Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTJST64D)

• DOT Name: SEC14-like protein 2 (SEC14L2)
• Synonyms: Alpha-tocopherol-associated protein; TAP; hTAP; Squalene transfer protein; Supernatant protein factor; SPF
• Gene Name: SEC14L2
• Related Disease:
  Advanced cancer
  Behcet disease
  Psoriasis
  Analgesia
  Ankylosing spondylitis
  Autoimmune disease
  Breast carcinoma
  Bronchiectasis
  Carcinoma of esophagus
  Cervical cancer
  Cervical carcinoma
  Cervical Intraepithelial neoplasia
  Clear cell renal carcinoma
  Coeliac disease
  Colon cancer
  Colon carcinoma
  Crohn disease
  Hepatitis B virus infection
  Hepatitis C virus infection
  Hepatocellular carcinoma
  Inborn error of immunity
  Juvenile idiopathic arthritis
  Lung neoplasm
  Metastatic malignant neoplasm
  Multiple sclerosis
  OPTN-related open angle glaucoma
  Renal cell carcinoma
  Rheumatoid arthritis
  Squamous cell carcinoma
  Tuberculosis
  Type-1 diabetes
  Ulcerative colitis
  Breast cancer
  Head and neck cancer
  Head and neck carcinoma
  Influenza
  Pulmonary tuberculosis
  Systemic lupus erythematosus
  Atopic dermatitis
  Carcinoma
  Colorectal carcinoma
  Dementia
  Herpes simplex infection
  Human papillomavirus infection
  Melanoma
  Non-small-cell lung cancer
  Prostate cancer
  Prostate carcinoma
  Skin cancer
• UniProt ID: S14L2_HUMAN
• PDB ID: 1O6U; 1OLM; 4OMJ; 4OMK
• Pfam ID: PF00650 ; PF03765
• Sequence:
  MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHV
  EFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDL
  LRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEE
  NYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVE
  YGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPG
  CVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSDPGI
  YVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLGAGTPK
• Function: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
• Tissue Specificity: Widely expressed. Strong expression in liver, brain and prostate.

Molecular Interaction Atlas (MIA) of This DOT

49 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Advanced cancer	DISAT1Z9	Definitive	Genetic Variation	[1]
Behcet disease	DISSYMBS	Definitive	Biomarker	[2]
Psoriasis	DIS59VMN	Definitive	Genetic Variation	[3]
Analgesia	DISK3TVI	Strong	Biomarker	[4]
Ankylosing spondylitis	DISRC6IR	Strong	Genetic Variation	[5]
Autoimmune disease	DISORMTM	Strong	Biomarker	[6]
Breast carcinoma	DIS2UE88	Strong	Biomarker	[7]
Bronchiectasis	DIS5MYEE	Strong	Biomarker	[8]
Carcinoma of esophagus	DISS6G4D	Strong	Biomarker	[9]
Cervical cancer	DISFSHPF	Strong	Genetic Variation	[10]
Cervical carcinoma	DIST4S00	Strong	Genetic Variation	[10]
Cervical Intraepithelial neoplasia	DISXP757	Strong	Genetic Variation	[11]
Clear cell renal carcinoma	DISBXRFJ	Strong	Biomarker	[12]
Coeliac disease	DISIY60C	Strong	Genetic Variation	[13]
Colon cancer	DISVC52G	Strong	Biomarker	[14]
Colon carcinoma	DISJYKUO	Strong	Biomarker	[14]
Crohn disease	DIS2C5Q8	Strong	Genetic Variation	[15]
Hepatitis B virus infection	DISLQ2XY	Strong	Genetic Variation	[16]
Hepatitis C virus infection	DISQ0M8R	Strong	Biomarker	[17]
Hepatocellular carcinoma	DIS0J828	Strong	Biomarker	[18]
Inborn error of immunity	DISNGCMN	Strong	Genetic Variation	[19]
Juvenile idiopathic arthritis	DISQZGBV	Strong	Genetic Variation	[20]
Lung neoplasm	DISVARNB	Strong	Altered Expression	[21]
Metastatic malignant neoplasm	DIS86UK6	Strong	Biomarker	[22]
Multiple sclerosis	DISB2WZI	Strong	Biomarker	[23]
OPTN-related open angle glaucoma	DISDR98A	Strong	Genetic Variation	[24]
Renal cell carcinoma	DISQZ2X8	Strong	Biomarker	[12]
Rheumatoid arthritis	DISTSB4J	Strong	Biomarker	[25]
Squamous cell carcinoma	DISQVIFL	Strong	Genetic Variation	[26]
Tuberculosis	DIS2YIMD	Strong	Genetic Variation	[27]
Type-1 diabetes	DIS7HLUB	Strong	Altered Expression	[28]
Ulcerative colitis	DIS8K27O	Strong	Genetic Variation	[15]
Breast cancer	DIS7DPX1	moderate	Biomarker	[7]
Head and neck cancer	DISBPSQZ	moderate	Biomarker	[29]
Head and neck carcinoma	DISOU1DS	moderate	Biomarker	[29]
Influenza	DIS3PNU3	moderate	Biomarker	[30]
Pulmonary tuberculosis	DIS6FLUM	moderate	Genetic Variation	[31]
Systemic lupus erythematosus	DISI1SZ7	moderate	Genetic Variation	[32]
Atopic dermatitis	DISTCP41	Limited	Genetic Variation	[33]
Carcinoma	DISH9F1N	Limited	Altered Expression	[34]
Colorectal carcinoma	DIS5PYL0	Limited	Biomarker	[35]
Dementia	DISXL1WY	Limited	Biomarker	[36]
Herpes simplex infection	DISL1SAV	Limited	Genetic Variation	[37]
Human papillomavirus infection	DISX61LX	Limited	Genetic Variation	[11]
Melanoma	DIS1RRCY	Limited	Biomarker	[38]
Non-small-cell lung cancer	DIS5Y6R9	Limited	Biomarker	[39]
Prostate cancer	DISF190Y	Limited	Biomarker	[40]
Prostate carcinoma	DISMJPLE	Limited	Biomarker	[40]
Skin cancer	DISTM18U	Limited	Biomarker	[38]

12 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate decreases the expression of SEC14-like protein 2 (SEC14L2).	[41]
Ciclosporin	DMAZJFX	Approved	Ciclosporin decreases the expression of SEC14-like protein 2 (SEC14L2).	[42]
Tretinoin	DM49DUI	Approved	Tretinoin increases the expression of SEC14-like protein 2 (SEC14L2).	[43]
Cisplatin	DMRHGI9	Approved	Cisplatin increases the expression of SEC14-like protein 2 (SEC14L2).	[44]
Estradiol	DMUNTE3	Approved	Estradiol increases the expression of SEC14-like protein 2 (SEC14L2).	[45]
Ivermectin	DMDBX5F	Approved	Ivermectin decreases the expression of SEC14-like protein 2 (SEC14L2).	[46]
Calcitriol	DM8ZVJ7	Approved	Calcitriol increases the expression of SEC14-like protein 2 (SEC14L2).	[47]
Testosterone	DM7HUNW	Approved	Testosterone increases the expression of SEC14-like protein 2 (SEC14L2).	[47]
Progesterone	DMUY35B	Approved	Progesterone increases the expression of SEC14-like protein 2 (SEC14L2).	[48]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the expression of SEC14-like protein 2 (SEC14L2).	[49]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the expression of SEC14-like protein 2 (SEC14L2).	[50]
Milchsaure	DM462BT	Investigative	Milchsaure decreases the expression of SEC14-like protein 2 (SEC14L2).	[51]

References

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