General Information of Disease (ID: DISAMG6N)

Disease Name Triple negative breast cancer
Synonyms triple-negative breast carcinoma; triple-receptor negative breast cancer; triple-negative breast cancer
Disease Class 2C60-2C6Y: Breast cancer
Definition An invasive breast carcinoma which is negative for expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).
Disease Hierarchy
DISS605N: Her2-receptor negative breast cancer
DISJLI0R: Estrogen-receptor negative breast cancer
DIS2UE88: Breast carcinoma
DISIBAIY: Progesterone-receptor negative breast cancer
DISAMG6N: Triple negative breast cancer
ICD Code
ICD-11
ICD-11: 2C60-2C65
Expand ICD-9
174175
Disease Identifiers
MONDO ID
MONDO_0005494
UMLS CUI
C4722518
MedGen ID
1649548

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 3 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Capivasertib DM9SKW8 Approved Small molecular drug [1]
Nivolumab DMAB9QE Approved Monoclonal antibody [2]
Trilaciclib DMP5A4T Approved NA [2]
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This Disease is Treated as An Indication in 16 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Adagloxad simolenin DMICKCQ Phase 3 Vaccine [3]
TKI258 DMYLT67 Phase 3 Small molecular drug [4]
Bemcentinib DM0YCPL Phase 2 Small molecular drug [5]
EFT508 DMX6RZG Phase 2 NA [2]
ENMD-2076 DMJZVPB Phase 2 Small molecular drug [2]
MCS-110 DM0CL4I Phase 2 NA [2]
PVX-410 DM6DK9A Phase 2 NA [6]
RX-5902 DMBOZPH Phase 2 NA [2]
SAR-566658 DMT4FI5 Phase 2 Antibody [2]
Tavokinogene telseplasmid DMZX0VF Phase 2 Gene therapy [2]
TPIV200 DM4UZRE Phase 2 NA [2]
Anti-meso-CAR vector transduced T cells DM5UQA9 Phase 1 CAR T Cell Therapy [7]
PF-06936308 DM4SCKT Phase 1 Vaccine [8]
PF-07104091 DMMJZ2E Phase 1 Small molecular drug [9]
PMD-026 DMIS8BV Phase 1 Small molecular drug [10]
SC-005 DMF7DU6 Phase 1 NA [2]
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⏷ Show the Full List of 16 Drug(s)
This Disease is Treated as An Indication in 4 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
MI-219 DM196LK Investigative Small molecular drug [11]
OSU-53 DMQPJXT Investigative Small molecular drug [12]
SB218078 DM7LARD Investigative Small molecular drug [13]
V158411 DMXLHIO Investigative Small molecular drug [14]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 345 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AKT3 TTO6SGY Limited Genetic Variation [15]
APEX1 TTHGL48 Limited Altered Expression [16]
ARRB1 TTMVD4A Limited Biomarker [17]
ATF4 TTQCKWT Limited Biomarker [18]
BECN1 TT5M7LN Limited Biomarker [19]
BSG TT5UJWD Limited Altered Expression [20]
CA9 TT2LVK8 Limited Biomarker [21]
CD47 TT28S46 Limited Biomarker [22]
CDH11 TTRGWZC Limited Altered Expression [23]
CHEK2 TT9ABMF Limited Biomarker [24]
CLK2 TT85TPS Limited Biomarker [25]
DDX5 TTZKPVC Limited Biomarker [26]
EEF2K TT1QFLA Limited Biomarker [27]
EPCAM TTZ8WH4 Limited Biomarker [28]
ETS1 TTTGPSD Limited Altered Expression [29]
EZR TTE47YC Limited Biomarker [30]
FABP5 TTNT2S6 Limited Altered Expression [31]
FOLR1 TTVC37M Limited Genetic Variation [32]
FOSL1 TTY8LZG Limited Biomarker [33]
FOXC1 TTNT3YA Limited Biomarker [34]
FSCN1 TTTRS9B Limited Biomarker [35]
FZD7 TTUQMO5 Limited Biomarker [36]
GPER1 TTDSB34 Limited Biomarker [30]
GRM1 TTVBPDM Limited Biomarker [37]
HDAC3 TT4YWTO Limited Biomarker [38]
HSPA5 TTW26OG Limited Altered Expression [39]
HTR7 TTO9X1H Limited Altered Expression [40]
IDUA TT0IUKX Limited Biomarker [41]
IFNB1 TT4TZ8J Limited Biomarker [42]
IL15 TTJFA35 Limited Biomarker [43]
ITGA11 TTANXZ7 Limited Biomarker [44]
ITGA6 TT165T3 Limited Biomarker [45]
ITGB1 TTBVIQC Limited Altered Expression [46]
KISS1R TT3KBZY Limited Altered Expression [47]
LAPTM4B TTEJQT0 Limited Biomarker [48]
LDHA TTW76JE Limited Biomarker [49]
MAP2K7 TT6QY3J Limited Biomarker [50]
MDM4 TT9OUDQ Limited Genetic Variation [51]
MTDH TTH6SA5 Limited Altered Expression [52]
NLRX1 TTKT026 Limited Altered Expression [53]
NR0B2 TT25A9Q Limited Genetic Variation [54]
NR1D1 TTAD1O8 Limited Altered Expression [55]
NR1I3 TTRANFM Limited Biomarker [56]
NT5E TTK0O6Y Limited Biomarker [57]
PDE7B TTWIEY9 Limited Biomarker [58]
PKM TT4LOT8 Limited Altered Expression [59]
PLK1 TTH4IP0 Limited Biomarker [60]
PSIP1 TTH9LDP Limited Altered Expression [61]
PTPN6 TT369M5 Limited Genetic Variation [54]
RIPK1 TTVJHX8 Limited Biomarker [62]
ROR1 TTDEJAU Limited Biomarker [63]
RPS6KA3 TTUM2ZR Limited Biomarker [64]
RPS6KB1 TTG0U4H Limited Biomarker [65]
SKP2 TT5B2EO Limited Altered Expression [66]
SOCS1 TT8COJM Limited Biomarker [67]
SPHK1 TTOHFIY Limited Biomarker [68]
TACSTD2 TTP2HE5 Limited Biomarker [69]
TLN1 TTQSMFG Limited Altered Expression [70]
TNFSF10 TTA5MS9 Limited Biomarker [71]
TP53BP1 TTX4UE9 Limited Biomarker [72]
TRIP10 TTKHTGE Limited Posttranslational Modification [73]
TRPC3 TTNVC34 Limited Biomarker [74]
TTK TTP7EGM Limited Biomarker [25]
WEE1 TTJFOAL Limited Biomarker [75]
YAP1 TT8UN2D Limited Biomarker [76]
ABCG1 TTMWDGU moderate Altered Expression [77]
BCL2A1 TTGT9C7 moderate Altered Expression [78]
BIRC2 TTQ5LRD moderate Biomarker [79]
BIRC3 TTAIWZN moderate Biomarker [80]
BRD2 TTDP48B moderate Altered Expression [81]
C1QBP TTWTD7F moderate Altered Expression [82]
CAPN1 TT1WBIJ moderate Biomarker [83]
CCNB1 TT9P6OW moderate Altered Expression [84]
CCNE1 TTCEJ4F moderate Altered Expression [85]
CD24 TTCTYNP moderate Altered Expression [86]
CD44 TTWFBT7 moderate Altered Expression [87]
CDC25C TTESBNC moderate Biomarker [88]
CDH2 TT1WS0T moderate Genetic Variation [89]
CDK12 TTJ21A9 moderate Biomarker [90]
CDK7 TTQYF7G moderate Biomarker [91]
CDK9 TT1LVF2 moderate Biomarker [92]
CFB TTA0P7K moderate Biomarker [93]
CXCR4 TTBID49 moderate Altered Expression [51]
DEPDC1 TT8S9CM moderate Altered Expression [94]
DYRK2 TT84OS6 moderate Biomarker [95]
EGLN2 TTMHFRY moderate Biomarker [96]
EIF4EBP1 TTKGEBL moderate Altered Expression [97]
EPHB2 TTKPV6O moderate Biomarker [98]
ESRRB TTKF0XS moderate Altered Expression [99]
FABP4 TTHWMFZ moderate Genetic Variation [100]
FGFBP1 TTV1YFT moderate Biomarker [101]
FOLH1 TT9G4N0 moderate Biomarker [102]
FOXM1 TTD3KOX moderate Biomarker [103]
GNRH1 TT0ID4A moderate Biomarker [104]
HBEGF TT15SL0 moderate Altered Expression [105]
HDAC8 TTT6LFV moderate Biomarker [106]
HSP90AA1 TT78R5H moderate Biomarker [107]
IL19 TT87RWS moderate Altered Expression [108]
IRF1 TT4TU3L moderate Biomarker [109]
ITCH TT5SEWD moderate Biomarker [110]
ITGA5 TTHIZP9 moderate Biomarker [111]
ITK TT3C80U moderate Genetic Variation [112]
KDM1A TTNR0UQ moderate Biomarker [113]
KDM2A TT8XTY2 moderate Altered Expression [114]
KDM5B TTCLI75 moderate Biomarker [115]
KISS1 TTU2O6T moderate Biomarker [116]
LIMK1 TTWL9TY moderate Biomarker [117]
LPAR1 TTQ6S1K moderate Altered Expression [118]
MAP3K21 TTSW9YL moderate Altered Expression [119]
MAP3K7 TTJQT60 moderate Biomarker [120]
MAPK9 TT3IVG2 moderate Biomarker [121]
MERTK TTO7LKR moderate Altered Expression [122]
MKNK1 TTEZAUX moderate Biomarker [123]
MUC1 TTBHFYQ moderate Biomarker [124]
MYB TT8V13P moderate Biomarker [125]
NCL TTK1V5Q moderate Altered Expression [126]
NEDD9 TT1UREA moderate Biomarker [127]
NEK2 TT3VZ24 moderate Biomarker [128]
NOD1 TTYSRXM moderate Biomarker [129]
NR4A1 TTMXE2Q moderate Biomarker [130]
NRP1 TTIPJCB moderate Biomarker [131]
OLFM4 TTK1CX7 moderate Biomarker [132]
OSM TTIVXSE moderate Biomarker [42]
PDCD1 TTNBFWK moderate Biomarker [133]
PHGDH TT8DRCK moderate Altered Expression [134]
PLAUR TTNOSTX moderate Biomarker [135]
PRDX5 TTLPJWH moderate Biomarker [136]
PTK6 TT6TH8V moderate Biomarker [137]
PTP4A3 TT7YM8D moderate Biomarker [138]
PTPRC TTUS45N moderate Altered Expression [139]
RAD51 TTC0G1L moderate Biomarker [140]
RALBP1 TTVSRUA moderate Biomarker [141]
RICTOR TT143WL moderate Altered Expression [142]
RPS6KA2 TT0ZW9O moderate Biomarker [64]
SLC16A3 TTG6VD5 moderate Altered Expression [143]
SLC1A5 TTF7WRM moderate Genetic Variation [144]
SLC7A11 TTBZMIO moderate Biomarker [145]
SMN1 TT8QL6X moderate Biomarker [146]
SRC TT6PKBN moderate Biomarker [147]
SYK TT2HUPM moderate Altered Expression [148]
TARDBP TT9RZ03 moderate Biomarker [149]
TBK1 TTMP03S moderate Biomarker [150]
TMPRSS6 TTL9KE7 moderate Genetic Variation [151]
TPX2 TT0PHL4 moderate Altered Expression [148]
USP2 TTUEQ1W moderate Biomarker [152]
VDAC1 TTAMKGB moderate Altered Expression [153]
ACVR1B TTPKHTZ Strong Altered Expression [154]
ADAM10 TTVXEGU Strong Altered Expression [155]
ADAM33 TTQICM2 Strong Biomarker [156]
ADAM8 TTQWYMD Strong Altered Expression [157]
ADORA2B TTNE7KG Strong Altered Expression [158]
AKR1C3 TT5ZWB6 Strong Biomarker [159]
ANXA1 TTUCK4B Strong Altered Expression [160]
ANXA2 TT4YANI Strong Altered Expression [161]
AQP3 TTLDNMQ Strong Altered Expression [162]
ARF1 TT70KXY Strong Biomarker [163]
ATAD2 TT9A0HI Strong Biomarker [164]
ATR TT8ZYBQ Strong Altered Expression [140]
AURKA TTPS3C0 Strong Altered Expression [165]
AXL TTZPY6J Strong Biomarker [166]
AZGP1 TTUPYLV Strong Biomarker [167]
BAK1 TTFM7V0 Strong Altered Expression [168]
BCL11A TTR61MW Strong Biomarker [169]
BRD3 TTHE657 Strong Altered Expression [170]
BRD9 TTR7L5Y Strong Genetic Variation [81]
BRIP1 TTZV7LJ Strong Genetic Variation [171]
CCK TT90CMU Strong Altered Expression [35]
CCL5 TT9DWLC Strong Biomarker [172]
CCNE2 TTLDRGX Strong Altered Expression [173]
CCR7 TT2GIDQ Strong Altered Expression [174]
CD69 TTPQE9F Strong Biomarker [175]
CDC20 TTBKFDV Strong Genetic Variation [176]
CDC25B TTR0SWN Strong Altered Expression [177]
CDC37 TT5SOEU Strong Biomarker [178]
CDC7 TTSMTDI Strong Biomarker [92]
CDK1 TTH6V3D Strong Biomarker [179]
CDK11B TT5Q79O Strong Altered Expression [180]
CDK13 TTRIM0E Strong Biomarker [90]
CDK19 TTNABU9 Strong Altered Expression [180]
CDK2 TT7HF4W Strong Biomarker [181]
CDK8 TTBJR4L Strong Altered Expression [182]
CEBPB TTUI35N Strong Biomarker [183]
CFI TT6ATLX Strong Biomarker [184]
CHUK TT1F8OQ Strong Biomarker [185]
CLDN6 TTKSV48 Strong Altered Expression [186]
CLK1 TTE6YDG Strong Biomarker [187]
CMA1 TT8VUE0 Strong Biomarker [188]
COPS5 TTSTNJR Strong Biomarker [189]
CRTC1 TT4GO0F Strong Biomarker [190]
CSPG4 TT7MYXI Strong Biomarker [191]
CTSS TTUMQVO Strong Biomarker [192]
DCLK3 TTMYK4Z Strong Biomarker [193]
DDR2 TTU98HG Strong Biomarker [194]
DEK TT1NMGV Strong Biomarker [195]
DHODH TTLVP78 Strong Biomarker [196]
DKK2 TTST5KX Strong Altered Expression [197]
DOT1L TTSZ8T1 Strong Altered Expression [198]
E2F2 TT5FYX0 Strong Biomarker [199]
EIF2AK3 TT79U1M Strong Altered Expression [200]
EIF4E TTZGCP6 Strong Altered Expression [123]
EIF5A2 TTH53G9 Strong Altered Expression [201]
ENAH TTY36UA Strong Biomarker [202]
EPHA1 TTLFZVU Strong Biomarker [203]
EPHB6 TTZEMUY Strong Biomarker [204]
EREG TTYSB89 Strong Biomarker [205]
ESRRA TTPNQAC Strong Biomarker [206]
F11R TT3C8EG Strong Biomarker [207]
F2RL2 TTVSEBF Strong Biomarker [208]
FKBP4 TTHY0FT Strong Biomarker [209]
FOLR2 TTT54CI Strong Genetic Variation [32]
FPR1 TT5Y4EM Strong Altered Expression [210]
FTH1 TT975ZT Strong Altered Expression [211]
GABRP TT3E0DI Strong Biomarker [212]
GCLM TTNFESW Strong Altered Expression [213]
GGCX TT76OLR Strong Altered Expression [214]
GMNN TT390KA Strong Altered Expression [215]
GPNMB TT7315J Strong Altered Expression [216]
GPRC6A TTI1PRE Strong Biomarker [217]
GRK3 TT5A4DX Strong Biomarker [218]
GRK5 TTTCXO0 Strong Altered Expression [219]
GRPR TTC1MVT Strong Altered Expression [219]
GUCY2D TTWNFC2 Strong Altered Expression [139]
HMGA1 TTBA219 Strong Biomarker [220]
HMGA2 TTSTVM0 Strong Biomarker [221]
IGFBP3 TTZHNQA Strong Biomarker [222]
IL1RAP TTWS50K Strong Altered Expression [223]
IMP3 TTEJA2R Strong Biomarker [224]
IRAK1 TTXAJWN Strong Biomarker [225]
JAG2 TTOJY1B Strong Altered Expression [226]
KDM4C TTV8CRH Strong Biomarker [227]
KDM5A TTIG67W Strong Biomarker [228]
KIF11 TTBGTCW Strong Biomarker [229]
KLB TTARBVH Strong Altered Expression [230]
KLK1 TT5T3P6 Strong Biomarker [231]
KLK4 TT4319X Strong Altered Expression [231]
KLK5 TTULSEW Strong Altered Expression [232]
LAG3 TTNVXAW Strong Biomarker [233]
LEPR TT0HD6V Strong Altered Expression [234]
LGR5 TTTSGRH Strong Altered Expression [235]
LIFR TTID542 Strong Biomarker [236]
LIPG TTHSZXO Strong Biomarker [237]
LONP1 TTM1VPZ Strong Biomarker [238]
LRP5 TT7VMG4 Strong Biomarker [239]
LRP6 TTSXOWE Strong Biomarker [239]
LTB4R2 TTVJX54 Strong Biomarker [240]
LY75 TTG180Q Strong Altered Expression [241]
MAGEA2 TTOZT28 Strong Biomarker [242]
MAOB TTGP7BY Strong Altered Expression [243]
MAP2K1 TTIDAPM Strong Biomarker [244]
MAP2K5 TTV3O87 Strong Biomarker [245]
MAP3K11 TTETX6Q Strong Biomarker [246]
MAP3K2 TTIX0ZU Strong Biomarker [247]
MAPK7 TTU6FSC Strong Biomarker [245]
MAS1 TTOISYB Strong Altered Expression [248]
MCOLN1 TT9XBVO Strong Biomarker [249]
MELK TTBZOTY Strong Biomarker [250]
MMP11 TTZW4MV Strong Biomarker [251]
MMP17 TTVSZKN Strong Altered Expression [252]
MRGPRX1 TTIX6PK Strong Biomarker [217]
MSLN TT4RXME Strong Altered Expression [253]
MST1R TTBQ3OC Strong Biomarker [254]
MTA1 TTO4HUS Strong Biomarker [255]
MTTP TTUS1RD Strong Biomarker [256]
MYCBP TTVW4XU Strong Biomarker [140]
NECTIN4 TTPO9EG Strong Altered Expression [257]
NEDD4 TT1QU6G Strong Altered Expression [258]
NISCH TT789FN Strong Altered Expression [259]
NOTCH4 TTXDIK2 Strong Altered Expression [154]
NPM1 TTHBS98 Strong Altered Expression [260]
NR3C1 TTOZRK6 Strong Altered Expression [261]
NRP2 TTRXUVC Strong Biomarker [262]
NTSR1 TTTUMEP Strong Biomarker [263]
OXER1 TT7WBSV Strong Biomarker [217]
P4HA1 TTNH25W Strong Altered Expression [264]
PAK4 TT7Y3BZ Strong Biomarker [265]
PCSK5 TTPFWHU Strong Biomarker [266]
PDGFRB TTI7421 Strong Biomarker [267]
PIM1 TTTN5QW Strong Biomarker [238]
PKN2 TTTHO0M Strong Biomarker [268]
PLIN1 TTIV27N Strong Altered Expression [269]
PML TTLH9NY Strong Biomarker [270]
POR TTOQ9GZ Strong Altered Expression [271]
PRKCA TTFJ8Q1 Strong Biomarker [272]
PRKD1 TTSLUMT Strong Altered Expression [179]
PRMT1 TTVOJAI Strong Biomarker [273]
PSMB5 TT68GPI Strong Biomarker [274]
PTK2B TTTEFBV Strong Biomarker [275]
PTK7 TTXH2ZN Strong Biomarker [276]
PTPN7 TT2C1DT Strong Altered Expression [277]
PTPRZ1 TT4SEA8 Strong Altered Expression [278]
RAB7A TTF6WAQ Strong Biomarker [150]
RAC1 TT2M9CG Strong Biomarker [279]
RACK1 TTJ10AL Strong Altered Expression [261]
RAPGEF3 TTOE7I0 Strong Biomarker [280]
RGMA TTURJV4 Strong Biomarker [34]
RIPK2 TTCQ2E5 Strong Biomarker [281]
RPS6KA1 TTIXKA4 Strong Biomarker [282]
SAA1 TTY0DN9 Strong Biomarker [283]
SCN8A TT54ERL Strong Biomarker [284]
SCUBE2 TTWREQP Strong Altered Expression [285]
SETD2 TTPC3H4 Strong Biomarker [286]
SIK2 TTCUGZR Strong Biomarker [287]
SIRT5 TTH0IOD Strong Biomarker [288]
SLC11A2 TT2IS7P Strong Altered Expression [289]
SLC16A1 TTN1J82 Strong Biomarker [188]
SLC25A1 TTTD730 Strong Genetic Variation [290]
SLC27A4 TT20AYF Strong Biomarker [291]
SLC5A1 TT2UE56 Strong Biomarker [292]
SLC9A1 TTGSEFH Strong Biomarker [143]
SMYD2 TT7YJFO Strong Altered Expression [293]
SOX5 TTXHSZK Strong Altered Expression [294]
SPRY1 TT0PSN6 Strong Biomarker [295]
SRD5A1 TTTU72V Strong Biomarker [296]
SRGN TTCHB06 Strong Biomarker [297]
STAR TTEI40H Strong Altered Expression [298]
SUV39H1 TTUWQTK Strong Altered Expression [299]
TACC3 TTQ4UFD Strong Biomarker [300]
TBX21 TTNF9PH Strong Altered Expression [301]
TDO2 TTXNCBV Strong Altered Expression [302]
THRB TTGER3L Strong Biomarker [303]
TKT TT04R7I Strong Biomarker [304]
TNFRSF13B TTL9OD4 Strong Biomarker [305]
TNFSF12 TTBTDM1 Strong Biomarker [306]
TNIK TTPB1W3 Strong Biomarker [121]
TNK2 TTIET93 Strong Biomarker [307]
TNKS TTVUSO7 Strong Biomarker [308]
TNKS2 TTFQI4H Strong Altered Expression [309]
TPH1 TTZSJHV Strong Altered Expression [40]
TRIM59 TT613U4 Strong Altered Expression [310]
TRPV2 TTBECWA Strong Altered Expression [311]
TUSC2 TTJ8O14 Strong Biomarker [312]
TXNRD1 TTR7UJ3 Strong Biomarker [313]
UCHL3 TT23UD6 Strong Biomarker [314]
ULK1 TT4D7MJ Strong Biomarker [315]
VTCN1 TTCK85E Strong Biomarker [316]
ZEB2 TTT2WK4 Strong Biomarker [317]
BRD7 TT07ZS1 Definitive Biomarker [318]
FANCF TTNZKFJ Definitive Posttranslational Modification [319]
GATA3 TT45KOB Definitive Biomarker [320]
LASP1 TTZJA87 Definitive Biomarker [321]
MSI1 TTSM4BA Definitive Biomarker [322]
NES TTHZ752 Definitive Altered Expression [323]
NTF3 TTZHKV9 Definitive Biomarker [324]
RRM1 TTWP0NS Definitive Biomarker [325]
SNCG TT5TQNZ Definitive Altered Expression [326]
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⏷ Show the Full List of 345 DTT(s)
This Disease Is Related to 9 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCC10 DTPS120 Limited Altered Expression [327]
SLC22A23 DTMJK12 moderate Biomarker [328]
ABCA9 DTE3V8W Strong Biomarker [329]
SLC22A17 DTXI9E6 Strong Biomarker [330]
SLC25A16 DTNU9EW Strong Biomarker [331]
SLC2A2 DTUJPOL Strong Biomarker [332]
SLC2A5 DTOR02F Strong Genetic Variation [333]
SLC4A7 DT03V27 Strong Biomarker [143]
SLC52A1 DT7NOKR Strong Biomarker [334]
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⏷ Show the Full List of 9 DTP(s)
This Disease Is Related to 11 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ALDH1A1 DE2JP1Y Limited Altered Expression [154]
DHRS3 DEXPVUN Limited Altered Expression [335]
UBASH3B DE10BJ5 moderate Biomarker [336]
CMPK1 DEMPH4I Strong Altered Expression [337]
CPA4 DEXKD7J Strong Biomarker [338]
CYP7B1 DE36TMY Strong Genetic Variation [339]
MAT2B DEKF1OH Strong Altered Expression [340]
SULT1A1 DEYWLRK Strong Altered Expression [341]
WARS1 DEPVE0M Strong Biomarker [342]
WARS2 DEPTKBQ Strong Biomarker [342]
NDUFS7 DEIW03B Definitive Biomarker [343]
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⏷ Show the Full List of 11 DME(s)
This Disease Is Related to 487 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ALDH1A3 OT1C9NKQ Limited Biomarker [344]
ARR3 OTRZ00CH Limited Biomarker [56]
BARD1 OTTC0Z9Y Limited Genetic Variation [345]
BTN3A2 OT3DIBU3 Limited Biomarker [346]
CBLL2 OTB4AD3V Limited Biomarker [347]
CEMIP OTK80FYN Limited Biomarker [348]
CLDN3 OT71MN9S Limited Altered Expression [349]
CXADR OT9ZP02A Limited Biomarker [56]
DCDC2 OTSUFH1H Limited Genetic Variation [350]
DNER OT2GH2E5 Limited Biomarker [81]
DUSP4 OT6WAO12 Limited Altered Expression [351]
ELAVL2 OT6EJ8MQ Limited Biomarker [352]
ELK1 OTH9MXD6 Limited Altered Expression [353]
ERO1A OTVKOQWM Limited Altered Expression [354]
FOXA1 OTEBY0TD Limited Biomarker [355]
FZD1 OTZATHVS Limited Genetic Variation [356]
FZD5 OTXFFY56 Limited Genetic Variation [356]
GHRH OT94U6MO Limited Biomarker [357]
GINS2 OT974IYI Limited Biomarker [358]
GNL3 OTILGYO4 Limited Altered Expression [359]
GOT2 OT6XBWN0 Limited Biomarker [360]
GRB7 OTF8Y9XY Limited Biomarker [361]
HPS5 OTLO2374 Limited Genetic Variation [350]
ID4 OTPMJ39I Limited Biomarker [362]
ILRUN OTE8FHQD Limited Biomarker [363]
ISL1 OTVNVKAX Limited Altered Expression [364]
ITGB5 OT21MF51 Limited Biomarker [365]
JMJD6 OTILR7E4 Limited Altered Expression [366]
JMY OTH5FFVK Limited Biomarker [367]
KIF22 OTY6X6BL Limited Biomarker [368]
KLF5 OT1ABI9N Limited Biomarker [369]
KRT5 OTVGI9HT Limited Altered Expression [370]
LGALS8 OT71LJ8T Limited Biomarker [371]
MPEG1 OT7DAO0F Limited Biomarker [41]
MSH6 OT46FP09 Limited Biomarker [372]
MTBP OTWLCW9C Limited Altered Expression [373]
MUL1 OT2JC9YR Limited Biomarker [347]
MYOF OTRFC3IJ Limited Biomarker [374]
MZF1 OTMVZCPW Limited Biomarker [353]
NUP98 OTNT12G2 Limited Altered Expression [375]
OBP2A OTBIJ5TI Limited Biomarker [368]
OC90 OT7K2WV8 Limited Biomarker [376]
PAEP OTQA0NV4 Limited Biomarker [377]
PARVA OTLKEWRY Limited Altered Expression [378]
PDLIM2 OTEURRPD Limited Biomarker [379]
PELP1 OTVXQNOT Limited Biomarker [137]
PIWIL1 OT7CRGZ3 Limited Biomarker [380]
PIWIL4 OTDA9MY0 Limited Biomarker [380]
PRKAA1 OT7TNF0L Limited Altered Expression [381]
PRKAA2 OTU1KZPV Limited Altered Expression [381]
PRKAB1 OT1OG4QZ Limited Altered Expression [381]
PTPN22 OTDCNTC3 Limited Biomarker [382]
RASA4 OTW0178L Limited Biomarker [74]
RPLP1 OT7B0SIB Limited Altered Expression [383]
RPS27 OTFXKY7P Limited Biomarker [41]
SARNP OTE0OVK5 Limited Altered Expression [384]
SMAD2 OTC6VB4K Limited Biomarker [385]
SOX4 OTSS40SS Limited Altered Expression [386]
SOX8 OTEJXYZM Limited Biomarker [387]
SRSF3 OTOFT707 Limited Biomarker [261]
TRIM13 OTQIUACB Limited Biomarker [56]
CRABP1 OTISDG5X Disputed Biomarker [388]
RAB1B OTAFCUAS Disputed Biomarker [389]
ACSL4 OTI71MUJ moderate Altered Expression [390]
ADAM12 OTZKOTDB moderate Biomarker [391]
ANKRD36B OT3MW415 moderate Altered Expression [242]
ANTXR1 OT5W1GPC moderate Biomarker [392]
ARHGAP24 OTCQCEZS moderate Biomarker [393]
ARRDC3 OTAKW7R9 moderate Biomarker [394]
AXIN2 OTRMGQNU moderate Biomarker [197]
BAD OT63ERYM moderate Biomarker [395]
BHLHE41 OTY9GJ1Y moderate Biomarker [396]
BTG2 OTZF6K1H moderate Biomarker [397]
C16orf82 OT77Z5Y5 moderate Genetic Variation [398]
CADM4 OT0TFMFE moderate Altered Expression [399]
CBX3 OTOP9RLD moderate Altered Expression [114]
CDCP1 OTD7RRWK moderate Altered Expression [400]
CHD4 OTBDEHDP moderate Biomarker [401]
CILK1 OTWOYEYP moderate Biomarker [402]
CKAP4 OTDUC9ME moderate Biomarker [403]
CLDN1 OT27KV99 moderate Biomarker [404]
COL11A2 OT3BQUBH moderate Biomarker [124]
CPEB2 OTKES4YR moderate Altered Expression [405]
DOCK1 OTCFV3ON moderate Altered Expression [406]
EDIL3 OTDVVNS0 moderate Altered Expression [407]
EIF4B OTE8TXA8 moderate Altered Expression [408]
ERCC1 OTNPYQHI moderate Biomarker [409]
ETV1 OT6PMJIK moderate Biomarker [410]
FANCI OTW8E3SC moderate Biomarker [411]
H2AX OT18UX57 moderate Posttranslational Modification [366]
HCP5 OTV0YRI8 moderate Altered Expression [412]
IKBKE OT5VYOSM moderate Biomarker [413]
ISYNA1 OT49ONSE moderate Biomarker [414]
ITGB4 OT28UK84 moderate Biomarker [415]
KIN OTB2DNQU moderate Biomarker [416]
LRPPRC OTXSK5LP moderate Biomarker [417]
MAP1LC3A OTPMGIU4 moderate Biomarker [418]
MAP1LC3B OTUYHB84 moderate Biomarker [418]
MECOM OTP983W8 moderate Altered Expression [174]
MOK OTQK7M9V moderate Altered Expression [215]
MTA2 OTCCYIQJ moderate Biomarker [419]
MTG1 OTC9U1LI moderate Altered Expression [279]
MTMR3 OTBIT23O moderate Altered Expression [420]
NOC2L OTNT7R33 moderate Biomarker [135]
NTS OTPGDNQS moderate Biomarker [421]
NUSAP1 OT85HIJ5 moderate Biomarker [422]
PALB2 OT6DNDBG moderate Genetic Variation [423]
PDCD4 OTZ6NXUX moderate Altered Expression [408]
PEA15 OTKCKTSX moderate Altered Expression [424]
PIP OTH719AH moderate Biomarker [425]
PMAIP1 OTXEE550 moderate Biomarker [426]
POLR2A OTHJQ1DZ moderate Biomarker [427]
PVR OT3N91T7 moderate Biomarker [428]
RAB6A OTLS86J5 moderate Altered Expression [279]
RASAL2 OTGMMX6W moderate Biomarker [429]
SDCBP OTS3NCC5 moderate Biomarker [430]
SFRP2 OT8GZ0CA moderate Biomarker [431]
SGSM3 OTIB1P8A moderate Biomarker [432]
SIX2 OTYOVGSC moderate Altered Expression [433]
SLC16A4 OT1YXBKC moderate Altered Expression [143]
SMC1A OT9ZMRK9 moderate Altered Expression [434]
SMG1 OTTS3SXE moderate Biomarker [183]
SMN2 OT54RLO1 moderate Biomarker [146]
SNAI2 OT7Y8EJ2 moderate Altered Expression [79]
SPAG5 OTCLJ56M moderate Altered Expression [140]
SPAG9 OT45AHMB moderate Biomarker [435]
SPANXB1 OTLMGC9T moderate Biomarker [436]
SRSF2 OTVDHO6U moderate Altered Expression [437]
TEAD1 OTK6971C moderate Biomarker [438]
TFPI2 OTZCRWOR moderate Biomarker [438]
TLE3 OTR9PH95 moderate Altered Expression [439]
TNNT1 OT8PBOAR moderate Genetic Variation [398]
TP73 OT0LUO47 moderate Biomarker [393]
ADSL OTSNJALL Strong Biomarker [96]
AHNAK OT6KH1WG Strong Biomarker [440]
ALPK1 OTBW6SGD Strong Biomarker [441]
ALX3 OTXZ25PZ Strong Biomarker [442]
ANKRD1 OTHJ7JV9 Strong Altered Expression [443]
ANP32E OTTWELUQ Strong Biomarker [444]
ANXA3 OTDD8OI7 Strong Altered Expression [445]
AP1S3 OTPCMV24 Strong Altered Expression [446]
AQP5 OT77GBY8 Strong Altered Expression [162]
ARHGAP1 OT0H2ZBZ Strong Altered Expression [447]
ARHGAP18 OTYMJP6H Strong Altered Expression [447]
ARID1B OTILK3Q7 Strong Altered Expression [448]
ASPM OTKXQMNA Strong Biomarker [449]
ATAD5 OTI8ABKF Strong Genetic Variation [450]
ATG9A OTAZWZH7 Strong Biomarker [451]
ATXN1 OTQF0HNR Strong Biomarker [452]
B3GNT3 OTVT1Q25 Strong Altered Expression [453]
BABAM1 OTCFPER6 Strong Genetic Variation [454]
BABAM2 OTOY7FNT Strong Genetic Variation [454]
BAG2 OTI6LD27 Strong Altered Expression [455]
BAG3 OTVXYUDQ Strong Biomarker [456]
BCAP31 OTKSACR4 Strong Biomarker [457]
BCAR1 OTKT2C2N Strong Altered Expression [458]
BCCIP OTFFKG79 Strong Genetic Variation [459]
BCL10 OT47MCLI Strong Biomarker [213]
BCL2L12 OTS6IFZY Strong Altered Expression [460]
BCL2L14 OT87E7HW Strong Genetic Variation [461]
BCL3 OT1M5B95 Strong Biomarker [462]
BHLHE40 OTITX14U Strong Altered Expression [105]
BID OTOSHSHU Strong Biomarker [463]
BMS1 OTEGQ8ZO Strong Biomarker [464]
BNIP3L OTJKOMXE Strong Biomarker [415]
BRCC3 OTK0ZN7Y Strong Genetic Variation [454]
BRMS1 OTV5A6LL Strong Altered Expression [465]
BTRC OT2EZDGR Strong Biomarker [466]
C1D OTI9PMN1 Strong Biomarker [467]
CALML3 OTM8DNQU Strong Biomarker [468]
CCDC54 OTW5WCX9 Strong Altered Expression [469]
CCN5 OTADU8JJ Strong Biomarker [470]
CCN6 OTRFHQ2Z Strong Biomarker [471]
CCNG1 OT17IA9L Strong Altered Expression [472]
CCNG2 OTII38K2 Strong Biomarker [473]
CCS OTXHT3QO Strong Biomarker [474]
CCT3 OTL6EOS1 Strong Genetic Variation [475]
CCT4 OT5D452X Strong Biomarker [476]
CD5L OTPY4WQR Strong Biomarker [175]
CD8A OTDWQJXK Strong Altered Expression [82]
CDC27 OTDT45XJ Strong Biomarker [477]
CDCA4 OT0AAXAC Strong Biomarker [478]
CDCA7 OT12HDZY Strong Biomarker [479]
CENPA OT0NEJ4X Strong Altered Expression [480]
CENPK OTKPUF8K Strong Biomarker [449]
CENPU OTQ4TZRS Strong Biomarker [481]
CHGB OT7SAQT2 Strong Genetic Variation [482]
CHMP2B OTZA7RJB Strong Altered Expression [289]
CHMP3 OT0963JJ Strong Altered Expression [483]
CHST9 OT1DEZRM Strong Genetic Variation [484]
CIP2A OTVS2GXA Strong Biomarker [485]
CLDN7 OTNE0XHQ Strong Biomarker [404]
CLEC2D OTVRLKPM Strong Biomarker [486]
CLTA OTLHOXMQ Strong Altered Expression [139]
CNOT9 OT1NIIQD Strong Altered Expression [275]
COL4A2 OTJK1LKN Strong Biomarker [487]
COL9A1 OTWBR27Y Strong Biomarker [284]
COL9A2 OT1ZBDBV Strong Biomarker [284]
COL9A3 OTCUJOEK Strong Biomarker [284]
COMP OTS2FPMI Strong Biomarker [284]
CORO1C OTXDF9T3 Strong Biomarker [488]
COTL1 OT6YCNLF Strong Biomarker [468]
CRAMP1 OT0X95YA Strong Biomarker [234]
CRB3 OTQKPTMU Strong Altered Expression [489]
CREB3L1 OT2JHIHM Strong Biomarker [490]
CSRP3 OTECBJMV Strong Biomarker [468]
CT83 OTQEGHAB Strong Altered Expression [491]
CUL1 OTXPE1UZ Strong Biomarker [492]
CYGB OTX153DQ Strong Altered Expression [493]
CYTB OTAHB98A Strong Altered Expression [494]
DAAM1 OT0VHIYZ Strong Altered Expression [495]
DAP OT5YLL7E Strong Biomarker [496]
DAXX OTX6O7PL Strong Biomarker [497]
DBP OTE0W7LN Strong Biomarker [498]
DCTN6 OTI8PIN9 Strong Altered Expression [499]
DDB2 OTO8HVVB Strong Altered Expression [500]
DEDD OTIL349E Strong Biomarker [501]
DHX37 OTM1A5KP Strong Biomarker [502]
DHX40 OTOL02QN Strong Biomarker [503]
DIAPH3 OTPOT23F Strong Altered Expression [504]
DLK2 OT56Y83S Strong Biomarker [505]
DMRT1 OT5PU9U1 Strong Altered Expression [289]
DOK1 OTGVRLW6 Strong Biomarker [506]
DSC1 OTNII6GZ Strong Biomarker [507]
DUSP6 OT4H6RKW Strong Biomarker [508]
DVL1 OTD67RF1 Strong Biomarker [509]
E2F6 OT2PN28R Strong Altered Expression [510]
ECT2 OTQDUCT6 Strong Biomarker [511]
EEF1A2 OT9Z23K5 Strong Altered Expression [512]
EFNA4 OTITKZQH Strong Altered Expression [513]
EI24 OTD4NOYS Strong Biomarker [514]
EIF4G1 OT2CF1E6 Strong Biomarker [515]
ELMO1 OTY2ORXK Strong Biomarker [516]
ELOVL1 OTIDTQ8R Strong Biomarker [517]
ELOVL5 OT375W1Z Strong Biomarker [517]
ENY2 OTTNU8RK Strong Altered Expression [518]
EPSTI1 OT75I1UH Strong Biomarker [519]
ERCC4 OTFIOPG1 Strong Genetic Variation [520]
ERCC6L OTE9V7D9 Strong Biomarker [521]
ESM1 OT331Y8V Strong Altered Expression [522]
ESRP1 OTNCS4SL Strong Biomarker [523]
EYA3 OTHLP1J3 Strong Biomarker [524]
FA2H OT8HA13U Strong Biomarker [525]
FABP7 OTRE2H4G Strong Biomarker [526]
FAM171A1 OT33BHEP Strong Biomarker [527]
FAM20C OTW5YZ7X Strong Biomarker [528]
FANCD2 OTVEB5LF Strong Biomarker [529]
FANCM OTNJG99Z Strong Genetic Variation [530]
FBLIM1 OTFHXMON Strong Biomarker [531]
FBXO5 OTTR957W Strong Biomarker [532]
FERD3L OTW351LV Strong Biomarker [73]
FHOD1 OTROM7N3 Strong Biomarker [533]
FOXE3 OTAUDKC1 Strong Biomarker [534]
FOXO3 OTHXQG4P Strong Altered Expression [535]
FOXO4 OT90X9LN Strong Altered Expression [536]
FSIP1 OTYLL6GM Strong Biomarker [537]
FZD6 OTBCPII8 Strong Altered Expression [356]
FZD8 OTZ9IRFL Strong Altered Expression [538]
GABARAPL1 OT4U7SBG Strong Biomarker [539]
GAS1 OTKJXG52 Strong Biomarker [540]
GBP1 OTUM7RPJ Strong Altered Expression [541]
GDF10 OTEVXGJ7 Strong Altered Expression [542]
GDF11 OTOSNMND Strong Biomarker [266]
GFPT1 OTQBDO45 Strong Altered Expression [543]
GFRA1 OT3WBVYB Strong Biomarker [544]
GGNBP2 OT7K9YZV Strong Altered Expression [545]
GLCE OTPRSHX5 Strong Genetic Variation [546]
GLRX3 OTUPAU1N Strong Biomarker [547]
GOPC OTRBGH71 Strong Biomarker [531]
GPR151 OT7EACU6 Strong Biomarker [217]
GPR161 OT80FYA3 Strong Biomarker [217]
GPS1 OT97FRYE Strong Biomarker [121]
GTF2H4 OTPD1DIU Strong Altered Expression [413]
GTSE1 OTPP742Z Strong Altered Expression [548]
H2BC12 OTQ8V0KG Strong Altered Expression [549]
HAND2 OTCXYW4Y Strong Altered Expression [550]
HBG1 OTVL4NSU Strong Biomarker [169]
HBG2 OT4J48JJ Strong Biomarker [169]
HCLS1 OTX7WGYN Strong Altered Expression [61]
HEATR6 OTD3MYS0 Strong Altered Expression [551]
HGS OTCYYCAC Strong Biomarker [552]
HNRNPK OTNPRM8U Strong Biomarker [553]
HNRNPM OTFU3OEZ Strong Genetic Variation [554]
HOXC6 OTBCRAZV Strong Biomarker [555]
HOXC8 OTJUYU8J Strong Biomarker [556]
HOXD13 OTWSC8TF Strong Biomarker [557]
HYAL2 OTTVINXW Strong Genetic Variation [558]
IFI27 OTI2XGIT Strong Altered Expression [499]
IFIT2 OTI4EOAR Strong Altered Expression [559]
IGF2BP2 OT4ZSEEE Strong Biomarker [224]
IGF2BP3 OTB97VIK Strong Altered Expression [560]
IL2RG OTRZ3OMY Strong Altered Expression [561]
IMMP2L OT9WGAFD Strong Biomarker [224]
INF2 OT8ZM13C Strong Biomarker [533]
ING2 OT6H0EWF Strong Altered Expression [82]
INPP4B OTLROA7G Strong Altered Expression [562]
IRF9 OTK4MYQJ Strong Altered Expression [563]
ITGA3 OTBCH21D Strong Altered Expression [564]
ITGA9 OTHN1IKA Strong Altered Expression [565]
JPT2 OTJGPA4T Strong Altered Expression [234]
KAT5 OTL7257A Strong Biomarker [566]
KCNH4 OTHJ8WTU Strong Altered Expression [567]
KCNH8 OT3I5FLB Strong Altered Expression [567]
KCNMB2 OTBXUQGK Strong Biomarker [518]
KDM2B OTDMCVW7 Strong Biomarker [568]
KDM8 OTCN5ST8 Strong Altered Expression [569]
KHSRP OTDHZARB Strong Altered Expression [61]
KIF14 OTXHT4JM Strong Posttranslational Modification [570]
KIF15 OTJRJEXL Strong Altered Expression [571]
KIF4A OT3UWL7D Strong Biomarker [572]
KIFC1 OTNQDS00 Strong Biomarker [573]
KLRB1 OTQ2959Y Strong Biomarker [486]
LAMA4 OTHI7TA0 Strong Biomarker [574]
LATS1 OTOOCG4R Strong Biomarker [575]
LGALS9 OT7MF91K Strong Altered Expression [576]
LIN9 OTLHW00C Strong Genetic Variation [577]
LNPK OTOBNX6G Strong Biomarker [422]
LOXL4 OT6XY2JL Strong Biomarker [578]
LPIN1 OTQ75KF2 Strong Altered Expression [579]
LRG1 OTLD0KWA Strong Biomarker [580]
LRP8 OTZ71YV2 Strong Biomarker [581]
LRRC26 OTXEFL76 Strong Biomarker [582]
LZTS1 OTXXL864 Strong Altered Expression [583]
MAFK OTZJUE4P Strong Biomarker [216]
MAPK13 OT0W9GE7 Strong Altered Expression [175]
MAPK8IP2 OTDUHLN0 Strong Biomarker [584]
MATN1 OTBRTCTQ Strong Altered Expression [337]
MBD2 OTUQPP0R Strong Altered Expression [437]
MCAT OTH07FIW Strong Biomarker [188]
MCTS1 OT7SAOJP Strong Biomarker [188]
MED1 OTOO24C4 Strong Biomarker [585]
MESD OT3B2H8F Strong Altered Expression [586]
MGP OTZWU3FU Strong Biomarker [556]
MMAB OTOWOEJN Strong Altered Expression [494]
MORC2 OT52A8BJ Strong Genetic Variation [554]
MRE11 OTGU8TZM Strong Biomarker [587]
MRGPRX3 OTRKCCDS Strong Biomarker [217]
MRGPRX4 OTOBHZVA Strong Biomarker [217]
NANOG OTUEY1FM Strong Biomarker [588]
NAPSA OT6F8IAL Strong Biomarker [425]
NCAPD2 OT8VGE2O Strong Biomarker [589]
NCAPG OT1AI9EO Strong Biomarker [329]
NCR3LG1 OT15YWU7 Strong Altered Expression [590]
NEDD4L OT1B19RU Strong Altered Expression [591]
NFIB OTX94PD0 Strong Biomarker [125]
NOL3 OT1K0L0D Strong Biomarker [592]
NONO OTN36Q6U Strong Biomarker [222]
NR2C2 OTDZWVOJ Strong Biomarker [120]
NRF1 OTOXWNV8 Strong Biomarker [593]
NRIP1 OTIZOJQV Strong Altered Expression [594]
NSD2 OTQ6SW4R Strong Biomarker [595]
NUDT18 OT03IQA5 Strong Biomarker [596]
PADI1 OT13WAQX Strong Biomarker [597]
PARD3 OTH5BPLO Strong Biomarker [208]
PCBP4 OTDLL4NB Strong Biomarker [598]
PCDHGB7 OTBNJN7B Strong Biomarker [599]
PCGF2 OTIY1J5L Strong Biomarker [600]
PDIK1L OTISF4KG Strong Altered Expression [180]
PEX14 OT98BZHE Strong Biomarker [601]
PFDN5 OTTKPTUP Strong Altered Expression [140]
PFN1 OTHTGA1H Strong Altered Expression [602]
PIK3R3 OTXGJ8N1 Strong Biomarker [603]
PIMREG OTKC8T3E Strong Altered Expression [480]
PKD1 OT5ALRZ5 Strong Biomarker [604]
PKD2 OTIXBU8H Strong Altered Expression [605]
PLCD1 OT6WFVXZ Strong Biomarker [606]
PLXNA1 OTN0BING Strong Biomarker [607]
POLD1 OTWO4UCJ Strong Biomarker [179]
POLE OTFM3MMU Strong Genetic Variation [372]
POU3F3 OT6BBXPD Strong Biomarker [608]
PPL OTTM4WDO Strong Altered Expression [175]
PRDM13 OTUNAFQW Strong Biomarker [609]
PRDM14 OTWZKY4L Strong Biomarker [610]
PRF1 OTFVXD7H Strong Biomarker [611]
PRICKLE1 OT9HHEM9 Strong Biomarker [511]
PRKD2 OTIFSVI8 Strong Altered Expression [179]
PRKD3 OT987HJI Strong Altered Expression [179]
PROCR OTRHED17 Strong Biomarker [612]
PRRX1 OTTZK5G8 Strong Biomarker [613]
PRRX2 OT8UR4AU Strong Biomarker [614]
PSMC3IP OT9UB5UO Strong Biomarker [519]
PSMD14 OTJWHMZ5 Strong Biomarker [597]
PSMD9 OT6Y5CC3 Strong Altered Expression [499]
PTPN12 OT5WA666 Strong Biomarker [615]
PTPN3 OTSLZBVY Strong Biomarker [616]
PTPRA OTZA82J1 Strong Biomarker [277]
PTPRF OTH5KF2D Strong Biomarker [617]
RAB1A OTKPHRD0 Strong Altered Expression [618]
RAB27A OT9SQRWY Strong Biomarker [251]
RAB5A OTFR2KM4 Strong Biomarker [279]
RAB7B OT60A0E9 Strong Biomarker [150]
RABEP2 OTO61X27 Strong Biomarker [619]
RAD51AP1 OTXM7UTD Strong Altered Expression [620]
RAD51D OTKOU5XN Strong Genetic Variation [621]
RASGRF1 OTNWJ7EN Strong Biomarker [88]
RASGRP1 OTX9WN2E Strong Biomarker [622]
RASSF6 OT25GVWY Strong Biomarker [623]
RBM3 OTAJ7R31 Strong Altered Expression [624]
RCOR1 OTREADPC Strong Biomarker [113]
RECQL OTPCH3JH Strong Biomarker [625]
RECQL5 OTVZMP1Q Strong Biomarker [626]
REST OTLL92LQ Strong Altered Expression [341]
RFC3 OT1MS7AO Strong Biomarker [627]
RGS20 OT6CGYHW Strong Biomarker [628]
RGS3 OTYG5OXI Strong Biomarker [629]
RIT1 OTVNOGOH Strong Biomarker [630]
RMDN2 OTK5WSFI Strong Biomarker [631]
RNF8 OTRR43PZ Strong Posttranslational Modification [632]
RPA1 OT76POLP Strong Altered Expression [633]
RPL39 OTL8TZHQ Strong Genetic Variation [634]
RPTOR OT4TQZ9F Strong Biomarker [635]
RSRC2 OTLE0KQM Strong Biomarker [636]
SAA2 OTYAVJWG Strong Biomarker [283]
SAFB OTGRV2LW Strong Biomarker [637]
SASH1 OTQA8BD4 Strong Genetic Variation [638]
SATB2 OT2W80XC Strong Biomarker [639]
SCGB3A1 OTIR98RB Strong Biomarker [496]
SCYL1 OTQ0IN7P Strong Biomarker [640]
SDS OT5WTJ2M Strong Biomarker [641]
SEMG1 OT6Z4BPQ Strong Genetic Variation [482]
SENP2 OTPQJXIR Strong Biomarker [642]
SEPHS2 OTTFXROR Strong Altered Expression [643]
SEPTIN4 OTD16B30 Strong Biomarker [644]
SET OTGYYQJO Strong Altered Expression [645]
SETBP1 OTKGCOSR Strong Biomarker [646]
SETD1A OTVVWRIC Strong Biomarker [580]
SFPQ OTLCIAPJ Strong Biomarker [222]
SIAH1 OT29A838 Strong Altered Expression [647]
SIDT1 OTJM5S74 Strong Biomarker [648]
SIGLEC7 OTNDLURR Strong Altered Expression [61]
SIN3A OTM8OZWV Strong Biomarker [169]
SIN3B OTFB59FK Strong Altered Expression [649]
SKA1 OTDYJ12A Strong Biomarker [650]
SKI OT4KJ8F6 Strong Biomarker [651]
SLC22A18 OT9C3KR4 Strong Biomarker [637]
SLFN12 OTTBXM25 Strong Altered Expression [652]
SLN OTERIU75 Strong Biomarker [653]
SMARCD3 OTLLG86W Strong Altered Expression [654]
SMR3B OTL5HNM8 Strong Biomarker [655]
SMURF2 OT3TRVL7 Strong Altered Expression [656]
SOD3 OTIOZQAB Strong Biomarker [657]
SPA17 OT8J7T7U Strong Altered Expression [469]
SPATA2 OTOA45GL Strong Altered Expression [658]
SPDYA OTYKC1AJ Strong Genetic Variation [659]
SPIN1 OT69VAOX Strong Altered Expression [660]
SPOP OTP0107S Strong Biomarker [661]
SPPL3 OT2HLJF6 Strong Biomarker [224]
SRL OT7IEBWZ Strong Biomarker [662]
SSBP1 OTH2PZWH Strong Biomarker [663]
ST3GAL6 OTB17Q43 Strong Altered Expression [664]
ST6GAL1 OT7US3NO Strong Altered Expression [665]
ST8SIA1 OTGND2YZ Strong Biomarker [666]
STING1 OTDAP4G0 Strong Biomarker [667]
SYNPO2 OTC3U0YH Strong Biomarker [668]
TAB1 OTPM6F85 Strong Altered Expression [669]
TARBP2 OT1QQ8H3 Strong Biomarker [670]
TBCE OTGBSTKS Strong Genetic Variation [671]
TBX1 OTQLBPRA Strong Altered Expression [672]
TET1 OTZDHT1D Strong Biomarker [673]
TEX9 OTMYCDCW Strong Biomarker [601]
TFCP2L1 OT7QIJ0X Strong Biomarker [674]
TGFBR3 OTQOOUC4 Strong Biomarker [675]
THBS2 OTXET551 Strong Biomarker [676]
TICAM2 OTK7GIJ5 Strong Altered Expression [499]
TIMM8A OTDX9687 Strong Biomarker [677]
TINAGL1 OTZZO56M Strong Biomarker [678]
TM4SF1 OTY0ECQN Strong Biomarker [679]
TMED7 OTONO8E6 Strong Altered Expression [499]
TMEM17 OTEU00OH Strong Altered Expression [680]
TMEM88 OTA96YEL Strong Biomarker [681]
TNMD OTHLVA9G Strong Biomarker [531]
TNS3 OTPG2D8Z Strong Altered Expression [682]
TRA2A OT5NHOO3 Strong Biomarker [636]
TRIB3 OTG5OS7X Strong Biomarker [683]
TRIML2 OT5QWTD2 Strong Altered Expression [684]
TTF1 OT4K90WD Strong Biomarker [425]
CHPT1 OT4FJ0K3 Definitive Biomarker [685]
DHDDS OTVLYBUS Definitive Biomarker [685]
EIF4A2 OT08H03R Definitive Biomarker [515]
LDHB OT9B1CT3 Definitive Biomarker [686]
NDUFS4 OTJKUYEE Definitive Genetic Variation [343]
RAB25 OTW0W6NP Definitive Biomarker [687]
RND1 OTOC223Z Definitive Biomarker [688]
SOX10 OTF25ULQ Definitive Altered Expression [320]
TIPIN OT9PZHXV Definitive Biomarker [689]
TMSB15A OTSBWCES Definitive Altered Expression [690]
TOX3 OTC9NR4W Definitive Genetic Variation [691]
------------------------------------------------------------------------------------
⏷ Show the Full List of 487 DOT(s)

References

1 ClinicalTrials.gov (NCT03997123) Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC (CAPItello-290). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 ClinicalTrials.gov (NCT03562637) Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC. U.S. National Institutes of Health.
4 ClinicalTrials.gov (NCT01262027) TKI258 for Metastatic Inflammatory Breast Cancer Patients. U.S. National Institutes of Health.
5 ClinicalTrials.gov (NCT03184558) Bemcentinib (BGB324) in Combination With Pembrolizumab in Patients With TNBC. U.S. National Institutes of Health.
6 ClinicalTrials.gov (NCT04634747) A Single-Arm, Open-Label, Multi-Center Phase II Study to Evaluate the Combination of PVX-410 + Pembrolizumab + Chemotherapy for Frontline Therapy of Metastatic, PD-L1+ Triple-Negative Breast Cancer (TNBC) in HLA-A2-Positive Patients. U.S. National Institutes of Health.
7 ClinicalTrials.gov (NCT02580747) Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART-meso
8 ClinicalTrials.gov (NCT03674827) Vaccine-Based Immunotherapy Regimen For NSCLC and TNBC. U.S. National Institutes of Health.
9 ClinicalTrials.gov (NCT04553133) PF-07104091 as a Single Agent and in Combination Therapy. U.S. National Institutes of Health.
10 ClinicalTrials.gov (NCT04115306) Phase 1/1b Study of Oral PMD-026 in Patients With Metastatic Breast Cancer and Metastatic Triple Negative Breast Cancer. U.S. National Institutes of Health.
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35 Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway.J Hematol Oncol. 2019 Jun 11;12(1):60. doi: 10.1186/s13045-019-0744-3.
36 Cell growth inhibition and apoptosis in breast cancer cells induced by anti-FZD7 scFvs: involvement of bioinformatics-based design of novel epitopes.Breast Cancer Res Treat. 2018 Jun;169(3):427-436. doi: 10.1007/s10549-017-4641-6. Epub 2018 Feb 6.
37 Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer.Sci Rep. 2018 Oct 30;8(1):16008. doi: 10.1038/s41598-018-34502-8.
38 Cytotoxic Activity of the Histone Deacetylase 3-Selective Inhibitor Pojamide on MDA-MB-231 Triple-Negative Breast Cancer Cells.Int J Mol Sci. 2019 Feb 13;20(4):804. doi: 10.3390/ijms20040804.
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41 Molecular design and anticancer activities of small-molecule monopolar spindle 1 inhibitors: A Medicinal chemistry perspective.Eur J Med Chem. 2019 Aug 1;175:247-268. doi: 10.1016/j.ejmech.2019.04.047. Epub 2019 Apr 20.
42 The opposing effects of interferon-beta and oncostatin-M as regulators of cancer stem cell plasticity in triple-negative breast cancer.Breast Cancer Res. 2019 Apr 29;21(1):54. doi: 10.1186/s13058-019-1136-x.
43 Avelumab, an IgG1 anti-PD-L1 Immune Checkpoint Inhibitor, Triggers NK Cell-Mediated Cytotoxicity and Cytokine Production Against Triple Negative Breast Cancer Cells.Front Immunol. 2018 Sep 20;9:2140. doi: 10.3389/fimmu.2018.02140. eCollection 2018.
44 Stromal integrin 11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors.BMC Cancer. 2019 Mar 15;19(1):234. doi: 10.1186/s12885-019-5449-z.
45 Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population.Stem Cell Reports. 2017 May 9;8(5):1392-1407. doi: 10.1016/j.stemcr.2017.03.026. Epub 2017 Apr 27.
46 FOXM1 transcriptionally regulates expression of integrin 1 in triple-negative breast cancer.Breast Cancer Res Treat. 2017 Jun;163(3):485-493. doi: 10.1007/s10549-017-4207-7. Epub 2017 Mar 30.
47 Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development.Front Endocrinol (Lausanne). 2018 Apr 30;9:192. doi: 10.3389/fendo.2018.00192. eCollection 2018.
48 Prognostic significance of LAPTM4B and p27kip1 expression in triple-negative breast cancer.Cancer Biomark. 2019;25(1):19-27. doi: 10.3233/CBM-182094.
49 Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer.Cell Metab. 2018 Jul 3;28(1):87-103.e6. doi: 10.1016/j.cmet.2018.04.022. Epub 2018 May 24.
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51 Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells.Breast Cancer Res. 2019 Jan 14;21(1):5. doi: 10.1186/s13058-018-1094-8.
52 A novel metadherin7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFB-SIRT3 axis.Oncogene. 2020 Mar;39(10):2088-2102. doi: 10.1038/s41388-019-1126-6. Epub 2019 Dec 5.
53 NLRX1 regulates TNF--induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells.Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1460-1476. doi: 10.1016/j.bbadis.2019.02.018. Epub 2019 Feb 23.
54 Sorafenib analogue SC-60 induces apoptosis through the SHP-1/STAT3 pathway and enhances docetaxel cytotoxicity in triple-negative breast cancer cells.Mol Oncol. 2017 Mar;11(3):266-279. doi: 10.1002/1878-0261.12033. Epub 2017 Feb 7.
55 High expression of NR1D1 is associated with good prognosis in triple-negative breast cancer patients treated with chemotherapy.Breast Cancer Res. 2019 Nov 28;21(1):127. doi: 10.1186/s13058-019-1197-x.
56 EGFR-specific CAR-T cells trigger cell lysis in EGFR-positive TNBC.Aging (Albany NY). 2019 Dec 4;11(23):11054-11072. doi: 10.18632/aging.102510. Epub 2019 Dec 4.
57 A Novel Specific Anti-CD73 Antibody Inhibits Triple-Negative Breast Cancer Cell Motility by Regulating Autophagy.Int J Mol Sci. 2019 Feb 28;20(5):1057. doi: 10.3390/ijms20051057.
58 Phosphodiesterase 7B/microRNA-200c relationship regulates triple-negative breast cancer cell growth.Oncogene. 2019 Feb;38(7):1106-1120. doi: 10.1038/s41388-018-0499-2. Epub 2018 Sep 12.
59 Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells.Mol Cells. 2019 Sep 30;42(9):628-636. doi: 10.14348/molcells.2019.0038.
60 Therapeutic potential of PLK1 inhibition in triple-negative breast cancer.Lab Invest. 2019 Sep;99(9):1275-1286. doi: 10.1038/s41374-019-0247-4. Epub 2019 Apr 17.
61 Inhibition of Triple-Negative Breast Cancer Tumor Growth by Electroacupuncture with Encircled Needling and Its Mechanisms in a Mice Xenograft Model.Int J Med Sci. 2019 Nov 9;16(12):1642-1651. doi: 10.7150/ijms.38521. eCollection 2019.
62 PPAR Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers.Mol Cancer Ther. 2017 Nov;16(11):2528-2542. doi: 10.1158/1535-7163.MCT-16-0739. Epub 2017 Aug 15.
63 Strictinin, a novel ROR1-inhibitor, represses triple negative breast cancer survival and migration via modulation of PI3K/AKT/GSK3 activity.PLoS One. 2019 May 31;14(5):e0217789. doi: 10.1371/journal.pone.0217789. eCollection 2019.
64 Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer.Mol Cancer Ther. 2016 Nov;15(11):2598-2608. doi: 10.1158/1535-7163.MCT-16-0106. Epub 2016 Aug 15.
65 Eribulin Synergistically Increases Anti-Tumor Activity of an mTOR Inhibitor by Inhibiting pAKT/pS6K/pS6 in Triple Negative Breast Cancer.Cells. 2019 Aug 30;8(9):1010. doi: 10.3390/cells8091010.
66 Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer.Oncogene. 2018 Oct;37(43):5701-5718. doi: 10.1038/s41388-018-0368-z. Epub 2018 Jun 18.
67 miR-4458 regulates cell proliferation and apoptosis through targeting SOCS1 in triple-negative breast cancer.J Cell Biochem. 2019 Aug;120(8):12943-12948. doi: 10.1002/jcb.28565. Epub 2019 Mar 14.
68 Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer.Cancer Res. 2019 Aug 15;79(16):4211-4226. doi: 10.1158/0008-5472.CAN-18-3803. Epub 2019 Jun 25.
69 Sacituzumab for the treatment of triple-negative breast cancer: the poster child of future therapy?.Expert Opin Investig Drugs. 2019 Feb;28(2):107-112. doi: 10.1080/13543784.2019.1555239. Epub 2018 Dec 17.
70 A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer.Clin Cancer Res. 2013 Apr 15;19(8):2061-70. doi: 10.1158/1078-0432.CCR-13-0082. Epub 2013 Mar 11.
71 CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death.Cancer Cell Int. 2019 Feb 4;19:26. doi: 10.1186/s12935-019-0740-2. eCollection 2019.
72 Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer.Mol Cancer Ther. 2017 Dec;16(12):2892-2901. doi: 10.1158/1535-7163.MCT-17-0170. Epub 2017 Sep 27.
73 A two-gene epigenetic signature for the prediction of response to neoadjuvant chemotherapy in triple-negative breast cancer patients.Clin Epigenetics. 2019 Feb 20;11(1):33. doi: 10.1186/s13148-019-0626-0.
74 TRPC3 Regulates the Proliferation and Apoptosis Resistance of Triple Negative Breast Cancer Cells through the TRPC3/RASA4/MAPK Pathway.Cancers (Basel). 2019 Apr 18;11(4):558. doi: 10.3390/cancers11040558.
75 Combined Inhibition of ATR and WEE1 as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer.Neoplasia. 2018 May;20(5):478-488. doi: 10.1016/j.neo.2018.03.003. Epub 2018 Mar 30.
76 Role of inhibitor of yes-associated protein 1 in triple-negative breast cancer with taxol-based chemoresistance.Cancer Sci. 2019 Feb;110(2):561-567. doi: 10.1111/cas.13888. Epub 2019 Jan 4.
77 Expression of LXR? ABCA1 and ABCG1 in human triplenegative breast cancer tissues.Oncol Rep. 2019 Nov;42(5):1869-1877. doi: 10.3892/or.2019.7279. Epub 2019 Aug 14.
78 MiR-140-5p inhibits cell proliferation and metastasis by regulating MUC1 via BCL2A1/MAPK pathway in triple negative breast cancer.Cell Cycle. 2019 Oct;18(20):2641-2650. doi: 10.1080/15384101.2019.1653107. Epub 2019 Aug 14.
79 cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells.Cell Death Differ. 2018 Dec;25(12):2147-2164. doi: 10.1038/s41418-018-0100-0. Epub 2018 Apr 19.
80 LncRNA HCP5 promotes triple negative breast cancer progression as a ceRNA to regulate BIRC3 by sponging miR-219a-5p.Cancer Med. 2019 Aug;8(9):4389-4403. doi: 10.1002/cam4.2335. Epub 2019 Jun 18.
81 GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer.Mol Cancer Res. 2019 Jul;17(7):1503-1518. doi: 10.1158/1541-7786.MCR-18-1121. Epub 2019 Apr 18.
82 Application of polymersomes engineered to target p32 protein for detection of small breast tumors in mice.Oncotarget. 2018 Apr 10;9(27):18682-18697. doi: 10.18632/oncotarget.24588. eCollection 2018 Apr 10.
83 Cisplatin Induces Apoptosis Through the Endoplasmic Reticulum-mediated, Calpain 1 Pathway in Triple-negative Breast Cancer Cells.Clin Breast Cancer. 2017 Jun;17(3):e103-e112. doi: 10.1016/j.clbc.2016.12.001. Epub 2016 Dec 24.
84 Antrodia salmonea induces G(2) cell-cycle arrest in human triple-negative breast cancer (MDA-MB-231) cells and suppresses tumor growth in athymic nude mice.J Ethnopharmacol. 2017 Jan 20;196:9-19. doi: 10.1016/j.jep.2016.12.018. Epub 2016 Dec 14.
85 The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression.Mol Cancer. 2019 Jan 8;18(1):4. doi: 10.1186/s12943-018-0933-7.
86 Eradication of cancer stem cells in triple negative breast cancer using doxorubicin/pluronic polymeric micelles.Nanomedicine. 2020 Feb;24:102124. doi: 10.1016/j.nano.2019.102124. Epub 2019 Nov 20.
87 CD44 Promotes PD-L1 Expression and Its Tumor-Intrinsic Function in Breast and Lung Cancers.Cancer Res. 2020 Feb 1;80(3):444-457. doi: 10.1158/0008-5472.CAN-19-1108. Epub 2019 Nov 13.
88 Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer.Cell Rep. 2018 Apr 3;23(1):112-126. doi: 10.1016/j.celrep.2018.03.039.
89 Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer.Stem Cells Int. 2017;2017:5091541. doi: 10.1155/2017/5091541. Epub 2017 Mar 14.
90 Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer.Cancer Cell. 2019 Nov 11;36(5):545-558.e7. doi: 10.1016/j.ccell.2019.09.004. Epub 2019 Oct 24.
91 Therapeutic Rationale to Target Highly Expressed CDK7 Conferring Poor Outcomes in Triple-Negative Breast Cancer.Cancer Res. 2017 Jul 15;77(14):3834-3845. doi: 10.1158/0008-5472.CAN-16-2546. Epub 2017 Apr 28.
92 A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy.Breast Cancer Res. 2019 Jul 1;21(1):77. doi: 10.1186/s13058-019-1161-9.
93 Intense dose-dense epirubicin, paclitaxel, cyclophosphamideversus weekly paclitaxel, liposomal doxorubicin (plus carboplatin in triple-negative breast cancer) for neoadjuvant treatment of high-risk early breast cancer (GeparOcto-GBG 84): A randomised phase III trial.Eur J Cancer. 2019 Jan;106:181-192. doi: 10.1016/j.ejca.2018.10.015. Epub 2018 Dec 5.
94 DEPDC1, negatively regulated by miR-26b, facilitates cell proliferation via the up-regulation of FOXM1 expression in TNBC.Cancer Lett. 2019 Feb 1;442:242-251. doi: 10.1016/j.canlet.2018.11.003. Epub 2018 Nov 9.
95 Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression.Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24881-24891. doi: 10.1073/pnas.1912033116. Epub 2019 Nov 21.
96 Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.Nat Commun. 2019 Nov 15;10(1):5177. doi: 10.1038/s41467-019-13168-4.
97 Expression of mTOR Signaling Pathway Molecules in Triple-Negative Breast Cancer.Pathobiology. 2019;86(5-6):315-321. doi: 10.1159/000503311. Epub 2019 Nov 8.
98 Varlitinib Downregulates HER/ERK Signaling and Induces Apoptosis in Triple Negative Breast Cancer Cells.Cancers (Basel). 2019 Jan 17;11(1):105. doi: 10.3390/cancers11010105.
99 The orphan nuclear receptor estrogen-related receptor beta (ERR) in triple-negative breast cancer.Breast Cancer Res Treat. 2020 Feb;179(3):585-604. doi: 10.1007/s10549-019-05485-5. Epub 2019 Nov 19.
100 A single-nucleotide polymorphism in the 3'-UTR region of the adipocyte fatty acid binding protein 4 gene is associated with prognosis of triple-negative breast cancer.Oncotarget. 2016 Apr 5;7(14):18984-98. doi: 10.18632/oncotarget.7920.
101 miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5.PLoS One. 2017 Apr 24;12(4):e0176395. doi: 10.1371/journal.pone.0176395. eCollection 2017.
102 Targeting of prostate-specific membrane antigen for radio-ligand therapy of triple-negative breast cancer.Breast Cancer Res. 2019 Oct 22;21(1):116. doi: 10.1186/s13058-019-1205-1.
103 FOXM1 plays a role in autophagy by transcriptionally regulating Beclin-1 and LC3 genes in human triple-negative breast cancer cells.J Mol Med (Berl). 2019 Apr;97(4):491-508. doi: 10.1007/s00109-019-01750-8. Epub 2019 Feb 7.
104 Durable Response of Androgen Receptor-Positive Male Breast Cancer to Goserelin.J Breast Cancer. 2019 Mar;22(1):141-148. doi: 10.4048/jbc.2019.22.e2.
105 BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion.Breast Cancer Res. 2018 Oct 1;20(1):117. doi: 10.1186/s13058-018-1046-3.
106 miR-483-3p suppresses the proliferation and progression of human triple negative breast cancer cells by targeting the HDAC8>oncogene.J Cell Physiol. 2020 Mar;235(3):2631-2642. doi: 10.1002/jcp.29167. Epub 2019 Sep 11.
107 Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents.Bioorg Med Chem. 2019 Apr 1;27(7):1370-1381. doi: 10.1016/j.bmc.2019.02.040. Epub 2019 Feb 20.
108 Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814. doi: 10.1016/j.taap.2019.114814. Epub 2019 Nov 9.
109 The relationship between nuclear factor (NF)-B family gene expression and prognosis in triple-negative breast cancer (TNBC) patients receiving adjuvant doxorubicin treatment.Sci Rep. 2016 Aug 22;6:31804. doi: 10.1038/srep31804.
110 Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/-catenin pathway.Neoplasma. 2019 Mar 5;66(2):232-239. doi: 10.4149/neo_2018_180710N460. Epub 2018 Sep 29.
111 In vivo -catenin attenuation by the integrin 5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis.Biomaterials. 2019 Jan;188:160-172. doi: 10.1016/j.biomaterials.2018.10.019. Epub 2018 Oct 18.
112 Therapeutic impact of Nintedanib with paclitaxel and/or a PD-L1 antibody in preclinical models of orthotopic primary or metastatic triple negative breast cancer.J Exp Clin Cancer Res. 2019 Jan 11;38(1):16. doi: 10.1186/s13046-018-0999-5.
113 Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.Front Immunol. 2019 Jun 12;10:1351. doi: 10.3389/fimmu.2019.01351. eCollection 2019.
114 KDM2A-dependent reduction of rRNA transcription on glucose starvation requires HP1 in cells, including triple-negative breast cancer cells.Oncotarget. 2019 Jul 30;10(46):4743-4760. doi: 10.18632/oncotarget.27092. eCollection 2019 Jul 30.
115 Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer.Sci Rep. 2019 Nov 27;9(1):17663. doi: 10.1038/s41598-019-54184-0.
116 KiSS1 gene as a novel mediator of TGF-mediated cell invasion in triple negative breast cancer.Cell Signal. 2018 Jan;42:1-10. doi: 10.1016/j.cellsig.2017.10.002. Epub 2017 Oct 6.
117 The microRNAs miR-200b-3p and miR-429-5p target the LIMK1/CFL1 pathway to inhibit growth and motility of breast cancer cells.Oncotarget. 2017 Jul 12;8(49):85276-85289. doi: 10.18632/oncotarget.19205. eCollection 2017 Oct 17.
118 Targeted Lipid Nanoemulsions Encapsulating Epigenetic Drugs Exhibit Selective Cytotoxicity on CDH1(-)/FOXM1(+) Triple Negative Breast Cancer Cells.Mol Pharm. 2019 May 6;16(5):1813-1826. doi: 10.1021/acs.molpharmaceut.8b01065. Epub 2019 Mar 29.
119 Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells.Oncogene. 2019 Apr;38(15):2860-2875. doi: 10.1038/s41388-018-0618-0. Epub 2018 Dec 14.
120 TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis.Nat Commun. 2018 May 18;9(1):1994. doi: 10.1038/s41467-018-04460-w.
121 The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK/Jun kinase pathway.J Biol Chem. 2018 Dec 28;293(52):20014-20028. doi: 10.1074/jbc.RA118.005796. Epub 2018 Nov 15.
122 MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents.Mol Cancer Ther. 2018 Nov;17(11):2297-2308. doi: 10.1158/1535-7163.MCT-17-1239. Epub 2018 Aug 9.
123 The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis.Cancers (Basel). 2019 Mar 3;11(3):299. doi: 10.3390/cancers11030299.
124 MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells.Cancer Res. 2019 Apr 15;79(8):2031-2041. doi: 10.1158/0008-5472.CAN-18-3259. Epub 2019 Mar 1.
125 MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene.J Pathol. 2018 Feb;244(2):143-150. doi: 10.1002/path.5006. Epub 2017 Dec 28.
126 Druggable Nucleolin Identifies Breast Tumours Associated with Poor Prognosis That Exhibit Different Biological Processes.Cancers (Basel). 2018 Oct 22;10(10):390. doi: 10.3390/cancers10100390.
127 Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior.Mol Cancer Res. 2017 Jun;15(6):670-682. doi: 10.1158/1541-7786.MCR-16-0411. Epub 2017 Feb 24.
128 Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells.Oncogene. 2014 May 1;33(18):2375-84. doi: 10.1038/onc.2013.183. Epub 2013 May 27.
129 Proteome profiling of triple negative breast cancer cells overexpressing NOD1 and NOD2 receptors unveils molecular signatures of malignant cell proliferation.BMC Genomics. 2019 Feb 21;20(1):152. doi: 10.1186/s12864-019-5523-6.
130 Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer.Oncotarget. 2017 Apr 29;8(33):54364-54377. doi: 10.18632/oncotarget.17532. eCollection 2017 Aug 15.
131 A versatile theranostic nanodevice based on an orthogonal bioconjugation strategy for efficient targeted treatment and monitoring of triple negative breast cancer.Nanomedicine. 2020 Feb;24:102120. doi: 10.1016/j.nano.2019.102120. Epub 2019 Oct 30.
132 LncRNA MIR503HG inhibits cell migration and invasion via miR-103/OLFM4 axis in triple negative breast cancer.J Cell Mol Med. 2019 Jul;23(7):4738-4745. doi: 10.1111/jcmm.14344. Epub 2019 May 6.
133 Proteolytic processing of PD-L1 by ADAM proteases in breast cancer cells.Cancer Immunol Immunother. 2020 Jan;69(1):43-55. doi: 10.1007/s00262-019-02437-2. Epub 2019 Dec 3.
134 Selective loss of phosphoserine aminotransferase 1 (PSAT1) suppresses migration, invasion, and experimental metastasis in triple negative breast cancer.Clin Exp Metastasis. 2020 Feb;37(1):187-197. doi: 10.1007/s10585-019-10000-7. Epub 2019 Oct 19.
135 A uPAR targeted nanoplatform with an NIR laser-responsive drug release property for tri-modal imaging and synergistic photothermal-chemotherapy of triple-negative breast cancer.Biomater Sci. 2020 Jan 21;8(2):720-738. doi: 10.1039/c9bm01495k.
136 Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer.Int J Cancer. 2020 Jan 1;146(1):123-136. doi: 10.1002/ijc.32410. Epub 2019 May 31.
137 Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.Cancer Res. 2016 Mar 15;76(6):1653-63. doi: 10.1158/0008-5472.CAN-15-2510. Epub 2016 Jan 29.
138 Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival.Cancer Res. 2016 Apr 1;76(7):1942-53. doi: 10.1158/0008-5472.CAN-14-0673. Epub 2016 Feb 26.
139 MiR-210 Is Overexpressed in Tumor-infiltrating Plasma Cells in Triple-negative Breast Cancer.J Histochem Cytochem. 2020 Jan;68(1):25-32. doi: 10.1369/0022155419892965. Epub 2019 Dec 1.
140 SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer.J Hematol Oncol. 2019 Feb 8;12(1):14. doi: 10.1186/s13045-019-0700-2.
141 MiR-145 promotes TNF--induced apoptosis by facilitating the formation of RIP1-FADDcaspase-8 complex in triple-negative breast cancer.Tumour Biol. 2016 Jul;37(7):8599-607. doi: 10.1007/s13277-015-4631-4. Epub 2016 Jan 6.
142 Selective mTORC2 Inhibitor Therapeutically Blocks Breast Cancer Cell Growth and Survival.Cancer Res. 2018 Apr 1;78(7):1845-1858. doi: 10.1158/0008-5472.CAN-17-2388. Epub 2018 Jan 22.
143 The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms.Int J Cancer. 2018 Jun 15;142(12):2529-2542. doi: 10.1002/ijc.31276. Epub 2018 Feb 7.
144 Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells.J Biol Chem. 2019 Mar 15;294(11):4012-4026. doi: 10.1074/jbc.RA118.006378. Epub 2019 Jan 11.
145 Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells.Cancer Sci. 2019 Oct;110(10):3173-3182. doi: 10.1111/cas.14181. Epub 2019 Oct 3.
146 Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity.Int J Nanomedicine. 2018 Nov 20;13:7771-7787. doi: 10.2147/IJN.S187089. eCollection 2018.
147 miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer.Cancer Res. 2016 Feb 15;76(4):927-39. doi: 10.1158/0008-5472.CAN-15-2321. Epub 2015 Dec 16.
148 CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer.BMC Cancer. 2019 Jan 21;19(1):96. doi: 10.1186/s12885-019-5290-4.
149 TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells.Stem Cells Dev. 2019 Jul 15;28(14):944-953. doi: 10.1089/scd.2019.0011. Epub 2019 Jun 11.
150 Phosphorylation of RAB7 by TBK1/IKK Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.Cancer Res. 2020 Jan 1;80(1):44-56. doi: 10.1158/0008-5472.CAN-19-1310. Epub 2019 Oct 29.
151 Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer.Int J Cancer. 2013 Nov 15;133(10):2334-40. doi: 10.1002/ijc.28254. Epub 2013 Jun 4.
152 Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy.Cell Death Dis. 2019 Mar 28;10(4):285. doi: 10.1038/s41419-019-1512-6.
153 Metabolic Reprograming Via Silencing of Mitochondrial VDAC1 Expression Encourages Differentiation of Cancer Cells.Mol Ther Nucleic Acids. 2019 Sep 6;17:24-37. doi: 10.1016/j.omtn.2019.05.003. Epub 2019 May 18.
154 Sulforaphane Suppresses the Growth of Triple-negative Breast Cancer Stem-like Cells In vitro and In vivo.Cancer Prev Res (Phila). 2019 Mar;12(3):147-158. doi: 10.1158/1940-6207.CAPR-18-0241. Epub 2019 Jan 24.
155 miR-365 inhibits cell invasion and migration of triple negative breast cancer through ADAM10.J BUON. 2019 Sep-Oct;24(5):1905-1912.
156 Down regulation of ADAM33 as a Predictive Biomarker of Aggressive Breast Cancer.Sci Rep. 2017 Mar 15;7:44414. doi: 10.1038/srep44414.
157 miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells.Breast Cancer Res. 2016 Apr 2;18(1):40. doi: 10.1186/s13058-016-0699-z.
158 Mutant TP53 modulates metastasis of triple negative breast cancer through adenosine A2b receptor signaling.Oncotarget. 2018 Oct 2;9(77):34554-34566. doi: 10.18632/oncotarget.26177. eCollection 2018 Oct 2.
159 Androgenic pathway in triple negative invasive ductal tumors: its correlation with tumor cell proliferation.Cancer Sci. 2013 May;104(5):639-46. doi: 10.1111/cas.12121. Epub 2013 Mar 15.
160 Triple-Negative Breast Cancer with High Levels of Annexin A1 Expression Is Associated with Mast Cell Infiltration, Inflammation, and Angiogenesis.Int J Mol Sci. 2019 Aug 27;20(17):4197. doi: 10.3390/ijms20174197.
161 ANXA2 expression in African American triple-negative breast cancer patients.Breast Cancer Res Treat. 2019 Feb;174(1):113-120. doi: 10.1007/s10549-018-5030-5. Epub 2018 Nov 26.
162 Expression of AQP3 and AQP5 as a prognostic marker in triple-negative breast cancer.Oncol Lett. 2018 Aug;16(2):2661-2667. doi: 10.3892/ol.2018.8955. Epub 2018 Jun 12.
163 ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions.Cell Signal. 2015 Mar;27(3):403-15. doi: 10.1016/j.cellsig.2014.11.032. Epub 2014 Dec 19.
164 Targeting bromodomain protein ANCCA/ATAD2 enhances the efficacy of DNAdamaging chemotherapy agents and radiation.Oncol Rep. 2020 Jan;43(1):318-327. doi: 10.3892/or.2019.7418. Epub 2019 Nov 27.
165 A novel orally available seleno-purine molecule suppresses triple-negative breast cancer cell proliferation and progression to metastasis by inducing cytostatic autophagy.Autophagy. 2019 Aug;15(8):1376-1390. doi: 10.1080/15548627.2019.1582951. Epub 2019 Mar 1.
166 AXL knockdown gene signature reveals a drug repurposing opportunity for a class of antipsychotics to reduce growth and metastasis of triple-negative breast cancer.Oncotarget. 2019 Mar 12;10(21):2055-2067. doi: 10.18632/oncotarget.26725. eCollection 2019 Mar 12.
167 Gene Expression Profiling for Diagnosis of Triple-Negative Breast Cancer: A Multicenter, Retrospective Cohort Study.Front Oncol. 2019 May 7;9:354. doi: 10.3389/fonc.2019.00354. eCollection 2019.
168 Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer.Cell Death Dis. 2018 Jan 26;9(2):137. doi: 10.1038/s41419-017-0169-2.
169 Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes.J Biol Chem. 2018 Feb 9;293(6):2125-2136. doi: 10.1074/jbc.M117.811463. Epub 2017 Dec 20.
170 BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition.Mol Cancer Res. 2018 Apr;16(4):580-586. doi: 10.1158/1541-7786.MCR-17-0568. Epub 2018 Feb 7.
171 Whole exome sequencing of breast cancer (TNBC) cases from India: association of MSH6 and BRIP1 variants with TNBC risk and oxidative DNA damage.Mol Biol Rep. 2018 Oct;45(5):1413-1419. doi: 10.1007/s11033-018-4307-4. Epub 2018 Aug 22.
172 Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade.Oncogene. 2019 Jan;38(3):390-405. doi: 10.1038/s41388-018-0451-5. Epub 2018 Aug 15.
173 PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer.Sci Rep. 2017 Feb 8;7:42319. doi: 10.1038/srep42319.
174 Ecotropic virus integration-1 and calreticulin as novel prognostic markers in triple-negative breast cancer: A retrospective cohort study.Oncol Lett. 2019 Aug;18(2):1847-1855. doi: 10.3892/ol.2019.10472. Epub 2019 Jun 12.
175 Brain-metastatic triple-negative breast cancer cells regain growth ability by altering gene expression patterns.Cancer Genomics Proteomics. 2013 Nov-Dec;10(6):265-75.
176 Cdc20 and securin overexpression predict short-term breast cancer survival.Br J Cancer. 2014 Jun 10;110(12):2905-13. doi: 10.1038/bjc.2014.252. Epub 2014 May 22.
177 MicroRNA-211, a direct negative regulator of CDC25B expression, inhibits triple-negative breast cancer cells' growth and migration.Tumour Biol. 2015 Jul;36(7):5001-9. doi: 10.1007/s13277-015-3151-6. Epub 2015 Feb 14.
178 Simvastatin functions as a heat shock protein 90 inhibitor against triple-negative breast cancer.Cancer Sci. 2018 Oct;109(10):3272-3284. doi: 10.1111/cas.13748. Epub 2018 Aug 26.
179 The Role and Mechanism of CRT0066101 as an Effective Drug for Treatment of Triple-Negative Breast Cancer.Cell Physiol Biochem. 2019;52(3):382-396. doi: 10.33594/000000027. Epub 2019 Mar 8.
180 Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.Breast Cancer Res. 2015;17:19. doi: 10.1186/s13058-015-0524-0. Epub 2015 Feb 11.
181 Cyclin E Overexpression Sensitizes Triple-Negative Breast Cancer to Wee1 Kinase Inhibition.Clin Cancer Res. 2018 Dec 15;24(24):6594-6610. doi: 10.1158/1078-0432.CCR-18-1446. Epub 2018 Sep 4.
182 Antitumor Activity of Vanicoside B Isolated from Persicaria dissitiflora by Targeting CDK8 in Triple-Negative Breast Cancer Cells.J Nat Prod. 2019 Nov 22;82(11):3140-3149. doi: 10.1021/acs.jnatprod.9b00720. Epub 2019 Oct 17.
183 Increasing intratumor C/EBP- LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer. J Exp Clin Cancer Res. 2018 Nov 27;37(1):286. doi: 10.1186/s13046-018-0967-0.
184 Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer.Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1570-E1577. doi: 10.1073/pnas.1719577115. Epub 2018 Jan 29.
185 Notch Signaling Regulates Mitochondrial Metabolism and NF-B Activity in Triple-Negative Breast Cancer Cells via IKK-Dependent Non-canonical Pathways.Front Oncol. 2018 Dec 4;8:575. doi: 10.3389/fonc.2018.00575. eCollection 2018.
186 CLDN6 enhances chemoresistance to ADM via AF-6/ERKs pathway in TNBC cell line MDAMB231.Mol Cell Biochem. 2018 Jun;443(1-2):169-180. doi: 10.1007/s11010-017-3221-8. Epub 2017 Nov 20.
187 Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G(1)-S Checkpoint.Mol Cancer Ther. 2018 Aug;17(8):1727-1738. doi: 10.1158/1535-7163.MCT-17-1084. Epub 2018 Jun 4.
188 MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer.Mol Cancer. 2019 Mar 18;18(1):42. doi: 10.1186/s12943-019-0988-0.
189 MicroRNA-17 acts as a tumor chemosensitizer by targeting JAB1/CSN5 in triple-negative breast cancer.Cancer Lett. 2019 Nov 28;465:12-23. doi: 10.1016/j.canlet.2019.08.016. Epub 2019 Aug 29.
190 Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population.Cancer Res. 2016 Jan 15;76(2):440-52. doi: 10.1158/0008-5472.CAN-15-1640-T. Epub 2015 Dec 16.
191 Enhanced targeting of triple-negative breast carcinoma and malignant melanoma by photochemical internalization of CSPG4-targeting immunotoxins.Photochem Photobiol Sci. 2018 May 16;17(5):539-551. doi: 10.1039/C7PP00358G.
192 A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer.J Oncol. 2019 Jun 27;2019:3980273. doi: 10.1155/2019/3980273. eCollection 2019.
193 CLR 125 Auger Electrons for the Targeted Radiotherapy of Triple-Negative Breast Cancer.Cancer Biother Radiopharm. 2018 Apr;33(3):87-95. doi: 10.1089/cbr.2017.2376.
194 Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer.Breast Cancer Res Treat. 2015 Feb;150(1):9-18. doi: 10.1007/s10549-015-3285-7. Epub 2015 Feb 10.
195 DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer.Oncotarget. 2017 Oct 17;8(58):98708-98722. doi: 10.18632/oncotarget.21864. eCollection 2017 Nov 17.
196 Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition.Oncotarget. 2017 Jul 12;8(56):95206-95222. doi: 10.18632/oncotarget.19199. eCollection 2017 Nov 10.
197 miR-221/222 activate the Wnt/-catenin signaling to promote triple-negative breast cancer.J Mol Cell Biol. 2018 Aug 1;10(4):302-315. doi: 10.1093/jmcb/mjy041.
198 Targeting Histone Methyltransferase DOT1L by a Novel Psammaplin A Analog Inhibits Growth and Metastasis of Triple-Negative Breast Cancer.Mol Ther Oncolytics. 2019 Oct 1;15:140-152. doi: 10.1016/j.omto.2019.09.005. eCollection 2019 Dec 20.
199 MiR-4319 Suppress the Malignancy of Triple-Negative Breast Cancer by Regulating Self-Renewal and Tumorigenesis of Stem Cells.Cell Physiol Biochem. 2018;48(2):593-604. doi: 10.1159/000491888. Epub 2018 Jul 18.
200 PERK-Phosphorylated eIF2 Pathway Suppresses Tumor Metastasis Through Downregulating Expression of Programmed Death Ligand 1 and CXCL5 in Triple-Negative Breast Cancer.Cancer Biother Radiopharm. 2017 Oct;32(8):282-287. doi: 10.1089/cbr.2017.2237.
201 MicroRNA-33a-5p overexpression sensitizes triple-negative breast cancer to doxorubicin by inhibiting eIF5A2 and epithelial-mesenchymal transition.Oncol Lett. 2019 Dec;18(6):5986-5994. doi: 10.3892/ol.2019.10984. Epub 2019 Oct 14.
202 MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer.Mol Cancer Ther. 2017 Jan;16(1):143-155. doi: 10.1158/1535-7163.MCT-16-0413. Epub 2016 Nov 3.
203 miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene.Carcinogenesis. 2015 Sep;36(9):1051-60. doi: 10.1093/carcin/bgv087. Epub 2015 Jun 18.
204 EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours.Oncogene. 2018 Jul;37(30):4073-4093. doi: 10.1038/s41388-018-0228-x. Epub 2018 Apr 27.
205 CD44 targeted redox-triggered self-assembly with magnetic enhanced EPR effects for effective amplification of gambogic acid to treat triple-negative breast cancer.Biomater Sci. 2019 Dec 17;8(1):212-223. doi: 10.1039/c9bm01171d.
206 STAT3 Targets ERR- to Promote Epithelial-Mesenchymal Transition, Migration, and Invasion in Triple-Negative Breast Cancer Cells.Mol Cancer Res. 2019 Nov;17(11):2184-2195. doi: 10.1158/1541-7786.MCR-18-1194. Epub 2019 Aug 19.
207 Antibiotic Tetrocarcin-A Down-regulates JAM-A, IAPs and Induces Apoptosis in Triple-negative Breast Cancer Models.Anticancer Res. 2019 Mar;39(3):1197-1204. doi: 10.21873/anticanres.13230.
208 Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3.Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3426-E3435. doi: 10.1073/pnas.1714573115. Epub 2018 Mar 26.
209 FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer.Theranostics. 2019 Sep 21;9(23):7003-7015. doi: 10.7150/thno.35561. eCollection 2019.
210 Inhibition of the AnxA1/FPR1 autocrine axis reduces MDA-MB-231 breast cancer cell growth and aggressiveness in vitro and in vivo.Biochim Biophys Acta Mol Cell Res. 2018 Sep;1865(9):1368-1382. doi: 10.1016/j.bbamcr.2018.06.010. Epub 2018 Jun 20.
211 A piRNA utilizes HILI and HIWI2 mediated pathway to down-regulate ferritin heavy chain 1 mRNA in human somatic cells.Nucleic Acids Res. 2018 Nov 16;46(20):10635-10648. doi: 10.1093/nar/gky728.
212 Identification and Validation of a Novel Biologics Target in Triple Negative Breast Cancer.Sci Rep. 2019 Oct 17;9(1):14934. doi: 10.1038/s41598-019-51453-w.
213 A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1-XBP1 Activation.Mol Cancer Res. 2018 May;16(5):745-753. doi: 10.1158/1541-7786.MCR-17-0307. Epub 2018 Feb 9.
214 Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells.Oncotarget. 2019 Mar 19;10(23):2292-2305. doi: 10.18632/oncotarget.26765. eCollection 2019 Mar 19.
215 Targeting AXL and RAGE to prevent geminin overexpression-induced triple-negative breast cancer metastasis.Sci Rep. 2019 Dec 16;9(1):19150. doi: 10.1038/s41598-019-55702-w.
216 The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.Sci Signal. 2017 Apr 11;10(474):eaak9397. doi: 10.1126/scisignal.aak9397.
217 G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4191-6. doi: 10.1073/pnas.1320239111. Epub 2014 Mar 5.
218 G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis.PLoS One. 2016 Apr 6;11(4):e0152856. doi: 10.1371/journal.pone.0152856. eCollection 2016.
219 Downregulation of GRK5 hampers the migration of breast cancer cells.Sci Rep. 2019 Oct 29;9(1):15548. doi: 10.1038/s41598-019-51923-1.
220 Clinical Implications of Extracellular HMGA1 in Breast Cancer.Int J Mol Sci. 2019 Nov 26;20(23):5950. doi: 10.3390/ijms20235950.
221 HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells.Mol Oncol. 2019 Feb;13(2):153-170. doi: 10.1002/1878-0261.12390. Epub 2018 Nov 28.
222 IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer.Cell Mol Life Sci. 2019 May;76(10):2015-2030. doi: 10.1007/s00018-019-03033-4. Epub 2019 Feb 6.
223 Synthetic human monoclonal antibody targets hIL1 receptor accessory protein chain with therapeutic potential in triple-negative breast cancer.Biomed Pharmacother. 2018 Nov;107:1064-1073. doi: 10.1016/j.biopha.2018.07.099. Epub 2018 Aug 25.
224 IMP2 and IMP3 cooperate to promote the metastasis of triple-negative breast cancer through destabilization of progesterone receptor.Cancer Lett. 2018 Feb 28;415:30-39. doi: 10.1016/j.canlet.2017.11.039. Epub 2017 Dec 5.
225 IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel.Nat Commun. 2015 Oct 27;6:8746. doi: 10.1038/ncomms9746.
226 Jagged2 promotes cancer stem cell properties of triple negative breast cancer cells and paclitaxel resistance via regulating microRNA-200.Eur Rev Med Pharmacol Sci. 2018 Sep;22(18):6008-6014. doi: 10.26355/eurrev_201809_15936.
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229 KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells.Oncotarget. 2017 Sep 8;8(54):92106-92118. doi: 10.18632/oncotarget.20785. eCollection 2017 Nov 3.
230 Klotho is a novel marker and cell survival factor in a subset of triple negative breast cancers.Oncotarget. 2016 Jan 19;7(3):2611-28. doi: 10.18632/oncotarget.6006.
231 Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer.Biol Chem. 2017 Sep 26;398(10):1151-1164. doi: 10.1515/hsz-2017-0122.
232 Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course.Genet Mol Res. 2015 Aug 14;14(3):9655-66. doi: 10.4238/2015.August.14.28.
233 The co-expression characteristics of LAG3 and PD-1 on the T cells of patients with breast cancer reveal a new therapeutic strategy.Int Immunopharmacol. 2020 Jan;78:106113. doi: 10.1016/j.intimp.2019.106113. Epub 2019 Dec 13.
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235 LGR5 overexpression confers poor relapse-free survival in breast cancer patients.BMC Cancer. 2018 Feb 22;18(1):219. doi: 10.1186/s12885-018-4018-1.
236 EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer.Mol Cancer Ther. 2019 Aug;18(8):1341-1354. doi: 10.1158/1535-7163.MCT-18-1258. Epub 2019 May 29.
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239 The Roles of Low-Density Lipoprotein Receptor-Related Proteins 5, 6, and 8 in Cancer: A Review.J Oncol. 2019 Mar 26;2019:4536302. doi: 10.1155/2019/4536302. eCollection 2019.
240 BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer.BMB Rep. 2018 Aug;51(8):373-377. doi: 10.5483/bmbrep.2018.51.8.127.
241 MEN1309/OBT076, a First-In-Class Antibody-Drug Conjugate Targeting CD205 in Solid Tumors. Mol Cancer Ther. 2019 Sep;18(9):1533-1543.
242 hMAGEA2 promotes progression of breast cancer by regulating Akt and Erk1/2 pathways.Oncotarget. 2017 Jun 6;8(23):37115-37127. doi: 10.18632/oncotarget.16184.
243 Evaluation of the Expression of Amine Oxidase Proteins in Breast Cancer.Int J Mol Sci. 2017 Dec 20;18(12):2775. doi: 10.3390/ijms18122775.
244 Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex.Cancer Discov. 2017 Mar;7(3):302-321. doi: 10.1158/2159-8290.CD-16-0653. Epub 2017 Jan 20.
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248 Expression of MAS1 in breast cancer.Cancer Sci. 2015 Sep;106(9):1240-8. doi: 10.1111/cas.12719. Epub 2015 Jul 20.
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252 Expression of MT4-MMP, EGFR, and RB in Triple-Negative Breast Cancer Strongly Sensitizes Tumors to Erlotinib and Palbociclib Combination Therapy.Clin Cancer Res. 2019 Mar 15;25(6):1838-1850. doi: 10.1158/1078-0432.CCR-18-1880. Epub 2018 Nov 30.
253 CRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions.Cancer Immunol Immunother. 2019 Mar;68(3):365-377. doi: 10.1007/s00262-018-2281-2. Epub 2018 Dec 6.
254 RON Receptor Tyrosine Kinase as a Therapeutic Target for Eradication of Triple-Negative Breast Cancer: Efficacy of Anti-RON ADC Zt/g4-MMAE.Mol Cancer Ther. 2018 Dec;17(12):2654-2664. doi: 10.1158/1535-7163.MCT-18-0252. Epub 2018 Oct 1.
255 Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer progression through the miR-661/MTA1 pathway.Biochem Biophys Res Commun. 2018 Nov 10;505(4):996-1002. doi: 10.1016/j.bbrc.2018.10.026. Epub 2018 Oct 9.
256 ABL tyrosine kinase inhibition variable effects on the invasive properties of different triple negative breast cancer cell lines.PLoS One. 2015 Mar 24;10(3):e0118854. doi: 10.1371/journal.pone.0118854. eCollection 2015.
257 Nectin-4 Expression Is an Independent Prognostic Biomarker and Associated With Better Survival in Triple-Negative Breast Cancer.Front Med (Lausanne). 2019 Sep 13;6:200. doi: 10.3389/fmed.2019.00200. eCollection 2019.
258 YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.Biochem Biophys Res Commun. 2019 Feb 5;509(2):448-454. doi: 10.1016/j.bbrc.2018.12.074. Epub 2018 Dec 26.
259 Expression of Nischarin negatively correlates with estrogen receptor and alters apoptosis, migration and invasion in human breast cancer. Biochem Biophys Res Commun. 2017 Mar 11;484(3):536-542.
260 Knockdown of nucleophosmin 1 suppresses proliferation of triple-negative breast cancer cells through activating CDH1/Skp2/p27kip1 pathway.Cancer Manag Res. 2018 Dec 21;11:143-156. doi: 10.2147/CMAR.S191176. eCollection 2019.
261 Cortisol-induced SRSF3 expression promotes GR splicing, RACK1 expression and breast cancer cells migration.Pharmacol Res. 2019 May;143:17-26. doi: 10.1016/j.phrs.2019.03.008. Epub 2019 Mar 9.
262 The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression.Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14174-14180. doi: 10.1073/pnas.1821194116. Epub 2019 Jun 24.
263 Ultrasound-guided delivery of thymidine kinase-nitroreductase dual therapeutic genes by PEGylated-PLGA/PIE nanoparticles for enhanced triple negative breast cancer therapy.Nanomedicine (Lond). 2018 May;13(9):1051-1066. doi: 10.2217/nnm-2017-0328. Epub 2018 May 23.
264 Collagen prolyl 4-hydroxylase 1 is essential for HIF-1 stabilization and TNBC chemoresistance.Nat Commun. 2018 Oct 26;9(1):4456. doi: 10.1038/s41467-018-06893-9.
265 A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth.Sci Rep. 2017 Feb 15;7:42555. doi: 10.1038/srep42555.
266 Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.Dev Cell. 2017 Nov 20;43(4):418-435.e13. doi: 10.1016/j.devcel.2017.10.027.
267 Blockade of PDGFR circumvents resistance to MEK-JAK inhibition via intratumoral CD8(+) T-cells infiltrationin triple-negative breast cancer.J Exp Clin Cancer Res. 2019 Feb 18;38(1):85. doi: 10.1186/s13046-019-1075-5.
268 Protein kinase C inhibitor chelerythrine selectively inhibits proliferation of triple-negative breast cancer cells.Sci Rep. 2017 May 17;7(1):2022. doi: 10.1038/s41598-017-02222-0.
269 A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability.Mol Cancer Res. 2019 Dec;17(12):2492-2507. doi: 10.1158/1541-7786.MCR-19-0264. Epub 2019 Sep 19.
270 Targeting PML in triple negative breast cancer elicits growth suppression and senescence.Cell Death Differ. 2020 Apr;27(4):1186-1199. doi: 10.1038/s41418-019-0407-5. Epub 2019 Oct 1.
271 CYPOR is a novel and independent prognostic biomarker of recurrence-free survival in triple-negative breast cancer patients.Int J Cancer. 2019 Feb 1;144(3):631-640. doi: 10.1002/ijc.31798. Epub 2018 Nov 7.
272 Protein kinase C enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin.BMC Cancer. 2017 Dec 7;17(1):832. doi: 10.1186/s12885-017-3827-y.
273 The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells.Breast Cancer. 2018 Jan;25(1):74-80. doi: 10.1007/s12282-017-0790-z. Epub 2017 Jun 22.
274 PSMB5 is associated with proliferation and drug resistance in triple-negative breast cancer.Int J Biol Markers. 2018 Jan;33(1):102-108. doi: 10.5301/ijbm.5000283.
275 Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway.Bosn J Basic Med Sci. 2019 Feb 12;19(1):52-59. doi: 10.17305/bjbms.2018.3399.
276 A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions.Sci Transl Med. 2017 Jan 11;9(372):eaag2611. doi: 10.1126/scitranslmed.aag2611.
277 HePTP promotes migration and invasion in triple-negative breast cancer cells via activation of Wnt/-catenin signaling.Biomed Pharmacother. 2019 Oct;118:109361. doi: 10.1016/j.biopha.2019.109361. Epub 2019 Aug 23.
278 Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-B pathway in breast cancer cells.Cell Commun Signal. 2018 Nov 29;16(1):92. doi: 10.1186/s12964-018-0304-4.
279 TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1/Rab5/Rac1 pathway.Cancer Cell Int. 2019 Sep 23;19:242. doi: 10.1186/s12935-019-0961-4. eCollection 2019.
280 cAMP regulated EPAC1 supports microvascular density, angiogenic and metastatic properties in a model of triple negative breast cancer.Carcinogenesis. 2018 Oct 8;39(10):1245-1253. doi: 10.1093/carcin/bgy090.
281 RIP2 enhances cell survival by activation of NF-B in triple negative breast cancer cells.Biochem Biophys Res Commun. 2018 Feb 26;497(1):115-121. doi: 10.1016/j.bbrc.2018.02.034. Epub 2018 Feb 6.
282 Inhibition of p90RSK activation sensitizes triple-negative breast cancer cells to cisplatin by inhibiting proliferation, migration and EMT.BMB Rep. 2019 Dec;52(12):706-711. doi: 10.5483/BMBRep.2019.52.12.234.
283 Serum amyloid A predisposes inflammatory tumor microenvironment in triple negative breast cancer.Oncotarget. 2019 Jan 11;10(4):511-526. doi: 10.18632/oncotarget.26566. eCollection 2019 Jan 11.
284 Pathological expression of tissue factor confers promising antitumor response to a novel therapeutic antibody SC1 in triple negative breast cancer and pancreatic adenocarcinoma.Oncotarget. 2017 Jul 10;8(35):59086-59102. doi: 10.18632/oncotarget.19175. eCollection 2017 Aug 29.
285 Upregulated SCUBE2 expression in breast cancer stem cells enhances triple negative breast cancer aggression through modulation of notch signaling and epithelial-to-mesenchymal transition.Exp Cell Res. 2018 Sep 15;370(2):444-453. doi: 10.1016/j.yexcr.2018.07.008. Epub 2018 Jul 5.
286 Biochemical and Anti-Triple Negative Metastatic Breast Tumor Cell Properties of Psammaplins.Mar Drugs. 2018 Nov 10;16(11):442. doi: 10.3390/md16110442.
287 SIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival.Mol Cell Biol. 2016 Nov 28;36(24):3048-3057. doi: 10.1128/MCB.00380-16. Print 2016 Dec 15.
288 SIRT5 as a biomarker for response to anthracycline-taxane-based neoadjuvant chemotherapy in triple-negative breast cancer.Oncol Rep. 2018 May;39(5):2315-2323. doi: 10.3892/or.2018.6319. Epub 2018 Mar 16.
289 Deferoxamine-inducedhigh expression of TfR1 and DMT1 enhanced iron uptake intriple-negative breast cancer cells by activatingIL-6/PI3K/AKTpathway.Onco Targets Ther. 2019 May 31;12:4359-4377. doi: 10.2147/OTT.S193507. eCollection 2019.
290 Somatic gene mutation analysis of triple negative breast cancers.Breast. 2016 Oct;29:202-7. doi: 10.1016/j.breast.2016.06.018. Epub 2016 Jul 7.
291 "Triple-punch" strategy for triple negative breast cancer therapy with minimized drug dosage and improved antitumor efficacy.ACS Nano. 2015 Feb 24;9(2):1367-78. doi: 10.1021/nn505729m. Epub 2015 Jan 26.
292 SGLT1 is required for the survival of triple-negative breast cancer cells via potentiation of EGFR activity.Mol Oncol. 2019 Sep;13(9):1874-1886. doi: 10.1002/1878-0261.12530. Epub 2019 Jun 14.
293 Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression.Cell Death Dis. 2018 Feb 27;9(3):326. doi: 10.1038/s41419-018-0347-x.
294 Effect of miR-146a-5p on proliferation and metastasis of triple-negative breast cancer via regulation of SOX5.Exp Ther Med. 2018 May;15(5):4515-4521. doi: 10.3892/etm.2018.5945. Epub 2018 Mar 9.
295 Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype.Sci Rep. 2016 Mar 15;6:23216. doi: 10.1038/srep23216.
296 The anti-androgen drug dutasteride renders triple negative breast cancer cells more sensitive to chemotherapy via inhibition of HIF-1-/VEGF-signaling.Gynecol Endocrinol. 2015 Feb;31(2):160-4. doi: 10.3109/09513590.2014.971235. Epub 2014 Oct 30.
297 SRGN-TGF2 regulatory loop confers invasion and metastasis in triple-negative breast cancer.Oncogenesis. 2017 Jul 10;6(7):e360. doi: 10.1038/oncsis.2017.53.
298 Overexpression of the steroidogenic acute regulatory protein in breast cancer: Regulation by histone deacetylase inhibition.Biochem Biophys Res Commun. 2019 Feb 5;509(2):476-482. doi: 10.1016/j.bbrc.2018.12.145. Epub 2018 Dec 27.
299 mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer.Clin Cancer Res. 2016 Apr 1;22(7):1699-712. doi: 10.1158/1078-0432.CCR-15-1772. Epub 2015 Nov 6.
300 Diverse, Biologically Relevant, and Targetable Gene Rearrangements in Triple-Negative Breast Cancer and Other Malignancies.Cancer Res. 2016 Aug 15;76(16):4850-60. doi: 10.1158/0008-5472.CAN-16-0058. Epub 2016 May 26.
301 T-bet(+) lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer.Breast Cancer Res Treat. 2019 Aug;176(3):569-577. doi: 10.1007/s10549-019-05256-2. Epub 2019 May 8.
302 Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression.Mol Cancer Res. 2019 Jan;17(1):30-41. doi: 10.1158/1541-7786.MCR-18-0246. Epub 2018 Sep 13.
303 Targeting thyroid hormone receptor beta in triple-negative breast cancer.Breast Cancer Res Treat. 2015 Apr;150(3):535-45. doi: 10.1007/s10549-015-3354-y. Epub 2015 Mar 28.
304 Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the -Ketoglutarate Signaling Pathway.Cancer Res. 2018 Jun 1;78(11):2799-2812. doi: 10.1158/0008-5472.CAN-17-2906. Epub 2018 Mar 29.
305 Silencing of the cytokine receptor TNFRSF13B: A new therapeutic target for triple-negative breast cancer.Cytokine. 2020 Jan;125:154790. doi: 10.1016/j.cyto.2019.154790. Epub 2019 Aug 7.
306 Development of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC.Mol Cancer Ther. 2014 Nov;13(11):2688-705. doi: 10.1158/1535-7163.MCT-14-0346. Epub 2014 Sep 19.
307 The non-receptor tyrosine kinase TNK2/ACK1 is a novel therapeutic target in triple negative breast cancer.Oncotarget. 2017 Jan 10;8(2):2971-2983. doi: 10.18632/oncotarget.13579.
308 Combination Treatment of Polo-Like Kinase 1 and Tankyrase-1 Inhibitors Enhances Anticancer Effect in Triple-negative Breast Cancer Cells.Anticancer Res. 2018 Mar;38(3):1303-1310. doi: 10.21873/anticanres.12352.
309 miR-490-3p inhibits the growth and invasiveness in triple-negative breast cancer by repressing the expression of TNKS2.Gene. 2016 Nov 15;593(1):41-47. doi: 10.1016/j.gene.2016.08.014. Epub 2016 Aug 6.
310 TRIM59 overexpression correlates with poor prognosis and contributes to breast cancer progression through AKT signaling pathway.Mol Carcinog. 2018 Dec;57(12):1792-1802. doi: 10.1002/mc.22897. Epub 2018 Sep 20.
311 The TRPV2 cation channels: from urothelial cancer invasiveness to glioblastoma multiforme interactome signature.Lab Invest. 2020 Feb;100(2):186-198. doi: 10.1038/s41374-019-0333-7. Epub 2019 Oct 25.
312 MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression.Sci Rep. 2019 Sep 3;9(1):12718. doi: 10.1038/s41598-019-49155-4.
313 Alantolactone promotes ER stress-mediated apoptosis by inhibition of TrxR1 in triple-negative breast cancer cell lines and in a mouse model.J Cell Mol Med. 2019 Mar;23(3):2194-2206. doi: 10.1111/jcmm.14139. Epub 2019 Jan 4.
314 A novel UCHL(3) inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair.Cell Death Dis. 2019 May 21;10(6):398. doi: 10.1038/s41419-019-1628-8.
315 Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo.Chem Sci. 2017 Apr 1;8(4):2687-2701. doi: 10.1039/c6sc05368h. Epub 2017 Jan 9.
316 B7-H4 overexpression contributes to poor prognosis and drug-resistance in triple-negative breast cancer.Cancer Cell Int. 2018 Jul 13;18:100. doi: 10.1186/s12935-018-0597-9. eCollection 2018.
317 Long non-coding RNA ZEB2-AS1 promotes the proliferation, metastasis and epithelial mesenchymal transition in triple-negative breast cancer by epigenetically activating ZEB2.J Cell Mol Med. 2019 May;23(5):3271-3279. doi: 10.1111/jcmm.14213. Epub 2019 Mar 1.
318 Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer.PLoS One. 2012;7(10):e47993. doi: 10.1371/journal.pone.0047993. Epub 2012 Oct 24.
319 Low incidence of methylation of the promoter region of the FANCF gene in Japanese primary breast cancer.Breast Cancer. 2011 Apr;18(2):120-3. doi: 10.1007/s12282-009-0175-z. Epub 2009 Oct 8.
320 A combination of GATA3 and SOX10 is useful for the diagnosis of metastatic triple-negative breast cancer.Hum Pathol. 2019 Mar;85:221-227. doi: 10.1016/j.humpath.2018.11.005. Epub 2018 Nov 20.
321 MicroRNA-203 suppresses cell proliferation and migration by targeting BIRC5 and LASP1 in human triple-negative breast cancer cells.J Exp Clin Cancer Res. 2012 Jun 19;31(1):58. doi: 10.1186/1756-9966-31-58.
322 Epigenetic regulation of cancer stem cell genes in triple-negative breast cancer.Am J Pathol. 2012 Jul;181(1):257-67. doi: 10.1016/j.ajpath.2012.03.019. Epub 2012 May 21.
323 Role of nestin expression in angiogenesis and breast cancer progression.Int J Oncol. 2018 Feb;52(2):527-535. doi: 10.3892/ijo.2017.4223. Epub 2017 Dec 11.
324 miR-200c targets a NF-B up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer.PLoS One. 2012;7(11):e49987. doi: 10.1371/journal.pone.0049987. Epub 2012 Nov 21.
325 Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer.Breast Cancer Res. 2012 Jul 19;14(4):R109. doi: 10.1186/bcr3230.
326 Expression of synuclein gamma indicates poor prognosis of triple-negative breast cancer.Med Oncol. 2013;30(3):612. doi: 10.1007/s12032-013-0612-x. Epub 2013 May 22.
327 Abcc10 status affects mammary tumour growth, metastasis, and docetaxel treatment response.Br J Cancer. 2014 Aug 12;111(4):696-707. doi: 10.1038/bjc.2014.326. Epub 2014 Jun 17.
328 Investigation of the SLC22A23 gene in laryngeal squamous cell carcinoma.BMC Cancer. 2018 Apr 27;18(1):477. doi: 10.1186/s12885-018-4381-y.
329 Novel key genes in triple-negative breast cancer identified by weighted gene co-expression network analysis.J Cell Biochem. 2019 Oct;120(10):16900-16912. doi: 10.1002/jcb.28948. Epub 2019 May 13.
330 HIC1 silencing in triple-negative breast cancer drives progression through misregulation of LCN2.Cancer Res. 2014 Feb 1;74(3):862-72. doi: 10.1158/0008-5472.CAN-13-2420. Epub 2013 Dec 2.
331 The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor.Oncotarget. 2015 May 10;6(13):11061-73. doi: 10.18632/oncotarget.3568.
332 The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter.J Food Drug Anal. 2018 Jan;26(1):221-231. doi: 10.1016/j.jfda.2017.03.009. Epub 2017 Apr 18.
333 Dual-targeting liposomes with active recognition of GLUT(5) and (v)(3) for triple-negative breast cancer.Eur J Med Chem. 2019 Dec 1;183:111720. doi: 10.1016/j.ejmech.2019.111720. Epub 2019 Sep 18.
334 Synthetic Indolactam V Analogues as Inhibitors of PAR2-Induced Calcium Mobilization in Triple-Negative Breast Cancer Cells.ChemMedChem. 2018 Jan 22;13(2):147-154. doi: 10.1002/cmdc.201700640. Epub 2018 Jan 4.
335 Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer.Breast Cancer Res. 2018 Nov 28;20(1):145. doi: 10.1186/s13058-018-1068-x.
336 Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11121-6.
337 Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients.Sci Rep. 2016 Aug 25;6:32027. doi: 10.1038/srep32027.
338 Carboxypeptidase A4 accumulation is associated with an aggressive phenotype and poor prognosis in triple-negative breast cancer.Int J Oncol. 2019 Mar;54(3):833-844. doi: 10.3892/ijo.2019.4675. Epub 2019 Jan 4.
339 LXR/RXR pathway signaling associated with triple-negative breast cancer in African American women.Breast Cancer (Dove Med Press). 2018 Dec 20;11:1-12. doi: 10.2147/BCTT.S185960. eCollection 2019.
340 MAT2B expression correlates with poor prognosis in triple-negative breast cancer.Cancer Manag Res. 2019 Jun 14;11:5501-5511. doi: 10.2147/CMAR.S200716. eCollection 2019.
341 The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor.Cell Rep. 2014 Nov 20;9(4):1318-32. doi: 10.1016/j.celrep.2014.10.011. Epub 2014 Nov 6.
342 Prediction of Recurrence and Survival for Triple-Negative Breast Cancer (TNBC) by a Protein Signature in Tissue Samples.Mol Cell Proteomics. 2015 Nov;14(11):2936-46. doi: 10.1074/mcp.M115.048967. Epub 2015 Jul 24.
343 Inherited predisposition to breast cancer among African American women.Breast Cancer Res Treat. 2015 Jan;149(1):31-9. doi: 10.1007/s10549-014-3195-0. Epub 2014 Nov 27.
344 ALDH1A3-regulated long non-coding RNA NRAD1 is a potential novel target for triple-negative breast tumors and cancer stem cells.Cell Death Differ. 2020 Jan;27(1):363-378. doi: 10.1038/s41418-019-0362-1. Epub 2019 Jun 13.
345 Landscape of pathogenic variations ina panel of 34 genes and cancer risk estimation from 5131 HBOC families.Genet Med. 2018 Dec;20(12):1677-1686. doi: 10.1038/s41436-018-0005-9. Epub 2018 Jul 10.
346 BTN3A2 serves as a prognostic marker and favors immune infiltration in triple-negative breast cancer.J Cell Biochem. 2020 Mar;121(3):2643-2654. doi: 10.1002/jcb.29485. Epub 2019 Nov 6.
347 E3 ubiquitin ligase CHIP attenuates cellular proliferation and invasion abilities in triple-negative breast cancer cells.Clin Exp Med. 2020 Feb;20(1):109-119. doi: 10.1007/s10238-019-00594-3. Epub 2019 Dec 16.
348 H3K27me3 loss plays a vital role in CEMIP mediated carcinogenesis and progression of breast cancer with poor prognosis.Biomed Pharmacother. 2020 Mar;123:109728. doi: 10.1016/j.biopha.2019.109728. Epub 2019 Dec 14.
349 High-level cytoplasmic claudin 3 expression is an independent predictor of poor survival in triple-negative breast cancer.BMC Cancer. 2018 Feb 27;18(1):223. doi: 10.1186/s12885-018-4141-z.
350 Half-sandwich Ru((6)-p-cymene) complexes featuring pyrazole appended ligands: Synthesis, DNA binding and in vitro cytotoxicity.J Inorg Biochem. 2019 May;194:74-84. doi: 10.1016/j.jinorgbio.2019.02.012. Epub 2019 Feb 23.
351 Statins affect ETS1-overexpressing triple-negative breast cancer cells by restoring DUSP4 deficiency.Sci Rep. 2016 Sep 8;6:33035. doi: 10.1038/srep33035.
352 Weighted correlation network analysis of triple-negative breast cancer progression: Identifying specific modules and hub genes based on the GEO and TCGA database.Oncol Lett. 2019 Aug;18(2):1207-1217. doi: 10.3892/ol.2019.10407. Epub 2019 May 27.
353 Myeloid Zinc Finger 1 (MZF1) Maintains the Mesenchymal Phenotype by Down-regulating IGF1R/p38 MAPK/ER Signaling Pathway in High-level MZF1-expressing TNBC cells.Anticancer Res. 2019 Aug;39(8):4149-4164. doi: 10.21873/anticanres.13574.
354 Cancer-associated oxidoreductase ERO1- promotes immune escape through up-regulation of PD-L1 in human breast cancer.Oncotarget. 2017 Apr 11;8(15):24706-24718. doi: 10.18632/oncotarget.14960.
355 Robust identification of target genes and outliers in triple-negative breast cancer data.Stat Methods Med Res. 2019 Oct-Nov;28(10-11):3042-3056. doi: 10.1177/0962280218794722. Epub 2018 Aug 27.
356 Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer.J Pathol. 2017 Feb;241(3):350-361. doi: 10.1002/path.4841. Epub 2016 Dec 29.
357 Expression of GHRH-R, a Potentially Targetable Biomarker, in Triple-negative Breast Cancer.Appl Immunohistochem Mol Morphol. 2018 Jan;26(1):1-5. doi: 10.1097/PAI.0000000000000622.
358 GINS2 regulates matrix metallopeptidase 9 expression and cancer stem cell property in human triple negative Breast cancer.Biomed Pharmacother. 2016 Dec;84:1568-1574. doi: 10.1016/j.biopha.2016.10.032. Epub 2016 Nov 6.
359 Nucleostemin expression in breast cancer is a marker of more aggressive phenotype and unfavorable patients' outcome: A STROBE-compliant article.Medicine (Baltimore). 2019 Mar;98(9):e14744. doi: 10.1097/MD.0000000000014744.
360 Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.Mol Oncol. 2019 Apr;13(4):959-977. doi: 10.1002/1878-0261.12466. Epub 2019 Mar 1.
361 Context-dependent role of Grb7 in HER2+ve and triple-negative breast cancer cell lines.Breast Cancer Res Treat. 2014 Feb;143(3):593-603. doi: 10.1007/s10549-014-2838-5. Epub 2014 Jan 25.
362 Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages.Breast Cancer Res. 2018 Jun 19;20(1):59. doi: 10.1186/s13058-018-0990-2.
363 A novel biomarker C6orf106 promotes the malignant progression of breast cancer.Tumour Biol. 2015 Sep;36(10):7881-9. doi: 10.1007/s13277-015-3500-5. Epub 2015 May 8.
364 ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple-negative breast cancer cells.Int J Mol Med. 2018 Nov;42(5):2343-2352. doi: 10.3892/ijmm.2018.3842. Epub 2018 Aug 27.
365 Integrin 5 contributes to the tumorigenic potential of breast cancer cells through the Src-FAK and MEK-ERK signaling pathways.Oncogene. 2013 Jun 20;32(25):3049-58. doi: 10.1038/onc.2012.320. Epub 2012 Jul 23.
366 JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity.Oncogene. 2019 Feb;38(7):980-997. doi: 10.1038/s41388-018-0466-y. Epub 2018 Sep 5.
367 Bio-Field Array: The Influence of Junction Mediating and Regulatory Protein Expression on Cytoskeletal Filament Behavior During Apoptosis in Triple-Negative Breast Cancer.Breast Cancer (Auckl). 2019 Feb 28;13:1178223419830981. doi: 10.1177/1178223419830981. eCollection 2019.
368 The histone deacetylase inhibitor OBP-801 and eribulin synergistically inhibit the growth of triple-negative breast cancer cells with the suppression of survivin, Bcl-xL, and the MAPK pathway.Breast Cancer Res Treat. 2018 Aug;171(1):43-52. doi: 10.1007/s10549-018-4815-x. Epub 2018 May 11.
369 Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Krppel-like factor 5 transcription by Sp1.Sci Rep. 2018 Jan 18;8(1):1138. doi: 10.1038/s41598-018-19489-6.
370 Potential clinically useful prognostic biomarkers in triple-negative breast cancer: preliminary results of a retrospective analysis.Breast Cancer (Dove Med Press). 2018 Nov 23;10:177-194. doi: 10.2147/BCTT.S175556. eCollection 2018.
371 Dual knockdown of Galectin-8 and its glycosylated ligand, the activated leukocyte cell adhesion molecule (ALCAM/CD166), synergistically delays in vivo breast cancer growth.Biochim Biophys Acta Mol Cell Res. 2019 Aug;1866(8):1338-1352. doi: 10.1016/j.bbamcr.2019.03.010. Epub 2019 Mar 21.
372 Germline TP53 and MSH6 mutations implicated in sporadic triple-negative breast cancer (TNBC): a preliminary study.Hum Genomics. 2019 Jan 10;13(1):4. doi: 10.1186/s40246-018-0186-y.
373 MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival.Mol Cancer Res. 2014 Sep;12(9):1216-24. doi: 10.1158/1541-7786.MCR-14-0069. Epub 2014 May 27.
374 Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer.Oncogene. 2017 Apr;36(15):2116-2130. doi: 10.1038/onc.2016.369. Epub 2016 Oct 24.
375 NUP98 - a novel predictor of response to anthracycline-based chemotherapy in triple negative breast cancer.BMC Cancer. 2019 Apr 2;19(1):236. doi: 10.1186/s12885-019-5407-9.
376 Ectopic Otoconin 90 expression in triple negative breast cancer cell lines is associated with metastasis functions.PLoS One. 2019 Feb 14;14(2):e0211737. doi: 10.1371/journal.pone.0211737. eCollection 2019.
377 Tumor-Targeting Micelles Based on Linear-Dendritic PEG-PTX(8) Conjugate for Triple Negative Breast Cancer Therapy.Mol Pharm. 2017 Oct 2;14(10):3409-3421. doi: 10.1021/acs.molpharmaceut.7b00430. Epub 2017 Aug 30.
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379 PDLIM2 Is a Marker of Adhesion and -Catenin Activity in Triple-Negative Breast Cancer.Cancer Res. 2019 May 15;79(10):2619-2633. doi: 10.1158/0008-5472.CAN-18-2787. Epub 2019 Mar 18.
380 Circulating noncoding RNAbiomarker potential in neoadjuvant chemotherapy of triple negative breast cancer?.Int J Oncol. 2020 Jan;56(1):47-68. doi: 10.3892/ijo.2019.4920. Epub 2019 Nov 25.
381 AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer.Breast Cancer Res. 2019 Feb 21;21(1):29. doi: 10.1186/s13058-019-1107-2.
382 (99m)Tc-Labeled LyP-1 for SPECT Imaging of Triple Negative Breast Cancer.Contrast Media Mol Imaging. 2019 Sep 25;2019:9502712. doi: 10.1155/2019/9502712. eCollection 2019.
383 RPLP1 promotes tumor metastasis and is associated with a poor prognosis in triple-negative breast cancer patients.Cancer Cell Int. 2018 Oct 25;18:170. doi: 10.1186/s12935-018-0658-0. eCollection 2018.
384 SARNP, a participant in mRNA splicing and export, negatively regulates E-cadherin expression via interaction with pinin.J Cell Physiol. 2020 Feb;235(2):1543-1555. doi: 10.1002/jcp.29073. Epub 2019 Jul 17.
385 Activating Transcription Factor 4 Modulates TGF-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling.Clin Cancer Res. 2018 Nov 15;24(22):5697-5709. doi: 10.1158/1078-0432.CCR-17-3125. Epub 2018 Jul 16.
386 An androgen receptor negatively induced long non-coding RNA ARNILA binding to miR-204 promotes the invasion and metastasis of triple-negative breast cancer.Cell Death Differ. 2018 Dec;25(12):2209-2220. doi: 10.1038/s41418-018-0123-6. Epub 2018 May 29.
387 SOX8 acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer.Carcinogenesis. 2019 Oct 16;40(10):1278-1287. doi: 10.1093/carcin/bgz034.
388 CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid.Mol Cancer. 2015 Jul 5;14:129. doi: 10.1186/s12943-015-0380-7.
389 Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-/SMAD signaling.Oncotarget. 2015 Jun 30;6(18):16352-65. doi: 10.18632/oncotarget.3877.
390 Regulatory mechanisms leading to differential Acyl-CoA synthetase 4 expression in breast cancer cells.Sci Rep. 2019 Jul 16;9(1):10324. doi: 10.1038/s41598-019-46776-7.
391 Phenotypic diversity of breast cancer-related mutations in metalloproteinase-disintegrin ADAM12.PLoS One. 2014 Mar 20;9(3):e92536. doi: 10.1371/journal.pone.0092536. eCollection 2014.
392 TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo.PLoS One. 2019 Oct 17;14(10):e0224015. doi: 10.1371/journal.pone.0224015. eCollection 2019.
393 p73 G4C14-to-A4T14 polymorphisms are positively correlated with triple-negative breast cancer in southwestern China.Med Oncol. 2013 Jun;30(2):515. doi: 10.1007/s12032-013-0515-x. Epub 2013 Feb 27.
394 Arrestin Domain Containing 3 Reverses Epithelial to Mesenchymal Transition and Chemo-Resistance of TNBC Cells by Up-Regulating Expression of miR-200b.Cells. 2019 Jul 10;8(7):692. doi: 10.3390/cells8070692.
395 Expression of the BAD pathway is a marker of triple-negative status and poor outcome.Sci Rep. 2019 Nov 25;9(1):17496. doi: 10.1038/s41598-019-53695-0.
396 p63, Sharp1, and HIFs: master regulators of metastasis in triple-negative breast cancer.Cancer Res. 2013 Aug 15;73(16):4978-81. doi: 10.1158/0008-5472.CAN-13-0962. Epub 2013 Aug 2.
397 MiR-25-3p promotes the proliferation of triple negative breast cancer by targeting BTG2.Mol Cancer. 2018 Jan 8;17(1):4. doi: 10.1186/s12943-017-0754-0.
398 Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial.Nat Med. 2018 May;24(5):628-637. doi: 10.1038/s41591-018-0009-7. Epub 2018 Apr 30.
399 Expression profile of CADM1 and CADM4 in triple negative breast cancer with primary systemic therapy.Oncol Lett. 2019 Jan;17(1):921-926. doi: 10.3892/ol.2018.9727. Epub 2018 Nov 19.
400 The PDGFR/ERK1/2 pathway regulates CDCP1 expression in triple-negative breast cancer.BMC Cancer. 2018 May 23;18(1):586. doi: 10.1186/s12885-018-4500-9.
401 Identification of CHD4-1 integrin axis as a prognostic marker in triple-negative breast cancer using next-generation sequencing and bioinformatics.Life Sci. 2019 Dec 1;238:116963. doi: 10.1016/j.lfs.2019.116963. Epub 2019 Oct 19.
402 Systemic Delivery of Tumor-Targeting siRNA Nanoparticles against an Oncogenic LncRNA Facilitates Effective Triple-Negative Breast Cancer Therapy.Bioconjug Chem. 2019 Mar 20;30(3):907-919. doi: 10.1021/acs.bioconjchem.9b00028. Epub 2019 Feb 21.
403 SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.Nature. 2012 Jul 19;487(7407):380-4. doi: 10.1038/nature11207.
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405 Serine/Arginine-Rich Splicing Factor 3 Modulates the Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2.Mol Cancer Res. 2019 Sep;17(9):1920-1930. doi: 10.1158/1541-7786.MCR-18-1291. Epub 2019 May 28.
406 DOCK1 Regulates Growth and Motility through the RRP1B-Claudin-1 Pathway in Claudin-Low Breast Cancer Cells.Cancers (Basel). 2019 Nov 8;11(11):1762. doi: 10.3390/cancers11111762.
407 MicroRNA-137 Inhibits Cancer Progression by Targeting Del-1 in Triple-Negative Breast Cancer Cells.Int J Mol Sci. 2019 Dec 6;20(24):6162. doi: 10.3390/ijms20246162.
408 RSK-mediated down-regulation of PDCD4 is required for proliferation, survival, and migration in a model of triple-negative breast cancer.Oncotarget. 2016 May 10;7(19):27567-83. doi: 10.18632/oncotarget.8375.
409 PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer.J Clin Invest. 2019 Mar 1;129(3):1211-1228. doi: 10.1172/JCI123319. Epub 2019 Feb 11.
410 miR-17-5p suppresses cell proliferation and invasion by targeting ETV1 in triple-negative breast cancer.BMC Cancer. 2017 Nov 10;17(1):745. doi: 10.1186/s12885-017-3674-x.
411 Overexpression of BLM promotes DNA damage and increased sensitivity to platinum salts in triple-negative breast and serous ovarian cancers.Ann Oncol. 2018 Apr 1;29(4):903-909. doi: 10.1093/annonc/mdy049.
412 Long noncoding RNA HCP5 contributes to cisplatin resistance in human triple-negative breast cancer via regulation of PTEN expression.Biomed Pharmacother. 2019 Jul;115:108869. doi: 10.1016/j.biopha.2019.108869. Epub 2019 Apr 24.
413 I cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts.BMC Cancer. 2018 May 25;18(1):595. doi: 10.1186/s12885-018-4507-2.
414 Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer.Breast Cancer Res. 2015 Feb 22;17(1):25. doi: 10.1186/s13058-015-0527-x.
415 ITGB4-mediated metabolic reprogramming of cancer-associated fibroblasts.Oncogene. 2020 Jan;39(3):664-676. doi: 10.1038/s41388-019-1014-0. Epub 2019 Sep 18.
416 Knockdown of DNA/RNA-binding protein KIN17 promotes apoptosis of triple-negative breast cancer cells.Oncol Lett. 2019 Jan;17(1):288-293. doi: 10.3892/ol.2018.9597. Epub 2018 Oct 18.
417 Bazedoxifene is a novel IL-6/GP130 inhibitor for treating triple-negative breast cancer.Breast Cancer Res Treat. 2019 Jun;175(3):553-566. doi: 10.1007/s10549-019-05183-2. Epub 2019 Mar 9.
418 Expression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer.Histopathology. 2013 Jan;62(2):275-86. doi: 10.1111/his.12002. Epub 2012 Nov 8.
419 MicroRNA-589 serves as a tumor suppressor microRNA through directly targeting metastasis-associated protein 2 in breast cancer.Oncol Lett. 2019 Sep;18(3):2232-2239. doi: 10.3892/ol.2019.10548. Epub 2019 Jun 28.
420 MTMR3 is upregulated in patients with breast cancer and regulates proliferation, cell cycle progression and autophagy in breast cancer cells.Oncol Rep. 2019 Nov;42(5):1915-1923. doi: 10.3892/or.2019.7292. Epub 2019 Aug 23.
421 Dimeric Prodrug Self-Delivery Nanoparticles with Enhanced Drug Loading and Bioreduction Responsiveness for Targeted Cancer Therapy.ACS Appl Mater Interfaces. 2018 Nov 21;10(46):39455-39467. doi: 10.1021/acsami.8b09730. Epub 2018 Nov 9.
422 Systemic Administration of siRNA with Anti-HB-EGF Antibody-Modified Lipid Nanoparticles for the Treatment of Triple-Negative Breast Cancer.Mol Pharm. 2018 Apr 2;15(4):1495-1504. doi: 10.1021/acs.molpharmaceut.7b01055. Epub 2018 Mar 12.
423 Spectrum and clinical relevance of PALB2 germline mutations in 7657 Chinese BRCA1/2-negative breast cancer patients.Breast Cancer Res Treat. 2020 Feb;179(3):605-614. doi: 10.1007/s10549-019-05483-7. Epub 2019 Nov 25.
424 PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells.FEBS Lett. 2015 Apr 13;589(9):1033-9. doi: 10.1016/j.febslet.2015.03.009. Epub 2015 Mar 18.
425 SOX10, GATA3, GCDFP15, Androgen Receptor, and Mammaglobin for the Differential Diagnosis Between Triple-negative Breast Cancer and TTF1-negative Lung Adenocarcinoma.Am J Surg Pathol. 2019 Mar;43(3):293-302. doi: 10.1097/PAS.0000000000001216.
426 Histone Deacetylase Inhibitor Enhances the Efficacy of MEK Inhibitor through NOXA-Mediated MCL1 Degradation in Triple-Negative and Inflammatory Breast Cancer.Clin Cancer Res. 2017 Aug 15;23(16):4780-4792. doi: 10.1158/1078-0432.CCR-16-2622. Epub 2017 May 2.
427 Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer.Nat Nanotechnol. 2019 Apr;14(4):388-397. doi: 10.1038/s41565-019-0381-6. Epub 2019 Feb 25.
428 CD155 contributes to the mesenchymal phenotype of triple-negative breast cancer.Cancer Sci. 2020 Feb;111(2):383-394. doi: 10.1111/cas.14276. Epub 2020 Jan 2.
429 miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer.Oncol Rep. 2016 Jul;36(1):65-71. doi: 10.3892/or.2016.4767. Epub 2016 Apr 25.
430 Syntenin1/MDA-9 (SDCBP) induces immune evasion in triple-negative breast cancer by upregulating PD-L1.Breast Cancer Res Treat. 2018 Sep;171(2):345-357. doi: 10.1007/s10549-018-4833-8. Epub 2018 May 29.
431 Development of a Novel Humanized Monoclonal Antibody to Secreted Frizzled-Related Protein-2 That Inhibits Triple-Negative Breast Cancer and Angiosarcoma Growth In Vivo.Ann Surg Oncol. 2019 Dec;26(13):4782-4790. doi: 10.1245/s10434-019-07800-2. Epub 2019 Sep 12.
432 A novel approach for targeted elimination of CSPG4-positive triple-negative breast cancer cells using a MAP tau-based fusion protein.Int J Cancer. 2016 Aug 15;139(4):916-27. doi: 10.1002/ijc.30119. Epub 2016 Apr 15.
433 SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program.Cancer Res. 2019 Feb 15;79(4):720-734. doi: 10.1158/0008-5472.CAN-18-1791. Epub 2019 Jan 3.
434 SMC1 promotes epithelial-mesenchymal transition in triple-negative breast cancer through upregulating Brachyury.Oncol Rep. 2016 Apr;35(4):2405-12. doi: 10.3892/or.2016.4564. Epub 2016 Jan 15.
435 Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells.Tumour Biol. 2016 Oct;37(10):13101-13110. doi: 10.1007/s13277-016-5240-6. Epub 2016 Jul 23.
436 Cancer Testis Antigen Promotes Triple Negative Breast Cancer Metastasis and is Traceable in the Circulating Extracellular Vesicles.Sci Rep. 2019 Aug 12;9(1):11632. doi: 10.1038/s41598-019-48064-w.
437 Obesity-induced MBD2_v2 expression promotes tumor-initiating triple-negative breast cancer stem cells.Mol Oncol. 2019 Apr;13(4):894-908. doi: 10.1002/1878-0261.12444. Epub 2019 Mar 1.
438 Therapeutic positioning of secretory acetylated APE1/Ref-1 requirement for suppression of tumor growth in triple-negative breast cancer in vivo.Sci Rep. 2018 Jun 7;8(1):8701. doi: 10.1038/s41598-018-27025-9.
439 Quadruple Negative Breast Cancers (QNBC) Demonstrate Subtype Consistency among Primary and Recurrent or Metastatic Breast Cancer.Transl Oncol. 2019 Mar;12(3):493-501. doi: 10.1016/j.tranon.2018.11.008. Epub 2018 Dec 27.
440 AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer.J Exp Clin Cancer Res. 2017 May 12;36(1):65. doi: 10.1186/s13046-017-0522-4.
441 ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer.Oncotarget. 2016 Dec 13;7(50):83278-83293. doi: 10.18632/oncotarget.13086.
442 Induction of AMPK activation by N,N'-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers.PLoS One. 2019 Mar 15;14(3):e0209392. doi: 10.1371/journal.pone.0209392. eCollection 2019.
443 Autophagy promotes triple negative breast cancer metastasis via YAP nuclear localization.Biochem Biophys Res Commun. 2019 Dec 3;520(2):263-268. doi: 10.1016/j.bbrc.2019.09.133. Epub 2019 Oct 5.
444 ANP32E induces tumorigenesis of triple-negative breast cancer cells by upregulating E2F1.Mol Oncol. 2018 Jun;12(6):896-912. doi: 10.1002/1878-0261.12202. Epub 2018 Apr 18.
445 The expression of ANXA3 and its relationship with the occurrence and development of breast cancer.J BUON. 2018 May-Jun;23(3):713-719.
446 Molecular pathogenesis of triple-negative breast cancer based on microRNA expression signatures: antitumor miR-204-5p targets AP1S3.J Hum Genet. 2018 Dec;63(12):1197-1210. doi: 10.1038/s10038-018-0510-3. Epub 2018 Sep 18.
447 ARHGAP18 Downregulation by miR-200b Suppresses Metastasis of Triple-Negative Breast Cancer by Enhancing Activation of RhoA.Cancer Res. 2017 Aug 1;77(15):4051-4064. doi: 10.1158/0008-5472.CAN-16-3141. Epub 2017 Jun 15.
448 Upregulated expression of AT-rich interactive domain-containing protein 1B predicts poor prognosis in patients with triple-negative breast cancer.Oncol Lett. 2019 Mar;17(3):3289-3295. doi: 10.3892/ol.2019.9961. Epub 2019 Jan 23.
449 Molecular features of triple negative breast cancer cells by genome-wide gene expression profiling analysis.Int J Oncol. 2013 Feb;42(2):478-506. doi: 10.3892/ijo.2012.1744. Epub 2012 Dec 18.
450 Rare ATAD5 missense variants in breast and ovarian cancer patients.Cancer Lett. 2016 Jun 28;376(1):173-7. doi: 10.1016/j.canlet.2016.03.048. Epub 2016 Apr 1.
451 ATG9A Is Overexpressed in Triple Negative Breast Cancer and Its In Vitro Extinction Leads to the Inhibition of Pro-Cancer Phenotypes.Cells. 2018 Dec 6;7(12):248. doi: 10.3390/cells7120248.
452 Immunization against HIF-1 Inhibits the Growth of Basal Mammary Tumors and Targets Mammary Stem Cells In Vivo.Clin Cancer Res. 2017 Jul 1;23(13):3396-3404. doi: 10.1158/1078-0432.CCR-16-1678. Epub 2016 Dec 30.
453 Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.Cancer Cell. 2018 Feb 12;33(2):187-201.e10. doi: 10.1016/j.ccell.2018.01.009.
454 Genetic evaluation of BRCA1 associated a complex genes with triple-negative breast cancer susceptibility in Chinese women.Oncotarget. 2016 Mar 1;7(9):9759-72. doi: 10.18632/oncotarget.7112.
455 Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.Cell Rep. 2017 Dec 5;21(10):2952-2964. doi: 10.1016/j.celrep.2017.11.026.
456 Correction: BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer.Oncotarget. 2019 May 3;10(33):3144. doi: 10.18632/oncotarget.26920. eCollection 2019 May 3.
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458 p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c-Kit activity.Stem Cells. 2013 Jul;31(7):1422-33. doi: 10.1002/stem.1403.
459 Roles of BCCIP deficiency in mammary tumorigenesis.Breast Cancer Res. 2017 Oct 18;19(1):115. doi: 10.1186/s13058-017-0907-5.
460 Differential roles of Bcl2L12 and its short variant in breast cancer lymph node metastasis.Oncol Rep. 2015 Aug;34(2):961-71. doi: 10.3892/or.2015.4071. Epub 2015 Jun 16.
461 Medullary Breast Carcinoma, a Triple-Negative Breast Cancer Associated with BCLG Overexpression.Am J Pathol. 2018 Oct;188(10):2378-2391. doi: 10.1016/j.ajpath.2018.06.021. Epub 2018 Aug 1.
462 Bcl-3 promotes proliferation and chemosensitivity in BL1 subtype of TNBC cells.Acta Biochim Biophys Sin (Shanghai). 2018 Nov 1;50(11):1141-1149. doi: 10.1093/abbs/gmy117.
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464 Similar outcomes between adenoid cystic carcinoma of the breast and invasive ductal carcinoma: a population-based study from the SEER 18 database.Oncotarget. 2017 Jan 24;8(4):6206-6215. doi: 10.18632/oncotarget.14052.
465 Down-regulation of BRMS1 by DNA hypermethylation and its association with metastatic progression in triple-negative breast cancer.Int J Clin Exp Pathol. 2015 Sep 1;8(9):11076-83. eCollection 2015.
466 -TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells.Exp Mol Med. 2015 Feb 27;47(2):e143. doi: 10.1038/emm.2014.127.
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469 Cancer testis antigen Sperm Protein 17 as a new target for triple negative breast cancer immunotherapy.Oncotarget. 2017 Aug 10;8(43):74378-74390. doi: 10.18632/oncotarget.20102. eCollection 2017 Sep 26.
470 CCN5/WISP-2 promotes growth arrest of triple-negative breast cancer cells through accumulation and trafficking of p27(Kip1) via Skp2 and FOXO3a regulation.Oncogene. 2015 Jun 11;34(24):3152-63. doi: 10.1038/onc.2014.250. Epub 2014 Aug 18.
471 CCN6 regulates IGF2BP2and HMGA2 signaling in metaplastic carcinomas of the breast.Breast Cancer Res Treat. 2018 Dec;172(3):577-586. doi: 10.1007/s10549-018-4960-2. Epub 2018 Sep 15.
472 CyclinG1 Amplification Enhances Aurora Kinase Inhibitor-Induced Polyploid Resistance and Inhibition of Bcl-2 Pathway Reverses the Resistance.Cell Physiol Biochem. 2017;43(1):94-107. doi: 10.1159/000480322. Epub 2017 Aug 25.
473 Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing.Mol Cancer. 2015 Feb 10;14:36. doi: 10.1186/s12943-015-0301-9.
474 Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis. Mol Cancer Ther. 2019 May;18(5):873-885.
475 Canadian Cancer Trials Group IND197: a phase II study of foretinib in patients with estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2-negative recurrent or metastatic breast cancer.Breast Cancer Res Treat. 2016 May;157(1):109-16. doi: 10.1007/s10549-016-3812-1. Epub 2016 Apr 26.
476 New halogenated constituents from Mangifera zeylanica Hook.f. and their potential anti-cancer effects in breast and ovarian cancer cells.J Ethnopharmacol. 2016 Aug 2;189:165-74. doi: 10.1016/j.jep.2016.05.047. Epub 2016 May 17.
477 MiR-27a modulates radiosensitivity of triple-negative breast cancer (TNBC) cells by targeting CDC27.Med Sci Monit. 2015 May 6;21:1297-303. doi: 10.12659/MSM.893974.
478 Knockdown of cell division cycle-associated protein 4 expression inhibits proliferation of triple negative breast cancer MDA-MB-231 cells in vitro and in vivo.Oncol Lett. 2019 May;17(5):4393-4400. doi: 10.3892/ol.2019.10077. Epub 2019 Feb 26.
479 Overexpression of CDCA7 predicts poor prognosis and induces EZH2-mediated progression of triple-negative breast cancer.Int J Cancer. 2018 Nov 15;143(10):2602-2613. doi: 10.1002/ijc.31766. Epub 2018 Sep 19.
480 Integrated analysis of expression profiling data identifies three genes in correlation with poor prognosis of triple-negative breast cancer.Int J Oncol. 2014 Jun;44(6):2025-33. doi: 10.3892/ijo.2014.2352. Epub 2014 Mar 20.
481 Centromere protein U (CENPU) enhances angiogenesis in triple-negative breast cancer by inhibiting ubiquitin-proteasomal degradation of COX-2.Cancer Lett. 2020 Jul 10;482:102-111. doi: 10.1016/j.canlet.2019.11.003. Epub 2019 Nov 6.
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484 CHST9 rs1436904 genetic variant contributes to prognosis of triple-negative breast cancer.Sci Rep. 2017 Sep 18;7(1):11802. doi: 10.1038/s41598-017-12306-6.
485 Cip2a/miR-301a feedback loop promotes cell proliferation and invasion of triple-negative breast cancer.J Cancer. 2019 Oct 15;10(24):5964-5974. doi: 10.7150/jca.35704. eCollection 2019.
486 Blocking LLT1 (CLEC2D, OCIL)-NKRP1A (CD161) interaction enhances natural killer cell-mediated lysis of triple-negative breast cancer cells.Am J Cancer Res. 2018 Jun 1;8(6):1050-1063. eCollection 2018.
487 siRNA-mediated suppression of collagen type iv alpha 2 (COL4A2) mRNA inhibits triple-negative breast cancer cell proliferation and migration.Oncotarget. 2017 Jan 10;8(2):2585-2593. doi: 10.18632/oncotarget.13716.
488 miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer.Mol Oncol. 2014 Dec;8(8):1690-702. doi: 10.1016/j.molonc.2014.07.006. Epub 2014 Jul 12.
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490 CREB3L1 as a potential biomarker predicting response of triple negative breast cancer to doxorubicin-based chemotherapy.BMC Cancer. 2018 Aug 13;18(1):813. doi: 10.1186/s12885-018-4724-8.
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499 Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells.Sci Rep. 2019 Sep 24;9(1):13748. doi: 10.1038/s41598-019-50141-z.
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502 Systematic Immunotherapy Target Discovery Using Genome-Scale InVivo CRISPR Screens in CD8T Cells.Cell. 2019 Aug 22;178(5):1189-1204.e23. doi: 10.1016/j.cell.2019.07.044.
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505 EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming.Nat Commun. 2019 Nov 6;10(1):5033. doi: 10.1038/s41467-019-13034-3.
506 EgoNet: identification of human disease ego-network modules.BMC Genomics. 2014 Apr 28;15:314. doi: 10.1186/1471-2164-15-314.
507 Proteomics Identification and Validation of Desmocollin-1 and Catechol-O-Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis.Proteomics. 2019 Nov;19(21-22):e1900073. doi: 10.1002/pmic.201900073. Epub 2019 Oct 28.
508 Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer.Int J Mol Sci. 2019 Jun 24;20(12):3080. doi: 10.3390/ijms20123080.
509 Acetylation of conserved DVL-1 lysines regulates its nuclear translocation and binding to gene promoters in triple-negative breast cancer.Sci Rep. 2019 Nov 7;9(1):16257. doi: 10.1038/s41598-019-52723-3.
510 miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.Mol Cancer Ther. 2014 Dec;13(12):3185-97. doi: 10.1158/1535-7163.MCT-14-0243. Epub 2014 Oct 15.
511 ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer.Br J Cancer. 2019 Apr;120(9):931-940. doi: 10.1038/s41416-019-0448-z. Epub 2019 Apr 11.
512 Elevated levels of eEF1A2 protein expression in triple negative breast cancer relate with poor prognosis.PLoS One. 2019 Jun 20;14(6):e0218030. doi: 10.1371/journal.pone.0218030. eCollection 2019.
513 First-in-human, phase I study of PF-06647263, an anti-EFNA4 calicheamicin antibody-drug conjugate, in patients with advanced solid tumors.Int J Cancer. 2019 Oct 1;145(7):1798-1808. doi: 10.1002/ijc.32154. Epub 2019 Feb 23.
514 MicroRNA-455-3p promotes invasion and migration in triple negative breast cancer by targeting tumor suppressor EI24.Oncotarget. 2017 Mar 21;8(12):19455-19466. doi: 10.18632/oncotarget.14307.
515 The CXCR4-LASP1-eIF4F Axis Promotes Translation of Oncogenic Proteins in Triple-Negative Breast Cancer Cells.Front Oncol. 2019 Apr 24;9:284. doi: 10.3389/fonc.2019.00284. eCollection 2019.
516 Downregulation of Dock1 and Elmo1 suppresses the migration and invasion of triple-negative breast cancer epithelial cells through the RhoA/Rac1 pathway.Oncol Lett. 2018 Sep;16(3):3481-3488. doi: 10.3892/ol.2018.9077. Epub 2018 Jul 4.
517 Differences in elongation of very long chain fatty acids and fatty acid metabolism between triple-negative and hormone receptor-positive breast cancer.BMC Cancer. 2017 Aug 29;17(1):589. doi: 10.1186/s12885-017-3554-4.
518 Integration of whole-genome sequencing and functional screening identifies a prognostic signature for lung metastasis in triple-negative breast cancer.Int J Cancer. 2019 Nov 15;145(10):2850-2860. doi: 10.1002/ijc.32329. Epub 2019 Apr 29.
519 Breast cancer genes PSMC3IP and EPSTI1 play a role in apoptosis regulation.PLoS One. 2015 Jan 15;10(1):e0115352. doi: 10.1371/journal.pone.0115352. eCollection 2015.
520 Combined genetic and nutritional risk models of triple negative breast cancer.Nutr Cancer. 2014;66(6):955-63. doi: 10.1080/01635581.2014.932397. Epub 2014 Jul 14.
521 Loss of PICH promotes chromosome instability and cell death in triple-negative breast cancer.Cell Death Dis. 2019 Jun 3;10(6):428. doi: 10.1038/s41419-019-1662-6.
522 Endocan as a prognostic biomarker of triple-negative breast cancer.Breast Cancer Res Treat. 2017 Jan;161(2):269-278. doi: 10.1007/s10549-016-4057-8. Epub 2016 Nov 25.
523 The GRHL2/ZEB Feedback Loop-A Key Axis in the Regulation of EMT in Breast Cancer.J Cell Biochem. 2017 Sep;118(9):2559-2570. doi: 10.1002/jcb.25974. Epub 2017 May 3.
524 Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation.J Clin Invest. 2018 Jun 1;128(6):2535-2550. doi: 10.1172/JCI96784. Epub 2018 May 14.
525 FA2H Exhibits Tumor Suppressive Roles on Breast Cancers via Cancer Stemness Control.Front Oncol. 2019 Oct 24;9:1089. doi: 10.3389/fonc.2019.01089. eCollection 2019.
526 Metabolic role of fatty acid binding protein 7 in mediating triple-negative breast cancer cell death via PPAR- signaling.J Lipid Res. 2019 Nov;60(11):1807-1817. doi: 10.1194/jlr.M092379. Epub 2019 Sep 4.
527 Estrogen receptor- regulation of microRNA-590 targets FAM171A1-a modifier of breast cancer invasiveness.Oncogenesis. 2019 Jan 9;8(1):5. doi: 10.1038/s41389-018-0113-z.
528 Systematic network-based discovery of a Fam20C inhibitor (FL-1607) with apoptosis modulation in triple-negative breast cancer.Mol Biosyst. 2016 Jun 21;12(7):2108-18. doi: 10.1039/c6mb00111d.
529 Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition.Mol Cancer Ther. 2015 Oct;14(10):2321-31. doi: 10.1158/1535-7163.MCT-15-0374. Epub 2015 Aug 20.
530 FANCM mutation c.5791C>T is a risk factor for triple-negative breast cancer in the Finnish population.Breast Cancer Res Treat. 2017 Nov;166(1):217-226. doi: 10.1007/s10549-017-4388-0. Epub 2017 Jul 12.
531 The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy.Acta Pharmacol Sin. 2017 Apr;38(4):513-523. doi: 10.1038/aps.2016.136. Epub 2017 Jan 2.
532 The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.Mol Cell. 2019 Jan 17;73(2):224-237.e6. doi: 10.1016/j.molcel.2018.11.003. Epub 2018 Dec 13.
533 Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.Breast Cancer (Auckl). 2018 Aug 24;12:1178223418792247. doi: 10.1177/1178223418792247. eCollection 2018.
534 Identification of FOXE3 transcription factor as a potent oncogenic factor in triple-negative breast cancer.Biochem Biophys Res Commun. 2020 Feb 26;523(1):78-85. doi: 10.1016/j.bbrc.2019.12.034. Epub 2019 Dec 9.
535 microRNA-155 positively regulates glucose metabolism via PIK3R1-FOXO3a-cMYC axis in breast cancer.Oncogene. 2018 May;37(22):2982-2991. doi: 10.1038/s41388-018-0124-4. Epub 2018 Mar 12.
536 FOXO3a expression is associated with lymph node metastasis and poor disease-free survival in triple-negative breast cancer.J Clin Pathol. 2018 Sep;71(9):806-813. doi: 10.1136/jclinpath-2018-205052. Epub 2018 Mar 27.
537 FSIP1 regulates autophagy in breast cancer.Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13075-13080. doi: 10.1073/pnas.1809681115. Epub 2018 Dec 3.
538 Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer.Mol Cancer Ther. 2013 Apr;12(4):491-8. doi: 10.1158/1535-7163.MCT-12-1090. Epub 2013 Feb 27.
539 GABARAPL1 acts as a potential marker and promotes tumor proliferation and metastasis in triple negative breast cancer.Oncotarget. 2017 Aug 10;8(43):74519-74526. doi: 10.18632/oncotarget.20159. eCollection 2017 Sep 26.
540 A soluble form of GAS1 inhibits tumor growth and angiogenesis in a triple negative breast cancer model.Exp Cell Res. 2014 Oct 1;327(2):307-17. doi: 10.1016/j.yexcr.2014.06.016. Epub 2014 Jun 30.
541 Guanylate-binding protein-1 is a potential new therapeutic target for triple-negative breast cancer.BMC Cancer. 2017 Nov 7;17(1):727. doi: 10.1186/s12885-017-3726-2.
542 GDF10 inhibits proliferation and epithelial-mesenchymal transition in triple-negative breast cancer via upregulation of Smad7.Aging (Albany NY). 2019 May 31;11(10):3298-3314. doi: 10.18632/aging.101983.
543 Altered glycometabolism affects both clinical features and prognosis of triple-negative and neoadjuvant chemotherapy-treated breast cancer.Tumour Biol. 2016 Jun;37(6):8159-68. doi: 10.1007/s13277-015-4729-8. Epub 2015 Dec 29.
544 circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a.J Exp Clin Cancer Res. 2017 Oct 16;36(1):145. doi: 10.1186/s13046-017-0614-1.
545 GGNBP2 suppresses triple-negative breast cancer aggressiveness through inhibition of IL-6/STAT3 signaling activation.Breast Cancer Res Treat. 2019 Feb;174(1):65-78. doi: 10.1007/s10549-018-5052-z. Epub 2018 Nov 19.
546 GLCE rs3865014 (Val597Ile) polymorphism is associated with breast cancer susceptibility and triple-negative breast cancer in Siberian population.Gene. 2017 Sep 10;628:224-229. doi: 10.1016/j.gene.2017.07.054. Epub 2017 Jul 20.
547 Identification of the Thioredoxin-Like 2 Autoantibody as a Specific Biomarker for Triple-Negative Breast Cancer.J Breast Cancer. 2018 Mar;21(1):87-90. doi: 10.4048/jbc.2018.21.1.87. Epub 2018 Mar 23.
548 GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.J Exp Clin Cancer Res. 2019 Apr 8;38(1):152. doi: 10.1186/s13046-019-1157-4.
549 Chemoresistance in the Human Triple-Negative Breast Cancer Cell Line MDA-MB-231 Induced by Doxorubicin Gradient Is Associated with Epigenetic Alterations in Histone Deacetylase.J Oncol. 2019 Jun 2;2019:1345026. doi: 10.1155/2019/1345026. eCollection 2019.
550 Long non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1 overexpression inhibits the proliferation of cancer cells by reducing RUNX2 expression in triple-negative breast cancer.Oncol Lett. 2019 Dec;18(6):6775-6780. doi: 10.3892/ol.2019.11001. Epub 2019 Oct 18.
551 Depletion of the Transcriptional Coactivator Amplified in Breast Cancer 1 (AIB1) Uncovers Functionally Distinct Subpopulations in Triple-Negative Breast Cancer.Neoplasia. 2019 Oct;21(10):963-973. doi: 10.1016/j.neo.2019.07.001. Epub 2019 Aug 19.
552 Identification of sample-specific regulations using integrative network level analysis.BMC Cancer. 2015 Apr 28;15:319. doi: 10.1186/s12885-015-1265-2.
553 hnRNPK S379 phosphorylation participates in migration regulation of triple negative MDA-MB-231 cells.Sci Rep. 2019 May 20;9(1):7611. doi: 10.1038/s41598-019-44063-z.
554 Cancer-Associated MORC2-Mutant M276I Regulates an hnRNPM-Mediated CD44 Splicing Switch to Promote Invasion and Metastasis in Triple-Negative Breast Cancer.Cancer Res. 2018 Oct 15;78(20):5780-5792. doi: 10.1158/0008-5472.CAN-17-1394. Epub 2018 Aug 9.
555 Long noncoding RNA Linc00339 promotes triple-negative breast cancer progression through miR-377-3p/HOXC6 signaling pathway.J Cell Physiol. 2019 Aug;234(8):13303-13317. doi: 10.1002/jcp.28007. Epub 2019 Jan 7.
556 Upregulation of MGP by HOXC8 promotes the proliferation, migration, and EMT processes of triple-negative breast cancer.Mol Carcinog. 2019 Oct;58(10):1863-1875. doi: 10.1002/mc.23079. Epub 2019 Jul 1.
557 Serum sPD-1 and sPD-L1 as Biomarkers for Evaluating the Efficacy of Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients.Clin Breast Cancer. 2019 Oct;19(5):326-332.e1. doi: 10.1016/j.clbc.2019.03.008. Epub 2019 Apr 11.
558 S100P and HYAL2 as prognostic markers for patients with triple-negative breast cancer.Exp Mol Pathol. 2015 Aug;99(1):180-7. doi: 10.1016/j.yexmp.2015.06.010. Epub 2015 Jun 22.
559 Baicalein Suppresses Stem Cell-Like Characteristics in Radio- and Chemoresistant MDA-MB-231 Human Breast Cancer Cells through Up-Regulation of IFIT2.Nutrients. 2019 Mar 14;11(3):624. doi: 10.3390/nu11030624.
560 Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R.Mol Cancer Ther. 2016 Jul;15(7):1545-56. doi: 10.1158/1535-7163.MCT-15-0865. Epub 2016 May 11.
561 IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers.Cancer Res. 2014 Sep 1;74(17):4908-21. doi: 10.1158/0008-5472.CAN-14-0637. Epub 2014 Jun 30.
562 INPP4B overexpression enhances the antitumor efficacy of PARP inhibitor AG014699 in MDA-MB-231 triple-negative breast cancer cells.Tumour Biol. 2014 May;35(5):4469-77. doi: 10.1007/s13277-013-1589-y. Epub 2014 Jan 14.
563 Interferon-beta represses cancer stem cell properties in triple-negative breast cancer.Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13792-13797. doi: 10.1073/pnas.1713728114. Epub 2017 Dec 11.
564 Combined mTOR inhibitor rapamycin and doxorubicin-loaded cyclicoctapeptide modified liposomes for targeting integrin 3 in triple-negative breast cancer.Biomaterials. 2014 Jul;35(20):5347-5358. doi: 10.1016/j.biomaterials.2014.03.036. Epub 2014 Apr 13.
565 Integrin 9 depletion promotes -catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis.Int J Cancer. 2019 Nov 15;145(10):2767-2780. doi: 10.1002/ijc.32359. Epub 2019 May 3.
566 Identification of epigenetic factors regulating the mesenchyme to epithelium transition by RNA interference screening in breast cancer cells.BMC Cancer. 2016 Aug 31;16(1):700. doi: 10.1186/s12885-016-2683-5.
567 MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase C-based triple-negative breast cancer cells.Oncotarget. 2016 Sep 13;7(37):59845-59859. doi: 10.18632/oncotarget.11337.
568 Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p15INK4B, p16INK4A, and p57KIP2 transcription.Acta Biochim Biophys Sin (Shanghai). 2018 Sep 1;50(9):897-904. doi: 10.1093/abbs/gmy084.
569 Overexpression of histone demethylase JMJD5 promotes metastasis and indicates a poor prognosis in breast cancer.Int J Clin Exp Pathol. 2015 Sep 1;8(9):10325-34. eCollection 2015.
570 KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. Neoplasia. 2014 Mar;16(3):247-56, 256.e2. doi: 10.1016/j.neo.2014.03.008.
571 Knockdown of Kinase Family 15 Inhibits Cancer Cell Proliferation In vitro and its Clinical Relevance in Triple-Negative Breast Cancer.Curr Mol Med. 2019;19(2):147-155. doi: 10.2174/1566524019666190308122108.
572 circKIF4A acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer.Mol Cancer. 2019 Feb 11;18(1):23. doi: 10.1186/s12943-019-0946-x.
573 Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer.Sci Rep. 2017 Feb 20;7:42289. doi: 10.1038/srep42289.
574 MiR-539 inhibits proliferation and migration of triple-negative breast cancer cells by down-regulating LAMA4 expression.Cancer Cell Int. 2018 Jan 30;18:16. doi: 10.1186/s12935-018-0512-4. eCollection 2018.
575 Expression of phosphorylated Hippo pathway kinases (MST1/2 and LATS1/2) in HER2-positive and triple-negative breast cancer patients treated with neoadjuvant therapy.Cancer Biol Ther. 2017 May 4;18(5):339-346. doi: 10.1080/15384047.2017.1312230. Epub 2017 Apr 7.
576 Effect of anthracycline and taxane on the expression of programmed cell death ligand-1 and galectin-9 in triple-negative breast cancer.Pathol Res Pract. 2018 Oct;214(10):1626-1631. doi: 10.1016/j.prp.2018.08.009. Epub 2018 Aug 17.
577 Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors.Cancer Res. 2017 Oct 1;77(19):5395-5408. doi: 10.1158/0008-5472.CAN-17-1571. Epub 2017 Aug 14.
578 LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer.Oncotarget. 2017 Feb 14;8(7):11977-11989. doi: 10.18632/oncotarget.14450.
579 Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival.FASEB J. 2017 Jul;31(7):2893-2904. doi: 10.1096/fj.201601353R. Epub 2017 Mar 27.
580 Dysregulation of non-histone molecule miR205 and LRG1 post-transcriptional de-regulation by SETD1A in triple negative breast cancer.Mol Biol Rep. 2019 Dec;46(6):6617-6624. doi: 10.1007/s11033-019-05079-w. Epub 2019 Sep 24.
581 Targeting LRP8 inhibits breast cancer stem cells in triple-negative breast cancer.Cancer Lett. 2018 Dec 1;438:165-173. doi: 10.1016/j.canlet.2018.09.022. Epub 2018 Sep 15.
582 Frequent downregulation of LRRC26 by epigenetic alterations is involved in the malignant progression of triple-negative breast cancer.Int J Oncol. 2018 May;52(5):1539-1558. doi: 10.3892/ijo.2018.4301. Epub 2018 Mar 5.
583 miR-1207-5p regulates the sensitivity of triple-negative breast cancer cells to Taxol treatment via the suppression of LZTS1 expression.Oncol Lett. 2019 Jan;17(1):990-998. doi: 10.3892/ol.2018.9687. Epub 2018 Nov 12.
584 TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR(+) Metastatic Triple-Negative Breast Cancer.Clin Cancer Res. 2020 May 1;26(9):2111-2123. doi: 10.1158/1078-0432.CCR-19-2170. Epub 2019 Dec 10.
585 Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.Nature. 2016 Jan 21;529(7586):413-417. doi: 10.1038/nature16508. Epub 2016 Jan 6.
586 Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion.J Cell Biochem. 2017 Sep;118(9):2968-2976. doi: 10.1002/jcb.25956. Epub 2017 May 30.
587 Expression of potential biomarkers associated with homologous recombination repair in patients with ovarian or triple-negative breast cancer.Cancer Biomark. 2016;16(1):145-52. doi: 10.3233/CBM-150550.
588 Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase.Nat Commun. 2018 Feb 8;9(1):578. doi: 10.1038/s41467-018-02938-1.
589 Non-SMC Condensin I Complex Subunit D2 Is a Prognostic Factor in Triple-Negative Breast Cancer for the Ability to Promote Cell Cycle and Enhance Invasion.Am J Pathol. 2020 Jan;190(1):37-47. doi: 10.1016/j.ajpath.2019.09.014. Epub 2019 Oct 12.
590 Knockdown of B7H6 inhibits tumor progression in triple-negative breast cancer.Oncol Lett. 2018 Jul;16(1):91-96. doi: 10.3892/ol.2018.8689. Epub 2018 May 10.
591 The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L.Oncogene. 2018 Jul;37(28):3879-3893. doi: 10.1038/s41388-018-0239-7. Epub 2018 Apr 17.
592 Long non-coding RNA (LncRNA) RMST in triple-negative breast cancer (TNBC): Expression analysis and biological roles research.J Cell Physiol. 2018 Oct;233(10):6603-6612. doi: 10.1002/jcp.26311. Epub 2018 Apr 17.
593 Inhibition of the Proteasome 2 Site Sensitizes Triple-Negative Breast Cancer Cells to 5 Inhibitors and Suppresses Nrf1 Activation.Cell Chem Biol. 2017 Feb 16;24(2):218-230. doi: 10.1016/j.chembiol.2016.12.016. Epub 2017 Jan 26.
594 Downregulation of RIP140 in triple-negative breast cancer inhibits the growth and proliferation of cancer cells.Oncol Lett. 2018 Jun;15(6):8784-8788. doi: 10.3892/ol.2018.8434. Epub 2018 Apr 5.
595 Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling.Acta Pharmacol Sin. 2019 Aug;40(8):1067-1075. doi: 10.1038/s41401-018-0199-z. Epub 2019 Jan 22.
596 Effect of bis(hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study.Int J Oncol. 2018 Jan;52(1):67-76. doi: 10.3892/ijo.2017.4204. Epub 2017 Nov 14.
597 PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling.Cancer Lett. 2017 Nov 28;409:30-41. doi: 10.1016/j.canlet.2017.08.019. Epub 2017 Aug 24.
598 Novel Copper Complexes That Inhibit the Proteasome and Trigger Apoptosis in Triple-Negative Breast Cancer Cells.ACS Med Chem Lett. 2019 Jul 25;10(9):1328-1335. doi: 10.1021/acsmedchemlett.9b00284. eCollection 2019 Sep 12.
599 PCDHGB7 Increases Chemosensitivity to Carboplatin by Inhibiting HSPA9 via Inducing Apoptosis in Breast Cancer.Dis Markers. 2019 Jul 8;2019:6131548. doi: 10.1155/2019/6131548. eCollection 2019.
600 MEL-18 loss mediates estrogen receptor- downregulation and hormone independence.J Clin Invest. 2015 May;125(5):1801-14. doi: 10.1172/JCI73743. Epub 2015 Mar 30.
601 An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection.Cancer Immunol Immunother. 2017 Dec;66(12):1529-1544. doi: 10.1007/s00262-017-2047-2. Epub 2017 Aug 2.
602 Expression and regulatory function of miRNA-182 in triple-negative breast cancer cells through its targeting of profilin 1.Tumour Biol. 2013 Jun;34(3):1713-22. doi: 10.1007/s13277-013-0708-0. Epub 2013 Feb 22.
603 Computational analysis of mRNA expression profiles identifies the ITG family and PIK3R3 as crucial genes for regulating triple negative breast cancer cell migration.Biomed Res Int. 2014;2014:536591. doi: 10.1155/2014/536591. Epub 2014 May 6.
604 PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer.Oncotarget. 2018 May 1;9(33):23208-23219. doi: 10.18632/oncotarget.25292. eCollection 2018 May 1.
605 Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells.Anticancer Res. 2013 Feb;33(2):393-9.
606 The Gh-PLC1 signaling axis drives metastatic progression in triple-negative breast cancer.J Hematol Oncol. 2017 Jun 2;10(1):114. doi: 10.1186/s13045-017-0481-4.
607 Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional Study.Sci Rep. 2017 Jun 12;7(1):3301. doi: 10.1038/s41598-017-03280-0.
608 LncRNA POU3F3 promotes proliferation and inhibits apoptosis of cancer cells in triple-negative breast cancer by inactivating caspase 9.Biosci Biotechnol Biochem. 2019 Jun;83(6):1117-1123. doi: 10.1080/09168451.2019.1588097. Epub 2019 Mar 7.
609 Large-scale in-silico identification of a tumor-specific antigen pool for targeted immunotherapy in triple-negative breast cancer.Oncotarget. 2019 Apr 2;10(26):2515-2529. doi: 10.18632/oncotarget.26808. eCollection 2019 Apr 2.
610 PRDM14 directly interacts with heat shock proteins HSP90 and glucose-regulated protein 78.Cancer Sci. 2018 Feb;109(2):373-383. doi: 10.1111/cas.13458. Epub 2017 Dec 28.
611 Inhibition on the growth of human MDA-MB-231 breast cancer cells in vitro and tumor growth in a mouse xenograft model by Se-containing polysaccharides from Pyracantha fortuneana.Nutr Res. 2016 Nov;36(11):1243-1254. doi: 10.1016/j.nutres.2016.09.012. Epub 2016 Oct 2.
612 Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers.Cell Res. 2019 Oct;29(10):832-845. doi: 10.1038/s41422-019-0225-9. Epub 2019 Sep 3.
613 miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer.J Cell Mol Med. 2016 May;20(5):864-73. doi: 10.1111/jcmm.12770. Epub 2016 Jan 28.
614 MiR-212-5p Suppresses the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer by Targeting Prrx2.Cell Physiol Biochem. 2017;44(5):1785-1795. doi: 10.1159/000485785. Epub 2017 Dec 6.
615 Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.Nat Med. 2018 May;24(4):505-511. doi: 10.1038/nm.4507. Epub 2018 Mar 26.
616 NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest.Oncogenesis. 2018 May 25;7(5):42. doi: 10.1038/s41389-018-0051-9.
617 LncRNA HOTAIR up-regulation is strongly related with lymph nodes metastasis and LAR subtype of Triple Negative Breast Cancer.J Cancer. 2019 May 12;10(9):2018-2024. doi: 10.7150/jca.29670. eCollection 2019.
618 Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.Oncol Rep. 2017 Mar;37(3):1619-1626. doi: 10.3892/or.2017.5404. Epub 2017 Jan 25.
619 IgA Fc-folate conjugate activates and recruits neutrophils to directly target triple-negative breast cancer cells.Breast Cancer Res Treat. 2018 Dec;172(3):551-560. doi: 10.1007/s10549-018-4941-5. Epub 2018 Aug 28.
620 Gene and lncRNA co-expression network analysis reveals novel ceRNA network for triple-negative breast cancer.Sci Rep. 2019 Oct 22;9(1):15122. doi: 10.1038/s41598-019-51626-7.
621 Associations between RAD51D germline mutations and breast cancer risk and survival in BRCA1/2-negative breast cancers.Ann Oncol. 2018 Oct 1;29(10):2046-2051. doi: 10.1093/annonc/mdy338.
622 Gene expression in triple-negative breast cancer in relation to survival.Breast Cancer Res Treat. 2018 Aug;171(1):199-207. doi: 10.1007/s10549-018-4816-9. Epub 2018 May 10.
623 Downregulation of RASSF6 promotes breast cancer growth and chemoresistance through regulation of Hippo signaling.Biochem Biophys Res Commun. 2018 Sep 18;503(4):2340-2347. doi: 10.1016/j.bbrc.2018.06.159. Epub 2018 Jul 2.
624 LINC00096 Promotes the Proliferation and Invasion by Sponging miR-383-5p and Regulating RBM3 Expression in Triple-Negative Breast Cancer.Onco Targets Ther. 2019 Dec 2;12:10569-10578. doi: 10.2147/OTT.S229659. eCollection 2019.
625 The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine.J Biol Chem. 2019 Oct 18;294(42):15330-15345. doi: 10.1074/jbc.RA119.008420. Epub 2019 Aug 23.
626 RECQL5 plays an essential role in maintaining genome stability and viability of triple-negative breast cancer cells.Cancer Med. 2019 Aug;8(10):4743-4752. doi: 10.1002/cam4.2349. Epub 2019 Jun 23.
627 Up-Regulation of RFC3 Promotes Triple Negative Breast Cancer Metastasis and is Associated With Poor Prognosis Via EMT.Transl Oncol. 2017 Feb;10(1):1-9. doi: 10.1016/j.tranon.2016.10.004. Epub 2016 Nov 23.
628 Regulator of G protein signaling 20 correlates with clinicopathological features and prognosis in triple-negative breast cancer.Biochem Biophys Res Commun. 2017 Apr 8;485(3):693-697. doi: 10.1016/j.bbrc.2017.02.106. Epub 2017 Feb 22.
629 MicroRNA?26?p inhibits the proliferation, migration, invasion, and angiogenesis of triplenegative breast cancer cells by targeting RGS3.Oncol Rep. 2019 Oct;42(4):1569-1579. doi: 10.3892/or.2019.7251. Epub 2019 Jul 26.
630 (212)Pb-Labeled Antibody 225.28 Targeted to Chondroitin Sulfate Proteoglycan 4 for Triple-Negative Breast Cancer Therapy in Mouse Models.Int J Mol Sci. 2018 Mar 21;19(4):925. doi: 10.3390/ijms19040925.
631 Large miRNA survival analysis reveals a prognostic four-biomarker signature for triple negative breast cancer.Genet Mol Biol. 2020 Mar 2;43(1):e20180269. doi: 10.1590/1678-4685-GMB-2018-0269. eCollection 2020.
632 Aberrant DNA methylation status of DNA repair genes in breast cancer treated with neoadjuvant chemotherapy.Genes Cells. 2013 Dec;18(12):1120-30. doi: 10.1111/gtc.12100. Epub 2013 Oct 28.
633 The lncRNA BORG facilitates the survival and chemoresistance of triple-negative breast cancers.Oncogene. 2019 Mar;38(12):2020-2041. doi: 10.1038/s41388-018-0586-4. Epub 2018 Nov 22.
634 Role of RPL39 in Metaplastic Breast Cancer.J Natl Cancer Inst. 2016 Dec 31;109(6):djw292. doi: 10.1093/jnci/djw292. Print 2017 Jun.
635 Inhibition of RPTOR overcomes resistance to EGFR inhibition in triple-negative breast cancer cells.Int J Oncol. 2018 Mar;52(3):828-840. doi: 10.3892/ijo.2018.4244. Epub 2018 Jan 15.
636 TRA2A Promoted Paclitaxel Resistance and Tumor Progression in Triple-Negative Breast Cancers via Regulating Alternative Splicing.Mol Cancer Ther. 2017 Jul;16(7):1377-1388. doi: 10.1158/1535-7163.MCT-17-0026. Epub 2017 Apr 17.
637 CLImAT-HET: detecting subclonal copy number alterations and loss of heterozygosity in heterogeneous tumor samples from whole-genome sequencing data.BMC Med Genomics. 2017 Mar 15;10(1):15. doi: 10.1186/s12920-017-0255-4.
638 Microarray-based SNP genotyping to identify genetic risk factors of triple-negative breast cancer (TNBC) in South Indian population.Mol Cell Biochem. 2018 May;442(1-2):1-10. doi: 10.1007/s11010-017-3187-6. Epub 2017 Sep 16.
639 MiR-31 inhibits migration and invasion by targeting SATB2 in triple negative breast cancer.Gene. 2016 Dec 5;594(1):47-58. doi: 10.1016/j.gene.2016.08.057. Epub 2016 Sep 1.
640 SCYL1 does not regulate REST expression and turnover.PLoS One. 2017 Jun 1;12(6):e0178680. doi: 10.1371/journal.pone.0178680. eCollection 2017.
641 Proteomic investigation on bio-corona of Au, Ag and Fe nanoparticles for the discovery of triple negative breast cancer serum protein biomarkers.J Proteomics. 2020 Feb 10;212:103581. doi: 10.1016/j.jprot.2019.103581. Epub 2019 Nov 12.
642 The role of sentrin-specific protease 2 substrate recognition in TGF--induced tumorigenesis.Sci Rep. 2018 Jun 28;8(1):9786. doi: 10.1038/s41598-018-28103-8.
643 Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer.Sci Rep. 2019 Nov 6;9(1):16131. doi: 10.1038/s41598-019-52718-0.
644 The Vitamin D Analog, MART-10, Attenuates Triple Negative Breast Cancer Cells Metastatic Potential.Int J Mol Sci. 2016 Apr 21;17(4):606. doi: 10.3390/ijms17040606.
645 Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progression.EBioMedicine. 2019 Feb;40:263-275. doi: 10.1016/j.ebiom.2018.12.032. Epub 2019 Jan 14.
646 MicroRNA-211-5p suppresses tumour cell proliferation, invasion, migration and metastasis in triple-negative breast cancer by directly targeting SETBP1.Br J Cancer. 2017 Jun 27;117(1):78-88. doi: 10.1038/bjc.2017.150. Epub 2017 Jun 1.
647 MiR-107 down-regulates SIAH1 expression in human breast cancer cells and silencing of miR-107 inhibits tumor growth in a nude mouse model of triple-negative breast cancer.Mol Carcinog. 2016 May;55(5):768-77. doi: 10.1002/mc.22320. Epub 2015 Apr 7.
648 Integrated Bioinformatics Data Analysis Reveals Prognostic Significance Of SIDT1 In Triple-Negative Breast Cancer.Onco Targets Ther. 2019 Oct 11;12:8401-8410. doi: 10.2147/OTT.S215898. eCollection 2019.
649 SIN3A and SIN3B differentially regulate breast cancer metastasis.Oncotarget. 2016 Nov 29;7(48):78713-78725. doi: 10.18632/oncotarget.12805.
650 Risk stratification of triple-negative breast cancer with core gene signatures associated with chemoresponse and prognosis.Breast Cancer Res Treat. 2019 Nov;178(1):185-197. doi: 10.1007/s10549-019-05366-x. Epub 2019 Jul 24.
651 SPHK1 regulates proliferation and survival responses in triple-negative breast cancer.Oncotarget. 2014 Aug 15;5(15):5920-33. doi: 10.18632/oncotarget.1874.
652 Schlafen12 Reduces the Aggressiveness of Triple Negative Breast Cancer through Post-Transcriptional Regulation of ZEB1 That Drives Stem Cell Differentiation.Cell Physiol Biochem. 2019;53(6):999-1014. doi: 10.33594/000000191.
653 Predicting Non-sentinel Lymph Node Metastases in Patients with a Positive Sentinel Lymph Node After Neoadjuvant Chemotherapy.Ann Surg Oncol. 2018 Oct;25(10):2867-2874. doi: 10.1245/s10434-018-6578-3. Epub 2018 Jun 28.
654 SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling.Mol Cell Biol. 2013 Aug;33(15):3011-25. doi: 10.1128/MCB.01443-12. Epub 2013 May 28.
655 PRL-3 engages the focal adhesion pathway in triple-negative breast cancer cells to alter actin structure and substrate adhesion properties critical for cell migration and invasion.Cancer Lett. 2016 Oct 1;380(2):505-512. doi: 10.1016/j.canlet.2016.07.017. Epub 2016 Jul 21.
656 Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.BMC Cancer. 2014 Feb 3;14:57. doi: 10.1186/1471-2407-14-57.
657 Use of Antimetastatic SOD3-Mimetic Albumin as a Primer in Triple Negative Breast Cancer.J Oncol. 2019 Feb 28;2019:3253696. doi: 10.1155/2019/3253696. eCollection 2019.
658 PD1 protein expression in tumor infiltrated lymphocytes rather than PDL1 in tumor cells predicts survival in triple-negative breast cancer.Cancer Biol Ther. 2018 May 4;19(5):373-380. doi: 10.1080/15384047.2018.1423919. Epub 2018 Feb 16.
659 Magnetic resonance imaging and molecular features associated with tumor-infiltrating lymphocytes in breast cancer.Breast Cancer Res. 2018 Sep 3;20(1):101. doi: 10.1186/s13058-018-1039-2.
660 Suppressive role exerted by microRNA-29b-1-5p in triple negative breast cancer through SPIN1 regulation.Oncotarget. 2017 Apr 25;8(17):28939-28958. doi: 10.18632/oncotarget.15960.
661 LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer.Oncogene. 2018 Nov;37(47):6166-6179. doi: 10.1038/s41388-018-0396-8. Epub 2018 Jul 12.
662 SAR optimization studies on a novel series of 2-anilinopyrimidines as selective inhibitors against triple-negative breast cancer cell line MDA-MB-468.Bioorg Med Chem Lett. 2019 Dec 15;29(24):126752. doi: 10.1016/j.bmcl.2019.126752. Epub 2019 Oct 24.
663 SSBP1 Suppresses TGF-Driven Epithelial-to-Mesenchymal Transition and Metastasis in Triple-Negative Breast Cancer by Regulating Mitochondrial Retrograde Signaling.Cancer Res. 2016 Feb 15;76(4):952-64. doi: 10.1158/0008-5472.CAN-15-1630. Epub 2015 Dec 16.
664 Hypoxia and serum deprivation induces glycan alterations in triple negative breast cancer cells.Biol Chem. 2018 Jun 27;399(7):661-672. doi: 10.1515/hsz-2018-0121.
665 MiR-214-3p regulates the viability, invasion, migration and EMT of TNBC cells by targeting ST6GAL1.Cytotechnology. 2019 Dec;71(6):1155-1165. doi: 10.1007/s10616-019-00352-z. Epub 2019 Nov 8.
666 ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.Mol Cancer Ther. 2018 Dec;17(12):2689-2701. doi: 10.1158/1535-7163.MCT-18-0399. Epub 2018 Sep 20.
667 PARP Inhibitor Efficacy Depends on CD8(+) T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer.Cancer Discov. 2019 Jun;9(6):722-737. doi: 10.1158/2159-8290.CD-18-1218. Epub 2019 Apr 23.
668 Synaptopodin-2 suppresses metastasis of triple-negative breast cancer via inhibition of YAP/TAZ activity.J Pathol. 2018 Jan;244(1):71-83. doi: 10.1002/path.4995.
669 Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway.Cancer Biol Ther. 2019;20(5):617-632. doi: 10.1080/15384047.2018.1539290. Epub 2018 Nov 21.
670 Up-regulation and worse prognostic marker of cytoplasmic TARBP2 expression in obstinate breast cancer.Med Oncol. 2014 Apr;31(4):868. doi: 10.1007/s12032-014-0868-9. Epub 2014 Feb 22.
671 Phase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Therapy for Triple-Negative and BRCA1/2 Mutation-Associated Breast Cancer With Assessment of a Tumor-Based Measure of Genomic Instability: PrECOG 0105.J Clin Oncol. 2015 Jun 10;33(17):1895-901. doi: 10.1200/JCO.2014.57.0085. Epub 2015 Apr 6.
672 Prognostic significance of expression of epithelial-mesenchymal transition driver brachyury in breast cancer and its association with subtype and characteristics.Oncol Lett. 2018 Jan;15(1):1037-1045. doi: 10.3892/ol.2017.7402. Epub 2017 Nov 14.
673 Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer.Theranostics. 2019 Jan 24;9(3):761-777. doi: 10.7150/thno.29520. eCollection 2019.
674 Circ-TFCP2L1 Promotes the Proliferation and Migration of Triple Negative Breast Cancer through Sponging miR-7 by Inhibiting PAK1.J Mammary Gland Biol Neoplasia. 2019 Dec;24(4):323-331. doi: 10.1007/s10911-019-09440-4. Epub 2019 Nov 27.
675 Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer.Breast Cancer Res. 2014 Jul 1;16(4):R69. doi: 10.1186/bcr3684.
676 Class I histone deacetylase inhibitor suppresses vasculogenic mimicry by enhancing the expression of tumor suppressor and anti-angiogenesis genes in aggressive human TNBC cells.Int J Oncol. 2019 Jul;55(1):116-130. doi: 10.3892/ijo.2019.4796. Epub 2019 May 6.
677 Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant.PLoS One. 2017 Feb 24;12(2):e0172832. doi: 10.1371/journal.pone.0172832. eCollection 2017.
678 Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling.Cancer Cell. 2019 Jan 14;35(1):64-80.e7. doi: 10.1016/j.ccell.2018.11.016. Epub 2019 Jan 3.
679 MicroRNA-206 inhibits metastasis of triple-negative breast cancer by targeting transmembrane 4 L6 family member 1.Cancer Manag Res. 2019 Jul 22;11:6755-6764. doi: 10.2147/CMAR.S199027. eCollection 2019.
680 TMEM17 promotes malignant progression of breast cancer via AKT/GSK3 signaling.Cancer Manag Res. 2018 Aug 2;10:2419-2428. doi: 10.2147/CMAR.S168723. eCollection 2018.
681 Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl.Oncotarget. 2015 Sep 22;6(28):25034-45. doi: 10.18632/oncotarget.4379.
682 Mitochondria Targeting and Destabilizing Hyaluronic Acid Derivative-Based Nanoparticles for the Delivery of Lapatinib to Triple-Negative Breast Cancer.Biomacromolecules. 2019 Feb 11;20(2):835-845. doi: 10.1021/acs.biomac.8b01449. Epub 2018 Dec 28.
683 Tribbles Homolog 3 Involved in Radiation Response of Triple Negative Breast Cancer Cells by Regulating Notch1 Activation.Cancers (Basel). 2019 Jan 22;11(2):127. doi: 10.3390/cancers11020127.
684 Characterization of ceRNA network to reveal potential prognostic biomarkers in triple-negative breast cancer.PeerJ. 2019 Sep 9;7:e7522. doi: 10.7717/peerj.7522. eCollection 2019.
685 Apatinib + CPT-11 + S-1 for treatment of refractory brain metastases in patient with triple-negative breast cancer: Case report and literature review.Medicine (Baltimore). 2018 Apr;97(15):e0349. doi: 10.1097/MD.0000000000010349.
686 An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.Cancer Res. 2012 Nov 15;72(22):5812-23. doi: 10.1158/0008-5472.CAN-12-1098. Epub 2012 Nov 8.
687 Tumor suppressor function of Rab25 in triple-negative breast cancer.Int J Cancer. 2010 Jun 15;126(12):2799-812. doi: 10.1002/ijc.24900.
688 The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.Nat Cell Biol. 2015 Jan;17(1):81-94. doi: 10.1038/ncb3082. Epub 2014 Dec 22.
689 TIPIN depletion leads to apoptosis in breast cancer cells.Mol Oncol. 2015 Oct;9(8):1580-98. doi: 10.1016/j.molonc.2015.04.010. Epub 2015 May 9.
690 Thymosin beta 15A (TMSB15A) is a predictor of chemotherapy response in triple-negative breast cancer.Br J Cancer. 2012 Nov 20;107(11):1892-900. doi: 10.1038/bjc.2012.475. Epub 2012 Oct 18.
691 Common breast cancer susceptibility loci are associated with triple-negative breast cancer.Cancer Res. 2011 Oct 1;71(19):6240-9. doi: 10.1158/0008-5472.CAN-11-1266. Epub 2011 Aug 15.