Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIZJ8M)

• Drug Name: Psoralen Drug Info
• Synonyms: Psoralen; 66-97-7; 7H-Furo[3,2-g]chromen-7-one; Ficusin; Furocoumarin; Psoralene; 7H-Furo[3,2-g][1]benzopyran-7-one; Psorline-P; 6,7-Furanocoumarin; furo[3,2-g]chromen-7-one; Furo[3,2-g]coumarin; Furo(4',5',6,7)coumarin; Furo(2',3',7,6)coumarin; Furo(3,2-g)-coumarin; Furo[4',5':6,7]coumarin; Furo[2',3':7,6]coumarin; NSC 404562; UNII-KTZ7ZCN2EX; 7H-Furo(3,2-g)(1)benzopyran-7-one; 7H-Furo[3,2-g]benzopyran-7-one; CCRIS 4343; Furo[2'.3':7.6]coumarin; HSDB 3528; KTZ7ZCN2EX; EINECS 200-639-7; 6-Hydroxy-5-benzofuranacrylic acid beta-lacto
• Cross-matching ID:
  PubChem CID: 6199
  ChEBI ID: CHEBI:27616
  CAS Number: CAS 66-97-7
  TTD Drug ID: DMIZJ8M

Molecule-Related Drug Atlas

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[4]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[5]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[6]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[7]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[8]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[9]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[10]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[11]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[12]
Budipine	DMODHQI	Migraine	8A80	Approved	[13]

Drug(s) Targeting Monoamine oxidase type A (MAO-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Moclobemide	DMNZWL7	Depression	6A70-6A7Z	Approved	[14]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[15]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[16]
Isocarboxazid	DMAF1NB	Depression	6A70-6A7Z	Approved	[17]
TRYPTAMINE	DMAFPHB	N. A.	N. A.	Phase 3	[18]
CHF-3381	DMQ2O8V	Neuropathic pain	8E43.0	Phase 2	[19]
Ladostigil	DMJSY3Q	Alzheimer disease	8A20	Phase 2	[20]
CX157	DMS2WB5	Mood disorder	6A60-6E23	Phase 2	[21]
PIPERINE	DMYEAB1	Vitiligo	ED63.0	Phase 1/2	[22]
Desoxypeganine	DMTR7EH	Alcohol dependence	6C40.2	Phase 1	[23]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[24]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[27]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[29]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[30]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[31]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[32]

Drug(s) Affected By Tyrosine-protein kinase ABL1 (ABL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[33]
Anagrelide	DMSQ8MD	Thrombocythemia	3B63	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[40]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[44]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[46]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[47]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[50]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[51]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Selenium	DM25CGV	N. A.	N. A.	Approved	[54]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[55]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[56]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[57]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[56]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[63]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[65]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[67]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[51]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[52]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[71]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[76]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[65]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[82]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[83]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[84]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[85]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[88]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[89]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[95]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[96]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[97]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[94]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[98]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[99]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[89]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[101]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[103]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[105]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[106]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[113]
Selenium	DM25CGV	N. A.	N. A.	Approved	[54]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[114]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[117]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[54]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[122]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[128]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[51]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[42]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[56]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[57]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[59]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[2]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[2]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[2]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Gene/Protein Processing	[2]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)	OTAFHAVI	ATF6A_HUMAN	Gene/Protein Processing	[2]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Gene/Protein Processing	[3]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Gene/Protein Processing	[2]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Gene/Protein Processing	[2]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Post-Translational Modifications	[2]
Eukaryotic translation initiation factor 2A (EIF2A)	OTWXELQP	EIF2A_HUMAN	Gene/Protein Processing	[2]

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