Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIW453)

Drug Name
Pelitinib Drug Info
Synonyms EKB-569; EKI-569; WAY-EKB-569
Indication
Disease Entry ICD 11 Status REF
Lymphoma 2A80-2A86 Phase 2 [1]
Cross-matching ID
PubChem CID
6445562
ChEBI ID
CHEBI:38927
CAS Number
CAS 257933-82-7
TTD Drug ID
DMIW453

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [5]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [6]
Gefitinib DM15F0X Colon adenocarcinoma Approved [7]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [8]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [9]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [10]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [11]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [12]
Epidermal growth factor DMVONE6 Vulnerary ND56.Z Approved [10]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [13]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [4]
Gefitinib DM15F0X Colon adenocarcinoma Approved [42]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [43]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [44]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [45]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [46]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Selenium DM25CGV N. A. N. A. Approved [48]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [49]
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Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [14]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [15]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [14]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [18]
Testosterone DM7HUNW Hot flushes GA30 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Ibrutinib DMHZCPO Mantle cell lymphoma 2A85.5 Approved [21]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [22]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [26]
Etretinate DM2CZFA Keratosis ED56 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
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Drug(s) Affected By B-cell lymphoma/leukemia 10 (BCL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Testosterone DM7HUNW Hot flushes GA30 Approved [35]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [37]
Menthol DMG2KW7 Back pain ME84.Z Approved [38]
Capsaicin DMGMF6V Back pain ME84.Z Approved [39]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
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Drug(s) Affected By Transcription factor Sp1 (SP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [56]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [57]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [58]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [61]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Verapamil DMA7PEW Angina pectoris BA40 Approved [63]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [64]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [66]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-1 (ATF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [71]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [72]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [70]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [73]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [74]
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Drug(s) Affected By B-cell lymphoma 3 protein (BCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Selenium DM25CGV N. A. N. A. Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Leflunomide DMR8ONJ Arthritis FA20 Approved [79]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [80]
Menthol DMG2KW7 Back pain ME84.Z Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [50]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [81]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [14]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [86]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [89]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [90]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [66]
Gefitinib DM15F0X Colon adenocarcinoma Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [94]
Selenium DM25CGV N. A. N. A. Approved [76]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [95]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [96]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [58]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [81]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Verapamil DMA7PEW Angina pectoris BA40 Approved [63]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [97]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [98]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Meloxicam DM2AR7L Arthritis FA20 Approved [101]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [102]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [26]
Selenium DM25CGV N. A. N. A. Approved [76]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [104]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [106]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [109]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 1 (NAIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [111]
Menthol DMG2KW7 Back pain ME84.Z Approved [38]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [112]
Bortezomib DMNO38U Leukemia Approved [113]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [114]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [115]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [116]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [117]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [118]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [81]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [119]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [120]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [123]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [124]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [125]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Gene/Protein Processing [3]
B-cell lymphoma/leukemia 10 (BCL10) OT47MCLI BCL10_HUMAN Gene/Protein Processing [3]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Gene/Protein Processing [3]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Gene/Protein Processing [3]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Cyclic AMP-dependent transcription factor ATF-1 (ATF1) OT251CI0 ATF1_HUMAN Gene/Protein Processing [3]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Gene/Protein Processing [4]

References

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2 EGFR tyrosine kinase inhibitor pelitinib regulates radiation-induced p65-dependent telomerase activation in squamous cell carcinoma.Radiat Res.2013 Mar;179(3):304-12.
3 Irreversible EGFR inhibitor EKB-569 targets low-LET -radiation-triggered rel orchestration and potentiates cell death in squamous cell carcinoma. PLoS One. 2011;6(12):e29705. doi: 10.1371/journal.pone.0029705. Epub 2011 Dec 29.
4 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
5 Nasopharyngeal carcinoma: Current treatment options and future directions. J Nasopharyng Carcinoma, 2014, 1(16): e16.
6 Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):13-7.
7 Gefitinib ('Iressa', ZD1839) and new epidermal growth factor receptor inhibitors. Br J Cancer. 2004 Feb 9;90(3):566-72.
8 Quantitative prediction of fold resistance for inhibitors of EGFR. Biochemistry. 2009 Sep 8;48(35):8435-48.
9 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
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11 Boehringer Ingelheim. Product Development Pipeline. June 2 2009.
12 Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles. J Med Chem. 2006 Dec 28;49(26):7868-76.
13 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
14 Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct;99(2):402-15. doi: 10.1111/j.1471-4159.2006.04005.x.
15 Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKbeta. Apoptosis. 2009 Jul;14(7):913-22. doi: 10.1007/s10495-009-0367-1.
16 Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. J Immunol. 2007 Feb 15;178(4):2507-16. doi: 10.4049/jimmunol.178.4.2507.
17 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
18 Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. J Biol Chem. 2005 Dec 9;280(49):41047-56. doi: 10.1074/jbc.M503713200. Epub 2005 Sep 30.
19 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
20 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
21 Blockade of oncogenic IB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11365-70. doi: 10.1073/pnas.1411701111. Epub 2014 Jul 21.
22 Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. Endocrinology. 2005 Mar;146(3):1491-7. doi: 10.1210/en.2004-0809. Epub 2004 Nov 24.
23 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
24 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
25 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
26 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
27 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
28 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
29 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
30 Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
31 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
32 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
33 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
34 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
35 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
36 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
37 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
38 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
39 Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
40 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
41 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
42 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
43 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
44 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
45 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
46 Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
47 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
48 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
49 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
50 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
51 Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Exp Cell Res. 2010 Aug 1;316(13):2174-88. doi: 10.1016/j.yexcr.2010.04.027. Epub 2010 May 8.
52 Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochem Pharmacol. 2008 May 15;75(10):1946-58. doi: 10.1016/j.bcp.2008.02.016. Epub 2008 Mar 10.
53 Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L419-28. doi: 10.1152/ajplung.00002.2005. Epub 2005 May 20.
54 Mechanistic basis for overcoming platinum resistance using copper chelating agents. Mol Cancer Ther. 2012 Nov;11(11):2483-94. doi: 10.1158/1535-7163.MCT-12-0580. Epub 2012 Aug 21.
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