Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6D7N8)

Drug Name
Propylthiouracil Drug Info
Synonyms
propylthiouracil; 51-52-5; 6-Propyl-2-thiouracil; Propacil; Prothyran; Prothiurone; Procasil; Propycil; Thiuragyl; Protiural; Prothiucil; Prothycil; Propyl-Thiorist; Propyl-Thyracil; 2-Mercapto-6-propylpyrimidin-4-ol; 6-N-Propylthiouracil; Propythiouracil; Propilthiouracil; Propyl-Thiorit; Propylthiorit; 6-Propylthiouracil; Propylthiouracile; Thyreostat II; 6-propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; Propiltiouracilo; 6-N-Propyl-2-thiouracil; 6-Thio-4-propyluracil; PTU (thyreostatic); Propylthiouracilum; 4-Propyl-2-thiouracil; Procasil; Propiltiouracile; PROPYL THIOURACIL; Propiltiouracile [DCIT]; Thyreos tat ii; HC210060; Propiltiouracilo [INN-Spanish]; Propylthiouracil (TN); Propylthiouracile [INN-French]; Propylthiouracilum [INN-Latin]; Ptu(thyreostatic); T0517-6237; Thyreostat propyl-thyracil; Propylthiouracil [INN:BAN:JAN]; Propylthiouracil (JP15/USP/INN); 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone; 2-Mercapto-4-hydroxy-6-n-propylpyrimidine; 2-Mercapto-6-propyl-4-pyrimidone; 2-Mercapto-6-propylpyrimid-4-one; 2-Thio-4-oxo-6-propyl-1,3-pyrimidine; 2-Thio-6-propyl-1,3-pyrimidin-4-one; 4-Hydroxy-2-mercapto-6-propylpyrimidine; 6 Propyl 2 Thiouracil; 6-(n-Propyl)-2-thiouracil; 6-Prop yl-2-thiouracil; 6-Propil-tiouracile; 6-Propil-tiouracile [Italian]; 6-Propyl-2-thio-2,4(1H,3H)-pyrimidinedione; 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione; 6-n-PROPYL-2-MERCAPTO-4-HYDROXYPYRIMIDINE; 6-propyl-2 thiouracil; 6-propyl-2-sulfanylidene-1H-pyrimidin-4-one; 6-propyl-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one; 6-propyl-2-thiopyrimidine-2,4(1H,3H)-dione; Propyl thiouracile
Indication
Disease Entry ICD 11 Status REF
Hyperthyroidism 5A02 Approved [1]
Thyroid crisis Approved [2]
Therapeutic Class
Antithyroid Agents
Cross-matching ID
PubChem CID
657298
ChEBI ID
CHEBI:8502
CAS Number
CAS 51-52-5
TTD Drug ID
DM6D7N8
ACDINA Drug ID
D00566

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Thyroid peroxidase (TPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbimazole DMULAI4 Hyperthyroidism 5A02 Approved [10]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [10]
TPO gene plasmid DMFL5XU Thrombocytopenia 3B64 Investigative [11]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [25]
Testosterone DM7HUNW Hot flushes GA30 Approved [44]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
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Drug(s) Affected By Taste receptor type 2 member 38 (TAS2R38)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [12]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [13]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [14]
PHENYLTHIOUREA DMM1IAU Discovery agent N.A. Investigative [12]
Drug(s) Affected By T-box transcription factor TBX3 (TBX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [7]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Panobinostat DM58WKG Chronic graft versus host disease Approved [19]
Leflunomide DMR8ONJ Arthritis FA20 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [7]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [22]
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Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [5]
Diazepam DM08E9O Alcohol withdrawal Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Selenium DM25CGV N. A. N. A. Approved [23]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [5]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [5]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [5]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [5]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [5]
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Drug(s) Affected By Thyroglobulin (TG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [25]
Testosterone DM7HUNW Hot flushes GA30 Approved [26]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [26]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [27]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [29]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [30]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
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Drug(s) Affected By Myeloperoxidase (MPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dapsone DM4LT8A Acne vulgaris ED80 Approved [32]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [33]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [32]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [35]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [36]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [39]
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Drug(s) Affected By Cathepsin B (CTSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [47]
Selenium DM25CGV N. A. N. A. Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [51]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [52]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [53]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [54]
Gefitinib DM15F0X Colon adenocarcinoma Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [57]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [7]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
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Drug(s) Affected By Integrin beta-5 (ITGB5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [7]
Panobinostat DM58WKG Chronic graft versus host disease Approved [63]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [7]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [65]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [7]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [22]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [66]
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Drug(s) Affected By Low-density lipoprotein receptor-related protein 2 (LRP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Panobinostat DM58WKG Chronic graft versus host disease Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [70]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [63]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [71]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [9]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [9]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [73]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [74]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [9]
Ethacrynic acid DM60QMR Edema MG29 Approved [9]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [9]
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Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Selenium DM25CGV N. A. N. A. Approved [23]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [79]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [82]
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Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [83]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [7]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [88]
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Drug(s) Affected By Krueppel-like factor 9 (KLF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Selenium DM25CGV N. A. N. A. Approved [23]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [7]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [92]
Leflunomide DMR8ONJ Arthritis FA20 Approved [20]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
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Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [93]
Diazepam DM08E9O Alcohol withdrawal Approved [5]
Dantrolene DM1D8XY Hyperthermia MG26 Approved [5]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [5]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [5]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [5]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [5]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [5]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [5]
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Drug(s) Affected By Carbonic anhydrase 6 (CA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Arsenic DMTL2Y1 N. A. N. A. Approved [95]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [96]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [97]
Drug(s) Affected By Basic salivary proline-rich protein 1 (PRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [13]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Iodothyronine deiodinase type I (DIO1) TTU3X26 IOD1_HUMAN Inhibitor [3]
Thyroid peroxidase (TPO) TT52XDZ PERT_HUMAN Inhibitor [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Gene/Protein Processing [5]
Basic salivary proline-rich protein 1 (PRB1) OTV0SYMD PRP1_HUMAN Drug Response [6]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [7]
Carbonic anhydrase 6 (CA6) OTIX56CJ CAH6_HUMAN Drug Response [6]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Gene/Protein Processing [8]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Gene/Protein Processing [7]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Gene/Protein Processing [7]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Gene/Protein Processing [9]
Integrin beta-5 (ITGB5) OT21MF51 ITB5_HUMAN Gene/Protein Processing [7]
Krueppel-like factor 9 (KLF9) OTBFEJRQ KLF9_HUMAN Gene/Protein Processing [7]

References

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2 Propylthiouracil FDA Label
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