Details of Disease

General Information of Disease (ID: DISX87ZH)

• Disease Name: Hyperthyroidism
• Synonyms: overactive thyroid
• Disease Class: 5A02: Thyrotoxicosis
• Definition: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
• Disease Hierarchy:
  DIS5T3X5: Thyroid disease
  DISX87ZH: Hyperthyroidism
• ICD Code:
  ICD-11: ICD-11: 5A02
  ICD-10: ICD-10: E05
  ICD-9: ICD-9: 242
  Expand ICD-11: '5A02
  Expand ICD-10: 'E05
  Expand ICD-9: 242
• Disease Identifiers:
  MONDO ID: MONDO_0004425
  MESH ID: D006980
  UMLS CUI: C0020550
  MedGen ID: 6972
  HPO ID: HP:0000836
  SNOMED CT ID: 34486009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 5 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Carbimazole	DMULAI4	Approved	Small molecular drug	[1]
Methimazole	DM25FL8	Approved	Small molecular drug	[2]
Potassium Perchlorate	DMSG6I7	Approved	Small molecular drug	[3]
Propylthiouracil	DM6D7N8	Approved	Small molecular drug	[4]
Sodium iodide I 131	DMEECG1	Approved	Small molecular drug	[3]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
GC-24	DMSF8B9	Investigative	Small molecular drug	[5]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 45 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
THRB	TTGER3L	Limited	Biomarker	[6]
FOXP3	TT1X3QF	moderate	Altered Expression	[7]
NRG4	TTWAGKJ	moderate	Altered Expression	[8]
ADCY1	TTV1ZSQ	Strong	Biomarker	[9]
AHSG	TTKF4WV	Strong	Altered Expression	[10]
ANXA1	TTUCK4B	Strong	Biomarker	[11]
ANXA2	TT4YANI	Strong	Biomarker	[11]
ANXA5	TT2Z83I	Strong	Biomarker	[11]
APOC3	TTXOZQ1	Strong	Biomarker	[12]
AQP1	TTSF1KH	Strong	Biomarker	[13]
ATP2A2	TTE6THL	Strong	Biomarker	[14]
AZGP1	TTUPYLV	Strong	Altered Expression	[15]
CA1	TTHQPL7	Strong	Biomarker	[16]
CAT	TTPS279	Strong	Biomarker	[17]
CGB3	TTUH273	Strong	Altered Expression	[18]
CS	TTZA6B3	Strong	Biomarker	[19]
CTH	TTLQUZS	Strong	Altered Expression	[20]
DIO1	TTU3X26	Strong	Biomarker	[21]
ENPP2	TTSCIM2	Strong	Biomarker	[22]
FCGRT	TTKLPHO	Strong	Altered Expression	[23]
GPR174	TTYUB4M	Strong	Genetic Variation	[24]
GPX1	TTYAHBP	Strong	Biomarker	[17]
HCN2	TT9EUT4	Strong	Altered Expression	[25]
KCNJ18	TTVW8QH	Strong	Genetic Variation	[26]
LIPE	TTLUQ8E	Strong	Altered Expression	[27]
NR1D1	TTAD1O8	Strong	Altered Expression	[28]
PDE10A	TTJW4LU	Strong	Genetic Variation	[29]
PDE3B	TTN34SQ	Strong	Biomarker	[27]
PON1	TT9LX82	Strong	Altered Expression	[30]
SERPINA6	TTJL8VG	Strong	Biomarker	[31]
SLC9A1	TTGSEFH	Strong	Biomarker	[32]
SOST	TTYRO4F	Strong	Biomarker	[33]
TH	TTUHP71	Strong	Biomarker	[34]
TXNRD3	TTDYFVB	Strong	Biomarker	[35]
UCP3	TT12RJK	Strong	Biomarker	[36]
ADIPOQ	TTXKA7D	Definitive	Biomarker	[37]
APOA1	TT5S8DR	Definitive	Biomarker	[38]
APOA2	TTGQA9W	Definitive	Biomarker	[38]
CTSL	TT36ETB	Definitive	Biomarker	[39]
GSR	TTEP6RV	Definitive	Therapeutic	[40]
IGF1R	TTQFBMY	Definitive	Biomarker	[41]
MCM7	TT1RM3F	Definitive	Biomarker	[42]
PCSK1	TTED9LZ	Definitive	Biomarker	[43]
SOD1	TTP9K3Q	Definitive	Therapeutic	[44]
UGT1A1	TT34ZAF	Definitive	Biomarker	[45]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC34A1	DT42EWA	Definitive	Biomarker	[46]

This Disease Is Related to 4 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
BAAT	DERA3OF	Strong	Biomarker	[47]
CYP7A1	DEDZRQ1	Strong	Biomarker	[48]
DIO3	DET89OV	Strong	Altered Expression	[49]
MAT2B	DEKF1OH	Strong	Biomarker	[35]

This Disease Is Related to 32 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SHBG	OTPWU5IW	Limited	Biomarker	[50]
GNAS	OTMH8BKJ	moderate	Genetic Variation	[51]
APOD	OTT77XW8	Strong	Altered Expression	[52]
BGLAP	OTK1YLWQ	Strong	Altered Expression	[53]
C6	OTCKR304	Strong	Genetic Variation	[54]
CARTPT	OTTE4V9S	Strong	Biomarker	[55]
CMAS	OTFQJG3C	Strong	Biomarker	[56]
COQ9	OTM2T1FI	Strong	Biomarker	[57]
CPQ	OTTNZNLD	Strong	Altered Expression	[58]
DIO2	OTGPNSLH	Strong	Altered Expression	[28]
DMP1	OTBWBWW7	Strong	Genetic Variation	[59]
FAM227B	OTDZYIIY	Strong	Genetic Variation	[29]
LHB	OT5GBOVJ	Strong	Altered Expression	[28]
LMOD1	OTZ2MEMG	Strong	Altered Expression	[60]
MAGI3	OTDJ5QUH	Strong	Genetic Variation	[61]
MICOS10	OTB6D21A	Strong	Genetic Variation	[29]
MPST	OTCDPH5D	Strong	Altered Expression	[20]
PAX8	OTRPD9MI	Strong	Biomarker	[62]
PDE8B	OT4217NK	Strong	Genetic Variation	[29]
PPARGC1A	OTHCDQ22	Strong	Altered Expression	[63]
PRDM11	OT6DX554	Strong	Genetic Variation	[29]
RNASET2	OTWY64L7	Strong	Genetic Variation	[24]
RNF213	OT4OVE9O	Strong	Genetic Variation	[64]
SERPINA7	OTUYVTSU	Strong	Altered Expression	[65]
SMG1	OTTS3SXE	Strong	Biomarker	[22]
TG	OT3ELHIJ	Strong	Biomarker	[66]
TMEM71	OTA7W26O	Strong	Genetic Variation	[29]
TSHB	OTFDI39D	Strong	Genetic Variation	[67]
BDH1	OT62RL5P	Definitive	Biomarker	[68]
CAB39	OT2CL9ST	Definitive	Biomarker	[69]
CP	OTM8JE4Y	Definitive	Biomarker	[70]
STK11	OT1YZSP3	Definitive	Biomarker	[69]

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