Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU3DNC)

Drug Name
Pentoxifylline Drug Info
Synonyms
Agapurin; Azupentat; Dimethyloxohexylxanthine; Durapental; Hemovas; Ikomio; Oxpentifylline; PENTOXYPHYLINE;PNX; Pentoxifilina; Pentoxifyllin; Pentoxifyllinum; Pentoxil; Pentoxiphyllin; Pentoxiphylline; Pentoxiphyllium; Pentoxyfylline; Pentoxyphyllin; Pentoxyphylline; Ralofect; Rentylin; Torental; Trental;Vasofirin; Vazofirin; Agapurin Retard; BL 191; BL191; EHT 0201; EHT0201; IN1161; P 1784; Artal (TN); BL-191; EHT-0201; EHT-201; Flexital (TN); Pentox (TN); Pentoxifilina [INN-Spanish]; Pentoxifyllinum [INN-Latin]; Pentoxil (TN); Pentoxin (TN); Trental (TN); Cis-9-Octadecenoyl coenzyme A; Pentoxifylline [USAN:INN:JAN]; Pentoxifylline (JAN/USP/INN); 1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion; 1-(5-Oxohexyl)-3,7-dimethylxanthine; 1-(5-Oxohexyl)theobromine; 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione; 3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione; 3,7-Dimethyl-1-(5-oxohexyl) xantine; 3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione; 3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione; 3,7-Dimethyl-1-(5-oxohexyl)xanthine; 3,7-Dimethyl-1-(5-oxohexyl)xantine; 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
Indication
Disease Entry ICD 11 Status REF
Alcoholic hepatitis DB94.1 Approved [1]
Intermittent claudication BD40.00 Approved [2]
Type-1 diabetes 5A10 Approved [1]
Peripheral vascular disease BD4Z Investigative [1]
Therapeutic Class
Vasodilator Agents
Cross-matching ID
PubChem CID
4740
ChEBI ID
CHEBI:7986
CAS Number
CAS 6493-05-6
TTD Drug ID
DMU3DNC
INTEDE Drug ID
DR1255
ACDINA Drug ID
D00517

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [6]
Nafamostat DMU1XOD Pancreatitis DC31-DC34 Approved [7]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [8]
Enbrel DM7RNP3 Arthritis FA20 Approved [9]
Golimumab DMHZV7X Psoriatic arthritis FA21 Approved [10]
Certolizumab DM5CL9Z Rheumatoid arthritis FA20 Approved [11]
Etanercept DMCV109 Arthritis FA20 Approved [12]
Adalimumab DMQMV1B Crohn disease DD70 Approved [13]
Infliximab DMH7OIA Crohn disease DD70 Approved [14]
Golnerminogene pradenovac DMKWV4B Esophageal cancer 2B70 Phase 3 [15]
Indomethacin DMSC4A7 Bursitis Approved [35]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [36]
Fructose DM43AN2 Vomiting MD90 Approved [5]
Ketoprofen DMRKXPT Bursitis Approved [5]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [38]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [39]
Gefitinib DM15F0X Colon adenocarcinoma Approved [40]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [16]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [17]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [21]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [22]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [23]
Verapamil DMA7PEW Angina pectoris BA40 Approved [24]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [25]
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Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Verapamil DMA7PEW Angina pectoris BA40 Approved [27]
Selenium DM25CGV N. A. N. A. Approved [28]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [33]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [34]
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Drug(s) Affected By Thrombomodulin (THBD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [50]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [51]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [52]
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Drug(s) Affected By Matrix metalloproteinase-14 (MMP14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [28]
Panobinostat DM58WKG Chronic graft versus host disease Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [55]
Clozapine DMFC71L Schizophrenia 6A20 Approved [56]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [57]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [58]
Cysteamine DMSYFM8 Nephropathic cystinosis 5C60 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Perforin-1 (PRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Testosterone enanthate DMB6871 N. A. N. A. Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Menthol DMG2KW7 Back pain ME84.Z Approved [62]
Bortezomib DMNO38U Leukemia Approved [63]
Arsenic DMTL2Y1 N. A. N. A. Approved [64]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [65]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [66]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [67]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [68]
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Drug(s) Affected By Granzyme B (GZMB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [70]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [71]
Menthol DMG2KW7 Back pain ME84.Z Approved [62]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [72]
Bortezomib DMNO38U Leukemia Approved [63]
Ethambutol DMR87LC Pulmonary tuberculosis 1B10.Z Approved [70]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [73]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [74]
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Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [76]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [76]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [81]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [83]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [84]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [86]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor necrosis factor (TNF) TTF8CQI TNFA_HUMAN Not Available [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Granzyme B (GZMB) OTPPVIRS GRAB_HUMAN Drug Response [5]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Drug Response [5]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Drug Response [5]
Matrix metalloproteinase-14 (MMP14) OT9C197Z MMP14_HUMAN Drug Response [5]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Drug Response [5]
Perforin-1 (PRF1) OTFVXD7H PERF_HUMAN Drug Response [5]
Thrombomodulin (THBD) OT8VHLKY TRBM_HUMAN Drug Response [5]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Drug Response [5]

References

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35 Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
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37 CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
38 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
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42 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
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48 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
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54 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
55 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
56 Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
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58 Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
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63 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
64 Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
65 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
66 Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D-dependent pathways. J Cell Physiol. 2010 May;223(2):343-51. doi: 10.1002/jcp.22043.
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69 All-trans retinoic acid negatively regulates cytotoxic activities of nature killer cell line 92. Biochem Biophys Res Commun. 2007 Jan 5;352(1):42-7. doi: 10.1016/j.bbrc.2006.10.132. Epub 2006 Nov 2.
70 Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. Chem Res Toxicol. 2016 Nov 21;29(11):1793-1795. doi: 10.1021/acs.chemrestox.6b00393. Epub 2016 Nov 9.
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75 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
76 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
77 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
78 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
79 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
80 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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