Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC0WNB)

Drug Name
Tetramethylpyrazine Drug Info
Synonyms Ligustizine; Ligustrazine; 2,3,5,6-Tetramethylpyrazine
Indication
Disease Entry ICD 11 Status REF
Neurological disorder 6B60 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
14296
ChEBI ID
CHEBI:133246
CAS Number
CAS 1124-11-4
TTD Drug ID
DMC0WNB

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Affected By Apolipoprotein C-III (APOC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [9]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [10]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [11]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [8]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [8]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [13]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [14]
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Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [15]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Ethanol DMDRQZU Chronic pain MG30 Approved [19]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [20]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [21]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [22]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [23]
Anacetrapib DMP2BFG Arteriosclerosis BD40 Phase 3 [23]
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Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [26]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [27]
Leflunomide DMR8ONJ Arthritis FA20 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [29]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [30]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [31]
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Drug(s) Affected By Acid-sensing ion channel 3 (ASIC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Arsenic DMTL2Y1 N. A. N. A. Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [34]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [35]
Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [10]
Fluoxetine DM3PD2C Bipolar depression Approved [38]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [11]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [39]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [45]
Haloperidol DM96SE0 Delirium Approved [22]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [48]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [10]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [57]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [60]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [61]
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Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [63]
Ethanol DMDRQZU Chronic pain MG30 Approved [64]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [63]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [65]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [66]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [67]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [68]
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Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [22]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Diazepam DM08E9O Alcohol withdrawal Approved [70]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [73]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
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Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Aripiprazole DM3NUMH Bipolar I disorder Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [82]
Ethacrynic acid DM60QMR Edema MG29 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [85]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [86]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [87]
Verapamil DMA7PEW Angina pectoris BA40 Approved [88]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Selenium DM25CGV N. A. N. A. Approved [91]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [92]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
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Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivacaftor DMZC1HS Cystic fibrosis CA25 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [9]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Miglustat DM5J64S Niemann-Pick disease type C Approved [97]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [98]
Milrinone DM8TUPF Congestive heart failure BD10 Approved [95]
Oxidized glutathione DM9EQC0 Breast cancer 2C60-2C65 Approved [99]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [101]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [102]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [107]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [108]
Testosterone DM7HUNW Hot flushes GA30 Approved [109]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [110]
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Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [112]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [113]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [115]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [116]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [119]
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Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [123]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [124]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [125]
Testosterone DM7HUNW Hot flushes GA30 Approved [126]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [127]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [126]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [128]
Verapamil DMA7PEW Angina pectoris BA40 Approved [88]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [129]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Selenium DM25CGV N. A. N. A. Approved [130]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [131]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [132]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [10]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [134]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Endothelin-1 (EDN1) TTJR60Z EDN1_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acid-sensing ion channel 3 (ASIC3) OTE9SSM4 ASIC3_HUMAN Gene/Protein Processing [3]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [4]
Apolipoprotein C-III (APOC3) OTW3520C APOC3_HUMAN Gene/Protein Processing [3]
Catalase (CAT) OTHEBX9R CATA_HUMAN Gene/Protein Processing [5]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [4]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Gene/Protein Processing [4]
Cystic fibrosis transmembrane conductance regulator (CFTR) OT6B22QH CFTR_HUMAN Gene/Protein Processing [6]
Cytochrome P450 11B1, mitochondrial (CYP11B1) OTKKL894 C11B1_HUMAN Gene/Protein Processing [3]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Gene/Protein Processing [4]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Gene/Protein Processing [7]

References

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2 Tetramethylpyrazine, a Chinese drug, blocks coronary vasoconstriction by endothelin-1 and decreases plasma endothelin-1 levels in experimental animals. J Cardiovasc Pharmacol. 1998;31 Suppl 1:S313-6.
3 Preparation of cardiovascular disease-related genes microarray and its application in exploring ligustrazine-induced changes in endothelial gene expression. Pol J Pharmacol. 2004 Jul-Aug;56(4):427-33.
4 Nrf2 knockdown attenuates the ameliorative effects of ligustrazine on hepatic fibrosis by targeting hepatic stellate cell transdifferentiation. Toxicology. 2016 Jul 15;365:35-47. doi: 10.1016/j.tox.2016.07.018. Epub 2016 Jul 28.
5 Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells. Food Chem Toxicol. 2017 Nov;109(Pt 2):930-940.
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8 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
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11 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
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13 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
14 Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
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18 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
19 Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats. Toxicol Appl Pharmacol. 2018 Apr 15;345:36-47.
20 Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R. Eur J Pharmacol. 2008 Apr 28;584(2-3):424-34. doi: 10.1016/j.ejphar.2008.02.001. Epub 2008 Feb 12.
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22 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
23 Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. J Pharmacol Exp Ther. 2015 Apr;353(1):27-34.
24 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
25 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
26 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
27 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
28 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
29 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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35 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
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38 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
39 Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages. Metabolism. 2003 May;52(5):652-7. doi: 10.1053/meta.2003.50100.
40 Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist. Biochem Pharmacol. 2010 May 1;79(9):1310-6. doi: 10.1016/j.bcp.2009.12.018. Epub 2010 Jan 8.
41 Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid. J Lipid Res. 2019 Apr;60(4):794-804. doi: 10.1194/jlr.M088880. Epub 2019 Feb 1.
42 Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1533-41. doi: 10.1016/j.bbrc.2005.04.071.
43 Inhibition of liver x receptor/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in vitro. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1228-36. doi: 10.1161/ATVBAHA.110.205500. Epub 2010 Mar 25.
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46 Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
47 Selenium deficiency alters epithelial cell morphology and responses to influenza. Free Radic Biol Med. 2007 Jun 15;42(12):1826-37.
48 Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: a quantitative study. Hepatology. 1991 Nov;14(5):811-7.
49 Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment. Eur Arch Psychiatry Clin Neurosci. 2004 Aug;254(4):231-5.
50 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
51 The effect of statins on lipids peroxidation and activities of antioxidants enzymes in patients with dyslipidemia. Przegl Lek. 2006;63(9):738-42.
52 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
53 Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
54 The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-). Food Funct. 2015 Apr;6(4):1098-107. doi: 10.1039/c5fo00076a.
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56 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
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