Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM458UM)

Drug Name

Captopril Drug Info

Synonyms

Acediur; Aceplus; Acepress; Acepril; Alopresin; Apopril; Asisten; Capoten; Captolane; Captoprilum; Captopryl; Captoril; Captril; Cesplon; Dilabar; Garranil; Hipertil; Hypertil; Isopresol; Lopirin; Lopril; MCO; Tenosbon; Tensiomin; Tensobon; Tensoprel; Lopirin [Switzerland]; C 4042; SA 333; SQ 14225; X8Z; Apopril (TN); Capoten (TN); Captoprilum [INN-Latin]; Garranil (discontinued); L-Captopril; SQ 14,225; SQ-14225; SQ-14534; SQ-14,225; SQ-14,534; Captopril (JP15/USP/INN); Captopril [USAN:INN:BAN:JAN]; D-3-Mercapto-2-methylpropionylproline; D-2-Methyl-3-mercaptopropanoyl-L-proline; D-3-Mercapto-2-methylpropanoyl-L-proline; [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline; N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline;(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline; (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid; (S)-1-(3-Mercapto-2-methyl-1-oxo-propyl)-L-proline; (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline; 1-((2S)-3-Mercapto-2-methylpropionyl)-L-proline; 1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline; 1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline (S,S); 1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline; 3-Mercapto-2-methylpropionyl-proline

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1] , [2]

Therapeutic Class

Antihypertensive Agents

Cross-matching ID

PubChem CID: 44093
ChEBI ID: CHEBI:3380
CAS Number: CAS 62571-86-2
TTD Drug ID: DM458UM
VARIDT Drug ID: DR00628
INTEDE Drug ID: DR0269
ACDINA Drug ID: D00096

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[7]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[8]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[9]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[10]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[12]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[13]
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[14]
Nicotine	DMWX5CO	Nicotine dependence	6C4A.2	Approved	[15]
Propranolol	DM79NTF	Migraine	8A80	Approved	[16]
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Drug(s) Metabolized By Thiopurine methyltransferase (TPMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[17]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[18]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[19]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Ergotidine	DM78IME	Respiratory allergy	4A80	Approved	[21]
Vitamin C	DMXJ7O8	Vitamin C deficiency	5B56	Approved	[22]
Cefazolin	DMPDYFR	Bacterial infection	1A00-1C4Z	Approved	[23]
Epinephrine	DM3KJBC	Allergy	4A80-4A85	Approved	[24]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[25]
Thioguanine	DM7NKEV	Acute myeloid leukaemia	2A60	Approved	[26]
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Drug(s) Transported By Peptide transporter 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[27]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[28]
Ampicillin	DMHWE7P	Bacterial infection	1A00-1C4Z	Approved	[29]
Losartan	DM72JXH	Hypertension	BA00-BA04	Approved	[30]
Enalapril	DMNFUZR	Hypertension	BA00-BA04	Approved	[31]
Cefazolin	DMPDYFR	Bacterial infection	1A00-1C4Z	Approved	[32]
Ceftriaxone	DMCEW64	Bacterial infection	1A00-1C4Z	Approved	[33]
Dexamethasone	DMMWZET	Rheumatoid arthritis	FA20	Approved	[28]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[30]
Irbesartan	DMTP1DC	Hypertension	BA00-BA04	Approved	[30]
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Drug(s) Targeting Angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Hypertension	BA00-BA04	Approved	[34]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[35]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[36]
Moexipril	DM26E4B	Hypertension	BA00-BA04	Approved	[37]
Ramipril	DM2R68E	Congestive heart failure	BD10	Approved	[38]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[39]
Trandolapril	DM4L6EU	Hypertension	BA00-BA04	Approved	[40]
Fosinopril	DM9NJ52	Hypertension	BA00-BA04	Approved	[41]
Lisinopril	DMUOK4C	Hypertension	BA00-BA04	Approved	[42]
Enalaprilat	DMPRBQV	Hypertension	BA00-BA04	Approved	[43]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin-converting enzyme (ACE)	TTL69WB	ACE_HUMAN	Inhibitor	[3]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[4]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[5]
Thiopurine methyltransferase (TPMT)	DEFQ8VO	TPMT_HUMAN	Substrate	[6]

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References

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37	Moexipril for treatment of primary biliary cirrhosis in patients with an incomplete response to ursodeoxycholic acid. Dig Dis Sci. 2010 Feb;55(2):476-83.
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