Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML8KTN)

Drug Name
Danazol Drug Info
Synonyms
Anatrol; Chronogyn; Cyclomen; Danatrol; Danazant; Danazole; Danazolum; Danocrine; Danogen; Danokrin; Danol; Danoval; Danzol; Ladogal; Norciden; Panacrine; Winobanin; Alphapharm Brand of Danazol; Antigen Brand of Danazol; Kendrick Brand of Danazol; Ratiopharm Brand of Danazol; Sanofi Brand of Danazol; Sanofi Synthelabo Brand ofDanazol; Sanofi Winthrop Brand of Danazol; WIN 17757; Danazol-ratiopharm; Danazolum [INN-Latin]; Danocrine (TN); WIN 17,757; WIN-17757; Win 17, 757; Danazol (JAN/USP/INN); Danazol [USAN:BAN:INN:JAN];[1,2]oxazolo[4',5':2,3]-17alpha-pregn-4-en-20-yn-17-ol; (1R,3aS,3bR,10aR,10bS,12aS)-1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol; (1S,2R,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4(8),5,9-trien-17-ol; 1-Ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol; 17-alpha-2,4-Pregnadien-20-yno(2,3-d)isoxazol-17-ol; 17-alpha-Pregn-4-en-20-yno(2,3-d)isoxazol-17-ol; 17-alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol; 17.Alpha.-Pregna-2, {4-dien-20-yno[2,3-d]isoxazol-17-ol}; 17alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol
Indication
Disease Entry ICD 11 Status REF
Menorrhagia GA20.50 Approved [1]
Breast cancer 2C60-2C65 Phase 2 [1]
Breast fibrocystic disease Investigative [2]
Endometriosis GA10 Investigative [2]
Therapeutic Class
Fertility Agents
Cross-matching ID
PubChem CID
28417
ChEBI ID
CHEBI:4315
CAS Number
CAS 17230-88-5
TTD Drug ID
DML8KTN
INTEDE Drug ID
DR2401
ACDINA Drug ID
D00165

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [12]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [13]
Estrone DM5T6US Acne vulgaris ED80 Approved [13]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [14]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [14]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [14]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [15]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [16]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [17]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [18]
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Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Testosterone DM7HUNW Hot flushes GA30 Approved [21]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [25]
Ethanol DMDRQZU Chronic pain MG30 Approved [26]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [4]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [27]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [28]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [28]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [29]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [27]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [28]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [30]
Gefitinib DM15F0X Colon adenocarcinoma Approved [27]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [7]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [27]
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Drug(s) Affected By Cytochrome P450 2J2 (CYP2J2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [35]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [38]
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Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [6]
Diazepam DM08E9O Alcohol withdrawal Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
Selenium DM25CGV N. A. N. A. Approved [40]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [6]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [6]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [6]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [6]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [6]
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Drug(s) Affected By Complement factor B (CFB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [45]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [46]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [48]
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Drug(s) Affected By Complement C3 (C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [52]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [56]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [52]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [57]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [10]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [58]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [59]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [61]
Ethacrynic acid DM60QMR Edema MG29 Approved [62]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [63]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [64]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [65]
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Drug(s) Affected By Plasma protease C1 inhibitor (SERPING1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [54]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [48]
Olanzapine DMPFN6Y Bipolar depression Approved [69]
Arsenic DMTL2Y1 N. A. N. A. Approved [70]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [71]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [72]
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Drug(s) Affected By Steryl-sulfatase (STS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [73]
Tazarotene DM8SMD1 Acne vulgaris ED80 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [75]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [74]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [73]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [76]
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Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [77]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [77]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [77]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [78]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [79]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [81]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [82]
Selenium DM25CGV N. A. N. A. Approved [83]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [84]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [85]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Gefitinib DM15F0X Colon adenocarcinoma Approved [88]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Etretinate DM2CZFA Keratosis ED56 Approved [91]
Prednisone DM2HG4X Acute asthma CA23 Approved [92]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [93]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [94]
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Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [95]
Diazepam DM08E9O Alcohol withdrawal Approved [6]
Dantrolene DM1D8XY Hyperthermia MG26 Approved [6]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [6]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [6]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [6]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [6]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [6]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Antagonist [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [4]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Gene/Protein Processing [5]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Gene/Protein Processing [6]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [7]
Complement C3 (C3) OTCH5GS0 CO3_HUMAN Gene/Protein Processing [8]
Complement factor B (CFB) OTZITNEJ CFAB_HUMAN Gene/Protein Processing [8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [9]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [10]
Cytochrome P450 2J2 (CYP2J2) OTJBTEH8 CP2J2_HUMAN Gene/Protein Processing [11]
Plasma protease C1 inhibitor (SERPING1) OT6CVN45 IC1_HUMAN Gene/Protein Processing [8]

References

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2 Danazol FDA Label
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