBI ID: CHEMBL301982
  CAS Number: CAS 34157-83-0
  TTD Drug ID: DMWQIJX

Molecule-Related Drug Atlas

Drug(s) Targeting Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[4]
Nafamostat	DMU1XOD	Pancreatitis	DC31-DC34	Approved	[5]
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[6]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[7]
Enbrel	DM7RNP3	Arthritis	FA20	Approved	[8]
Golimumab	DMHZV7X	Psoriatic arthritis	FA21	Approved	[9]
Certolizumab	DM5CL9Z	Rheumatoid arthritis	FA20	Approved	[10]
Etanercept	DMCV109	Arthritis	FA20	Approved	[11]
Adalimumab	DMQMV1B	Crohn disease	DD70	Approved	[12]
Infliximab	DMH7OIA	Crohn disease	DD70	Approved	[13]

Drug(s) Targeting Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[14]
Rilonacept	DMGLUQS	Arthritis	FA20	Approved	[15]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[16]
Canakinumab	DM8HLO5	Autosomal dominant familial periodic fever		Approved	[9]
Diacerein	DMN2Q5I	N. A.	N. A.	Phase 4	[17]
XOMA 052	DMOKQV7	Type-2 diabetes	5A11	Phase 3	[18]
ABT-981	DM6PTIX	Osteoarthritis	FA00-FA05	Phase 2	[19]
AC-201	DMB0TNL	Type-2 diabetes	5A11	Phase 2	[20]
LY-2189102	DMU81BH	Cardiovascular disease	BA00-BE2Z	Phase 2	[21]
TT-301	DM4QV8Y	Alzheimer disease	8A20	Phase 1	[22]

Drug(s) Affected By Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (GATD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[24]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[29]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[31]

Drug(s) Affected By Cell division cycle 7-related protein kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[38]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[39]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[40]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Selenium	DM25CGV	N. A.	N. A.	Approved	[31]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[47]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[50]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[51]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[55]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[60]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[63]

Drug(s) Affected By Nibrin (NBN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[69]

Drug(s) Affected By E3 ubiquitin-protein ligase MYCBP2 (MYCBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[74]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[75]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[76]

Drug(s) Affected By Carbonyl reductase 3 (CBR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[78]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Bortezomib	DMNO38U	Leukemia		Approved	[79]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[77]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[81]

Drug(s) Affected By High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[86]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]

Drug(s) Affected By E3 ubiquitin-protein ligase listerin (LTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[88]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[63]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[63]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]

Drug(s) Affected By Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[95]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[98]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[99]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[103]
Selenium	DM25CGV	N. A.	N. A.	Approved	[31]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[31]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[107]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[108]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[63]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[111]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[82]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[121]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[122]

Drug(s) Affected By DnaJ homolog subfamily A member 1 (DNAJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Haloperidol	DM96SE0	Delirium		Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[129]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[129]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[130]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[133]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[135]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[138]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]

Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[141]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Venetoclax	DM8I94Y	Chronic lymphocytic leukaemia	2A82.0	Approved	[145]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[146]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[147]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]

Drug(s) Affected By Malate dehydrogenase, mitochondrial (MDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[151]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[31]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[152]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[153]

Drug(s) Affected By Kappa-type opioid receptor (OPRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[156]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[157]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[158]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[159]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[160]

Drug(s) Affected By Heat shock 70 kDa protein 13 (HSPA13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[163]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]

Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[167]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]

Drug(s) Affected By Ephrin-B2 (EFNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[169]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[174]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[176]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[174]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[178]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[82]

Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[167]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[184]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[38]

Drug(s) Affected By Transcriptional activator protein Pur-alpha (PURA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Haloperidol	DM96SE0	Delirium		Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[186]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[187]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[187]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[189]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[174]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[174]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[174]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[191]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[192]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[190]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[174]

Drug(s) Affected By Transcription factor SOX-4 (SOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[82]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[169]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[170]

Drug(s) Affected By Phosphatidate phosphatase LPIN1 (LPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[31]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[57]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[194]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[79]

Drug(s) Affected By AT-rich interactive domain-containing protein 5B (ARID5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Indomethacin	DMSC4A7	Bursitis		Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]

Drug(s) Affected By Neuronal regeneration-related protein (NREP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[63]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[167]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[108]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[199]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]

Drug(s) Affected By Max-binding protein MNT (MNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[78]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]

Drug(s) Affected By Cbp/p300-interacting transactivator 2 (CITED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[78]

Drug(s) Affected By Protein adenylyltransferase FICD (FICD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[186]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[203]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[204]

Drug(s) Affected By GTP-binding protein 2 (GTPBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[61]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[79]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]

Drug(s) Affected By Large ribosomal subunit protein uL18m (MRPL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[206]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Serine/threonine-protein kinase TAO3 (TAOK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[209]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[86]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[210]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]

Drug(s) Affected By Small conductance calcium-activated potassium channel protein 2 (KCNN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[167]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[213]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[214]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[215]

Drug(s) Affected By Calcyclin-binding protein (CACYBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[217]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[206]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[218]

Drug(s) Affected By Myoneurin (MYNN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[167]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[157]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[75]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[153]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[203]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[219]

Drug(s) Affected By SAFB-like transcription modulator (SLTM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[153]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[203]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[70]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[70]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[222]

Drug(s) Affected By Oxidative stress-responsive serine-rich protein 1 (OSER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[80]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Selenium	DM25CGV	N. A.	N. A.	Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[108]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[225]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[199]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[132]

Drug(s) Affected By Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Haloperidol	DM96SE0	Delirium		Approved	[129]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]

Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[226]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Transcription factor MafB (MAFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[155]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[172]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Sestrin-1 (SESN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[222]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[63]

Drug(s) Affected By Stress-associated endoplasmic reticulum protein 1 (SERP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[230]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[231]

Drug(s) Affected By Alpha-crystallin B chain (CRYAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[67]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[233]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[234]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[238]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[239]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[239]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[234]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[83]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[135]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[31]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[247]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[250]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[166]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[252]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Selenium	DM25CGV	N. A.	N. A.	Approved	[254]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[166]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[255]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[256]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[257]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[258]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Selenium	DM25CGV	N. A.	N. A.	Approved	[259]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[260]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[261]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[50]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[266]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[267]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[266]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[268]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[271]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[274]
Fructose	DM43AN2	Vomiting	MD90	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[108]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[280]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[282]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[283]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[285]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[286]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Fructose	DM43AN2	Vomiting	MD90	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[287]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[288]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[289]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[291]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[291]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[292]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[104]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[291]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-1 beta (IL1B)	TTRYK0X	IL1B_HUMAN	Suppressor	[1]
Tumor necrosis factor (TNF)	TTF8CQI	TNFA_HUMAN	Suppressor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1)	OTC7AFHT	AHSA1_HUMAN	Gene/Protein Processing	[2]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[2]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[2]
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Gene/Protein Processing	[3]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[2]
AT-rich interactive domain-containing protein 5B (ARID5B)	OTUQ4CQY	ARI5B_HUMAN	Gene/Protein Processing	[2]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[2]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Gene/Protein Processing	[2]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Gene/Protein Processing	[3]
Calcyclin-binding protein (CACYBP)	OTJMZD2T	CYBP_HUMAN	Gene/Protein Processing	[2]

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