Details of Disease

General Information of Disease (ID: DISXP757)

Disease Name	Cervical Intraepithelial neoplasia
Synonyms	Neoplasia, Cervical Intraepithelial; Cervix Intraepithelial Neoplasia; Cervical Intraepithelial Neoplasia; Cervical Intraepithelial Neoplasms; Uterine Cervix Intraepithelial Neoplasia; Cervical Intraepithelial Neoplasm; Intraepithelial Neoplasia, Cervical; Intraepithelial Neoplasms, Cervical; Neoplasm, Cervical Intraepithelial; Cervical intraepithelial neoplasia; Intraepithelial Neoplasia of Cervix Uteri; NEOPL CERVICAL INTRAEPITHELIAL; Cervical Dysplasia; Intraepithelial Neoplasia of the Cervix Uteri; Intraepithelial Neoplasia of Uterine Cervix; Intraepithelial Neoplasia of the Cervix; Intraepithelial Neoplasia of the Uterine Cervix; Intraepithelial Neoplasia of Cervix; Neoplasms, Cervical Intraepithelial; Cervix Uteri Intraepithelial Neoplasia; Intraepithelial Neoplasm, Cervical
Disease Class	2E66: Cervical intraepithelial neoplasia
Disease Hierarchy	DISOAROS: Dysplasia of cervix DISXP757: Cervical Intraepithelial neoplasia
ICD Code	ICD-11 ICD-11: 2E66.1 ICD-10 ICD-10: N87.2 Expand ICD-11 '2E66.1 Expand ICD-10 'N87.2 Expand ICD-9 233.1,622.10
Disease Identifiers	MONDO ID MONDO_0022394 UMLS CUI C0206708 MedGen ID 60214 HPO ID HP:0032242 SNOMED CT ID 285636001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Aminolevulinic acid hci	DMS4BLQ	Approved	Small molecular drug	[1]
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This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
VGX-3100	DMMQ2U9	Phase 3	NA	[2]
ADXS-HPV	DMC8NAO	Phase 2	Vaccine	[3]
Tipapkinogene sovacivec	DM5XRMA	Phase 2	NA	[4]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Verpasep caltespen	DMFJORV	Discontinued in Phase 3	Vaccine	[5]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 37 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DUT	TTH6MBO	Limited	Genetic Variation	[6]
GNAO1	TTAXD8Z	Limited	Genetic Variation	[7]
HLA-DQB2	TTL7VOU	Limited	Genetic Variation	[7]
MAP2K5	TTV3O87	Limited	Genetic Variation	[8]
SLIT2	TTDWK85	Limited	Biomarker	[9]
APOBEC3G	TTP96KH	Disputed	Altered Expression	[10]
CACNA2D2	TTU8P3M	moderate	Biomarker	[11]
EZR	TTE47YC	moderate	Altered Expression	[12]
LCN2	TTKTLAI	moderate	Biomarker	[13]
MKI67	TTB4UNG	moderate	Altered Expression	[14]
PRLR	TTBPXMA	moderate	Altered Expression	[15]
STS	TTHM0R1	moderate	Biomarker	[16]
TUSC2	TTJ8O14	moderate	Genetic Variation	[17]
ACVR2A	TTX2DRI	Strong	Posttranslational Modification	[18]
AGK	TTJETQC	Strong	Biomarker	[19]
ATRAID	TTFLIKM	Strong	Altered Expression	[20]
BUB1	TT78309	Strong	Genetic Variation	[21]
CA9	TT2LVK8	Strong	Biomarker	[22]
DCLK3	TTMYK4Z	Strong	Altered Expression	[23]
ENPEP	TT9PBIL	Strong	Altered Expression	[24]
ERAP1	TT60XFL	Strong	Altered Expression	[25]
GMNN	TT390KA	Strong	Altered Expression	[26]
IDO2	TTALN9W	Strong	Biomarker	[27]
IFNAR2	TTMQB37	Strong	Altered Expression	[28]
IMP3	TTEJA2R	Strong	Biomarker	[29]
LIPA	TTS8T1M	Strong	Biomarker	[30]
MASP2	TTR01E9	Strong	Biomarker	[31]
MKRN1	TTITER7	Strong	Biomarker	[32]
MTR	TTUTO39	Strong	Biomarker	[33]
PTGER3	TTPNGDE	Strong	Altered Expression	[34]
REG3A	TTL4H8N	Strong	Genetic Variation	[17]
SERPIND1	TT8XSKJ	Strong	Biomarker	[35]
SLC6A5	TTI0138	Strong	Altered Expression	[36]
TAP1	TT7JZI8	Strong	Posttranslational Modification	[23]
TP53BP1	TTX4UE9	Strong	Altered Expression	[37]
UBE3A	TTUZX6V	Strong	Biomarker	[38]
XPNPEP2	TTI9MBZ	Strong	Altered Expression	[39]
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⏷ Show the Full List of 37 DTT(s)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC52A3	DTBVQIO	Limited	Altered Expression	[40]
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This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CMPK1	DEMPH4I	Limited	Altered Expression	[41]
ACP3	DEDW5H6	moderate	Genetic Variation	[17]
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This Disease Is Related to 84 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CENPH	OTPOO9LK	Limited	Altered Expression	[42]
CMPK2	OTOG90R0	Limited	Altered Expression	[41]
EXT1	OTRPALJK	Limited	Genetic Variation	[8]
LAMA3	OTFME7HT	Limited	Genetic Variation	[8]
MIA2	OTOGTUTU	Limited	Altered Expression	[43]
PEG3	OTHQW98S	Limited	Posttranslational Modification	[44]
SEMA4A	OT8901H3	Limited	Biomarker	[45]
ASAP1	OT4DLRYY	moderate	Genetic Variation	[17]
ASAP2	OTGEXULW	moderate	Genetic Variation	[17]
EI24	OTD4NOYS	moderate	Genetic Variation	[46]
ITGA9	OTHN1IKA	moderate	Biomarker	[47]
MRPS30	OTDXIAGG	moderate	Genetic Variation	[17]
MTPAP	OT6HQ02S	moderate	Genetic Variation	[17]
PAPOLA	OTPHD65D	moderate	Genetic Variation	[17]
PPP2R1B	OTFIHQGD	moderate	Biomarker	[48]
PYCARD	OT67RON3	moderate	Biomarker	[16]
ROBO2	OTFJ9FQW	moderate	Biomarker	[9]
ACSL1	OTB06ESI	Strong	Genetic Variation	[49]
ADSS1	OTF6FE38	Strong	Biomarker	[50]
ANKS4B	OT1MREUS	Strong	Genetic Variation	[51]
ASCL1	OTI4X44G	Strong	Biomarker	[52]
CADM1	OTRWG9QS	Strong	Posttranslational Modification	[53]
CANX	OTYP1F6J	Strong	Altered Expression	[23]
CCNA1	OTX4HD45	Strong	Posttranslational Modification	[54]
CENPA	OT0NEJ4X	Strong	Altered Expression	[55]
CFDP1	OTXY7J96	Strong	Posttranslational Modification	[56]
CPVL	OTOJL31C	Strong	Biomarker	[57]
CTDSPL	OTZJ0CZK	Strong	Genetic Variation	[58]
DPH1	OT0QU3JY	Strong	Altered Expression	[59]
EEF1A1	OT00THXS	Strong	Altered Expression	[60]
EFEMP2	OT0I2B4J	Strong	Altered Expression	[61]
EIF4G2	OTEO98CR	Strong	Posttranslational Modification	[56]
EMC6	OT9IHH51	Strong	Biomarker	[62]
EPB41L3	OTS6CHG2	Strong	Posttranslational Modification	[63]
HAVCR1	OT184CRZ	Strong	Altered Expression	[64]
HLA-DQB1	OTVVI3UI	Strong	Genetic Variation	[65]
IL9R	OTILCLXA	Strong	Biomarker	[66]
KDM4B	OT5P1UPY	Strong	Altered Expression	[67]
KIR2DL5B	OTSV0JL9	Strong	Genetic Variation	[68]
KIR2DS4	OT00N6UJ	Strong	Genetic Variation	[68]
KLF13	OTMIKHZ4	Strong	Altered Expression	[69]
LAMTOR5	OTER0U8L	Strong	Altered Expression	[70]
LHX8	OT0DFL7C	Strong	Biomarker	[52]
LIMD1	OTN1CG6R	Strong	Genetic Variation	[71]
LPIN1	OTQ75KF2	Strong	Altered Expression	[72]
LRBA	OTOUZN9G	Strong	Biomarker	[73]
MAL	OTBM30SW	Strong	Biomarker	[74]
MCM5	OTAHLB62	Strong	Biomarker	[75]
MEST	OT8Q4U8Y	Strong	Posttranslational Modification	[76]
METTL9	OT3YR9B2	Strong	Altered Expression	[72]
MIB1	OT5C404P	Strong	Biomarker	[77]
MMUT	OTBBBV70	Strong	Biomarker	[78]
MTREX	OTSQY30V	Strong	Genetic Variation	[79]
MYBL2	OTZ3JX8Q	Strong	Biomarker	[80]
MYO1B	OTGZUJ0I	Strong	Altered Expression	[81]
NET1	OTZHNMJV	Strong	Altered Expression	[36]
NRK	OTGR01FF	Strong	Biomarker	[82]
NUMB	OTMB586Q	Strong	Biomarker	[83]
PANK2	OTFBW889	Strong	Genetic Variation	[51]
PAX1	OT0Y3MIM	Strong	Posttranslational Modification	[84]
PDAP1	OTJSWMOD	Strong	Genetic Variation	[17]
PLAA	OTZ7NJGA	Strong	Biomarker	[79]
POLR2D	OTW7RZ18	Strong	Biomarker	[85]
POU2F2	OTPV0J0C	Strong	Altered Expression	[86]
POU4F1	OTMHYGWQ	Strong	Biomarker	[87]
PRPF38B	OTQLH551	Strong	Altered Expression	[36]
PSMA1	OTNBVM2U	Strong	Biomarker	[35]
PSMD2	OT6HZHN7	Strong	Posttranslational Modification	[56]
RAB5A	OTFR2KM4	Strong	Biomarker	[62]
RAN	OT2TER5M	Strong	Altered Expression	[88]
RAPGEF5	OT53VS75	Strong	Biomarker	[89]
RBBP4	OTG3BT3M	Strong	Altered Expression	[90]
RP9	OTGQY66H	Strong	Altered Expression	[72]
RUBCNL	OTMQIDOI	Strong	Biomarker	[91]
SASH1	OTQA8BD4	Strong	Biomarker	[92]
SEC14L2	OTJST64D	Strong	Genetic Variation	[93]
SEC62	OTCWEL5F	Strong	Altered Expression	[94]
SIX1	OT70YYWM	Strong	Altered Expression	[95]
SMARCAL1	OTTKXLUZ	Strong	Genetic Variation	[51]
SMOC1	OTJG2JQY	Strong	Altered Expression	[28]
ST6GALNAC5	OTH91ETM	Strong	Biomarker	[52]
STIL	OT9799VN	Strong	Biomarker	[96]
SYCP3	OTKOF54H	Strong	Altered Expression	[97]
TSPAN1	OTZQPIYK	Strong	Altered Expression	[36]
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⏷ Show the Full List of 84 DOT(s)

References

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31	MASP-1 and MASP-2 Serum Levels Are Associated With Worse Prognostic in Cervical Cancer Progression.Front Immunol. 2018 Nov 23;9:2742. doi: 10.3389/fimmu.2018.02742. eCollection 2018.
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33	Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and risk of cervical intraepithelial neoplasia II/III and cervical cancer: a meta-analysis.Mol Med Rep. 2013 Sep;8(3):919-27. doi: 10.3892/mmr.2013.1589. Epub 2013 Jul 16.
34	The role of EP3-receptor expression in cervical dysplasia.J Cancer Res Clin Oncol. 2019 Feb;145(2):313-319. doi: 10.1007/s00432-018-2785-3. Epub 2018 Nov 7.
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36	Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas.Int J Cancer. 2002 Jun 20;99(6):771-5. doi: 10.1002/ijc.10442.
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66	Th9 cytokines curb cervical cancer progression and immune evasion.Hum Immunol. 2019 Dec;80(12):1020-1025. doi: 10.1016/j.humimm.2019.09.009. Epub 2019 Sep 25.
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68	A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia.Tissue Antigens. 2005 Mar;65(3):252-9. doi: 10.1111/j.1399-0039.2005.00359.x.
69	KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8.Oncogene. 2016 Oct 20;35(42):5565-5575. doi: 10.1038/onc.2016.97. Epub 2016 Apr 4.
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