Details of Disease

Disease Name

Laryngeal squamous cell carcinoma

LXSC; squamous cell carcinoma of the larynx; epidermoid carcinoma of larynx; epidermoid carcinoma of the larynx; larynx epidermoid carcinoma; larynx squamous cell carcinoma; squamous cell carcinoma of larynx; laryngeal epidermoid carcinoma; laryngeal squamous cell carcinoma; laryngeal throat squamous cell cancer

Definition

A squamous cell carcinoma that arises from the larynx. It is the most common histologic type of laryngeal carcinoma. It can arise from the glottis, supraglottic area, or it can be transglottic. Glottic squamous cell carcinoma is the most frequent laryngeal carcinoma in the United States. The symptoms, clinical behavior and the prognosis depend on the site of origin within the larynx.

Disease Hierarchy

DISQVIFL: Squamous cell carcinoma

DIS0UVDG: Squamous head and neck cell carcinom

DISNHCIV: Laryngeal carcinoma

DIS9UUVF: Laryngeal squamous cell carcinoma

Disease Identifiers

MONDO ID

MONDO_0005595

MESH ID

D000077195

UMLS CUI

C0280324

MedGen ID

83630

Orphanet ID

494550

SNOMED CT ID

405822008

General Information of Disease (ID: DIS9UUVF)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cetuximab	DMLNCE0	Approved	Antibody	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 35 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FADS2	TTT2VDU	Limited	Genetic Variation	[2]
TNFRSF10B	TTW20TU	Limited	SusceptibilityMutation	[3]
ADAMTS4	TTYG6BU	moderate	Altered Expression	[4]
ADAMTS5	TTXSU2Y	moderate	Biomarker	[4]
ARRB1	TTMVD4A	moderate	Biomarker	[5]
CDK8	TTBJR4L	moderate	Biomarker	[6]
CTCFL	TTY0RZT	moderate	Biomarker	[7]
EPHA7	TTAHTVG	moderate	Biomarker	[8]
ESRRG	TT9ZRHB	moderate	Posttranslational Modification	[9]
GMNN	TT390KA	moderate	Altered Expression	[10]
HOXB13	TTZ6I58	moderate	Biomarker	[11]
ITPR2	TTK9OV3	moderate	Altered Expression	[12]
LTA4H	TTXZEAJ	moderate	Biomarker	[13]
PDPK1	TTYMGWX	moderate	Altered Expression	[14]
PLK2	TT976FS	moderate	Biomarker	[15]
PLOD2	TT8MEUD	moderate	Biomarker	[16]
PRLR	TTBPXMA	moderate	Altered Expression	[17]
SLC7A11	TTBZMIO	moderate	Altered Expression	[18]
SSTR5	TT2BC4G	moderate	Posttranslational Modification	[19]
ST8SIA4	TTDP8YM	moderate	Biomarker	[20]
WWP1	TTBWMKT	moderate	Biomarker	[21]
AURKA	TTPS3C0	Strong	Altered Expression	[22]
BCL11A	TTR61MW	Strong	Genetic Variation	[23]
DIO1	TTU3X26	Strong	Biomarker	[24]
EPHB6	TTZEMUY	Strong	Biomarker	[25]
EZR	TTE47YC	Strong	Biomarker	[26]
FSCN1	TTTRS9B	Strong	Altered Expression	[27]
MMP10	TTXLEG7	Strong	Biomarker	[28]
MTNR1A	TT0WAIE	Strong	Biomarker	[29]
PRKDC	TTK3PY9	Strong	Altered Expression	[30]
PTEN	TTXJ3W7	Strong	Altered Expression	[31]
S100A8	TT4AF6N	Strong	Genetic Variation	[32]
STC2	TT4EFTR	Strong	Biomarker	[24]
TACSTD2	TTP2HE5	Strong	Altered Expression	[33]
WEE1	TTJFOAL	Strong	Biomarker	[34]
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⏷ Show the Full List of 35 DTT(s)

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC22A23	DTMJK12	moderate	Genetic Variation	[35]
SLC39A14	DTZ6IJW	moderate	Biomarker	[36]
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This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
FADS1	DE05S8C	Strong	Genetic Variation	[37]
PARK7	DEPOVCH	Strong	Biomarker	[38]
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This Disease Is Related to 86 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CIB2	OT9ZJX1I	Limited	Biomarker	[39]
ING1	OTEZBRKW	Limited	SomaticCausalMutation	[40]
ACYP2	OTRB4S6X	moderate	Genetic Variation	[41]
ADAMTS3	OT2U6VF5	moderate	Altered Expression	[4]
AIMP1	OTTA5C3U	moderate	Biomarker	[13]
ALG3	OTPOL1QW	moderate	Biomarker	[42]
ASPG	OT5E2EKR	moderate	Biomarker	[43]
BCL2L12	OTS6IFZY	moderate	Biomarker	[44]
CAMSAP1	OT1N2182	moderate	Biomarker	[45]
CAVIN2	OTFHHDRU	moderate	Genetic Variation	[46]
CCNA1	OTX4HD45	moderate	Altered Expression	[47]
CCNB2	OTIEXTDK	moderate	Biomarker	[48]
CCNG2	OTII38K2	moderate	Altered Expression	[49]
CDK2AP1	OTNFOHDJ	moderate	Altered Expression	[50]
CHAF1A	OTXSSY4H	moderate	Altered Expression	[51]
CHAF1B	OTOMK4KH	moderate	Altered Expression	[51]
CHD5	OTS5EVHH	moderate	Posttranslational Modification	[52]
CKS2	OTPTMHIV	moderate	Biomarker	[53]
CLDN11	OTNN6UTL	moderate	Posttranslational Modification	[54]
CMTM3	OTS75IGC	moderate	Genetic Variation	[55]
CNOT7	OTJBKCPI	moderate	Altered Expression	[51]
CNOT8	OT6CMCS0	moderate	Altered Expression	[51]
CRKL	OTOYSD1R	moderate	Biomarker	[56]
DACH1	OTMKNAGG	moderate	Biomarker	[57]
DCUN1D5	OTHPMYHX	moderate	Altered Expression	[58]
DIAPH1	OTZBYPLH	moderate	Altered Expression	[59]
DIAPH2	OTBEYFEZ	moderate	Genetic Variation	[60]
DIAPH3	OTPOT23F	moderate	Biomarker	[60]
ECT2	OTQDUCT6	moderate	Biomarker	[61]
FAM107A	OTBG61YZ	moderate	Posttranslational Modification	[62]
FOXJ1	OT7LLBZ7	moderate	Biomarker	[63]
GBX2	OTW0ZI4D	moderate	Biomarker	[64]
INPPL1	OTCDAVBQ	moderate	Biomarker	[65]
KLK11	OT5PKX7Y	moderate	Biomarker	[66]
LOXL4	OT6XY2JL	moderate	Altered Expression	[67]
LZTS2	OTQFSQEE	moderate	Posttranslational Modification	[68]
MAF	OT1GR3IZ	moderate	Altered Expression	[12]
MAP2K4	OTZPZX11	moderate	Altered Expression	[69]
MCM4	OT19PNNG	moderate	Biomarker	[70]
MDC1	OTEUQH4J	moderate	Biomarker	[71]
MMP20	OT16S5S3	moderate	Biomarker	[72]
MMP25	OT3BG37V	moderate	Biomarker	[72]
MMUT	OTBBBV70	moderate	Altered Expression	[70]
MYO5A	OTMWLP3E	moderate	Biomarker	[73]
NABP1	OTFTNFHW	moderate	Genetic Variation	[46]
PDCD5	OT6T2DDL	moderate	Altered Expression	[74]
PLAGL2	OT6AP4V2	moderate	Altered Expression	[75]
PLXNB1	OTCA7JIT	moderate	Altered Expression	[76]
PPP1R3A	OTJL9VYP	moderate	Biomarker	[28]
PRDX3	OTLB2WEU	moderate	Biomarker	[77]
PTOV1	OT94WT5X	moderate	Biomarker	[78]
RASSF2	OT2JHDO4	moderate	Altered Expression	[79]
SOX1	OTVI1RAR	moderate	Biomarker	[80]
SPON2	OTE7JLNM	moderate	Biomarker	[81]
TENM1	OTSKSU4V	moderate	Biomarker	[82]
TP53BP2	OTOWJ2Y4	moderate	Biomarker	[83]
TRA2B	OTZYQW52	moderate	Altered Expression	[84]
TRAPPC10	OTF6EAQX	moderate	Biomarker	[36]
TSR2	OTSIWJQJ	moderate	Altered Expression	[85]
ALG1	OTVXPA9E	Strong	Biomarker	[29]
ANKRD36B	OT3MW415	Strong	Biomarker	[86]
CADM1	OTRWG9QS	Strong	Biomarker	[87]
CBY1	OTAKMUS2	Strong	Posttranslational Modification	[88]
DCUN1D1	OT8UJLZU	Strong	Biomarker	[89]
DNLZ	OT48CG1W	Strong	Biomarker	[25]
ENTPD5	OTFH05B9	Strong	Biomarker	[90]
EOMES	OTB9VQFA	Strong	Posttranslational Modification	[91]
FGF3	OT9PK2SI	Strong	Altered Expression	[92]
GALNT7	OTUJSCAO	Strong	Altered Expression	[93]
HOXB9	OTMVHQOU	Strong	Biomarker	[94]
INTS2	OT2N5TCK	Strong	Biomarker	[95]
MT1B	OTUA4FFH	Strong	Biomarker	[29]
MT1E	OTXJKU4Y	Strong	Biomarker	[29]
MT1F	OTZVUYG1	Strong	Biomarker	[29]
MT1G	OTAV1OCR	Strong	Biomarker	[29]
MT1H	OT0MVBM6	Strong	Biomarker	[29]
MT1M	OTVT8PLU	Strong	Biomarker	[29]
MT1X	OT9AKFVS	Strong	Biomarker	[29]
MYCT1	OTZ8A9L3	Strong	Biomarker	[96]
PCDH17	OTRK0M05	Strong	Altered Expression	[97]
PDCD4	OTZ6NXUX	Strong	Biomarker	[98]
PKD2	OTIXBU8H	Strong	Biomarker	[99]
PRPF31	OTSJ0Z1Y	Strong	Biomarker	[100]
PTPRD	OTZPJ3GX	Strong	Posttranslational Modification	[101]
SATB2	OT2W80XC	Strong	Biomarker	[102]
SH3GL2	OTOE443G	Strong	Biomarker	[103]
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⏷ Show the Full List of 86 DOT(s)

References

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2	Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.Nat Genet. 2014 Oct;46(10):1110-4. doi: 10.1038/ng.3090. Epub 2014 Sep 7.
3	Causes of death in a cohort of 260 plutonium workers.Health Phys. 1998 Sep;75(3):236-40. doi: 10.1097/00004032-199809000-00001.
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18	SLC7A11, a component of cysteine/glutamate transporter, is a novel biomarker for the diagnosis and prognosis in laryngeal squamous cell carcinoma.Oncol Rep. 2017 Nov;38(5):3019-3029. doi: 10.3892/or.2017.5976. Epub 2017 Sep 20.
19	Aberrant methylation-mediated downregulation of lncRNA SSTR5-AS1 promotes progression and metastasis of laryngeal squamous cell carcinoma.Epigenetics Chromatin. 2019 Jun 13;12(1):35. doi: 10.1186/s13072-019-0283-8.
20	Expression of polysialic acid in primary laryngeal squamous cell carcinoma.Life Sci. 2017 Mar 15;173:73-79. doi: 10.1016/j.lfs.2017.02.002. Epub 2017 Feb 7.
21	Small Nucleolar RNA Host Gene 12 (SNHG12) Promotes Proliferation and Invasion of Laryngeal Cancer Cells via Sponging miR-129-5p and Potentiating WW Domain-Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Expression.Med Sci Monit. 2019 Jul 26;25:5552-5560. doi: 10.12659/MSM.917088.
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23	Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma.PLoS One. 2017 Feb 22;12(2):e0171116. doi: 10.1371/journal.pone.0171116. eCollection 2017.
24	Comprehensive analysis of differentially expressed profiles of lncRNAs, mRNAs, and miRNAs in laryngeal squamous cell carcinoma in order to construct a ceRNA network and identify potential biomarkers.J Cell Biochem. 2019 Oct;120(10):17963-17974. doi: 10.1002/jcb.29063. Epub 2019 May 24.
25	Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma. Neoplasia. 2007 Mar;9(3):192-9. doi: 10.1593/neo.06781.
26	Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma.Genet Mol Res. 2014 Sep 29;13(3):8002-13. doi: 10.4238/2014.September.29.13.
27	Promoter Methylation-Regulated miR-145-5p Inhibits Laryngeal Squamous Cell Carcinoma Progression by Targeting FSCN1.Mol Ther. 2019 Feb 6;27(2):365-379. doi: 10.1016/j.ymthe.2018.09.018. Epub 2018 Sep 27.
28	Integrated miRNA and mRNA expression analysis uncovers drug targets in laryngeal squamous cell carcinoma patients.Oral Oncol. 2019 Jun;93:76-84. doi: 10.1016/j.oraloncology.2019.04.018. Epub 2019 Apr 29.
29	Potential biomarkers for head and neck squamous cell carcinoma.Laryngoscope. 2003 Mar;113(3):393-400. doi: 10.1097/00005537-200303000-00001.
30	Expression of DNA-dependent protein kinase catalytic subunit in laryngeal squamous cell carcinoma and its importance.Exp Ther Med. 2018 Apr;15(4):3295-3301. doi: 10.3892/etm.2018.5826. Epub 2018 Feb 1.
31	Long noncoding RNA SOX2-OT facilitates laryngeal squamous cell carcinoma development by epigenetically inhibiting PTEN via methyltransferase EZH2.IUBMB Life. 2019 Sep;71(9):1230-1239. doi: 10.1002/iub.2026. Epub 2019 Feb 27.
32	UreA and cagA genes of Helicobacter pylori in Egyptian patients with laryngeal squamous cell carcinoma and benign laryngeal polyps: a cohort study.Eur Arch Otorhinolaryngol. 2016 Oct;273(10):3243-8. doi: 10.1007/s00405-016-4114-2. Epub 2016 May 25.
33	Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway.Mol Med Rep. 2015 Jul;12(1):865-70. doi: 10.3892/mmr.2015.3485. Epub 2015 Mar 13.
34	Inhibition of WEE1 Suppresses the Tumor Growth in Laryngeal Squamous Cell Carcinoma.Front Pharmacol. 2018 Sep 28;9:1041. doi: 10.3389/fphar.2018.01041. eCollection 2018.
35	Investigation of the SLC22A23 gene in laryngeal squamous cell carcinoma.BMC Cancer. 2018 Apr 27;18(1):477. doi: 10.1186/s12885-018-4381-y.
36	lncRNA TMEM51-AS1 and RUSC1-AS1 function as ceRNAs for induction of laryngeal squamous cell carcinoma and prediction of prognosis.PeerJ. 2019 Sep 10;7:e7456. doi: 10.7717/peerj.7456. eCollection 2019.
37	FADS1 rs174549 Polymorphism May Predict a Favorable Response to Chemoradiotherapy in Oral Cancer Patients.J Oral Maxillofac Surg. 2017 Jan;75(1):214-220. doi: 10.1016/j.joms.2016.07.005. Epub 2016 Jul 25.
38	DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells.Mol Med Rep. 2015 Aug;12(2):2003-8. doi: 10.3892/mmr.2015.3617. Epub 2015 Apr 15.
39	p57(kip2) expression is related to carcinogenesis and tumor progression in laryngeal tissues.Acta Otolaryngol. 2006 Mar;126(3):301-5. doi: 10.1080/00016480500388851.
40	Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.Cancer Res. 2000 Jun 15;60(12):3143-6.
41	Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males.Mol Genet Genomic Med. 2019 Jul;7(7):e00731. doi: 10.1002/mgg3.731. Epub 2019 May 29.
42	Combined expression and prognostic significance of PPFIA1 and ALG3 in head and neck squamous cell carcinoma.Mol Biol Rep. 2019 Jun;46(3):2693-2701. doi: 10.1007/s11033-019-04712-y. Epub 2019 Feb 25.
43	Deprivation of asparagine triggers cytoprotective autophagy in laryngeal squamous cell carcinoma.Appl Microbiol Biotechnol. 2017 Jun;101(12):4951-4961. doi: 10.1007/s00253-017-8221-9. Epub 2017 Mar 28.
44	Positive BCL2L12 expression predicts favorable prognosis in patients with laryngeal squamous cell carcinoma.Cancer Biomark. 2019;25(2):141-149. doi: 10.3233/CBM-181772.
45	MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1).Int J Oncol. 2014 May;44(5):1678-84. doi: 10.3892/ijo.2014.2321. Epub 2014 Mar 5.
46	DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival.Oncotarget. 2016 Nov 29;7(48):79596-79604. doi: 10.18632/oncotarget.12865.
47	Mutant p53 and cyclin A1 protein expression in primary laryngeal squamous cell carcinomas do not correlate to second primary tumours of the head and neck.ANZ J Surg. 2009 Jan-Feb;79(1-2):48-54. doi: 10.1111/j.1445-2197.2008.04799.x.
48	Recurrent CDK1 overexpression in laryngeal squamous cell carcinoma.Tumour Biol. 2016 Aug;37(8):11115-26. doi: 10.1007/s13277-016-4991-4. Epub 2016 Feb 24.
49	MicroRNA-93 regulates cyclin G2 expression and plays an oncogenic role in laryngeal squamous cell carcinoma.Int J Oncol. 2015 Jan;46(1):161-74. doi: 10.3892/ijo.2014.2704. Epub 2014 Oct 10.
50	miR-205 promotes proliferation and invasion of laryngeal squamous cell carcinoma by suppressing CDK2AP1 expression.Biol Res. 2015 Oct 29;48:60. doi: 10.1186/s40659-015-0052-5.
51	Overexpression of chromatin assembly factor-1/p60 predicts biological behaviour of laryngeal carcinomas.Acta Otorhinolaryngol Ital. 2017 Feb;37(1):17-24. doi: 10.14639/0392-100X-867.
52	The involvement of CHD5 hypermethylation in laryngeal squamous cell carcinoma.Oral Oncol. 2011 Jul;47(7):601-8. doi: 10.1016/j.oraloncology.2011.05.003. Epub 2011 Jun 1.
53	MicroRNA-26a inhibits proliferation and tumorigenesis via targeting CKS2 in laryngeal squamous cell carcinoma.Clin Exp Pharmacol Physiol. 2018 May;45(5):444-451. doi: 10.1111/1440-1681.12890. Epub 2018 Jan 8.
54	The Clinical Signification of Claudin-11 Promoter Hypermethylation for Laryngeal Squamous Cell Carcinoma.Med Sci Monit. 2017 Jul 26;23:3635-3640. doi: 10.12659/msm.904751.
55	Elevated methylation of CMTM3 promoter in the male laryngeal squamous cell carcinoma patients.Clin Biochem. 2016 Nov;49(16-17):1278-1282. doi: 10.1016/j.clinbiochem.2016.08.002. Epub 2016 Aug 10.
56	Recurrent amplification in the 22q11 region in laryngeal squamous cell carcinoma results in overexpression of the CRKL but not the MAPK1 oncogene.Cancer Biomark. 2010-2011;8(1):11-9. doi: 10.3233/DMA-2011-0814.
57	Effect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma.Head Face Med. 2018 Sep 27;14(1):20. doi: 10.1186/s13005-018-0177-1.
58	In vitro biological characterization of DCUN1D5 in DNA damage response.Asian Pac J Cancer Prev. 2012;13(8):4157-62. doi: 10.7314/apjcp.2012.13.8.4157.
59	DIAPH1 Is Upregulated and Inhibits Cell Apoptosis through ATR/p53/Caspase-3 Signaling Pathway in Laryngeal Squamous Cell Carcinoma.Dis Markers. 2019 Jan 14;2019:6716472. doi: 10.1155/2019/6716472. eCollection 2019.
60	DIAPH2 alterations increase cellular motility and may contribute to the metastatic potential of laryngeal squamous cell carcinoma.Carcinogenesis. 2019 Oct 16;40(10):1251-1259. doi: 10.1093/carcin/bgz035.
61	Epithelial cell transforming sequence 2 expression is associated with the progression of laryngeal squamous cell carcinoma.Oncol Lett. 2019 Jun;17(6):5699-5704. doi: 10.3892/ol.2019.10226. Epub 2019 Apr 8.
62	Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors.Sci Rep. 2017 Jul 14;7(1):5386. doi: 10.1038/s41598-017-05857-1.
63	Knockdown of FOXJ1 inhibits the proliferation, migration, invasion, and glycolysis in laryngeal squamous cell carcinoma cells.J Cell Biochem. 2019 Sep;120(9):15874-15882. doi: 10.1002/jcb.28858. Epub 2019 May 6.
64	MicroRNA-4497 functions as a tumor suppressor in laryngeal squamous cell carcinoma via negatively modulation the GBX2.Auris Nasus Larynx. 2019 Feb;46(1):106-113. doi: 10.1016/j.anl.2018.05.005. Epub 2018 May 26.
65	Descending-SHIP2-mediated radiosensitivity enhancement through PI3K/Akt signaling pathway in laryngeal squamous cell carcinoma.Biomed Pharmacother. 2019 Oct;118:109392. doi: 10.1016/j.biopha.2019.109392. Epub 2019 Aug 29.
66	Low mRNA expression levels of kallikrein-related peptidase 4 (KLK4) predict short-term relapse in patients with laryngeal squamous cell carcinoma.Biol Chem. 2014 Sep;395(9):1051-62. doi: 10.1515/hsz-2014-0139.
67	Differential expression of LOXL4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma.Clin Otolaryngol. 2016 Jun;41(3):206-10. doi: 10.1111/coa.12498. Epub 2016 Feb 4.
68	LZTS2 promoter hypermethylation: a potential biomarker for the diagnosis and prognosis of laryngeal squamous cell carcinoma.World J Surg Oncol. 2018 Mar 2;16(1):42. doi: 10.1186/s12957-018-1349-y.
69	Overexpression of mitogen-activated protein kinase kinase 4 and nuclear factor-kappaB in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis.Oncol Rep. 2009 Jul;22(1):89-95.
70	Minichromosome maintenance (MCM) protein 4 overexpression is a potential prognostic marker for laryngeal squamous cell carcinoma.J BUON. 2017 Sep-Oct;22(5):1272-1277.
71	NFBD1/MDC1 participates in the regulation of proliferation and apoptosis in human laryngeal squamous cell carcinoma.Clin Transl Oncol. 2018 Apr;20(4):534-541. doi: 10.1007/s12094-017-1748-5. Epub 2017 Sep 18.
72	Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma.Acta Otolaryngol. 2011 Jul;131(7):769-73. doi: 10.3109/00016489.2011.560186. Epub 2011 Apr 5.
73	MYO5A inhibition by miR-145 acts as a predictive marker of occult neck lymph node metastasis in human laryngeal squamous cell carcinoma.Onco Targets Ther. 2018 Jun 21;11:3619-3635. doi: 10.2147/OTT.S164597. eCollection 2018.
74	Expression and clinical significance of the programmed cell death 5 gene and protein in laryngeal squamous cell carcinoma.J Int Med Res. 2013 Dec;41(6):1838-47. doi: 10.1177/0300060513498021.
75	Regulation of cell proliferation and migration in gallbladder cancer by zinc finger X-chromosomal protein.Gene. 2013 Oct 10;528(2):261-6. doi: 10.1016/j.gene.2013.06.064. Epub 2013 Jul 13.
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