Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM50RUD)

Drug Name
brucine Drug Info
Synonyms 10,11-dimethoxy strychnine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
442021
ChEBI ID
CHEBI:3193
CAS Number
CAS 357-57-3
TTD Drug ID
DM50RUD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Muscarinic acetylcholine receptor (CHRM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetylcholine DMDF79Z Cataract 9B10 Approved [9]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [10]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [11]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [12]
Clidinium DMUMQZ0 Abdominal stomach pain DD91.4 Approved [13]
Oxybutynin hydrochloride DMF2KLU Urinary incontinence MF50.2 Approved [14]
Incruse Ellipta DM32GSJ Chronic obstructive pulmonary disease CA22 Approved [15]
Revefenacin DMMP5SI Chronic obstructive pulmonary disease CA22 Approved [16]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [17]
Isopropamide iodide DMQYV60 Allergic rhinitis CA08.0 Approved [18]
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Drug(s) Targeting Muscarinic acetylcholine receptor M3 (CHRM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolterodine DMSHPW8 Overactive bladder GC50.0 Approved [19]
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [20]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [21]
Ipratropium DMFQ320 Obstructive lung disease CA22.Z Approved [22]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [23]
Methacholine Chloride DMGS4QH Asthma CA23 Approved [24]
SMT-D002 DM1I93C Seborrhea ED91.2 Approved [25]
Solifenacin DMG592Q Overactive bladder GC50.0 Approved [26]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [27]
Cevimeline DMWSMND Sjogren syndrome 4A43.20 Approved [28]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [29]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Panobinostat DM58WKG Chronic graft versus host disease Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Testosterone DM7HUNW Hot flushes GA30 Approved [34]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Acetylcholine DMDF79Z Cataract 9B10 Approved [36]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [36]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [37]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [38]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [39]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [41]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [48]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [49]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [50]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [51]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [54]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [55]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [56]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [57]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [58]
Fructose DM43AN2 Vomiting MD90 Approved [59]
Ketoprofen DMRKXPT Bursitis Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [61]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [63]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
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Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Aripiprazole DM3NUMH Bipolar I disorder Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [72]
Ethacrynic acid DM60QMR Edema MG29 Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [74]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [75]
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Drug(s) Affected By Cathepsin D (CTSD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [82]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
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Drug(s) Affected By Muscarinic acetylcholine receptor M2 (CHRM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [86]
Gallamine Triethiodide DMPO0MS Stabilize muscle contraction FB3Z Approved [86]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Acetylcholine DMDF79Z Cataract 9B10 Approved [88]
Omadacycline DMR2J95 Acute bacterial skin infection 1C41 Approved [89]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [90]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [29]
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [91]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [92]
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Drug(s) Affected By Muscarinic acetylcholine receptor M4 (CHRM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ALCURONIUM DM2U4XQ Anaesthesia 9A78.6 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Acetylcholine DMDF79Z Cataract 9B10 Approved [88]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [8]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [94]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [29]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [29]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [92]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [95]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Selenium DM25CGV N. A. N. A. Approved [97]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [102]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [103]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [104]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [105]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [106]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [107]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [108]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Verapamil DMA7PEW Angina pectoris BA40 Approved [110]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [111]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [61]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [112]
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Drug(s) Affected By Protein-lysine 6-oxidase (LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [115]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Ethanol DMDRQZU Chronic pain MG30 Approved [118]
Ampicillin DMHWE7P Acute epiglottitis Approved [115]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [119]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [120]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [121]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [111]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [122]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [123]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [124]
Meloxicam DM2AR7L Arthritis FA20 Approved [125]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [126]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [127]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [105]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Verapamil DMA7PEW Angina pectoris BA40 Approved [110]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [128]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [122]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [129]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Meloxicam DM2AR7L Arthritis FA20 Approved [131]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [132]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor (CHRM) TTOXS3C NOUNIPROTAC Modulator (allosteric modulator) [2]
Muscarinic acetylcholine receptor M3 (CHRM3) TTQ13Z5 ACM3_HUMAN Modulator (allosteric modulator) [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [3]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [4]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [5]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [6]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Gene/Protein Processing [3]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Gene/Protein Processing [3]
Muscarinic acetylcholine receptor M2 (CHRM2) OTUMZ2WR ACM2_HUMAN Protein Interaction/Cellular Processes [7]
Muscarinic acetylcholine receptor M3 (CHRM3) OTKSD095 ACM3_HUMAN Protein Interaction/Cellular Processes [7]
Muscarinic acetylcholine receptor M4 (CHRM4) OTF0F0FF ACM4_HUMAN Protein Interaction/Cellular Processes [8]

References

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26 Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout ... Eur J Pharmacol. 2009 Aug 1;615(1-3):201-6.
27 Interaction of neuromuscular blocking drugs with recombinant human m1-m5 muscarinic receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1998 Nov;125(5):1088-94.
28 Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor ... Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G112-G123.
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36 Assessment of false transmitters as treatments for nerve agent poisoning. Toxicol Lett. 2020 Mar 15;321:21-31. doi: 10.1016/j.toxlet.2019.12.010. Epub 2019 Dec 9.
37 Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
38 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
39 Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
40 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
41 Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
42 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
43 Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
44 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
45 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
46 A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
47 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
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49 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
50 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
51 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
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53 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
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56 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
57 Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
58 A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
59 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
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