| 1 |
Monocarboxylate Transporter 4 (MCT4) Overexpression Is Correlated with Poor Prognosis of Osteosarcoma.Med Sci Monit. 2019 Jun 9;25:4278-4284. doi: 10.12659/MSM.912272.
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| 2 |
Neonatal hyperglycemia alters the neurochemical profile, dendritic arborization and gene expression in the developing rat hippocampus.NMR Biomed. 2018 May;31(5):e3910. doi: 10.1002/nbm.3910. Epub 2018 Mar 13.
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| 3 |
Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells.Pancreas. 2016 Aug;45(7):1036-47. doi: 10.1097/MPA.0000000000000571.
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| 4 |
Identification of a pyruvate-to-lactate signature in pancreatic intraductal papillary mucinous neoplasms.Pancreatology. 2018 Jan;18(1):46-53. doi: 10.1016/j.pan.2017.11.006. Epub 2017 Nov 14.
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| 5 |
Role of monocarboxylate transporter 4 in Alzheimer disease.Neurotoxicology. 2020 Jan;76:191-199. doi: 10.1016/j.neuro.2019.11.006. Epub 2019 Nov 16.
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| 6 |
Vesicular trafficking-related proteins as the potential therapeutic target for breast cancer.Protoplasma. 2020 Mar;257(2):345-352. doi: 10.1007/s00709-019-01462-3. Epub 2019 Dec 11.
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| 7 |
Monocarboxylate transporters MCT1 and MCT4 are independent prognostic biomarkers for the survival of patients with clear cell renal cell carcinoma and those receiving therapy targeting angiogenesis.Urol Oncol. 2018 Jun;36(6):311.e15-311.e25. doi: 10.1016/j.urolonc.2018.03.014. Epub 2018 Apr 12.
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| 8 |
Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.Virchows Arch. 2008 Feb;452(2):139-46. doi: 10.1007/s00428-007-0558-5. Epub 2008 Jan 10.
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| 9 |
Prognostic value of monocarboxylate transporter 4 in patients with esophageal squamous cell carcinoma.Oncol Rep. 2018 Nov;40(5):2906-2915. doi: 10.3892/or.2018.6706. Epub 2018 Sep 13.
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| 10 |
MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis.Oncotarget. 2016 Jul 12;7(28):43492-43503. doi: 10.18632/oncotarget.9523.
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| 11 |
Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner.Oncogene. 2014 Aug 28;33(35):4433-41. doi: 10.1038/onc.2013.390. Epub 2013 Sep 30.
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| 12 |
Targeted inhibition of MCT4 disrupts intracellular pH homeostasis and confers self-regulated apoptosis on hepatocellular carcinoma.Exp Cell Res. 2019 Nov 1;384(1):111591. doi: 10.1016/j.yexcr.2019.111591. Epub 2019 Aug 31.
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| 13 |
High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma. Oncol Lett. 2017 Nov;14(5):5727-5734.
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| 14 |
Intratumoral lactate metabolism in Barrett's esophagus and adenocarcinoma.Oncotarget. 2017 Apr 4;8(14):22894-22902. doi: 10.18632/oncotarget.15284.
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| 15 |
Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis.J Clin Invest. 2019 May 21;129(8):3277-3292. doi: 10.1172/JCI124012.
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| 16 |
Monocarboxylate transporters in cancer.Mol Metab. 2020 Mar;33:48-66. doi: 10.1016/j.molmet.2019.07.006. Epub 2019 Jul 27.
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| 17 |
Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis.Arthritis Rheumatol. 2015 Nov;67(11):2888-96. doi: 10.1002/art.39270.
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| 18 |
Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.Oncotarget. 2015 Oct 20;6(32):33568-86. doi: 10.18632/oncotarget.5598.
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| 19 |
MCT4 promotes cell proliferation and invasion of castration-resistant prostate cancer PC-3 cell line.EXCLI J. 2019 Mar 21;18:187-194. doi: 10.17179/excli2018-1879. eCollection 2019.
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| 20 |
Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells.Cancer Cell Int. 2019 Jun 28;19:170. doi: 10.1186/s12935-019-0889-8. eCollection 2019.
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| 21 |
Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized (13)C Pyruvate MRI.Cancers (Basel). 2018 Sep 5;10(9):313. doi: 10.3390/cancers10090313.
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| 22 |
Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer.Front Oncol. 2018 Aug 28;8:324. doi: 10.3389/fonc.2018.00324. eCollection 2018.
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| 23 |
Oncometabolites as biomarkers in thyroid cancer: a systematic review.Cancer Manag Res. 2019 Feb 25;11:1829-1841. doi: 10.2147/CMAR.S188661. eCollection 2019.
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| 24 |
The NF-B/miR-425-5p/MCT4 axis: A novel insight into diabetes-induced endothelial dysfunction.Mol Cell Endocrinol. 2020 Jan 15;500:110641. doi: 10.1016/j.mce.2019.110641. Epub 2019 Nov 8.
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| 25 |
Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix.BMC Cancer. 2014 Oct 8;14:751. doi: 10.1186/1471-2407-14-751.
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| 26 |
Altered metabolic and transporter characteristics of vastus lateralis in chronic obstructive pulmonary disease.J Appl Physiol (1985). 2008 Sep;105(3):879-86. doi: 10.1152/japplphysiol.90458.2008. Epub 2008 Jul 17.
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| 27 |
New insight into the role of metabolic reprogramming in melanoma cells harboring BRAF mutations.Biochim Biophys Acta. 2016 Nov;1863(11):2710-2718. doi: 10.1016/j.bbamcr.2016.08.007. Epub 2016 Aug 16.
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| 28 |
The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms.Int J Cancer. 2018 Jun 15;142(12):2529-2542. doi: 10.1002/ijc.31276. Epub 2018 Feb 7.
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| 29 |
Lactic acid induces lactate transport and glycolysis/OXPHOS interconversion in glioblastoma.Biochem Biophys Res Commun. 2018 Sep 5;503(2):888-894. doi: 10.1016/j.bbrc.2018.06.092. Epub 2018 Jun 21.
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| 30 |
Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.Haematologica. 2017 Jul;102(7):1247-1257. doi: 10.3324/haematol.2016.163030. Epub 2017 Apr 6.
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| 31 |
Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma.Cell Oncol (Dordr). 2019 Jun;42(3):303-318. doi: 10.1007/s13402-019-00426-2. Epub 2019 Feb 21.
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| 32 |
The prognostic significance of the expression of monocarboxylate transporter 4 in patients with right- or left-sided colorectal cancer.Asia Pac J Clin Oncol. 2019 Apr;15(2):e49-e55. doi: 10.1111/ajco.13077. Epub 2018 Sep 30.
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| 33 |
An overview of MCT1 and MCT4 in GBM: small molecule transporters with large implications.Am J Cancer Res. 2018 Oct 1;8(10):1967-1976. eCollection 2018.
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| 34 |
Inhibition of CREB-mediated ZO-1 and activation of NF-B-induced IL-6 by colonic epithelial MCT4 destroys intestinal barrier function.Cell Prolif. 2019 Nov;52(6):e12673. doi: 10.1111/cpr.12673. Epub 2019 Aug 16.
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| 35 |
Bitter melon juice-intake modulates glucose metabolism and lactate efflux in tumors in its efficacy against pancreatic cancer.Carcinogenesis. 2019 Sep 18;40(9):1164-1176. doi: 10.1093/carcin/bgz114.
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| 36 |
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
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| 37 |
Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
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| 38 |
Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
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| 39 |
Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
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| 40 |
Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
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| 41 |
Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
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| 42 |
Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
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| 43 |
Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
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| 44 |
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
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| 45 |
Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
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| 46 |
Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
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| 47 |
Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
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| 48 |
In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
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| 49 |
Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
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| 50 |
Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
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| 51 |
Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
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| 52 |
Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
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| 53 |
From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
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| 54 |
Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
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| 55 |
Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
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| 56 |
Gene profiles of a human alveolar epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis. Toxicol Lett. 2009 Feb 25;185(1):16-22. doi: 10.1016/j.toxlet.2008.11.017. Epub 2008 Dec 6.
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