Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM05FXR)

Drug Name
Meclofenamic acid Drug Info
Synonyms
Arquel; Meclofenamate; Acide meclofenamique; Acido meclofenamico; Acidum meclofenamicum; Meclophenamic acid; CL 583; INF 4668; Acide meclofenamique [INN-French]; Acido meclofenamico [INN-Spanish]; Acidum meclofenamicum [INN-Latin]; INF-4668; Meclomen (free acid); Meclofenamic acid (USAN/INN); Meclofenamic acid [USAN:INN:BAN]; N-(2,6-Dichloro-3-methylphenyl)anthranilic acid; N-(2,6-Dichloro-m-tolyl)anthranilic acid; N-(3-Methyl-2,6-dichlorophenyl)anthranilic acid; 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid; 2-(2,6-Dichloro-3-methylphenyl)aminobenzoic acid; 2-(2,6-dichloro-3-methylanilino)benzoic acid; 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid
Indication
Disease Entry ICD 11 Status REF
Ankylosing spondylitis FA92.0 Approved [1]
Dysmenorrhea GA34.3 Approved [2]
Joint pain ME82 Approved [1]
Menorrhagia GA20.50 Approved [2]
Osteoarthritis FA00-FA05 Approved [3]
Pain MG30-MG3Z Approved [4]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
4037
ChEBI ID
CHEBI:6710
CAS Number
CAS 644-62-2
TTD Drug ID
DM05FXR
INTEDE Drug ID
DR2291
ACDINA Drug ID
D00388

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase (COX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [12]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [13]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [14]
Dexibuprofen DMFYBD0 Ankylosing spondylitis FA92.0 Approved [15]
Ketorolac DMI4EL5 Postoperative inflammation 1A00-CA43.1 Approved [16]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [17]
Aceclofenac DMZDF0B Inflammation 1A00-CA43.1 Approved [18]
Lornoxicam DMYZFXN Migraine 8A80 Approved [19]
Morniflumate DM9UTDE Otitis media AA80-AB0Z Approved [20]
Nepafenac DMYK490 Osteoarthritis FA00-FA05 Approved [21]
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Drug(s) Metabolized By Cytochrome P450 102A1 (cyp102)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [22]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [6]
Propranolol DM79NTF Angina pectoris BA40 Approved [23]
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [22]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [24]
Chlorzoxazone DMCYVDT Acute pain MG31 Approved [24]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [22]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [22]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [6]
GEA-6414 DM8J0MK N. A. N. A. Phase 1/2 [6]
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Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [26]
Fructose DM43AN2 Vomiting MD90 Approved [27]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [28]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [31]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [32]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [33]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [34]
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Drug(s) Affected By Sulfotransferase 1E1 (SULT1E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [11]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Estrone DM5T6US Acne vulgaris ED80 Approved [36]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [11]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [36]
Ethanol DMDRQZU Chronic pain MG30 Approved [37]
Folic Acid DMEMBJC Colorectal carcinoma Approved [38]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [39]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [40]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [36]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [41]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [42]
Minoxidil DMA2Z4F Alopecia ED70 Approved [43]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [44]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [48]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Diazepam DM08E9O Alcohol withdrawal Approved [50]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [51]
Desogestrel DM27U4Y Contraception QA21 Approved [51]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [7]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [7]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [55]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [7]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [59]
Testosterone DM7HUNW Hot flushes GA30 Approved [60]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [55]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [61]
Diazepam DM08E9O Alcohol withdrawal Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [7]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [7]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [63]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [55]
Ethacrynic acid DM60QMR Edema MG29 Approved [62]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [7]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [59]
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Drug(s) Affected By Aldo-keto reductase family 1 member C4 (AKR1C4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Benzbromarone DMC3YUA Gout FA25 Approved [65]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [50]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [50]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [66]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [67]
Indomethacin DMSC4A7 Bursitis Approved [65]
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Drug(s) Affected By L-selectin (SELL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meloxicam DM2AR7L Arthritis FA20 Approved [9]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [70]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [9]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [71]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [9]
Phenylbutazone DMAYL0T Chronic pain MG30 Approved [9]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Inhibitor [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 102A1 (cyp102) Main DME DE4OGUF CPXB_BACMB Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [7]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [7]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [7]
Aldo-keto reductase family 1 member C4 (AKR1C4) OTW2MMOF AK1C4_HUMAN Gene/Protein Processing [8]
L-selectin (SELL) OT6RAJZR LYAM1_HUMAN Gene/Protein Processing [9]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) OT7FOIK2 LOX5_HUMAN Gene/Protein Processing [10]
Sulfotransferase 1A1 (SULT1A1) OT0K7JIE ST1A1_HUMAN Gene/Protein Processing [11]
Sulfotransferase 1E1 (SULT1E1) OTGPJ517 ST1E1_HUMAN Gene/Protein Processing [11]

References

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