Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0VQN3)

Drug Name

Ofloxacin Drug Info

Synonyms

Bactocin; DEXTROFLOXACINE; Danoflox; Effexin; Exocin; Exocine; Flobacin; Flodemex; Flotavid; Flovid; Floxal; Floxil; Floxin; Floxstat; Fugacin; Inoflox; Kinflocin; Kinoxacin; Liflox; Loxinter; Marfloxacin; Medofloxine; Mergexin; Novecin; Nufafloqo; OFLX; OFX; Obide; Occidal; Ocuflox; Ofcin; Oflin; Oflocee; Oflocet; Oflocin; Oflodal; Oflodex; Oflodura; Oflox; Ofloxacina; Ofloxacine; Ofloxacino; Ofloxacinum; Ofloxin; Ofus; Onexacin; Operan; Orocin; Otonil; Oxaldin; Pharflox; Praxin; Puiritol; Qinolon; Qipro; Quinolon; Quotavil; Rilox; Sinflo; Tabrin; Taravid; Tariflox; Tarivid; Telbit; Tructum; Viotisone; Visiren; XED; Zanocin; Floxin otic; Ofloxacin Otic; Ofloxacina [DCIT]; Ofloxacine [French]; Ofloxacino [Spanish]; Ofloxacinum [Latin]; Uro Tarivid; DL 8280; HOE 280; O 8757; ORF 18489; PT 01; DL-8280; FLOXIN IN DEXTROSE 5%; FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER; Floxin Otic (TN); HOE-280; Hoe-280; Marfloxacin (TN); O-Flox; ORF-28489; Ocuflox (TN); Ru-43280; WP-0405; Ofloxacin (JP15/USP/INN); Ofloxacin [USAN:BAN:INN:JAN]; Ofloxacin, (S)-Isomer; DL-8280, HOE-280, Exocin, Flobacin, Floxin, Floxil, Monoflocet, Ofloxacin; (+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperaz inyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; (+/-)-Floxin; (-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazin-6-carbonsaeure; 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Acute gonococcal cervicitis		Approved	[1]
Acute maxillary sinusitis		Approved	[1]
Anthrax	1B97	Approved	[1]
Bacillary dysentery	1A02	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Bronchitis	CA20	Approved	[1]
Chancroid		Approved	[1]
Chronic tubotympanic suppurative otitis media		Approved	[1]
Cystitis	GC00	Approved	[1]
Latent tuberculosis infection		Approved	[1]
Malignant otitis externa caused by Pseudomonas aeruginosa		Approved	[1]
Mycoplasma pneumoniae pneumonia		Approved	[1]
Pneumonia	CA40	Approved	[1]
Prostatitis		Approved	[1]
Pyelonephritis		Approved	[1]
Staphylococcal pneumonia		Approved	[1]
Staphylococcus aureus infection		Approved	[1]
Streptococcal pneumonia		Approved	[1]
Traveler's diarrhea	ME05.1	Approved	[1]
Urinary tract infection	GC08	Approved	[1]
Pneumonia caused by chlamydia		Investigative	[1]

Therapeutic Class

Antibiotics

Cross-matching ID

PubChem CID: 4583
ChEBI ID: CHEBI:7731
CAS Number: CAS 82419-36-1
TTD Drug ID: DM0VQN3
VARIDT Drug ID: DR00517
INTEDE Drug ID: DR2298
ACDINA Drug ID: D00483

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Bacterial DNA gyrase (Bact gyrase)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Grepafloxacin	DMGLX0T	Chronic bronchitis	CA20.1	Approved	[12]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[3]
Levofloxacin	DMS60RB	Acute maxillary sinusitis		Approved	[3]
Gatifloxacin	DMSL679	Acute gonococcal cervicitis		Approved	[3]
Norfloxacin	DMIZ6W2	Acute gonococcal cervicitis		Approved	[3]
Ozenoxacin	DM6KZMG	Impetigo	1B72	Approved	[13]
Sparfloxacin	DMB4HCT	Bacterial infection	1A00-1C4Z	Approved	[3]
Gemifloxacin	DMHT34O	Bacterial infection	1A00-1C4Z	Approved	[3]
Besifloxacin	DMPHXMI	Ocular inflammation	9C61.24	Approved	[14]
Finafloxacin	DMZEONG	Urinary tract infection	GC08	Approved	[15]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[18]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[21]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[23]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[24]
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Drug(s) Affected By Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[10]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[10]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[29]
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Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[10]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[31]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[10]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[5]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[5]
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Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[10]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[10]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[5]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[10]
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Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[10]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[37]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[10]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[5]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[5]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[10]
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Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[39]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[6]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[6]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[40]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[39]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[41]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[39]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[42]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[39]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[43]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[52]
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Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[8]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[8]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[8]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
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Drug(s) Affected By Integrin beta-4 (ITGB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[61]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[9]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
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Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[66]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[7]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[67]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[66]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[73]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[74]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[75]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[76]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[77]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[77]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[78]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[79]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[80]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[81]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[77]
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Drug(s) Affected By Rho GTPase-activating protein 45 (ARHGAP45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Indapamide	DMGN1PW	Edema	MG29	Approved	[8]
Cefepime	DMHVWIK	Bacterial infection	1A00-1C4Z	Approved	[8]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[83]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[85]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial DNA gyrase (Bact gyrase)	TTN6J5F	GYRA_STAAU; GYRB_STAAU	Modulator	[3]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Gene/Protein Processing	[5]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[6]
Collagenase 3 (MMP13)	OTY8BZIE	MMP13_HUMAN	Gene/Protein Processing	[7]
HLA class I histocompatibility antigen, alpha chain E (HLA-E)	OTX1CTFB	HLAE_HUMAN	Gene/Protein Processing	[8]
Integrin beta-4 (ITGB4)	OT28UK84	ITB4_HUMAN	Gene/Protein Processing	[9]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Gene/Protein Processing	[5]
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH)	OTUG4BWA	PAHX_HUMAN	Gene/Protein Processing	[10]
Potassium voltage-gated channel subfamily H member 2 (KCNH2)	OTZX881H	KCNH2_HUMAN	Protein Interaction/Cellular Processes	[11]
Protein DEPP1 (DEPP1)	OTB36PHJ	DEPP1_HUMAN	Gene/Protein Processing	[5]
Rho GTPase-activating protein 45 (ARHGAP45)	OTL86FEQ	HMHA1_HUMAN	Gene/Protein Processing	[8]

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